Roach was a senior fellow at the department of molecular biotechnology at the University of Washington from 1999 to 2000. In 2001, he became a research scientist at the Institute for Systems Biology.
In 2009, Roach was first author on a project which sequenced the whole genomes of a family of four, including two children affected by Miller syndrome and primary ciliary dyskinesia. This effort identified the cause of Miller syndrome, a simple recessive Mendelian disorder. It also produced the first complete whole-chromosomal parental haplotypes in humans. Parental haplotyping is the process of assigning all the variants in the genome to paternal and maternal chromosomes. The team applied these techniques to identify genetic mutations related to several genetic diseases, including genes for Adams–Oliver syndrome, alternating hemiplegia of childhood, certain subtypes of epilepsy, palmoplantar keratoderma, and Fanconi anemia.
From 2007 to 2009, he was scientific director of the High-Throughput Analysis Core (HAC) laboratory at Seattle Children's Hospital. Since 2009, he has been a senior research scientist at the Institute for Systems Biology. Roach's group currently applies systems biology to complex genetic diseases, including Alzheimer's disease.
In 2020, Roach was involved in a project to map out the molecular phylogenetics of Washington state's initial SARS-CoV-2 outbreak.
Roach has authored more than 70 publications with over 9000 citations.
Xiao W, Wu L, Yavas G, Simonyan V, Ning B, Hong H (2016). "Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine". Pharmaceutics. 8 (2): 15. doi:10.3390/pharmaceutics8020015. PMC 4932478. PMID 27110816.{{cite journal}}: CS1 maint: multiple names: authors list (link) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932478
Timmerman, Luke (August 10, 2016). Hood: Trailblazer of the Genomics Age. Bandera Press. p. 265. ISBN 978-0997709308. 978-0997709308
Jones, Neil C. (2004). An introduction to bioinformatics algorithms. Pevzner, Pavel. Cambridge, MA: MIT Press. p. 300. ISBN 978-0-262-25643-8. OCLC 57559562. 978-0-262-25643-8
Hood, Lee (1 July 2008). "A Personal Journey of Discovery: Developing Technology and Changing Biology". Annual Review of Analytical Chemistry. 1 (1): 1–43. Bibcode:2008ARAC....1....1H. doi:10.1146/annurev.anchem.1.031207.113113. PMID 20636073. S2CID 6436663. /wiki/Bibcode_(identifier)
Vence, Tracy (November 2011). "Genome analysis: With New Algorithm, Researchers Generate Haplotypes for Two Families". Genome Technology. November 2011. https://www.genomeweb.com/sequencing/new-algorithm-researchers-generate-haplotypes-two-families-using-whole-genome-se#.YCGv1i1h3T8
Hood, Lee (1 July 2008). "A Personal Journey of Discovery: Developing Technology and Changing Biology". Annual Review of Analytical Chemistry. 1 (1): 1–43. Bibcode:2008ARAC....1....1H. doi:10.1146/annurev.anchem.1.031207.113113. PMID 20636073. S2CID 6436663. /wiki/Bibcode_(identifier)
Scher, Steve (October 24, 2011). "Genomes and Future Technology". Weekday. NPR. KUOW. https://kuow.org/authors/weekday
Hood, Lee (1 July 2008). "A Personal Journey of Discovery: Developing Technology and Changing Biology". Annual Review of Analytical Chemistry. 1 (1): 1–43. Bibcode:2008ARAC....1....1H. doi:10.1146/annurev.anchem.1.031207.113113. PMID 20636073. S2CID 6436663. /wiki/Bibcode_(identifier)
Roach, Jared (1995). "Pairwise end sequencing: a unified approach to genomic mapping and sequencing". Genomics. 26 (2): 345–353. doi:10.1016/0888-7543(95)80219-C. PMID 7601461. /wiki/Doi_(identifier)
Jones, Neil C. (2004). An introduction to bioinformatics algorithms. Pevzner, Pavel. Cambridge, MA: MIT Press. p. 300. ISBN 978-0-262-25643-8. OCLC 57559562. 978-0-262-25643-8
"ISB's Jared Roach on Why Two Technologies Are Better than One". GenomeWeb. June 8, 2005. Retrieved October 23, 2020. https://www.genomeweb.com/arrays/isb-s-jared-roach-why-two-technologies-are-better-one
