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RING1
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<h2 id="function">Function</h2> <p>This gene belongs to the RING finger family, members of which encode proteins characterized by a <a href="/facts/RING_finger_domain/g6EtFQbn">RING domain</a>, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is <a href="/facts/Contiguous_distribution/SAI9lJq9">contiguous</a> with the RING finger genes FABGL and HKE4.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p> <h2 id="interactions">Interactions</h2> <p>RING1 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/CBX8/QaVeGDBF">CBX8</a>,<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> <a href="/facts/BMI1/cI4eN4yQ">BMI1</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> and <a href="/facts/RYBP/K4zIL2B2">RYBP</a>.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a><a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Lovering R, Hanson IM, Borden KL, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJ, Trowsdale J, Freemont PS (Mar 1993). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46035">"Identification and preliminary characterization of a protein motif related to the zinc finger"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 90 (6): 2112–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1993PNAS...90.2112L">1993PNAS...90.2112L</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.90.6.2112">10.1073/pnas.90.6.2112</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46035">46035</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7681583">7681583</a>.</li> <li>Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP (Jul 1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232264">"RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor"</a>. <i>Molecular and Cellular Biology</i>. 17 (7): 4105–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.17.7.4105">10.1128/mcb.17.7.4105</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232264">232264</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9199346">9199346</a>.</li> <li>Kikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H (Jun 1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes". <i>Genomics</i>. 42 (3): 422–35. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1997.4745">10.1006/geno.1997.4745</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9205114">9205114</a>.</li> <li>Satijn DP, Otte AP (Jan 1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83865">"RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity"</a>. <i>Molecular and Cellular Biology</i>. 19 (1): 57–68. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.19.1.57">10.1128/mcb.19.1.57</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83865">83865</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9858531">9858531</a>.</li> <li>García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171420">"RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1"</a>. <i>The EMBO Journal</i>. 18 (12): 3404–18. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2F18.12.3404">10.1093/emboj/18.12.3404</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171420">1171420</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10369680">10369680</a>.</li> <li>Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Sep 2000). <a href="https://doi.org/10.1074%2Fjbc.M001835200">"HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties"</a>. <i>The Journal of Biological Chemistry</i>. 275 (37): 28785–92. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M001835200">10.1074/jbc.M001835200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10825164">10825164</a>.</li> <li>Trimarchi JM, Fairchild B, Wen J, Lees JA (Feb 2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29289">"The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 98 (4): 1519–24. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.041597698">10.1073/pnas.041597698</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29289">29289</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11171983">11171983</a>.</li> <li>Dahiya A, Wong S, Gonzalo S, Gavin M, Dean DC (Sep 2001). <a href="https://doi.org/10.1016%2FS1097-2765%2801%2900346-X">"Linking the Rb and polycomb pathways"</a>. <i>Molecular Cell</i>. 8 (3): 557–69. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS1097-2765%2801%2900346-X">10.1016/S1097-2765(01)00346-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11583618">11583618</a>.</li> <li>Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (May 2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". <i>Science</i>. 296 (5570): 1132–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002Sci...296.1132O">2002Sci...296.1132O</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1069861">10.1126/science.1069861</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12004135">12004135</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:34863978">34863978</a>.</li> <li>Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). <a href="https://deepblue.lib.umich.edu/bitstream/2027.42/72663/1/j.1365-2443.2002.00565.x.pdf">"MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation"</a> (PDF). <i>Genes to Cells</i>. 7 (8): 835–50. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1365-2443.2002.00565.x">10.1046/j.1365-2443.2002.00565.x</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/2027.42%2F72663">2027.42/72663</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12167161">12167161</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23060582">23060582</a>.</li> <li>Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134016">"The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans"</a>. <i>Molecular and Cellular Biology</i>. 22 (17): 6070–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.22.17.6070-6078.2002">10.1128/MCB.22.17.6070-6078.2002</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134016">134016</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12167701">12167701</a>.</li> <li>Gil J, Bernard D, Martínez D, Beach D (Jan 2004). "Polycomb CBX7 has a unifying role in cellular lifespan". <i>Nature Cell Biology</i>. 6 (1): 67–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fncb1077">10.1038/ncb1077</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14647293">14647293</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23315124">23315124</a>.</li> <li>Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). <a href="https://doi.org/10.1111%2Fj.1365-2443.2004.00705.x">"Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase"</a>. <i>Genes to Cells</i>. 9 (2): 105–20. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1365-2443.2004.00705.x">10.1111/j.1365-2443.2004.00705.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15009096">15009096</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:21813024">21813024</a>.</li> <li>Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (Oct 2004). "Role of histone H2A ubiquitination in Polycomb silencing". <i>Nature</i>. 431 (7010): 873–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2004Natur.431..873W">2004Natur.431..873W</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature02985">10.1038/nature02985</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15386022">15386022</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4344378">4344378</a>.</li> <li>Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H (Feb 2005). <a href="https://doi.org/10.1016%2Fj.febslet.2005.01.022">"The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2"</a>. <i>FEBS Letters</i>. 579 (5): 1220–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005FEBSL.579.1220Q">2005FEBSL.579.1220Q</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.febslet.2005.01.022">10.1016/j.febslet.2005.01.022</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15710417">15710417</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:8214807">8214807</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=RING1+protein%2C+human">RING1+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Hanson IM, Poustka A, Trowsdale J (Jun 1991). "New genes in the class II region of the human major histocompatibility complex". Genomics. 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID 1906426. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: RING1 ring finger protein 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: RING1 ring finger protein 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". The Journal of Biological Chemistry. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164. <a href="https://doi.org/10.1074%2Fjbc.M001835200" target="_blank">https://doi.org/10.1074%2Fjbc.M001835200</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP (Jul 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular Biology. 17 (7): 4105–13. doi:10.1128/mcb.17.7.4105. PMC 232264. PMID 9199346. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232264" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232264</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Satijn DP, Otte AP (Jan 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". Molecular and Cellular Biology. 19 (1): 57–68. doi:10.1128/mcb.19.1.57. PMC 83865. PMID 9858531. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83865" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83865</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026. <a href="/wiki/Bibcode_(identifier)" target="_blank">/wiki/Bibcode_(identifier)</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171420" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171420</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> </ol>