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Janssen Pharmaceuticals
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<h2 id="subsidiaries">Subsidiaries</h2> <ul><li><a href="/facts/Actelion/VSQE7N41">Actelion</a></li> <li><a href="/facts/Cilag/WMm8Dkgu">Cilag AG</a></li> <li><a href="/facts/Janssen_Biotech/D8sYYEUt">Janssen Biotech</a> (formerly <i>Centocor</i>)<a class="footnote-ref" id="fnref:1" href="#fn:1"><sup>1</sup></a></li> <li><a href="/facts/Janssen_Vaccines/RnJh5K35">Janssen Vaccines</a> (formerly <i>Crucell</i>)<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a></li> <li><a href="/facts/Tibotec/vLUrpINK">Tibotec</a></li></ul> <h2 id="history">History</h2> <p>The roots of what would become Janssen Pharmaceuticals date back to 1933. In 1933, <a href="/facts/Constant_Janssen/zJ8muUEx">Constant Janssen</a>, the father of Paul Janssen, acquired the right to distribute the pharmaceutical products of <a href="/facts/Gedeon_Richter_Ltd./6cDXF60o">Richter</a>, a Hungarian pharmaceutical company, for Belgium, the Netherlands and <a href="/facts/Belgian_Congo/KeenpcUJ">Belgian Congo</a>. On 23 October 1934, he founded the <i>N.V. Produkten Richter</i> in <a href="/facts/Turnhout/1CT9mIAD">Turnhout</a>. In 1937, Constant Janssen acquired an old factory building in the <i>Statiestraat 78</i> in <a href="/facts/Turnhout/1CT9mIAD">Turnhout</a> for his growing company, which he expanded during <a href="/facts/World_War_II/2efV5L1U">World War II</a> into a four-story building. Still a student, Paul Janssen assisted in the development of <a href="/facts/Paracetamol/SNDfQWcf">paracetamol</a> (USP: acetaminophen, often referred to generically under the trademark <a href="/facts/Tylenol_(brand)/tWIjkbma">Tylenol</a>) under the name <a href="/facts/Perdolan/SNDfQWcf">Perdolan</a>, which would later become well-known. After the war, the name for the company products was changed to <i>Eupharma</i>, although the company name <i>Richter</i> would remain until 1956.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> </p><p>Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the <i>Statiestraat</i>, still within the <i>Richter-Eupharma</i> company of his father. In 1955, he and his team developed their first drug, Neomeritine (<a href="/facts/Ambucetamide/X3j9fqLl">ambucetamide</a>), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed to <i>NV Laboratoria Pharmaceutica C. Janssen</i> (named after Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971 to 1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the <i>N.V. Research Laboratorium C. Janssen</i>. </p><p>On 25 October 1961, the company was acquired by the American corporation <a href="/facts/Johnson_%26_Johnson/DSfqnVrM">Johnson & Johnson</a>. The negotiations with Johnson & Johnson were led by <a href="/facts/Frans_Van_den_Bergh/KndvzeCu">Frans Van den Bergh</a>, head of the board of directors. On 10 February 1964, the name was changed to <i>Janssen Pharmaceutica N.V.</i> and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen, <a href="/facts/Bob_Stouthuysen/zBgceajU">Bob Stouthuysen</a> and Frans Van Den Bergh. When, in 1971 to 1972 the pharmaceutical production also moved to Beerse, the move from Turnhout was completed. Between 1990 and 2004, Janssen expanded worldwide, and the company grew to about 28,000 employees worldwide. </p><p>From the beginning, Janssen emphasized research on new drug development as its core activity. The research department established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded to perform research