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Dinitrobisphenol A
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<h2 id="carcinogenicity">Carcinogenicity</h2> <p>It has been proposed that dinitrobisphenol A might be formed <i>in vivo</i> by <a href="/facts/Peroxynitrite/01XSE9PJ">peroxynitrite</a> mediated oxidations of bisphenol A and that it may exhibit higher toxicity than BPA itself.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> 3,3'-Dinitrobisphenol A is found to be <a href="/facts/Genotoxic/fRUJaqxo">genotoxic</a> in male ICR mice on a micronucleus test.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> Its <a href="/facts/Estrogenic/dPEewnDV">estrogenic</a> potential is not known however it has shown some binding to estrogen-related receptor gamma to an extent.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Bisphenol_A/8AAPhAh0">Bisphenol A</a></li> <li><a href="/facts/Tetrabromobisphenol_A/1FAF62Ko">Tetrabromobisphenol A</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Sulzberg, Theodore; Cotter, Robert J. (1969). "Synthesis and polymerization of a dinitrobisphenol a: A new polycarbonate synthesis". Journal of Polymer Science Part B: Polymer Letters. 7 (3): 185. Bibcode:1969JPoSL...7..185S. doi:10.1002/pol.1969.110070303. <a href="/wiki/Bibcode_(identifier)" target="_blank">/wiki/Bibcode_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Babu, Sainath; Pathak, Chintan; Uppu, Satvika; Jones, Conrad; Fronczek, Frank R.; Uppu, Rao M. (2011). "3,3′-Dinitrobisphenol A". Acta Crystallographica Section E. 67 (10): o2556. doi:10.1107/S1600536811035458. PMC 3201564. PMID 22065402. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201564" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201564</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Masuda, Shuichi; Terashima, Yumeko; Sano, Ayako; Kuruto, Ryoko; Sugiyama, Yasumasa; Shimoi, Kayoko; Tanji, Kenichi; Yoshioka, Hisashi; Terao, Yoshiyasu; Kinae, Naohide (August 2005). "Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitrite". Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 585 (1–2): 137–146. doi:10.1016/j.mrgentox.2005.04.005. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Toyoizumi, Tomoyasu; Deguchi, Yuya; Masuda, Shuichi; Kinae, Naohide (2014). "Genotoxicity and Estrogenic Activity of 3,3′-Dinitrobisphenol a in Goldfish". Bioscience, Biotechnology, and Biochemistry. 72 (8): 2118. doi:10.1271/bbb.80193. <a href="https://doi.org/10.1271%2Fbbb.80193" target="_blank">https://doi.org/10.1271%2Fbbb.80193</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Babu, Sainath; Vellore, Nadeem A.; Kasibotla, Agasthya V.; Dwayne, Harlan J.; Stubblefield, Michael A.; Uppu, Rao M. (2012). "Molecular docking of bisphenol a and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>