Wade, Nicholas (March 11, 2010). "Disease Cause is Pinpointed with Genome". New York Times. p. 1. https://www.nytimes.com/2010/03/11/health/research/11gene.html
Stewart, Kirsten (March 10, 2010). "Unraveling one family's genome". The Salt Lake Tribune. https://archive.sltrib.com/story.php?ref=/utah/ci_14648608
Ada Hamosh (February 16, 2017). "DIHYDROOROTATE DEHYDROGENASE; DHODH". Online Mendelian Inheritance in Man (OMIM). National Library of Medicine. Retrieved February 8, 2021. https://www.omim.org/entry/126064
Vence, Tracy (November 2011). "Genome analysis: With New Algorithm, Researchers Generate Haplotypes for Two Families". Genome Technology. November 2011. https://www.genomeweb.com/sequencing/new-algorithm-researchers-generate-haplotypes-two-families-using-whole-genome-se#.YCGv1i1h3T8
Chen, Rui; Snyder, Michael (January 2013). "Promise of personalized omics to precision medicine". Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5 (1): 73–82. doi:10.1002/wsbm.1198. ISSN 1939-005X. PMC 4154620. PMID 23184638. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154620
Capuano, Alessandro; Garone, Giacomo; Tiralongo, Giuseppe; Graziola, Federica (2020). "Alternating Hemiplegia of Childhood: Understanding the Genotype-Phenotype Relationship of ATP1A3 Variations". The Application of Clinical Genetics. 13: 71–81. doi:10.2147/TACG.S210325. ISSN 1178-704X. PMC 7125306. PMID 32280259. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125306
Ceccaldi, Raphael; Sarangi, Prabha; D'Andrea, Alan D. (June 2016). "The Fanconi anaemia pathway: new players and new functions". Nature Reviews. Molecular Cell Biology. 17 (6): 337–349. doi:10.1038/nrm.2016.48. ISSN 1471-0080. PMID 27145721. S2CID 1712640. https://pubmed.ncbi.nlm.nih.gov/27145721
Marla J. F. O'Neill (October 5, 2015). "ADAMS-OLIVER SYNDROME 6; AOS6". Online Mendelian Inheritance in Man (OMIM). National Library of Medicine. Retrieved February 8, 2021. https://www.omim.org/entry/616589
Cassandra L. Kniffin (January 8, 2015). "SYNTAXIN 1B; STX1B". Online Mendelian Inheritance in Man (OMIM). National Library of Medicine. Retrieved February 8, 2021. https://www.omim.org/entry/601485
Marla J. F. O'Neill (June 1, 2015). "TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY V, MEMBER 3; TRPV3". Online Mendelian Inheritance in Man (OMIM). National Library of Medicine. Retrieved February 8, 2021. https://www.omim.org/entry/607066
"Institute for Systems Biology". ISB. Retrieved February 8, 2021. https://isbscience.org/bio/jared-roach-md-phd/
"Personalized Coaching Decreases Cognitive Decline in Early-Stage Alzheimer's Disease Patients". Journal of Alzheimer's Disease. October 16, 2023. https://www.j-alz.com/content/personalized-coaching-decreases-cognitive-decline-early-stage-alzheimers-disease-patients
Kamb, Lewis (March 31, 2020). "Flood of coronavirus data overwhelms Washington state's disease-reporting system, leading to lag in data". Seattle Times. https://www.seattletimes.com/seattle-news/flood-of-coronavirus-data-overwhelms-states-disease-reporting-system-leading-to-lag-in-data/
Kamb, Lewis (May 14, 2020). "When did coronavirus really hit Washington? 2 Snohomish County residents with antibodies were ill in December". Seattle Times. https://www.seattletimes.com/seattle-news/antibody-test-results-of-2-snohomish-county-residents-throw-into-question-timeline-of-coronaviruss-u-s-arrival/
Doughton, Sandi (May 26, 2020). "New analysis may rewrite the history of Washington state's coronavirus outbreak". Seattle Times. https://www.seattletimes.com/seattle-news/health/genetic-analysis-raises-more-questions-about-the-history-of-washington-states-coronavirus-outbreak/
""Roach JCC" on NCBI Pubmed". Retrieved 5 November 2022. https://pubmed-ncbi-nlm-nih-gov.pitt.idm.oclc.org/?term=Roach+JC&cauthor_id=35733645
"Jared Roach Profile on Google Scholar". Retrieved 5 November 2022. https://scholar.google.com/citations?user=hjId8NEAAAAJ