into new drugs at Beerse and in other laboratories around the globe. Janssen became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica still has offices in Belgium in <a href="/facts/Berchem/FCEke2sj">Berchem</a> (<a href="/facts/Janssen-Cilag/DSfqnVrM">Janssen-Cilag</a>), a chemical factory in <a href="/facts/Geel/R8dY01CC">Geel</a>, and <a href="/facts/Janssen_Biotech/D8sYYEUt">Janssen Biotech</a> in <a href="/facts/Olen,_Belgium/djQbsQY4">Olen</a>. </p><p>The chemical production plant in Geel makes <a href="/facts/Active_ingredient/oeDx5S19">active ingredients</a> for the company's medicines. In 1975, the first plant of a new chemical factory <i>Plant I</i> was established in Geel, <i>Plant II</i> was opened in 1977, <i>Plant III'</i> in 1984, and <i>Plant IV</i> in 1995. In 1999 the remaining chemical production in Beerse was transferred to Geel. About 80% of its active components are manufactured there. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of <a href="/facts/Johnson_%26_Johnson/DSfqnVrM">Johnson & Johnson</a>. In 1995, the <i>Center for Molecular Design</i> (CMD) was founded by Paul Janssen and <a href="/facts/Paul_Lewi/VGIlIPVF">Paul Lewi</a>. </p><p>In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the United States with the reorganization of research activities in the <i>Johnson & Johnson Pharmaceutical Research Development</i> (JJPRD) organization. The research activities of the <i>Janssen Research Foundation</i> (JRF) and the <i>R.W. Johnson Pharmaceutical Research Institute</i> (PRI) (United States) were merged into the new global research organization. A new building for pharmaceutical development was completed in Beerse in 2001. In 2002, a new logistics and informatics centre was opened at a new site, <i>Beerse 2</i>. In 2003 two new research buildings were constructed, the <i>Discovery Research Center</i> (DRC), and the <i>Drug Safety Evaluation Center</i> (DSEC). On 27 October 2004, the <i>Paul Janssen Research Center</i>, for discovery research, was inaugurated. </p><p>In 2011, Johnson & Johnson subsidiary Centocor became <a href="/facts/Janssen_Biotech/D8sYYEUt">Janssen Biotech</a>, part of Janssen Pharmaceuticals.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p><p>Also in 2011, Johnson & Johnson acquired Crucell, and assigned it to Janssen. The acquisition of Crucell provided Janssen with a disease prevention arm. By 2014, Crucell was renamed <a href="/facts/Janssen_Vaccines/RnJh5K35">Janssen Vaccines</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p><p>In March 2015, Janssen licensed <a href="/facts/Tipifarnib/ooWXYyBp">tipifarnib</a> (a <a href="/facts/Farnesyl_transferase/uo7npIzy">farnesyl transferase</a> inhibitor) to Kura Oncology who will assume sole responsibility for developing and commercialising the anti-cancer drug.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> Later in the same month the company announced that Galapagos Pharma had regained the rights to the anti-inflammatory drug candidate GLPG1690 as well as two other compounds including GLPG1205 (a first-in-class inhibitor of <a href="/facts/GPR84/QEKTLjv5">GPR84</a>).<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p><p>In May 2016, the company launched a collaboration MacroGenics and the preclinical cancer treatment, MGD015. The deal could net MacroGenics more than $740 million.