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PIK3R2
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<h2 id="interactions">Interactions</h2> <p>PIK3R2 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/CRKL/72KHdCRt">CRKL</a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a></li> <li><a href="/facts/Cbl_gene/YND39pME">Cbl gene</a>,<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a></li> <li><a href="/facts/Epidermal_growth_factor/CpyH5tYs">Epidermal growth factor</a>,<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li> <li><a href="/facts/FYN/qCAEbIAb">FYN</a>,<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a></li> <li><a href="/facts/HER2%2fneu/xue3SgcA">HER2/neu</a>,<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a></li> <li><a href="/facts/Macrophage_colony-stimulating_factor/StPNuIRM">Macrophage colony-stimulating factor</a>,<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> and</li> <li><a href="/facts/P110%25CE%25B4/QpAWgSS1">PIK3CD</a>.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li></ul> <h2 id="clinical-relevance">Clinical relevance</h2> <p>PIK3R2 mutations were recently shown to be associated with <a href="/facts/Polymicrogyria/krCSDST3">polymicrogyria</a>.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). <a href="https://doi.org/10.1189%2Fjlb.0503206">"Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways"</a>. <i>Journal of Leukocyte Biology</i>. 74 (5): 676–682. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1189%2Fjlb.0503206">10.1189/jlb.0503206</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12960231">12960231</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:11362623">11362623</a>.</li> <li>Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024">"Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system"</a>. <i>The Biochemical Journal</i>. 288 ( Pt 2) (2): 395–405. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1042%2Fbj2880395">10.1042/bj2880395</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024">1132024</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1334406">1334406</a>.</li> <li>Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). <a href="https://doi.org/10.1016%2FS0021-9258%2817%2945429-9">"Purification and characterization of phosphoinositide 3-kinase from rat liver"</a>. <i>The Journal of Biological Chemistry</i>. 265 (32): 19704–19711. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2817%2945429-9">10.1016/S0021-9258(17)45429-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2174051">2174051</a>.</li> <li>Truitt KE, Hicks CM, Imboden JB (March 1994). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191424">"Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells"</a>. <i>The Journal of Experimental Medicine</i>. 179 (3): 1071–1076. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1084%2Fjem.179.3.1071">10.1084/jem.179.3.1071</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191424">2191424</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7509360">7509360</a>.</li> <li>Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". <i>Biochemistry</i>. 34 (17): 5971–5979. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi00017a026">10.1021/bi00017a026</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7537096">7537096</a>.</li> <li>Craparo A, O'Neill TJ, Gustafson TA (June 1995). <a href="https://doi.org/10.1074%2Fjbc.270.26.15639">"Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor"</a>. <i>The Journal of Biological Chemistry</i>. 270 (26): 15639–15643. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.26.15639">10.1074/jbc.270.26.15639</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7541045">7541045</a>.</li> <li>He W, O'Neill TJ, Gustafson TA (October 1995). <a href="https://doi.org/10.1074%2Fjbc.270.40.23258">"Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains"</a>. <i>The Journal of Biological Chemistry</i>. 270 (40): 23258–23262. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.40.23258">10.1074/jbc.270.40.23258</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7559478">7559478</a>.</li> <li>Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995). <a href="https://doi.org/10.1074%2Fjbc.270.43.25985">"Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin"</a>. <i>The Journal of Biological Chemistry</i>. 270 (43): 25985–25991. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.43.25985">10.1074/jbc.270.43.25985</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7592789">7592789</a>.</li> <li>Hartley D, Meisner H, Corvera S (August 1995). <a href="https://doi.org/10.1074%2Fjbc.270.31.18260">"Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl"</a>. <i>The Journal of Biological Chemistry</i>. 270 (31): 18260–18263. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.31.18260">10.1074/jbc.270.31.18260</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7629144">7629144</a>.</li> <li>Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994). <a href="https://doi.org/10.1016%2FS0021-9258%2818%2943790-8">"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity"</a>. <i>The Journal of Biological Chemistry</i>. 269 (48): 30154–30157. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2818%2943790-8">10.1016/S0021-9258(18)43790-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7982920">7982920</a>.