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C-type lectin
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<h2 id="classification">Classification</h2> <p>Drickamer <i>et al.</i> classified C-type lectins into 7 subgroups (I to VII) based on the order of the various <a href="/facts/Protein_domains/oUpFcSsl">protein domains</a> in each protein.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> Most recently, three further subgroups were added (XV to XVII).<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <table><tbody><tr><th>Group</th><th>Name</th><th>Associated domains</th></tr><tr><td>I</td><td><a href="/facts/Lectican/X2DdXW9e">Lecticans</a></td><td><a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF</a>, <a href="/facts/Apolipoprotein_H/e9jX8qDz">Sushi</a>, Ig and Link domains</td></tr><tr><td>II</td><td><a href="/facts/Asialoglycoprotein/xnEBanfl">Asialoglycoprotein</a> and DC receptors</td><td>None</td></tr><tr><td>III</td><td><a href="/facts/Collectin/zsUrlrGC">Collectins</a></td><td>None</td></tr><tr><td>IV</td><td><a href="/facts/Selectin/MGhkFp24">Selectins</a></td><td><a href="/facts/Apolipoprotein_H/e9jX8qDz">Sushi</a> and <a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF</a> domains</td></tr><tr><td>V</td><td><a href="/facts/Natural_killer_cell/A3THWxrJ">NK - cell</a> receptors</td><td>None</td></tr><tr><td>VI</td><td>Multi-CTLD endocytic receptors</td><td>FnII and Ricin domains</td></tr><tr><td>VII</td><td>Reg group</td><td>None</td></tr><tr><td>VIII</td><td><a href="/facts/Chondrolectin/WQvrWQRQ">Chondrolectin</a>, <a href="/facts/Layilin/bw2mMUtz">Layilin</a></td><td>None</td></tr><tr><td>IX</td><td><a href="/facts/Tetranectin/M7AcHI7K">Tetranectin</a></td><td>None</td></tr><tr><td>X</td><td><a href="/facts/PKD1/UwHJLDCV">Polycystin</a></td><td>WSC, REJ, PKD domains</td></tr><tr><td>XI</td><td>Attractin (<a href="/facts/ATRN/P3DyHFjn">ATRN</a>)</td><td>PSI, <a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF</a> and CUB domains</td></tr><tr><td>XII</td><td><a href="/facts/Major_basic_protein/VD2SMdvE">Eosinophil major basic protein</a> (EMBP)</td><td>None</td></tr><tr><td>XIII</td><td><a href="/facts/DGCR2/A1QqJncs">DGCR2</a></td><td>None</td></tr><tr><td>XIV</td><td><a href="/facts/Thrombomodulin/Ioxyy7gN">Thrombomodulin</a>, <a href="/facts/CD93/3WRMtjzl">CD93</a>, <a href="/facts/CD248/71co6zYv">CD248</a>, CLEC14A</td><td><a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF</a> domains <a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a></td></tr><tr><td>XV</td><td><a href="/facts/Bimlec/16As7Bqm">Bimlec</a></td><td>None</td></tr><tr><td>XVI</td><td>SEEC</td><td><a href="/facts/Sterol_carrier_protein/xsreA1HU">SCP</a> and <a href="/facts/Epidermal_growth_factor/CpyH5tYs">EGF</a> domains</td></tr><tr><td>XVII</td><td>CBCP/<a href="/facts/Frem1/m4MEfBp1">Frem1</a>/QBRICK</td><td>CSPG repeats and <a