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p><p>In September 2017 Janssen teamed up with the <a href="/facts/Biomedical_Advanced_Research_and_Development_Authority/uEpDk2HN">Biomedical Advanced Research and Development Authority</a> (BARDA), a unit of the <a href="/facts/United_States_Department_of_Health_and_Human_Services/eS90vYmd">U.S. Department of Health and Human Services</a>, to create pandemic <a href="/facts/Influenza_vaccine/6J8BBKN1">flu vaccines</a>. BARDA gave Janssen $43 million in the first year and $273 million over five years for the contract. One of the projects in the contract is the development of a universal flu vaccine. The intent of the vaccine would be to protect people against all or most flu strains.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> </p><p>On 5 March 2019, the <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> approved Janssen's <a href="/facts/Spravato/4FM0G8FI">Spravato</a> (<a href="/facts/Esketamine/4FM0G8FI">esketamine</a> <a href="/facts/Nasal_spray/zLm4BmWx">nasal spray</a>) for treatment-resistant <a href="/facts/Major_depressive_disorder/l2lQeWqr">major depressive disorder</a>. This marked the first approval of a new type of antidepressant in decades.<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> </p><p>In 2021, Janssen became a defendant in a trial against several opioid manufacturers filed by New York Attorney General <a href="/facts/Letitia_James/L6F8zh58">Letitia James</a>.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> The company was removed from the case after Johnson & Johnson agreed to a pay a $230 million settlement to New York State.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> </p> <h3>Janssen Biotech</h3> <p>The subsidiary Janssen Biotech, Inc. was founded in <a href="/facts/Philadelphia/2bFFCCTU">Philadelphia</a> in 1979 as Centocor Biotech, Inc., with an initial goal to develop new diagnostic assays using <a href="/facts/Monoclonal_antibody/4rUBWB87">monoclonal antibody</a> technology. </p> <h4>Centocor Biotech</h4> <p>In 1982, Centocor became a publicly traded company.<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> In the early 1980s, the company moved to <a href="/facts/Malvern,_Pennsylvania/t0NG0jEj">Malvern, Pennsylvania</a>.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> In 1984, Centocor opened an overseas plant in <a href="/facts/Leiden/rs70mHlG">Leiden</a>, the <a href="/facts/Netherlands/y8xn5stT">Netherlands</a>.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a> </p><p>In 1997, eighteen years after its foundation, Centocor achieved its first year of operating profitability.<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> In 1998, Centocor sold its diagnostic division to <a href="/facts/Fujirebio/qQmVmnuI">Fujirebio, Inc.</a><a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a> </p><p>In 1999, Centocor became a wholly owned subsidiary of <a href="/facts/Johnson_%26_Johnson/DSfqnVrM">Johnson & Johnson</a>.<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a> </p><p>In 2004, Centocor purchased a new manufacturing plant in <a href="/facts/St._Louis,_Missouri/22beLecX">St. Louis, Missouri</a>, and is opening a new manufacturing facility in <a href="/facts/County_Cork,_Ireland/bhEYI189">County Cork, Ireland</a>. The Dutch plant has been expanded substantially with a $250 million investment in additional production facilities, which were opened in 2006. </p><p>In 2007, Centocor broke new ground in advertising by releasing <a href="/facts/Innerstate/Jmd2ALAG">Innerstate</a>, believed to be the first theatrically released documentary film both created and entirely funded by a drug company, to promote Remicade (<a href="/facts/Infliximab/pk8CdtFV">Infliximab</a>).