</li> <li>August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". <i>International Immunology</i>. 6 (5): 769–774. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fintimm%2F6.5.769">10.1093/intimm/6.5.769</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8080844">8080844</a>.</li> <li>Fukazawa T, Miyake S, Band V, Band H (June 1996). <a href="https://doi.org/10.1074%2Fjbc.271.24.14554">"Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins"</a>. <i>The Journal of Biological Chemistry</i>. 271 (24): 14554–14559. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.24.14554">10.1074/jbc.271.24.14554</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8662998">8662998</a>.</li> <li>Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996). <a href="https://doi.org/10.1074%2Fjbc.271.38.22961">"Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells"</a>. <i>The Journal of Biological Chemistry</i>. 271 (38): 22961–22964. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.38.22961">10.1074/jbc.271.38.22961</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8798481">8798481</a>.</li> <li>Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). <a href="https://doi.org/10.1074%2Fjbc.272.15.10248">"Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)"</a>. <i>The Journal of Biological Chemistry</i>. 272 (15): 10248–10253. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.15.10248">10.1074/jbc.272.15.10248</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9092574">9092574</a>.</li> <li>Vanhaesebroeck B, <a href="/facts/Melanie_Welham/JFfmQ65J">Welham MJ</a>, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20722">"P110delta, a novel phosphoinositide 3-kinase in leukocytes"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 94 (9): 4330–4335. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1997PNAS...94.4330V">1997PNAS...94.4330V</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.94.9.4330">10.1073/pnas.94.9.4330</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20722">20722</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9113989">9113989</a>.</li> <li>Briand G, Barbeau B, Tremblay M (February 1997). <a href="https://doi.org/10.1006%2Fviro.1996.8399">"Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase"</a>. <i>Virology</i>. 228 (2): 171–179. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fviro.1996.8399">10.1006/viro.1996.8399</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9123823">9123823</a>.</li> <li>Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997). <a href="https://doi.org/10.1038%2Fsj.onc.1201123">"Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site"</a>. <i>Oncogene</i>. 14 (22): 2619–2631. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1201123">10.1038/sj.onc.1201123</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9178760">9178760</a>.</li> <li>Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997). <a href="https://doi.org/10.1074%2Fjbc.272.30.19000">"Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle"</a>. <i>The Journal of Biological Chemistry</i>. 272 (30): 19000–19007. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.30.19000">10.1074/jbc.272.30.19000</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9228082">9228082</a>.</li> <li>Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". <i>European Journal of Immunology</i>. 27 (9): 2457–2465. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Feji.1830270946">10.1002/eji.1830270946</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9341793">9341793</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33397908">33397908</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789–793. PMID 1314371. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=5296&rn=1" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=5296&rn=1</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632055" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632055</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–10253. doi:10.1074/jbc.272.15.10248. PMID 9092574. <a href="https://doi.org/10.1074%2Fjbc.272.15.10248" target="_blank">https://doi.org/10.1074%2Fjbc.272.15.10248</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830. <a href="https://doi.org/10.1093%2Fintimm%2F13.1.13" target="_blank">https://doi.org/10.1093%2Fintimm%2F13.1.13</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". The Journal of Biological Chemistry. 270 (31): 18260–18263. doi:10.1074/jbc.270.31.18260. PMID 7629144. <a href="https://doi.org/10.1074%2Fjbc.270.31.18260" target="_blank">https://doi.org/10.1074%2Fjbc.270.31.18260</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". The Biochemical Journal. 288 ( Pt 2) (2): 395–405. doi:10.1042/bj2880395. PMC 1132024. PMID 1334406. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4330–4335. Bibcode:1997PNAS...94.4330V. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989. <a href="/wiki/Melanie_Welham" target="_blank">/wiki/Melanie_Welham</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study". The Lancet. Neurology. 14 (12): 1182–1195. doi:10.1016/S1474-4422(15)00278-1. PMC 4672724. PMID 26520804. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672724" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672724</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> </ol>