Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
Structural analog
open-in-new
<h2 id="examples">Examples</h2> <a href="/facts/Alcohols/Y0SCTDkh">Alcohols</a> <a href="/facts/Substituted_phenethylamine/dte6TQxS">Phenethylamines</a> <h2 id="neurotransmitter-analog">Neurotransmitter analog</h2> <p>A neurotransmitter analog is a structural analogue of a <a href="/facts/Neurotransmitter/LlpYFSU3">neurotransmitter</a>, typically a <a href="/facts/Drug/FFFUI9n4">drug</a>. Some examples include: </p> <ul><li><a href="/facts/Catecholamine_analogue/dte6TQxS">Catecholamine analogue</a></li> <li><a href="/facts/Serotonin_analogue/rNKEIl5T">Serotonin analogue</a></li> <li><a href="/facts/GABA_analogue/pB9LPzCW">GABA analogue</a></li></ul> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Derivative_(chemistry)/JYcbLkbm">Derivative (chemistry)</a></li> <li><a href="/facts/Federal_Analogue_Act/TjlKpUsG">Federal Analogue Act</a>, a United States bill banning chemical analogues of illegal drugs</li> <li><a href="/facts/Functional_analog_(chemistry)/LkIBCkxN">Functional analog</a>, compounds with similar physical, chemical, biochemical, or pharmacological properties</li> <li><a href="/facts/Homologous_series/7PKCuvzm">Homolog</a>, a compound of a series differing only by repeated units</li> <li><a href="/facts/Transition_state_analog/Vl9JeN2d">Transition state analog</a></li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="http://shiny.bioinf.jku.at/Analoging/">Analoging in ChEMBL, DrugBank and the Connectivity Map</a> – a free web-service for finding structural analogs in <a href="/facts/ChEMBL/xjm6zS43">ChEMBL</a>, <a href="/facts/DrugBank/ycxhRlLA">DrugBank</a>, and the Connectivity Map</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Willett, Peter; Barnard, John M.; Downs, Geoffrey M. (1998). "Chemical Similarity Searching" (PDF). Journal of Chemical Information and Computer Sciences. 38 (6): 983–996. CiteSeerX 10.1.1.453.1788. doi:10.1021/ci9800211. <a href="http://www.cust.edu.tw/mathmet/qsar_ref/Willett_1998.pdf" target="_blank">http://www.cust.edu.tw/mathmet/qsar_ref/Willett_1998.pdf</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>A. M. Johnson; G. M. Maggiora (1990). Concepts and Applications of Molecular Similarity. New York: John Wiley & Sons. ISBN 978-0-471-62175-1. <a href="978-0-471-62175-1" target="_blank">978-0-471-62175-1</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>N. Nikolova; J. Jaworska (2003). "Approaches to Measure Chemical Similarity - a Review". QSAR & Combinatorial Science. 22 (9–10): 1006–1026. doi:10.1002/qsar.200330831. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Martin, Yvonne C.; Kofron, James L.; Traphagen, Linda M. (2002). "Do Structurally Similar Molecules Have Similar Biological Activity?". Journal of Medicinal Chemistry. 45 (19): 4350–4358. doi:10.1021/jm020155c. PMID 12213076. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Schnecke, Volker & Boström, Jonas (2006). "Computational chemistry-driven decision making in lead generation". Drug Discovery Today. 11 (1–2): 43–50. doi:10.1016/S1359-6446(05)03703-7. PMID 16478690. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Rester, Ulrich (2008). "From virtuality to reality - Virtual screening in lead discovery and lead optimization: A medicinal chemistry perspective". Current Opinion in Drug Discovery & Development. 11 (4): 559–68. PMID 18600572. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>