Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
Mucin 7
open-in-new
<h2 id="human-variations">Human variations</h2> <p><a href="/facts/Human/rlcTENsr">Humans</a> carry either a five or six <a href="/facts/Tandem_repeat/V40yCKFJ">tandem repeat</a> version of the gene. In other primates, the number of repeats found is 4-5 for <a href="/facts/Gorilla/akNvDd3d">gorillas</a>, 5 for <a href="/facts/Chimpanzee/JXSpFsHy">chimpanzees</a>, 6-7 for <a href="/facts/Orangutan/UNSyBlk5">orangutans</a>, 8-10 for <a href="/facts/Macaques/r2tPXVFu">macaques</a>, 10-11 for <a href="/facts/Baboon/qz7J3AoC">baboons</a> and 11-12 for <a href="/facts/Green_monkey/Hwoh876l">green monkeys</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). <a href="https://doi.org/10.18388%2Fabp.2000_3960">"Structure and biosynthesis of human salivary mucins"</a>. <i>Acta Biochimica Polonica</i>. 47 (4): 1067–79. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.18388%2Fabp.2000_3960">10.18388/abp.2000_3960</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11996097">11996097</a>.</li> <li>Bobek LA, Tsai H, Biesbrock AR, Levine MJ (September 1993). <a href="https://doi.org/10.1016%2FS0021-9258%2820%2980762-5">"Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)"</a>. <i>The Journal of Biological Chemistry</i>. 268 (27): 20563–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2820%2980762-5">10.1016/S0021-9258(20)80762-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7690757">7690757</a>.</li> <li>Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD (October 1997). <a href="https://doi.org/10.1093%2Fglycob%2F7.7.965">"Molecular characterization of a major high molecular weight mucin from human sublingual gland"</a>. <i>Glycobiology</i>. 7 (7): 965–73. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fglycob%2F7.7.965">10.1093/glycob/7.7.965</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9363439">9363439</a>.</li> <li>Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ (April 1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". <i>Biochemistry</i>. 37 (14): 4916–27. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi972612a">10.1021/bi972612a</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9538010">9538010</a>.</li> <li>Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM (May 2001). <a href="https://doi.org/10.1038%2Fsj.ejhg.5200642">"Genetic polymorphism of MUC7: allele frequencies and association with asthma"</a>. <i>European Journal of Human Genetics</i>. 9 (5): 347–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.ejhg.5200642">10.1038/sj.ejhg.5200642</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11378823">11378823</a>.</li> <li>Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H (July 2002). <a href="https://doi.org/10.1016%2FS0014-5793%2802%2903007-7">"Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12"</a>. <i>FEBS Letters</i>. 524 (1–3): 211–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2802%2903007-7">10.1016/S0014-5793(02)03007-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12135769">12135769</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:84453381">84453381</a>.</li> <li>Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H (November 2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". <i>FEBS Letters</i>. 531 (2): 115–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2802%2903399-9">10.1016/S0014-5793(02)03399-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12417297">12417297</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:221288147">221288147</a>.</li> <li>Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". <i>Archives of Medical Research</i>. 33 (5): 499–505. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0188-4409%2802%2900395-8">10.1016/S0188-4409(02)00395-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12459324">12459324</a>.</li> <li>Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (January 2003). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". <i>Biochemical and Biophysical Research Communications</i>. 300 (3): 738–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0006-291X%2802%2902908-X">10.1016/S0006-291X(02)02908-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12507512">12507512</a>.</li> <li>Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF (June 2003). "MG2 and lactoferrin form a heterotypic complex in salivary secretions". <i>Journal of Dental Research</i>. 82 (6): 471–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1177%2F154405910308200613">10.1177/154405910308200613</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12766201">12766201</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23276142">23276142</a>.</li> <li>Ge J, Catt DM, Gregory RL (November 2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC523000">"Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen"</a>. <i>Infection and Immunity</i>. 72 (11): 6748–52. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FIAI.72.11.6748-6752.2004">10.1128/IAI.72.11.6748-6752.2004</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC523000">523000</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15501816">15501816</a>.</li> <li>Grys TE, Siegel MB, Lathem WW, Welch RA (March 2005). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064933">"The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells"</a>. <i>Infection and Immunity</i>. 73 (3): 1295–303. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FIAI.73.3.1295-1303.2005">10.1128/IAI.73.3.1295-1303.2005</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064933">1064933</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15731026">15731026</a>.</li> <li>Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. 437 (7062): 1173–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</li> <li>Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD (October 2005). "Two-hybrid analysis of human salivary mucin MUC7 interactions". <i>Biochimica et Biophysica Acta (BBA) - Molecular Cell Research</i>. 1746 (1): 65–72. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.bbamcr.2005.08.007">10.1016/j.bbamcr.2005.08.007</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16203048">16203048</a>.</li> <li>Li S, Intini G, Bobek LA (July 2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658701">"Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo"</a>. <i>American Journal of Respiratory Cell and Molecular Biology</i>. 35 (1): 95–102. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1165%2Frcmb.2005-0305OC">10.1165/rcmb.2005-0305OC</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658701">2658701</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16514118">16514118</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ (February 1996). "Structure and chromosomal localization of the human salivary mucin gene, MUC7". Genomics. 31 (3): 277–82. doi:10.1006/geno.1996.0049. PMID 8838308. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: MUC7 mucin 7, secreted". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4589" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4589</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August 2016). "Recent evolution of the salivary mucin MUC7". Scientific Reports. 6: 31791. Bibcode:2016NatSR...631791X. doi:10.1038/srep31791. PMC 4997351. PMID 27558399. This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997351" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997351</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August 2016). "Recent evolution of the salivary mucin MUC7". Scientific Reports. 6: 31791. Bibcode:2016NatSR...631791X. doi:10.1038/srep31791. PMC 4997351. PMID 27558399. This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997351" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997351</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>