The series featured super-powered humans and their madcap adventures. The team is formed by Dr. Billy Hayes, a research scientist at the Humanidyne Institute who specializes in "human anomalies". He works with shrinking Dr. Elvin "El" Lincoln, and together they recruit electrically powered Johnny Bukowski, a rock-and-roll musician, and Gloria Dinallo, a telekinetic teenager.
A double-length TV pilot and 15 additional episodes were produced; however, one episode did not air before the show was cancelled due to low ratings.
The name "Misfits of Science" and other conceptual ideas were the brainchild of then-president of NBC Entertainment, Brandon Tartikoff. He explained of the series "We'll rely on the National Enquirer for story ideas. It's loosely inspired by the dynamics we saw in Ghostbusters... sort of a kick-back, Friday type of show."1
The ninth episode was the first paid writing job for Tim Kring, who later originated and produced the thematically similar Heroes in 2006.
The main title sequence and its theme song were unusual for TV shows of the era. Donald Todd, head writer and story editor, described them as follows:
The main titles are fun. It's still kind of... it's really forward-looking. Jim [Parriott] was forward-looking in many ways, and we fought a lot about that, but it starts off with Bobby Short doing the theme, and then there's the kicking over of the TV and into the more contemporary version of the theme. He was trying to say, "We're not doing that show, we're doing this show, and it's more hip." And I remember the people at Universal going, "Why don't you do it without the TV? We don't like the TV!" And I don't think they gave him the budget for it. I think we had to find it ourselves. It's a really cheap thing, it's just a guy playing piano and then a foot kicking over a TV, but it was really controversial, because back then nobody did anything interesting with the main titles. You just showed the characters sliding into frame. But I remember that was pretty cool. And Jim wrote it.2
In France, the series was known as Superminds, in Germany, as Die Spezialisten unterwegs (The Specialists On The Way), in Brazil, as "Curto-Circuito" ("Short Circuit"), in Mexico, Colombia, Peru and rest of Latin America as Los Cientificos Rebeldes (The Rebel Scientists).
On January 25, 2008, the series was released in Germany as a 5-disc DVD box set (Region 2) with all episodes (including the final episode, which was originally unaired on NBC but broadcast in Germany) with both English and German audios and German subtitles. The release was entitled “Die Spezialisten Unterwegs”, translates literally to “The Specialists On The Go”.
On September 19, 2012, the series was released on DVD in France as Superminds.
Holloway, Diane (July 8, 1985). "NBC Tests 'High Concept' With 'Misfits of Science'". The Palm Beach Post. Cox News Service. Retrieved November 9, 2014. https://news.google.com/newspapers?id=ctwiAAAAIBAJ&sjid=-84FAAAAIBAJ&pg=948%2C4691815 ↩
Harris, Will (2013). Misfits of Science: An Oral History. SED Productions. ASIN B00CH7QHQ0. /wiki/ASIN_(identifier) ↩