<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> </p> <h4>Centocor Ortho Biotech</h4> <p>In 2008, Centocor, Inc. and Ortho Biotech Inc. merged to form Centocor Ortho Biotech Inc. </p><p>In June 2010, Centocor Ortho Biotech acquired RespiVert, a privately held <a href="/facts/Drug_discovery/LLdDNvjy">drug discovery</a> company focused on developing small-molecule, inhaled therapies for the treatment of pulmonary diseases.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a> </p> <h4>As Janssen Biotech</h4> <p>In June 2011, Centocor Ortho Biotech changed its name to Janssen Biotech, Inc. as part of a global effort to unite the Janssen Pharmaceutical Companies around the world under a common identity.<a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a> </p><p>In December 2014, the company announced it would co-develop MacroGenics cancer drug candidate (MGD011) which targets both <a href="/facts/CD19/zs1uF4S3">CD19</a> and <a href="/facts/CD3_(immunology)/TRM7er2v">CD3</a> proteins in treating <a href="/facts/B-cell/6Y1tgwwp">B-cell</a> malignant tumours. This could net MacroGenics up to $700 million.<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a> </p><p>In January 2015, the company announced it would use <a href="/facts/Ionis_Pharmaceuticals/8482Fvyr">Ionis Pharmaceuticals</a>' (formerly Isis Pharmaceuticals) RNA-targeting technology to discover and develop <a href="/facts/Antisense/hcKgNvy6">antisense</a> drugs targeting autoimmune disorders of the gastrointestinal tract.<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a> </p><p>In December 2019, XBiotech Inc. announced it would sell its novel antibody treatment (<a href="/facts/Bermekimab/pGme0col">bermekimab</a>) that neutralizes <a href="/facts/Interleukin-1/dSToCWMd">interleukin-1</a> alpha (IL-1⍺) to Janssen Biotech, Inc.<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a><a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a> </p> <h3>COVID-19 vaccine development</h3> <p class="note">Main article: <a href="/facts/Janssen_COVID-19_vaccine/a6ePrE7M">Janssen COVID-19 vaccine</a></p> <p>On 27 March 2020, the U.S. <a href="/facts/Biomedical_Advanced_Research_and_Development_Authority/uEpDk2HN">Biomedical Advanced Research and Development Authority</a> (BARDA) allocated $456 million for J&J (Janssen) to develop a vaccine against the <a href="/facts/Severe_acute_respiratory_syndrome_coronavirus_2/DxF8rDc1">novel coronavirus</a>.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a><a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> </p> <h3>In China</h3> <p>Janssen Pharmaceuticals was the first Western pharmaceutical company to set up a pharmaceutical factory in the People's Republic of China.<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a> </p><p>In 1976, Paul Janssen met <a href="/facts/Ma_Haide/zcX3MeuY">Ma Haide</a> (born George Shafik Hatem), a Lebanese-American doctor who had started working in China in 1933. After three days of meetings, the two agreed to bring a modernized pharmaceutical business to China. When <a href="/facts/Deng_Xiaoping/qloJ6G8m">Deng Xiaoping</a> opened China to the West in 1978, Janssen sent <a href="/facts/Paul_Appermont/atvxxD8h">Paul Appermont</a> and <a href="/facts/Joos_Horsten/frcfV1r9">Joos Horsten</a> to set up the project.