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Given Imaging
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<h2 id="history">History</h2> <p>Given Imaging was founded in 1998 by Gavriel Meron and Rafael Development Corporation (RDC) Ltd. based on the purchase of an early patent from Rafael Advanced Defense Systems Ltd. Initial funding for the company was provided by <a href="/facts/Elron_Electronic_Industries/kgTcFwKx">Elron Electronic Industries</a>, Israel's leading technology holding company, in cooperation with Rafael. Today, <a href="/facts/Elron_Electronic_Industries/kgTcFwKx">Elron</a> still holds 28% Given Imaging's shares.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> The idea for the solution was developed by Dr. Iddan, while working in the missile division of Rafael, where he envisioned that missile technology could be miniaturized to create a medical product.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p><p>The company's first <a href="/facts/Capsule_endoscopy/BooUNE3D">capsule endoscopy</a> products was named M2A capsule and received it <a href="/facts/CE_marking/F13U8QXp">CE marking</a> in May 2001 and in August 2001 was cleared by the <a href="/facts/US_Food_and_Drug_Administration/rCEnh9WB">US Food and Drug Administration</a> (FDA) for visualization of abnormalities of the small intestine<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> The capsule uses a radio developed for Given by Zarlink Semiconductor's medical team in San Diego and Jarfalla, Sweden. </p><p>In October 2001, Given Imaging had an <a href="/facts/Initial_public_offering/2NntDhrG">Initial public offering</a> on <a href="/facts/NASDAQ/C6GlcQcB">NASDAQ</a> under ticker GIVN.)<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> In September 2004, M2A capsule re-branded PillCam SB(R). </p><p>In March 2004, Given Imaging became a member of the <a href="/facts/Tel_Aviv_Stock_Exchange/PgfM57U5">Tel Aviv Stock Exchange</a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p><p>In November 2004, US FDA clears PillCam(R) ESO for the esophagus </p><p>In May 2006, US FDA clears Agile Patency System<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p><p>In October 2006, PillCam COLON was cleared for marketing in the European Union (CE Mark)<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p><p>In December 2008, Given Imaging acquired Bravo pH Monitoring System(R) </p><p>In May 2009, 1 millionth PillCam capsule was sold<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p><p>In September 2009, PillCam COLON 2 receives CE Mark<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> </p><p>In July 2012, Given Imaging's <a href="/facts/Capsule_endoscopy/BooUNE3D">capsule endoscopy</a> featured in a live broadcast on the <a href="/facts/BBC/qFateIz8">BBC</a>, when the reporter Michael Mosley spent the day as an exhibit at <a href="/facts/The_Science_Museum/1mwwq0oj">the Science Museum</a> in London, after swallowing a PillCam which transmitted live pictures to a public screen.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p><p>In February 2014, 100% of Given Imaging's shares were purchased by <a href="/facts/Covidien/XjzzVQGX">Covidien</a>, making it a <a href="/facts/Private_Company/B4wdkyJX">Private Company</a> fully owned by Covidien. As a result, its shares are no longer traded neither in NASDAQ nor in TASE<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> </p><p>In 2015 <a href="/facts/Covidien/XjzzVQGX">Covidien</a> was purchased by <a href="/facts/Medtronic/dms8dHG5">Medtronic</a> </p> <h2 id="products">Products</h2> <h3>PillCam SB</h3> <p>PillCam SB is a tool for visualization of the entire small bowel and detection of small bowel abnormalities. No sedation is needed, however bowel prep is needed. A liquid bowel prep is consumed before the procedure emptying the bowel completely, this allows clear photos to be taken.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> </p> <h3>PillCam ESO</h3> <p>PillCam ESO provides a method for visualization of the esophagus.<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> </p> <h3>PillCam COLON 2</h3> <p>PillCam COLON 2 is complementary to traditional colonoscopy and is used for patients who have received incomplete colonoscopy, are contraindicated for colonoscopy or are unwilling to undergo traditional colonoscopy. </p> <h3>PillCam CROHN'S</h3> <p>The PillCam CROHN’S system offers direct visualization of the entire small bowel and colonic mucosa with a noninvasive procedure. </p> <h3>PillCam Express</h3> <p>In May 2010, Given Imaging released a new manually guided GI scope based on PillCam swallowable devices. In cases where patient anatomy does not allow for natural passage of large tablets the size of traditional PillCams, the PillCam Express can be delivered through the stomach and into the small intestine with help of an endoscope and a proprietary balloon deployment mechanism.