Once Upon a Time... Life brought back the edutainment formula that has Once Upon a Time... Man but that had been left out on Once Upon a Time... Space. The series combined entertaining story lines with factual information, presented metaphorically.
The series used the same recurring lead characters as the other series in the Once Upon a Time... franchise: certain represent the cells that make up the body's systems and defense mechanisms, such as red blood cells, white blood cells and platelets, while antagonists represent viruses and bacteria that threaten to attack the human body. Every episode of the series featured a different organ or system within the human body (like the brain, the heart, the circulatory system, etc.).
In addition to its countries of origin, the series was also aired in the Arab states of the Persian Gulf, Armenia, Australia, Austria, Brazil, Chile, Croatia, Czechoslovakia, Denmark, Finland, Gabon, Germany, Greece, Haiti, Hungary, Iceland, Ireland, Israel, Italy, Kenya, Liechtenstein, Mauritius, Mexico, Morocco, Norway, Poland, Portugal, Romania, the Soviet Union, Senegal, Singapore, Slovakia, Slovenia, South Africa, South Korea, Sweden, Syria, Taiwan, Thailand, Turkey, the United Kingdom, Venezuela, Yugoslavia, and Zimbabwe.
The main theme music and instrumental score for the series as a whole are composed by Michel Legrand. The opening song "Hymne à la Vie" (French for "Hymn for Life") was performed in the original French-language version by Sandra Kim,3 winner of the Eurovision Song Contest 1986.4 The song was released as a single in 1986 by Carrere Records (14.148).5 In the English-language dub, its lyrics were translated and was retitled as "This Life is Life, That's Life!".6
A soundtrack album collecting all the instrumental music of the series was released in 2001 by Loga-Rythme (LR-677005) as a part of the Anime Classique range.78
All music is composed by Michel Legrand.
The series makes use of recurring human characters originally from both Once Upon a Time... Man and Once Upon a Time... Space. Every character in the series appeared as a real person (the old intelligent doctor, the dedicated blonde mother, the boy and the girl, their obese friend, and the pair of bullies) and anthropomorphic representations of cells and cellular functions within the human body.
The series describes a "society inside the body" with a strong pyramidal stratification of work.9
In some English-language versions, the title is rendered as "Once Upon a Time – Life" in the opening credits.
A partwork version called How My Body Works was produced for the United Kingdom in 50 hardback volumes, each with about 30 A4-sized pages, described as "an Orbis play & learn collection". In it, some of the characters have different names: The Professor for the Maestro; Captain Courageous and Ace for the lymphocyte B crafts' pilots; Plasmus and Globina for Hemo and Globin, Corpo for Jumbo; Toxicus, Germus and Infectius for the bacterium characters; Virulus for the virus character. VHS copies of the English-language television episodes were included with issues.
A DVD box set of all the episodes of the series was produced by Procidis, and distributed locally by various distributors.10 The DVD series was produced in French, English, Polish, Finnish, German, Italian, Hebrew, Norwegian, Hungarian, Dutch and Swedish, but was not released in the United Kingdom. In 2011, the DVD box set was available in English in Canada, distributed by Imavision.
Full episodes are available on Youtube.11
Most biological terminology is translated with care, but a few mistakes were made and there are some anachronisms.
Known in Japan as The Science of Life: Micro Patrol (Japanese: 生命の科学ミクロパトロール, Hepburn: Seimei no Kagaku: Mikuro Patorōru) /wiki/Japanese_language ↩
"株式会社エイケン オフィシャルサイト". www.eiken-anime.jp (in Japanese). Retrieved 2025-01-29. https://eiken-anime.jp/works/%E7%94%9F%E5%91%BD%E3%81%AE%E7%A7%91%E5%AD%A6%E3%83%9F%E3%82%AF%E3%83%AD%E3%83%91%E3%83%88%E3%83%AD%E3%83%BC%E3%83%AB/ ↩
Archived at Ghostarchive and the Wayback Machine: "Il était une fois... La Vie - Le Générique". YouTube. 8 April 2017. https://ghostarchive.org/varchive/youtube/20211205/kNnpHAszq64 ↩
"Final of Bergen 1986". European Broadcasting Union. Archived from the original on 16 April 2021. Retrieved 16 April 2021. https://eurovision.tv/event/bergen-1986/final ↩
"Sandra Kim – Hymne À La Vie". Discogs. 1986. Retrieved 5 July 2025. https://www.discogs.com/release/6091517-Sandra-Kim-Hymne-À-La-Vie ↩
Once Upon a Time... (Hello Maestro) (2011-03-30). Once upon a time... Life - Opening Theme. Retrieved 2025-01-29 – via YouTube. https://www.youtube.com/watch?v=imP2MZxoM-s ↩
"Il Était Une Fois... La Vie- Soundtrack details - SoundtrackCollector.com". Soundtrack Collector.com. 2002. Retrieved 5 July 2025. https://www.soundtrackcollector.com/title/91518/Il+Était+Une+Fois...+La+Vie ↩
"Michel Legrand – Il Etait Une Fois... La Vie (Bande Originale Du Dessin Animé)". Discogs. 2001. Retrieved 5 July 2025. https://www.discogs.com/release/764425-Michel-Legrand-Il-Etait-Une-Fois-La-Vie-Bande-Originale-Du-Dessin-Animé ↩
Brodesco, Alberto (2011). "I've Got you under my Skin: Narratives of the Inner Body in Cinema and Television". Nuncius: Journal of the Material and Visual History of Science. 26 (1): 214. doi:10.1163/182539111x569829. PMID 21936210. Retrieved 24 August 2012. https://unitn.academia.edu/AlbertoBrodesco/Papers/824001/_Ive_Got_you_under_my_Skin_Narratives_of_the_Inner_Body_in_Cinema_and_Television_Nuncius._Journal_of_the_material_and_visual_history_of_science_vol._26_Ways_of_Voyaging_Through_the_Human_Body_2011_pp._201-221 ↩
"Procidis - Collection DVD". Archived from the original on 2007-10-16. Retrieved 2007-10-21. https://web.archive.org/web/20071016044547/http://www.procidis.com/gb/collection/d_dvd.html ↩
"Once Upon a time... Life". YouTube. Retrieved 2025-01-29. https://www.youtube.com/playlist?list=PLKnJDcjkfEp0AEalF2mrq-wOSX8jCAMnz ↩