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a> </p><p>In 1983, Janssen signed a cooperative contract to modernize production in an old chemical factory in the city of <a href="/facts/Hanzhong/FY8dG24f">Hanzhong</a>, in <a href="/facts/Shaanxi/tNvSEe3v">Shaanxi</a>. This factory would soon produce the active compound of Janssen products such as <a href="/facts/Mebendazole/b0sMTV1e">mebendazole</a>. In 1985, operating as Xian-Janssen Pharmaceuticals, a large factory was opened in the city of <a href="/facts/Xi%27an/yaIdymtu">Xi'an</a>, also in Shaanxi province.<a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> </p> <h2 id="drugs-developed">Drugs developed</h2> <table><tbody><tr><th>R-code</th><th>Name</th><th>Brand name</th><th>Synthesized</th><th>Marketed</th></tr><tr><td>R5</td><td><a href="/facts/Ambucetamide/X3j9fqLl">ambucetamide</a></td><td>Neomeritine</td><td>1953</td><td>1955</td></tr><tr><td>R79</td><td><a href="/facts/Isopropamide_iodide/lAD0Tfx5">isopropamide iodide</a></td><td>Priamide-Janssen</td><td>1954</td><td>1955</td></tr><tr><td>R253</td><td><a href="/facts/Diisopromine/aN6nwcpP">diisopromine</a></td><td>Bilagol</td><td>1955</td><td>1956</td></tr><tr><td>R516</td><td><a href="/facts/Cinnarizine/nTTAydG4">cinnarizine</a></td><td>Stugeron</td><td>1955</td><td>1958</td></tr><tr><td>R875</td><td><a href="/facts/Dextromoramide/7m90oAPt">dextromoramide</a></td><td>Palfium</td><td>1955</td><td>1957</td></tr><tr><td>R1132</td><td><a href="/facts/Diphenoxylate/VyxRYrx3">diphenoxylate</a></td><td>Reasec</td><td>1956</td><td>1960</td></tr><tr><td>R1625</td><td><a href="/facts/Haloperidol/ue4TJKmu">haloperidol</a></td><td>Haldol</td><td>1958</td><td>1959</td></tr><tr><td>R2498</td><td><a href="/facts/Trifluperidol/7yJQFce1">trifluperidol</a></td><td>Triperidol</td><td>1959</td><td>1961</td></tr><tr><td>R3345</td><td><a href="/facts/Pipamperone/85v5drH9">pipamperone</a></td><td>Dipiperon</td><td>1960</td><td>1961</td></tr><tr><td>R3365</td><td><a href="/facts/Piritramide/tkUelYx5">piritramide</a></td><td>Dipidolor</td><td>1960</td><td>1967</td></tr><tr><td>R4263</td><td><a href="/facts/Fentanyl/MMD9GdD3">fentanyl</a><a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a><a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a></td><td>Sublimaze</td><td>1960</td><td>1963</td></tr><tr><td>R4584</td><td><a href="/facts/Benperidol/Qz367Jtd">benperidol</a></td><td>Frenactyl</td><td>1961</td><td>1965</td></tr><tr><td>R4749</td><td><a href="/facts/Droperidol/TDaCJtsy">droperidol</a><a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a></td><td>Dehydrobenzperidol</td><td>1961</td><td>1963</td></tr><tr><td>R4845</td><td><a href="/facts/Bezitramide/dwprG800">bezitramide</a></td><td>Burgodin</td><td>1961</td><td>1971</td></tr><tr><td>R6218</td><td><a href="/facts/Fluspirilene/FGtUJD6f">fluspirilene</a></td><td>Imap</td><td>1963</td><td>1971</td></tr><tr><td>R6238</td><td><a href="/facts/Pimozide/FmQ8Jy4y">pimozide</a></td><td>Orap</td><td>1963</td><td>1970</td></tr><tr><td>R7904</td><td><a href="/facts/Lidoflazine/b8G7NTYK">lidoflazine</a></td><td>Clinium</td><td>1964</td><td>1969</td></tr><tr><td>R11333</td><td><a href="/facts/Bromperidol/3d2Rl1c3">bromperidol</a></td><td>Impromen</td><td>1966</td><td>1981</td></tr><tr><td>R12564</td><td><a href="/facts/Levamisole/1XGQzV6c">levamisole</a></td><td>Ergamisol</td><td>1966</td><td>1969</td></tr><tr><td>R13672</td><td><a href="/facts/Haloperidol/ue4TJKmu">haloperidol decanoate</a></td><td>Haldol decanoas</td><td>1967</td><td>1981</td></tr><tr><td>R14889</td><td><a href="/facts/Miconazole_nitrate/PjA5UgFB">miconazole nitrate</a></td><td>Daktarin</td><td>1967</td><td>1971</td></tr><tr><td>R14950</td><td><a href="/facts/Flunarizine/I9QbG8AH">flunarizine</a></td><td>Sibelium</td><td>1967</td><td>1977</td></tr><tr><td>R15889</td><td><a