PhylomeDB

<h2 id="new-steps-on-phylomedb">New steps on phylomeDB</h2>
<p>The tree searching engine of PhylomeDB was updated to provide a gene-centric view of all phylomeDB resources. Thus, after a protein or gene search, all the available trees in phylomeDB are listed and organized by phylome and tree type. Users can switch among all available seed and collateral trees without missing the focus on the searched protein or gene.
</p><p>In phylomeDB v4 all the information available for each tree is now shown using an integrated layout in which tree topology, taxonomy data, alignments and domain annotations, and event-age (phylostratigraphy) information are rendered in the same figure using the newest visualization features provided by the ETE toolkit v2.2:
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<ol><li><a href="/facts/Pfam/BKJa293w">Pfam</a> domains have been mapped to each alignment in our database and are now displayed in a compact panel at the right side of the tree. For each sequence, domains and their names are shown, they can be clicked to obtain a short description and the external link to Pfam. Protein regions not mapped to domains are shown using the standard amino acid color codes, while gap regions are represented by a flat line.</li>
<li>Tree images have been also simplified to improve readability. Mappings and/or cross-linking to general and organism-oriented databases has been extended to include the major Arabidopsis thaliana sequence database <a href="/facts/The_Arabidopsis_Information_Resource/6UR5u3C3">TAIR</a>, Drosophila’s <a href="/facts/Flybase/23EKKvl3">Flybase</a>, as well as the Ascomycete-based genome database Genolevures.</li>
<li>Speciation and duplication events are indicated using different node colors and branch support values are now automatically highlighted for lowly supported partitions using a transparent red bubble inversely proportional to the branch bootstrap or aLRT value.</li>
<li>Internal tree searches can be performed for any of the annotated node attributes  while links to other databases are provided through the contextual menu of the tree browser that appear when clicking any node.</li></ol>
<p>Also, users can download relevant data, including the whole database, a specific phylome or, from the tree entry page, the relevant data corresponding to that tree. In this new release we have implemented the possibility to download orthology predictions from a tree in the recently developed OrthoXML standard format, in addition to a tabulated format.
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<h2 id="quest-for-orthologs">Quest for Orthologs</h2>
<p>The Quest for Orthologs (QfO) consortium involve more than 30 phylogenomic databases. The main of the consortium is improve and standardize orthology predictions through collaboration and discuss about new emerging methods.
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<ol><li>link to: <a href="http://questfororthologs.org/">Quest for Orthologs</a></li>
<li>link to: <a href="http://genome.crg.es/~tgabaldon/QfO4/index.html">2015 Meeting QfO</a></li></ol>
<h2 id="see-also">See also</h2>
<ul><li><a href="/facts/Genomics/pVU3BGpL">Genomics</a></li>
<li><a href="/facts/Phylogeny/f5vVEpeY">Phylogeny</a></li>
<li><a href="/facts/Phylogenomics/MsclFvpS">Phylogenomics</a></li></ul>

<h2 id="external-links">External links</h2>
<ul><li><a href="http://phylomedb.org">PhylomeDB</a></li>
<li><a href="http://www.crg.eu/en/programmes-groups/comparative-genomics">Toni Gabaldón Lab</a></li>
<li><a href="http://www.crg.eu/">Centre for Genomic Regulation</a></li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>Huerta-Cepas, Jaime; Capella-Gutierrez, S; Pryszcz, LP; Marcet-Houben, M; Gabaldón, T (Jan 2014). "PhylomeDB v4: zooming into the plurality of evolutionary histories of a genome". Nucleic Acids Res. 42 (Database issue). England: D897–902. doi:10.1093/nar/gkt1177. PMC 3964985. PMID 24275491. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964985" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964985</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
<li id="fn:2"><p>Huerta-Cepas, J; Bueno, A; Dopazo, J; Gabaldón, T (Jan 2008). "PhylomeDB: a database for genome-wide collections of gene phylogenies". Nucleic Acids Res. 36 (Database issue). England: D491–6. doi:10.1093/nar/gkm899. PMC 2238872. PMID 17962297. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238872" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238872</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li>
<li id="fn:3"><p>Huerta-Cepas, Jaime; Capella-Gutierrez, S; Pryszcz, LP; Denisov, I; Kormes, D; Marcet-Houben, M; Gabaldón, T (Jan 2011). "PhylomeDB v3.0: an expanding repository of genome-wide collections of trees, alignments and phylogeny-based orthology and paralogy predictions". Nucleic Acids Res. 39 (Database issue). England: D556–60. doi:10.1093/nar/gkq1109. PMC 3013701. PMID 21075798. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013701" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013701</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li>
<li id="fn:4"><p>Capella-Gutierrez, S; Silla-Martínez, JM; Gabaldón, T (Aug 2009). "trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses". Bioinformatics. 25 (Database issue): 1972–3. doi:10.1093/bioinformatics/btp348. PMC 2712344. PMID 19505945. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712344" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712344</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li>
<li id="fn:5"><p>Huerta-Cepas, J; Dopazo, J; Gabaldón, T (Jan 2010). "ETE: a python Environment for Tree Exploration". BMC Bioinformatics. 11 (Database issue): 24. doi:10.1186/1471-2105-11-24. PMC 2820433. PMID 20070885. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820433" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820433</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li>
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PhylomeDB open-in-new

PhylomeDB