Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
SHROOM3
open-in-new
<h2 id="clinical-relevance">Clinical relevance</h2> <p>Mutations in this gene have been shown to cause <a href="/facts/Heterotaxy/qTnWC1fX">heterotaxy</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> A similar protein in mice is required for proper <a href="/facts/Neurulation/awsFwAGt">neurulation</a>,<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> eye,<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> and gut development.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a><a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Juriloff DM, Harris MJ (2000). <a href="https://doi.org/10.1093%2Fhmg%2F9.6.993">"Mouse models for neural tube closure defects"</a>. <i>Hum. Mol. Genet</i>. 9 (6): 993–1000. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fhmg%2F9.6.993">10.1093/hmg/9.6.993</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10767323">10767323</a>.</li> <li>Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). <a href="https://doi.org/10.1074%2Fmcp.M500021-MCP200">"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer"</a>. <i>Mol. Cell. Proteomics</i>. 4 (6): 785–95. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fmcp.M500021-MCP200">10.1074/mcp.M500021-MCP200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15778465">15778465</a>.</li> <li>Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". <i>Proteomics</i>. 4 (2): 339–46. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fpmic.200300528">10.1002/pmic.200300528</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14760703">14760703</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:8868600">8868600</a>.</li> <li>Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (2000). <a href="https://doi.org/10.1093%2Fdnares%2F7.2.143">"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"</a>. <i>DNA Res</i>. 7 (2): 143–50. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F7.2.143">10.1093/dnares/7.2.143</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10819331">10819331</a>.</li> <li>Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). <a href="https://doi.org/10.1101%2Fgr.8.11.1097">"Toward a complete human genome sequence"</a>. <i>Genome Res</i>. 8 (11): 1097–108. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.8.11.1097">10.1101/gr.8.11.1097</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9847074">9847074</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Hildebrand JD, Soriano P (1999). "Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice". Cell. 99 (5): 485–97. doi:10.1016/S0092-8674(00)81537-8. PMID 10589677. S2CID 17185521. <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981537-8" target="_blank">https://doi.org/10.1016%2FS0092-8674%2800%2981537-8</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Hagens O, Ballabio A, Kalscheuer V, Kraehenbuhl JP, Schiaffino MV, Smith P, Staub O, Hildebrand J, Wallingford JB (2006). "A new standard nomenclature for proteins related to Apx and Shroom". BMC Cell Biol. 7 (1): 18. doi:10.1186/1471-2121-7-18. PMC 1481537. PMID 16615870. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481537" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481537</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: SHROOM3 shroom family member 3". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57619" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57619</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM (2011). "SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing". Genome Biol. 12 (9): R91. doi:10.1186/gb-2011-12-9-r91. PMC 3308054. PMID 21936905. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308054" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308054</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Hildebrand JD, Soriano P (1999). "Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice". Cell. 99 (5): 485–97. doi:10.1016/S0092-8674(00)81537-8. PMID 10589677. S2CID 17185521. <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981537-8" target="_blank">https://doi.org/10.1016%2FS0092-8674%2800%2981537-8</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"Entrez Gene: SHROOM3 shroom family member 3". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57619" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57619</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Plageman TF, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA (2010). "Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination". Development. 137 (3): 405–15. doi:10.1242/dev.045369. PMC 2858910. PMID 20081189. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858910" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858910</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL (2011). "Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis". Development. 138 (20): 4423–32. doi:10.1242/dev.065789. PMC 3177312. PMID 21880782. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177312" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177312</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Plageman TF, Zacharias AL, Gage PJ, Lang RA (2011). "Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis". Developmental Biology. 357 (1): 227–34. doi:10.1016/j.ydbio.2011.06.027. PMC 3619216. PMID 21726547. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619216" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619216</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> </ol>