href="/facts/Lorcainide/ee6J76qW">lorcainide</a></td><td>Remivox</td><td>1968</td><td>1983</td></tr><tr><td>R16341</td><td><a href="/facts/Penfluridol/wxKse6ob">penfluridol</a></td><td>Semap</td><td>1968</td><td>1973</td></tr><tr><td>R16470</td><td><a href="/facts/Dexetimide/RjAR6haM">dexetimide</a></td><td>Tremblex</td><td>1968</td><td>1972</td></tr><tr><td>R16659</td><td><a href="/facts/Etomidate/qv2lldku">etomidate</a><a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a><a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a></td><td>Hypnomidate</td><td>1964</td><td>1977</td></tr><tr><td>R17635</td><td><a href="/facts/Mebendazole/b0sMTV1e">mebendazole</a></td><td>Vermox</td><td>1968</td><td>1972</td></tr><tr><td>R18553</td><td><a href="/facts/Loperamide/SWzRnbnH">loperamide</a></td><td>Imodium</td><td>1969</td><td>1973</td></tr><tr><td>R33800</td><td><a href="/facts/Sufentanil/XlPJVIzB">sufentanil</a><a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a></td><td>Sufenta</td><td>1974</td><td>1979</td></tr><tr><td>R33812</td><td><a href="/facts/Domperidone/aXnJHT1y">domperidone</a></td><td>Motilium</td><td>1974</td><td>1978</td></tr><tr><td>R35443</td><td><a href="/facts/Oxatomide/R9RDCfvN">oxatomide</a></td><td>Tinset</td><td>1975</td><td>1981</td></tr><tr><td>R39209</td><td><a href="/facts/Alfentanil/xU2RhEDM">alfentanil</a><a class="footnote-ref" id="fnref:39" href="#fn:39"><sup>39</sup></a><a class="footnote-ref" id="fnref:40" href="#fn:40"><sup>40</sup></a></td><td>Rapifen</td><td>1976</td><td>1983</td></tr><tr><td>R33799</td><td><a href="/facts/Carfentanil/bCnYQJhh">carfentanil</a><a class="footnote-ref" id="fnref:41" href="#fn:41"><sup>41</sup></a></td><td>Wildnil</td><td>1976</td><td>1980?</td></tr><tr><td>R41400</td><td><a href="/facts/Ketoconazole/UQcvnER5">ketoconazole</a></td><td>Nizoral</td><td>1976</td><td>1981</td></tr><tr><td>R43512</td><td><a href="/facts/Astemizole/kAkzphl7">astemizole</a></td><td>Hismanal</td><td>1977</td><td>1983</td></tr><tr><td>R46541</td><td><a href="/facts/Bromperidol/3d2Rl1c3">bromperidol decanoate</a></td><td>Impromen decanoas</td><td>1978</td><td>1984</td></tr><tr><td>R49945</td><td><a href="/facts/Ketanserin/UANlgLWq">ketanserin tartrate</a></td><td>Sufrexal</td><td>1980</td><td>1987</td></tr><tr><td>R50547</td><td><a href="/facts/Levocabastine/AUC0KbdW">levocabastine</a></td><td>Livostin/Livocab</td><td>1979</td><td>1989</td></tr><tr><td>R51211</td><td><a href="/facts/Itraconazole/x7IeB92o">itraconazole</a></td><td>Sporanox</td><td>1980</td><td>1986</td></tr><tr><td>R51619</td><td><a href="/facts/Cisapride/9JMdgmW8">cisapride</a></td><td>Prepulsid</td><td>1980</td><td>1989</td></tr><tr><td>R64766</td><td><a href="/facts/Risperidone/xpFEYzoF">risperidone</a></td><td>Risperdal</td><td>1984</td><td>1993</td></tr><tr><td>R207910</td><td><a href="/facts/Bedaquiline/2SHKyb3o">bedaquiline</a></td><td>Sirturo</td><td>2004</td><td>2012</td></tr></tbody></table> <p>Janssen Pharmaceuticals has developed and brought to the market about 70 new active substances (<a href="/facts/New_chemical_entity/Hdth911v">NCE</a>), of which the most well-known are (name may differ): </p> <ul><li><a href="/facts/Imodium/SWzRnbnH">Imodium</a> (against diarrhoea. Active substance: <a href="/facts/Loperamide/SWzRnbnH">loperamide</a>)</li> <li><a href="/facts/Motilium/aXnJHT1y">Motilium</a> (against flatulence and bowel impairments. Active substance: <a href="/facts/Domperidone/aXnJHT1y">domperidone</a>)</li> <li><a href="/facts/Reminyl/SQURXsm4">Reminyl</a> (against <a