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E2F3
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<h2 id="function">Function</h2> <p>The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <h2 id="interactions">Interactions</h2> <p>E2F3 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/TFE3/Tbbg5tDc">TFE3</a>,<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> <a href="/facts/IGF2/HnxTYloa">IGF2</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> and <a href="/facts/RYBP/K4zIL2B2">RYBP</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/E2F/18zluKwA">E2F</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). <a href="https://doi.org/10.1093%2Fdnares%2F1.5.223">"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1"</a>. <i>DNA Research</i>. 1 (5): 223–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F1.5.223">10.1093/dnares/1.5.223</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7584044">7584044</a>.</li> <li>Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230484">"In vivo association of E2F and DP family proteins"</a>. <i>Molecular and Cellular Biology</i>. 15 (5): 2536–46. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.15.5.2536">10.1128/mcb.15.5.2536</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC230484">230484</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7739537">7739537</a>.</li> <li><a href="/facts/Jan_Karlseder/EIoqV1Mo">Karlseder J</a>, Rotheneder H, Wintersberger E (Apr 1996). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231152">"Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F"</a>. <i>Molecular and Cellular Biology</i>. 16 (4): 1659–67. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.16.4.1659">10.1128/mcb.16.4.1659</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231152">231152</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8657141">8657141</a>.</li> <li>Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (Jul 1996). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38791">"DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 93 (15): 7594–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1996PNAS...93.7594R">1996PNAS...93.7594R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.93.15.7594">10.1073/pnas.93.15.7594</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC38791">38791</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8755520">8755520</a>.</li> <li>Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (Jul 1996). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". <i>Journal of Cell Science</i>. 109 (7): 1717–26. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1242%2Fjcs.109.7.1717">10.1242/jcs.109.7.1717</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8832394">8832394</a>.</li> <li>Hofmann F, Livingston DM (Apr 1996). <a href="https://doi.org/10.1101%2Fgad.10.7.851">"Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit"</a>. <i>Genes & Development</i>. 10 (7): 851–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.10.7.851">10.1101/gad.10.7.851</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8846921">8846921</a>.</li> <li>Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24637">"The subcellular localization of E2F-4 is cell-cycle dependent"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 94 (10): 5095–100. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1997PNAS...94.5095L">1997PNAS...94.5095L</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.94.10.5095">10.1073/pnas.94.10.5095</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24637">24637</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9144196">9144196</a>.</li> <li>Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L (Jul 1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232239">"Specific regulation of E2F family members by cyclin-dependent kinases"</a>. <i>Molecular and Cellular Biology</i>. 17 (7): 3867–75. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.17.7.3867">10.1128/mcb.17.7.3867</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232239">232239</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9199321">9199321</a>.</li> <li>Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (Jul 1998). "Differential activities of E2F family members: unique functions in regulating transcription". <i>Molecular Carcinogenesis</i>. 22 (3): 190–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F%28SICI%291098-2744%28199807%2922%3A3%3C190%3A%3AAID-MC7%3E3.0.CO%3B2-P">10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9688145">9688145</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:42749241">42749241</a>.</li> <li>Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA (Mar 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316459">"E2f3 is critical for normal cellular proliferation"</a>. <i>Genes & Development</i>. 14 (6): 690–703. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.14.6.690">10.1101/gad.14.6.690</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316459">316459</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10733529">10733529</a>.</li> <li>Takahashi Y, Rayman JB, Dynlacht BD (Apr 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316494">"Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression"</a>. <i>Genes & Development</i>. 14 (7): 804–16. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.14.7.804">10.1101/gad.14.7.804</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC316494">316494</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10766737">10766737</a>.</li> <li>Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR (May 2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85655">"Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins"</a>. <i>Molecular and Cellular Biology</i>. 20 (10): 3626–32. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.20.10.3626-3632.2000">10.1128/MCB.20.10.3626-3632.2000</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85655">85655</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10779352">10779352</a>.</li> <li>He Y, Armanious MK, Thomas MJ, Cress WD (Jul 2000). <a href="https://doi.org/10.1038%2Fsj.onc.1203682">"Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region"</a>. <i>Oncogene</i>. 19 (30): 3422–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1203682">10.1038/sj.onc.1203682</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10918599">10918599</a>.</li> <li>Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M (Dec 2001). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". <i>European Journal of Biochemistry</i>. 268 (23): 6076–82. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.0014-2956.2001.02555.x">10.1046/j.0014-2956.2001.02555.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11733001">11733001</a>.</li> <li>Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ (Jan 2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155318">"Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis"</a>. <i>Genes & Development</i>. 16 (2): 235–44. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.943102">10.1101/gad.943102</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155318">155318</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11799066">11799066</a>.</li> <li>Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD (Jan 2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155321">"E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints"</a>. <i>Genes & Development</i>. 16 (2): 245–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.949802">10.1101/gad.949802</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155321">155321</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11799067">11799067</a>.</li> <li>He Y, Cress WD (Jun 2002). <a href="https://doi.org/10.1074%2Fjbc.M202629200">"E2F-3B is a physiological target of cyclin A"</a>. <i>The Journal of Biological Chemistry</i>. 277 (26): 23493–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M202629200">10.1074/jbc.M202629200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11980909">11980909</a>.</li> <li>Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC131074">"Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function"</a>. <i>The EMBO Journal</i>. 21 (21): 5775–86. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2Fcdf577">10.1093/emboj/cdf577</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC131074">131074</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12411495">12411495</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=E2F3+protein%2C+human">E2F3+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC364853" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC364853</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: E2F3 E2F transcription factor 3". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155231" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC155231</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Julian CL, Jeffrey B (March 25, 2013). "Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3". The Proceedings of the National Academy of Sciences. 110 (15): 6181–86. doi:10.1073/pnas.1219079110. PMC 3625270. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625270" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625270</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC131074" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC131074</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> </ol>