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> </p> <h3>Bravo pH Monitoring System</h3> <p>The Bravo pH Monitoring System is a catheter-free ambulatory pH test.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a> Ambulatory pH testing is considered the gold standard for pH measurement and monitoring of gastric reflux, helping clinicians manage gastroesophageal reflux disease (GERD). Featuring data collection for up to 96 hours, Bravo allows patients to maintain their regular diets and activities, accurately reflecting normal physiologic conditions. </p> <h3>Sierra Scientific Instruments</h3> <p>In April 2010, Given Imaging acquired Sierra Scientific Instruments.<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> </p> <h2 id="headquarters-and-plants">Headquarters and plants</h2> <p>The company's corporate headquarters, research and development laboratories, and manufacturing facilities are located in <a href="/facts/Yokneam_Illit/IrANxuhf">Yokneam</a>, Israel.<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a><a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a> It maintains offices in <a href="/facts/Duluth%2c_Georgia/FChej65H">Duluth, Georgia</a> and <a href="/facts/Heerlen/PY6aPjto">Heerlen</a>, <a href="/facts/Netherlands/y8xn5stT">Netherlands</a>. Additional sales and marketing offices are located in <a href="/facts/France/CxIeIKM3">France</a>, <a href="/facts/Japan/U5mz0SRT">Japan</a>, <a href="/facts/Australia/qLHpbppq">Australia</a>, and <a href="/facts/Singapore/CQDkhUvD">Singapore</a>. The company also has a plant in <a href="/facts/Ireland/35vYxXdP">Ireland</a>. </p><p>Given Imaging's wholly owned subsidiary, Sierra Scientific Instruments, is located in <a href="/facts/Los_Angeles/pyXpYEX9">Los Angeles</a>, California, with manufacturing operations in Vietnam. </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Science_and_technology_in_Israel/nYEht2yK">Science and technology in Israel</a></li> <li><a href="/facts/Health_care_in_Israel/I7oQUALh">Health care in Israel</a></li> <li><a href="/facts/List_of_Israeli_inventions_and_discoveries/IsxBpaug">List of Israeli inventions and discoveries</a></li> <li><a href="/facts/Silicon_Wadi/aNCEzSEn">Silicon Wadi</a></li> <li><a href="/facts/Startup_Village%2c_Yokneam/IrANxuhf">Startup Village, Yokneam</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Invest in Israel: Given Imaging". Archived from the original on 2011-07-21. Retrieved 2010-10-14. <a href="https://web.archive.org/web/20110721142613/http://www.investinisrael.gov.il/NR/exeres/01104877-8720-4F39-8441-BD24EC58D8B9.htm" target="_blank">https://web.archive.org/web/20110721142613/http://www.investinisrael.gov.il/NR/exeres/01104877-8720-4F39-8441-BD24EC58D8B9.htm</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Elron Announces That Given Imaging, Held Directly and Indirectly 15% by Elron, Announced Initial Public Offering. Business Wire, October 4, 2001[dead link] <a href="http://www.highbeam.com/doc/1G1-78880412.html" target="_blank">http://www.highbeam.com/doc/1G1-78880412.html</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"RDC – Rafael Development Corporation Ltd - Given Imaging Copnay History". Archived from the original on 2014-08-02. Retrieved 2019-12-29. <a href="https://web.archive.org/web/20140802064832/http://www.rdc.co.il/default.asp?catid=%7BCAB37C31-E9B2-4549-ABC6-64327B120209%7D" target="_blank">https://web.archive.org/web/20140802064832/http://www.rdc.co.il/default.asp?catid=%7BCAB37C31-E9B2-4549-ABC6-64327B120209%7D</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Athena: Clinical Policy Bulletin: Capsule Endoscopy <a href="http://www.aetna.com/cpb/medical/data/500_599/0588.html" target="_blank">http://www.aetna.com/cpb/medical/data/500_599/0588.html</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Given Imaging: First IPO since August IPO Report - MarketWatch - 4 Oct 2001 <a href="http://www.marketwatch.com/story/given-imaging-first-ipo-since-august" target="_blank">http://www.marketwatch.com/story/given-imaging-first-ipo-since-august</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Given Imaging Registration Document March 22, 2004 <a href="http://maya.tase.co.il/bursa/report.asp?report_cd=94385" target="_blank">http://maya.tase.co.il/bursa/report.asp?report_cd=94385</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>"Given Imaging's Agile(TM) Patency System Receives US