Alternatively, many advanced methods for spatial normalization are building on structure preserving transformations homeomorphisms and diffeomorphisms since they carry smooth submanifolds smoothly during transformation. Diffeomorphisms are generated in the modern field of Computational Anatomy based on diffeomorphic flows, also called diffeomorphic mapping. However, such transformations via diffeomorphisms are not additive, although they form a group with function composition and acting non-linearly on the images via group action. For this reason, flows which generalize the ideas of additive groups allow for generating large deformations that preserve topology, providing 1-1 and onto transformations. Computational methods for generating such transformation are often called LDDMM1234 which provide flows of diffeomorphisms as the main computational tool for connecting coordinate systems corresponding to the geodesic flows of Computational Anatomy.
There is a number of programs that implement both estimation and application of a warp-field. It is a part of the SPM and AIR programs as well as MRI Studio and MRI Cloud.org.56
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