href="/facts/Calx-beta_motif/J1YnqHn4">CalX-beta</a> domains</td></tr></tbody></table> <p>CLECs include: </p> <ul><li><a href="/facts/CLEC1A/YLRMx0C0">CLEC1A</a>, <a href="/facts/CLEC1B/sKv9nMGn">CLEC1B</a></li> <li>CLEC2A, <a href="/facts/CLEC2B/fgaIqJ4I">CLEC2B</a>, <a href="/facts/CD69/UIpJsN0w">CD69</a> (CLEC2C), <a href="/facts/CLEC2D/L2sRUvUj">CLEC2D</a>, CLEC2L</li> <li>CLEC3A, <a href="/facts/CLEC3B/M7AcHI7K">CLEC3B</a></li> <li><a href="/facts/CLEC4A/0Ah2NrcG">CLEC4A</a>, <a href="/facts/CLEC4C/e1IJATUa">CLEC4C</a>, CLEC4D, <a href="/facts/CLEC4E/kQDpHhxY">CLEC4E</a>, CLEC4F, CLEC4G, <a href="/facts/ASGR1/79CPhkSE">ASGR1</a> (CLEC4H1), <a href="/facts/ASGR2/SvQEXJ3T">ASGR2</a> (CLEC4H2), <a href="/facts/FCER2/sdk79KrG">FCER2</a> (CLEC4J), <a href="/facts/CD207/qsl9pY5f">CD207</a> (CLEC4K), <a href="/facts/CD209/8hQuEvIq">CD209</a> (CLEC4L), <a href="/facts/CLEC4M/59lmuo7a">CLEC4M</a></li> <li><a href="/facts/CLEC5A/3vvccPNL">CLEC5A</a></li> <li><a href="/facts/CLEC6A/oxJWKxUY">CLEC6A</a></li> <li><a href="/facts/CLEC7A/hPPxd0e6">CLEC7A</a></li> <li><a href="/facts/OLR1/b1xcHqDx">OLR1</a> (CLEC8A)</li> <li><a href="/facts/CLEC9A/ezLoInFq">CLEC9A</a></li> <li><a href="/facts/CLEC10A/xVfd1lzp">CLEC10A</a></li> <li><a href="/facts/CLEC11A/dp78fywJ">CLEC11A</a></li> <li><a href="/facts/CLEC12A/7YGGn36S">CLEC12A</a>, CLEC12B</li> <li><a href="/facts/CD302/16As7Bqm">CD302</a> (CLEC13A), <a href="/facts/LY75/UspBKzzn">LY75</a> (CLEC13B), <a href="/facts/PLA2R1/YyoQg90f">PLA2R1</a> (CLEC13C), <a href="/facts/MRC1/x2JClStd">MRC1</a> (CLEC13D), <a href="/facts/MRC2/x2JClStd">MRC2</a> (CLEC13E)</li> <li>CLEC14A</li> <li><a href="/facts/CLEC16A/HSIC9BIK">CLEC16A</a></li> <li>CLEC17A</li></ul> <p>The "NK Cell lectin-like receptors" are a very closely related group:<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p> <ul><li><a href="/facts/KLRA1/v4IDQeyY">KLRA1</a></li> <li><a href="/facts/KLRB1/lFW6ejvv">KLRB1</a> (CLEC5B)</li> <li>KLRC1, <a href="/facts/KLRC2/kXDVbLXB">KLRC2</a>, KLRC3, <a href="/facts/KLRC4/KCw009gX">KLRC4</a></li> <li><a href="/facts/KLRD1/FWNKz27N">KLRD1</a></li> <li>KLRF1 (CLEC5C)</li> <li><a href="/facts/KLRG1/hQhJCTrU">KLRG1</a> (CLEC15A), KLRG2 (CLEC15B)</li> <li><a href="/facts/NKG2D/hX8yIBAD">KLRK1</a></li></ul> <p>Additional proteins containing this domain include: </p> <ul><li>AGC1; ATRNL1</li> <li><a href="/facts/BCAN/kyUXbrlq">BCAN</a></li> <li><a href="/facts/CD248/71co6zYv">CD248</a>; <a href="/facts/CD72/xVUWPkrb">CD72</a>; <a href="/facts/CD93/3WRMtjzl">CD93</a>; <a href="/facts/CHODL/WQvrWQRQ">CHODL</a>; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; <a href="/facts/COLEC10/RH1oSWKo">COLEC10</a>; COLEC11; <a href="/facts/COLEC12/fuBYXS6L">COLEC12</a>; <a href="/facts/CSPG3/vnYpgUPE">CSPG3</a></li> <li><a href="/facts/FCER2/sdk79KrG">FCER2</a>; <a href="/facts/FREM1/m4MEfBp1">FREM1</a>; HBXBP;</li> <li><a href="/facts/LAYN/bw2mMUtz">LAYN</a>; LOC348174; LOC728276</li> <li><a