Phosphatidylinositol 3-kinase-related kinase

<h2 id="members">Members</h2>
<p>The human PIKK family includes six members:
</p>
<table><tbody><tr><th>Gene</th><th>Protein</th><th>Function</th></tr><tr><td><a href="/facts/Ataxia_telangiectasia_mutated/oBMxx2Y7">ATM</a></td><td>ataxia-telangiectasia mutated</td><td>response to DNA damage</td></tr><tr><td><a href="/facts/Ataxia_telangiectasia_and_Rad3_related/QlDNk6rq">ATR</a></td><td>ataxia- and Rad3-related</td><td>"</td></tr><tr><td><a href="/facts/DNA-PKcs/L7mc4Mg9">PRKDC</a></td><td>DNA-dependent protein kinase catalytic subunit (DNA-PKcs)</td><td>"</td></tr><tr><td><a href="/facts/Mammalian_target_of_rapamycin/5l2dVa1p">MTOR</a></td><td>mammalian target of rapamycin (mTOR)</td><td>nutrient-regulated kinase that controls metabolism and cell growth</td></tr><tr><td><a href="/facts/SMG1_(gene)/XvnPVgVr">SMG1</a></td><td>suppressor of morphogenesis in genitalia</td><td>regulates nonsense-mediated <a href="/facts/Messenger_RNA/oUL6qxQn">mRNA</a> decay</td></tr><tr><td><a href="/facts/Transformation%2ftranscription_domain-associated_protein/bSpGKYkH">TRRAP</a></td><td>transformation/transcription domain-associated protein</td><td>transcription factor <a href="/facts/Coactivator_(genetics)/0lVABmQx">co-activator</a></td></tr></tbody></table>
<h2 id="structure">Structure</h2>
<p>PIKKs proteins contain the following four <a href="/facts/Protein_domain/oUpFcSsl">domains</a>:
</p>
<ol><li><a href="/facts/N-terminus/yKYpuaBJ">N-terminus</a> FRAP-ATM- TRRAP (FAT) domain, <a href="/facts/Pfam/BKJa293w">Pfam</a> <a href="https://www.ebi.ac.uk/interpro/entry/pfam/PF02259">PF02259</a></li>
<li>kinase domain (KD; <a href="/facts/Phosphoinositide_3-kinase/e5rtq0VG">PI3_PI4_kinase</a>),</li>
<li>PIKK- regulatory domain (PRD), and</li>
<li><a href="/facts/C-terminus/ws4scHgT">C-terminus</a> FAT-C-terminal (FATC) domain <a href="/facts/Pfam/BKJa293w">Pfam</a> <a href="https://www.ebi.ac.uk/interpro/entry/pfam/PF02260">PF02260</a></li></ol>

<h2 id="external-links">External links</h2>
<ul><li><a href="http://kinase.com/wiki/index.php/Kinase_Family_PIKK">Kinase Family PIKK</a> at <a href="http://kinase.com/wiki/index.php/Main_Page">WikiKinome</a>.</li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". EMBO J. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC 2752028. PMID 19779456. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752028" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752028</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
</ol>

Phosphatidylinositol 3-kinase-related kinase open-in-new

Phosphatidylinositol 3-kinase-related kinase