People

• El Güero Gil (d. 1999), nickname for Alfredo Gil, Mexican guitarist/vocalist, co-founder of trio Los Panchos and inventor of the Requinto guitar
• El Güero Jaibo (d. 1993), aka Juan Francisco Murillo Díaz, a member of the Tijuana Cartel
• El Güero Loco, one of the many aliases of Ivan Martin, a member of the Chicano Hip-hop group, Delinquent Habits.
• El Güero Palma, nickname for Héctor Luis Palma Salazar, a Mexican drug trafficker
• White Mexicans in general

Arts, entertainment, and media

• Guero (book) ("Later"), a 1643 Basque-language book by Pedro Agerre
• Guero Davila, a character in Queen of the South

Films

• El Güero Estrada (1997), Mexican film directed by Gilberto De Anda and scored by Gustavo Ramírez Reyes
• Güeros (2014), Mexican film directed by Alonso Ruizpalacios

Music

• Guero (1970), a piano study by German composer Helmut Lachenmann
• Guero (2005), an album by Beck
• Guerolito (2005), a remix album by Beck, featuring all of the songs from Guero except for the hidden track, "Send a Message to Her"
• Matando Gueros (1993), an album by the Mexican metal-band Brujeria