As has been the case since 2013, all teams played their four division opponents 19 times each for a total of 76 games. They played six or seven games against each of the other ten same-league opponents for a total of 66 games, and 20 interleague games. The primary interleague match-ups were AL East vs NL East, AL Central vs NL Central, and AL West vs NL West. Since "natural rivalry" matchups were part of the three-year divisional rotation, the schedule format for interleague games was different from previous years. The 20 interleague games each team played two three-game series (one home, one away) against its natural rival (total of six games), two two-game series (one home, one away) against each team for two other opponents (total of eight games), and a single three-game series against each team for the last two (one home, one away; total of six games).
Under the new collective bargaining agreement reached in December 2016, the regular season was extended to 187 days in order to add four additional off-days for all teams. All teams were scheduled to play Opening Day, March 29—the earliest domestic start of a regular season in league history until the 2019 season. The Sunday night game before the All-Star Game was replaced by a single, nationally televised game on the Thursday after the All-Star Game (which for 2018, was played between the St. Louis Cardinals and Chicago Cubs), before all other teams returned from break the next day.
The Oakland Athletics added a kelly green alternate jersey to commemorate the franchise's 50th anniversary in Oakland. The uniforms are used during every Friday home game.
The Washington Nationals added a second navy blue jersey to commemorate the team's hosting of the 2018 All-Star Game. The uniform features the script "Nationals" in white with red trim and numerals in red with white trim.
Both the Cincinnati Reds and the Pittsburgh Pirates replaced their camouflage uniforms with new white alternate jerseys featuring olive and military green logos, letters and numbers.
As is the custom for the reigning World Series champions, the Astros wore gold-lettered uniforms at their home opener April 2 and 3.
The Royals wore an alternate uniform with a crown atop the R, and a cap with a crown instead of the "KC", on June 30 in Seattle.
All US-based teams wore Stars and Stripes caps and uniforms from July 2–4, ending with Independence Day. Teams wore caps denoting what league they play for (there were nine interleague series during the time period).
The Royals wore Spanish-language "Los Reales" uniforms September 1.
The Phillies will wear their 1980s powder blue uniforms for select Thursday home games.
The White Sox and Brewers wore 1980s throwbacks June 2 and 3.
The Mariners marked the 20th anniversary of their 1998 "Turn Ahead the Clock" promotion by wearing the uniforms from that game June 30 against Kansas City.
The Brewers and Pirates wore Negro league throwbacks July 13. The Brewers wore the uniforms of the Milwaukee Bears, and the Pirates wore the uniforms of the Pittsburgh Crawfords.
The Brewers wore Milwaukee Bears uniforms August 2. Their opponents, the Rockies, wore their regular uniforms.
The Angels wore California Angels throwbacks from 1976 to 1985 on August 27.
The Rays wore their 1998 inaugural throwbacks on March 31 against the Boston Red Sox, on June 9 against the Seattle Mariners, and on June 23 against the New York Yankees, along with September 8 against the Baltimore Orioles.
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Blue Jays retiring No. 32 for Roy Halladay. MLB.com. Published on February 12, 2018. Retrieved on February 12, 2018 https://www.mlb.com/news/blue-jays-retiring-no-32-for-roy-halladay/c-266307654
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