Marketing Clearance, Medical News Today, 17 May 2006". Archived from the original on 24 September 2010. Retrieved 16 October 2010. <a href="https://web.archive.org/web/20100924040720/http://www.medicalnewstoday.com/articles/43358.php" target="_blank">https://web.archive.org/web/20100924040720/http://www.medicalnewstoday.com/articles/43358.php</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>"Pillcam(R) COLON May Be A Cost-Effective Strategy For Preventing Colo-Rectal Cancer, Study, Medical News Today 11 Apr 2008". Archived from the original on 4 January 2009. Retrieved 16 October 2010. <a href="https://web.archive.org/web/20090104150653/http://www.medicalnewstoday.com/articles/103575.php" target="_blank">https://web.archive.org/web/20090104150653/http://www.medicalnewstoday.com/articles/103575.php</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Given Imaging Announces One Millionth PillCam Video Capsule, Marketwire May 20, 2009 <a href="http://www.marketwire.com/press-release/Given-Imaging-Announces-One-Millionth-PillCam-Video-Capsule-NASDAQ-GIVN-992283.htm" target="_blank">http://www.marketwire.com/press-release/Given-Imaging-Announces-One-Millionth-PillCam-Video-Capsule-NASDAQ-GIVN-992283.htm</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Given Imaging'c PillCam COLON 2 video capsule and system receives the CE mark for sale in Europe, The Medical News, 14. September <a href="http://www.news-medical.net/news/20090914/Given-Imagingc-PillCam-COLON-2-video-capsule-and-system-receives-the-CE-mark-for-sale-in-Europe.aspx" target="_blank">http://www.news-medical.net/news/20090914/Given-Imagingc-PillCam-COLON-2-video-capsule-and-system-receives-the-CE-mark-for-sale-in-Europe.aspx</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>The second brain in our stomachs, 12 July 2012, Michael Mosley, BBC <a href="https://www.bbc.co.uk/news/health-18779997" target="_blank">https://www.bbc.co.uk/news/health-18779997</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Announcement Regarding Completion of Merging with Covidien <a href="http://maya.tase.co.il/bursa/report.asp?report_cd=881071&CompCd=2200" target="_blank">http://maya.tase.co.il/bursa/report.asp?report_cd=881071&CompCd=2200</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>"Given Imaging to Launch Advanced PillCam(TM) SB Video Capsule for the small bowel". Archived from the original on 2009-02-20. Retrieved 2010-10-14. <a href="https://web.archive.org/web/20090220051006/http://www.medicalnewstoday.com/articles/31745.php" target="_blank">https://web.archive.org/web/20090220051006/http://www.medicalnewstoday.com/articles/31745.php</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: a prospective three-center pilot study. Endoscopy. 2006;38(1):1-5. 20. Eliakim R, Fireman Z, Gralnek IM, Yassin K, Waterman M, Kopelman Y, Lachter J, Koslowsky B, Adler SN. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy. 2006 Oct;38(10):963-70. <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>MedGadget: PillCam Express <a href="https://archive.today/20120712074447/http://medgadget.com/archives/2010/05/pillcam_express_when_traditional_pillcam_is_too_hard_to_swallow.html" target="_blank">https://archive.today/20120712074447/http://medgadget.com/archives/2010/05/pillcam_express_when_traditional_pillcam_is_too_hard_to_swallow.html</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>"Endoscopy Unit - Bravo PH Monitoring System - Wooster Community Hospital". Archived from the original on 2010-10-25. Retrieved 2010-10-16. <a href="https://web.archive.org/web/20101025160755/http://www.woosterhospital.org/pages/hospitalservices/Endoscopy.aspx" target="_blank">https://web.archive.org/web/20101025160755/http://www.woosterhospital.org/pages/hospitalservices/Endoscopy.aspx</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>Given Imaging Acquires Sierra Scientific Instruments | MDDI Magazine <a href="http://www.mddionline.com/article/given-imaging-acquires-sierra-scientific-instruments" target="_blank">http://www.mddionline.com/article/given-imaging-acquires-sierra-scientific-instruments</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Updating website <a href="http://medtronicsolutions.medtronic.com/given-imaging" target="_blank">http://medtronicsolutions.medtronic.com/given-imaging</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Present website (July 2023) <a href="https://www.medtronic.com/us-en/healthcare-professionals/medical-specialties/gastroenterology.html" target="_blank">https://www.medtronic.com/us-en/healthcare-professionals/medical-specialties/gastroenterology.html</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> </ol>