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TRNP1
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<h2 id="function">Function</h2> <p>Trnp1 binds to DNA with high affinity.<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> Its direct molecular function is unknown, it has no known molecular motif and therefore may represent a new class of molecules.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p><p>Trnp1 has a very strong effect on <a href="/facts/Cellular_proliferation/wbArMaJU">cellular proliferation</a>, Trnp1 dramatically increases the proliferation rate <i>in vitro</i> an <i>in vivo</i>.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p><p>In addition to its stem cell function during brain development, there are data suggesting that Trnp1 might play a crucial role in <a href="/facts/Cancer_cell/HXSQQjhw">cancer cells</a> - Trnp1 has been described in gene expression analysis in cancer types.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> the very strong proliferation capacity may be responsible for its <a href="/facts/Oncogenic/PC8wc1Mf">oncogenic</a> potential. Specifically, Trnp1 (together with other factors) serves as a <a href="/facts/Biomarker_(medicine)/uVSh5z78">biomarker</a> for specific colon cancer subtypes.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a><a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Fernández V, Llinares-Benadero C, Borrell V (May 2016). "Cerebral cortex expansion and folding: what have we learned?". The EMBO Journal. 35 (10): 1021–44. doi:10.15252/embj.201593701. PMC 4868950. PMID 27056680. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868950" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868950</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Martínez-Martínez MÁ, De Juan Romero C, Fernández V, Cárdenas A, Götz M, Borrell V (June 2016). "A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels". Nature Communications. 7: 11812. Bibcode:2016NatCo...711812M. doi:10.1038/ncomms11812. PMC 4897765. PMID 27264089. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897765" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897765</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M (April 2013). "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate". Cell. 153 (3): 535–49. doi:10.1016/j.cell.2013.03.027. hdl:10261/338716. PMID 23622239. <a href="https://doi.org/10.1016%2Fj.cell.2013.03.027" target="_blank">https://doi.org/10.1016%2Fj.cell.2013.03.027</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Kanth P, Bronner MP, Boucher KM, Burt RW, Neklason DW, Hagedorn CH, Delker DA (June 2016). "Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype". Cancer Prevention Research. 9 (6): 456–65. doi:10.1158/1940-6207.CAPR-15-0363. PMC 4941619. PMID 27026680. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941619" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941619</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Kanth P, Bronner MP, Boucher KM, Burt RW, Neklason DW, Hagedorn CH, Delker DA (June 2016). "Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype". Cancer Prevention Research. 9 (6): 456–65. doi:10.1158/1940-6207.CAPR-15-0363. PMC 4941619. PMID 27026680. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941619" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941619</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>US application 20190032147, Delker D, Kanth P, "Methods and compositions for predicting a colon cancer subtype", published 31 January 2019, assigned to University of Utah Research Foundation <a href="https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=2019032147A1&KC=A1&FT=D&ND=3&date=20190131&DB=&locale=en_EP" target="_blank">https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=2019032147A1&KC=A1&FT=D&ND=3&date=20190131&DB=&locale=en_EP</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> </ol>