href="/facts/Alzheimer%27s_disease/w7Ad6tdg">Alzheimer's disease</a> (dementia). Active substance: <a href="/facts/Galantamine/SQURXsm4">galantamine</a>)</li> <li><a href="/facts/Daktarin/PjA5UgFB">Daktarin</a> (against fungal infections. Active substance: <a href="/facts/Miconazole/PjA5UgFB">miconazole</a>)</li> <li><a href="/facts/Nizoral/UQcvnER5">Nizoral</a> (against <a href="/facts/Dandruff/JnKQHFzM">dandruff</a>, Active substance: <a href="/facts/Ketoconazole/UQcvnER5">ketoconazole</a>)</li> <li><a href="/facts/Duragesic/MMD9GdD3">Duragesic</a> (fentanyl patch for pain suppression. Active substance: <a href="/facts/Fentanyl/MMD9GdD3">fentanyl</a>)</li> <li><a href="/facts/Vermox/b0sMTV1e">Vermox</a> (against intestinal worms. Active substance: <a href="/facts/Mebendazole/b0sMTV1e">mebendazole</a>)</li> <li><a href="/facts/Risperdal/xpFEYzoF">Risperdal</a> (antipsychotic, against mental illness such as schizophrenia. Active substance: <a href="/facts/Risperidone/xpFEYzoF">risperidone</a>)</li></ul> <h3>WHO Model List of Essential Medicines</h3> <p>Eight original Janssen drugs have been included on the <a href="/facts/WHO_Model_List_of_Essential_Medicines/6kmu81Xm">WHO Model List of Essential Medicines</a>: </p> <ul><li>Imodium (<a href="/facts/Loperamide/SWzRnbnH">loperamide</a>)</li> <li>Haldol (<a href="/facts/Haloperidol/ue4TJKmu">haloperidol</a>)</li> <li>Ergamisol (<a href="/facts/Levamisole/1XGQzV6c">levamisole</a>)</li> <li>Daktarin (<a href="/facts/Miconazole/PjA5UgFB">miconazole</a>)</li> <li>Vermox (<a href="/facts/Mebendazole/b0sMTV1e">mebendazole</a>)</li> <li>Nizoral (<a href="/facts/Ketoconazole/UQcvnER5">ketoconazole</a>) (Removed in 2005)</li> <li>Risperdal (<a href="/facts/Risperidone/xpFEYzoF">risperidone</a>)</li> <li>Sirturo (<a href="/facts/Bedaquiline/2SHKyb3o">bedaquiline</a>) – an diarylquinoline anti-tuberculosis drug, discovered by <a href="/facts/Koen_Andries/dJ0xjmj5">Koen Andries</a> and his team, which promises a shorter and simpler <a href="/facts/Tuberculosis_treatment/bT0S5wkz">treatment</a> for <a href="/facts/Multi-drug-resistant_tuberculosis/cNBgP2jb">multi-drug-resistant tuberculosis</a> (MDR-TB).</li></ul> <h3>Centocor products</h3> <p>In 1984, Centocor developed their first product approved by the <a href="/facts/Food_and_Drug_Administration_(United_States)/rCEnh9WB">U.S. Food and Drug Administration</a> (FDA) – a diagnostic test used to detect the <a href="/facts/Rabies/rPDyNHwL">rabies</a> virus. </p><p>In 1998, the company launched its top-selling monoclonal antibody <a href="/facts/Remicade/pk8CdtFV">Remicade</a> (<a href="/facts/Infliximab/pk8CdtFV">infliximab</a>) for its first FDA approved indication in <a href="/facts/Crohn%27s_disease/zm55cBtd">Crohn's disease</a>. Subsequently, Remicade's market has expanded with approvals for <a href="/facts/Rheumatoid_arthritis/qFK4Xwv7">rheumatoid arthritis</a>, <a href="/facts/Ankylosing_spondylitis/tHgAlJNd">ankylosing spondylitis</a>, <a href="/facts/Psoriatic_arthritis/X3onPL9T">psoriatic arthritis</a>, <a href="/facts/Ulcerative_colitis/BIkyFzRj">ulcerative colitis</a>, and <a href="/facts/Pediatric/hnkMfLeg">pediatric</a> Crohn's disease. Remicade was approved for plaque psoriasis in September 2006. </p><p>Centocor also markets ReoPro (<a href="/facts/Abciximab/NyYBWkPU">abciximab</a>), a biologic agent indicated as an adjunct to coronary <a href="/facts/Angioplasty/j2ausFmb">angioplasty</a> (<a href="/facts/Percutaneous_transluminal_coronary_angioplasty/2zlAdul0">PTCA</a>). </p><p>In 2009, the U.S. FDA approved <a href="/facts/Simponi/mfc1pYJd">Simponi</a>, a human monoclonal antibody for treatment for arthritis, which was co-developed with <a href="/facts/Medarex/IBEjM5uX">Medarex</a>, Inc.