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Calcium buffering
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<h2 id="clinical-significance">Clinical significance</h2> <p>Alterations in calcium buffering within the cytosol have been implicated in the tendency to <a href="/facts/Heart_arrhythmia/ooEpr46Q">arrhythmias</a> (abnormal cardiac rhythms) in some genetic mutations known to cause <a href="/facts/Hypertrophic_cardiomyopathy/NmPkh1rh">hypertrophic cardiomyopathy</a>.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> Genetic mutations affecting <a href="/facts/Calsequestrin/odATfI1K">calsequestrin</a> are responsible for an <a href="/facts/Dominance_(genetics)/DsvtPyQU">autosomal recessive</a> form of <a href="/facts/Catecholaminergic_polymorphic_ventricular_tachycardia/ybbXGBcw">catecholaminergic polymorphic ventricular tachycardia</a>, an inherited cardiac condition that can lead to sudden death.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> Calcium buffering within atrial myocytes is affected by ageing in large animal models, elevating sarcoplasmic reticulum calcium content, which could potentially contribute towards a tendency to <a href="/facts/Atrial_fibrillation/Rzkq1tmN">atrial fibrillation</a>.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Calcium_channel/4C7vusSt">Calcium channel</a></li> <li><a href="/facts/Cellular_communication_(biology)/6oYAVP9I">Cellular communication (biology)</a></li> <li><a href="/facts/Excitation_contraction_coupling/EbloCYfV">Excitation contraction coupling</a></li> <li><a href="/facts/Protein_domain/oUpFcSsl">Protein dynamics</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Gilabert JA (2012). "Cytoplasmic calcium buffering". Advances in Experimental Medicine and Biology. 740: 483–98. doi:10.1007/978-94-007-2888-2_20. ISBN 978-94-007-2887-5. PMID 22453955. {{cite journal}}: Cite journal requires |journal= (help) <a href="978-94-007-2887-5" target="_blank">978-94-007-2887-5</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>M., Bers, D. (2001). Excitation-contraction coupling and cardiac contractile force (2nd ed.). Dordrecht: Kluwer Academic Publishers. ISBN 9780792371588. OCLC 47659382.{{cite book}}: CS1 maint: multiple names: authors list (link) <a href="9780792371588" target="_blank">9780792371588</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>M., Bers, D. (2001). Excitation-contraction coupling and cardiac contractile force (2nd ed.). Dordrecht: Kluwer Academic Publishers. ISBN 9780792371588. OCLC 47659382.{{cite book}}: CS1 maint: multiple names: authors list (link) <a href="9780792371588" target="_blank">9780792371588</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Smith GL, Eisner DA (May 2019). "Calcium Buffering in the Heart in Health and Disease". Circulation. 139 (20): 2358–2371. doi:10.1161/CIRCULATIONAHA.118.039329. PMC 6520234. PMID 31082292. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520234" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520234</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Schwaller B (November 2010). "Cytosolic Ca2+ buffers". Cold Spring Harbor Perspectives in Biology. 2 (11): a004051. doi:10.1101/cshperspect.a004051. PMC 2964180. PMID 20943758. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964180" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964180</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>M., Bers, D. (2001). Excitation-contraction coupling and cardiac contractile force (2nd ed.). Dordrecht: Kluwer Academic Publishers. ISBN 9780792371588. OCLC 47659382.{{cite book}}: CS1 maint: multiple names: authors list (link) <a href="9780792371588" target="_blank">9780792371588</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Briston SJ, Dibb KM, Solaro RJ, Eisner DA, Trafford AW (November 2014). "Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes". Cardiovascular Research. 104 (2): 347–54. doi:10.1093/cvr/cvu201. PMC 4240166. PMID 25183792. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240166" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240166</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Eisner, David; Neher, Erwin; Taschenberger, Holger; Smith, Godfrey (2023-06-16). "Physiology of intracellular calcium buffering". Physiological Reviews. doi:10.1152/physrev.00042.2022. ISSN 1522-1210. PMC 11550887. PMID 37326298. S2CID 259174431. <a href="https://pubmed.ncbi.nlm.nih.gov/37326298" target="_blank">https://pubmed.ncbi.nlm.nih.gov/37326298</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Schober T, Huke S, Venkataraman R, Gryshchenko O, Kryshtal D, Hwang HS, Baudenbacher FJ, Knollmann BC (July 2012). "Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia". Circulation Research. 111 (2): 170–9. doi:10.1161/CIRCRESAHA.112.270041. PMC 3393041. PMID 22647877. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393041" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393041</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Lieve KV, van der Werf C, Wilde AA (May 2016). "Catecholaminergic Polymorphic Ventricular Tachycardia". Circulation Journal. 80 (6): 1285–91. doi:10.1253/circj.CJ-16-0326. PMID 27180891. <a href="https://doi.org/10.1253%2Fcircj.CJ-16-0326" target="_blank">https://doi.org/10.1253%2Fcircj.CJ-16-0326</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Clarke JD, Caldwell JL, Pearman CM, Eisner DA, Trafford AW, Dibb KM (October 2017). "2+ handling in old sheep atrial myocytes". The Journal of Physiology. 595 (19): 6263–6279. doi:10.1113/JP274053. PMC 5621500. PMID 28752958. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621500" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621500</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> </ol>