href="/facts/MAFA/nIxQWBDS">MAFA</a>; <a href="/facts/MBL2/9eBWpShX">MBL2</a>; MGC34761; <a href="/facts/MICL/Hsnp1un0">MICL</a>; <a href="/facts/MRC1L1/x2JClStd">MRC1L1</a></li> <li><a href="/facts/OLR1/b1xcHqDx">OLR1</a></li> <li>PAP; <a href="/facts/PKD1/UwHJLDCV">PKD1</a>; PKD1L2; <a href="/facts/PLA2R1/YyoQg90f">PLA2R1</a>; <a href="/facts/PRG2/VD2SMdvE">PRG2</a>; PRG3</li> <li><a href="/facts/REG1A/9c5ztU1n">REG1A</a>; <a href="/facts/REG1B/UafkkAAx">REG1B</a>; <a href="/facts/REG3A/uE6kdGn3">REG3A</a>; <a href="/facts/REG3G/tjMIVNRk">REG3G</a>; <a href="/facts/REG4/vXvjXvyQ">REG4</a></li> <li><a href="/facts/SELE/TgQqFPLm">SELE</a>; <a href="/facts/SELL/cGc7gx1E">SELL</a>; <a href="/facts/SELP/2MXhKsQJ">SELP</a>; <a href="/facts/SFTPA1/53Igs4In">SFTPA1</a>; <a href="/facts/SFTPA2/qSmCthaw">SFTPA2</a>; <a href="/facts/SFTPA2B/qSmCthaw">SFTPA2B</a>; <a href="/facts/SFTPD/hDUwzSJS">SFTPD</a>; SRCL</li> <li><a href="/facts/THBD/Ioxyy7gN">THBD</a></li> <li><a href="/facts/VCAN/MJSQGfVF">VCAN</a></li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="http://www.functionalglycomics.org/">Functional Glycomics Gateway</a>, a collaboration between the <a href="/facts/Consortium_for_Functional_Glycomics/xok238bf">Consortium for Functional Glycomics</a> and <a href="/facts/Nature_Publishing_Group/eTRtG9m7">Nature Publishing Group</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. S2CID 7084402. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) <a href="https://meshb.nlm.nih.gov/record/ui?name=C-Type+Lectin" target="_blank">https://meshb.nlm.nih.gov/record/ui?name=C-Type+Lectin</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. Bibcode:2009CBio...19.R375C. doi:10.1016/j.cub.2009.03.032. PMID 19439262. S2CID 17409821. <a href="https://doi.org/10.1016%2Fj.cub.2009.03.032" target="_blank">https://doi.org/10.1016%2Fj.cub.2009.03.032</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 45: 207–32. doi:10.1016/S0079-6603(08)60870-3. ISBN 978-0-12-540045-9. PMID 8341801. <a href="978-0-12-540045-9" target="_blank">978-0-12-540045-9</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. 69 (69): 59–72. doi:10.1042/bss0690059. PMID 12655774. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259. S2CID 7084402. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Khan, K. A.; McMurray, J. L.; Mohammed, F.; Bicknell, R. (2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC 6852297. PMID 31287944. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852297" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852297</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>NK+Cell+Lectin-Like+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) <a href="https://meshb.nlm.nih.gov/record/ui?name=NK+Cell+Lectin-Like+Receptors" target="_blank">https://meshb.nlm.nih.gov/record/ui?name=NK+Cell+Lectin-Like+Receptors</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> </ol>