<a class="footnote-ref" id="fnref:42" href="#fn:42"><sup>42</sup></a> </p> <h2 id="risperdal-deception">Risperdal deception</h2> <p>In 2004, the <a href="/facts/United_States_Department_of_Justice/2SuTuevo">United States Department of Justice</a> began investigating sales practices surrounding the antipsychotic drug <a href="/facts/Risperidone/xpFEYzoF">risperidone</a> (<a href="/facts/Risperdal/xpFEYzoF">Risperdal</a>). In 2010, the agency joined a <a href="/facts/Whistleblower/Ah5QHEW1">whistleblower</a> suit alleging that despite being warned by the U.S. <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> not to promote Risperdal as effective and safe for elderly patients, in whom it was known to be associated with early death, Johnson & Johnson and Janssen Pharmaceuticals paid pharmacists at <a href="/facts/Omnicare/52sH5c6r">Omnicare</a>, the largest supplier of pharmaceuticals to nursing homes, tens of millions of dollars in bribes and <a href="/facts/Kickback_(bribery)/2L4nDI73">kickbacks</a> to promote the drug to physicians for this unapproved use.<a class="footnote-ref" id="fnref:43" href="#fn:43"><sup>43</sup></a><a class="footnote-ref" id="fnref:44" href="#fn:44"><sup>44</sup></a> </p><p>The lawsuit resulted in a 2012 provisional settlement totaling $2.3 billion,<a class="footnote-ref" id="fnref:45" href="#fn:45"><sup>45</sup></a> with Omnicare having already settled for around $100 million.<a class="footnote-ref" id="fnref:46" href="#fn:46"><sup>46</sup></a> Four states were awarded damages: Louisiana ($258 million in 2010), South Carolina ($327 million in 2011), Texas ($158 million in 2012), and Arkansas ($1.2 billion in 2012).<a class="footnote-ref" id="fnref:47" href="#fn:47"><sup>47</sup></a> </p><p>Former head of sales and president of Janssen <a href="/facts/Alex_Gorsky/4kkxAr4n">Alex Gorsky</a>, who according to the Department of Justice "was actively involved" in the fraud, became CEO of Johnson & Johnson in 2012.<a class="footnote-ref" id="fnref:48" href="#fn:48"><sup>48</sup></a> </p> <h2 id="see-also">See also</h2> <ul> <li>Belgium portal</li><li>Companies portal</li></ul> <ul><li><a href="/facts/Janssen-Cilag/DSfqnVrM">Janssen-Cilag</a></li> <li><a href="/facts/Didier_de_Chaffoy_de_Courcelles/BGrUGQlG">Didier de Chaffoy de Courcelles</a></li> <li><a href="/facts/Paul_Stoffels/QpI3vBXH">Paul Stoffels</a></li> <li><a href="/facts/Staf_Van_Reet/ccRaCFRb">Staf Van Reet</a></li> <li><a href="/facts/Jan_Schuurkes/mcnE83xs">Jan Schuurkes</a></li> <li><a href="/facts/Tibotec/vLUrpINK">Tibotec</a></li> <li><a href="/facts/Rega_Institute_for_Medical_Research/XR4YyIcK">Rega Institute for Medical Research</a></li> <li><a href="/facts/Drug_development/k34jgV4B">Drug development</a></li> <li><a href="/facts/Nanovid_microscopy/z91x2Hj5">Nanovid microscopy</a></li> <li><a href="/facts/Joan_Daemen/cqdIFHHG">Joan Daemen</a></li> <li><a href="/facts/Biotech_and_pharmaceutical_companies_in_the_New_York_metropolitan_area/eynBP6LT">Biotech and pharmaceutical companies in the New York metropolitan area</a></li> <li><a href="/facts/List_of_companies_of_Belgium/2G9q3pfN">List of companies of Belgium</a></li> <li><a href="/facts/List_of_pharmaceutical_companies/6Do5vAp2">List of pharmaceutical companies</a></li></ul> <h3>Bibliography</h3> <ul><li>Magiels, Geerdt (2004). <i>Paul Janssen – Pionier in farma en in China</i> (in Dutch). <a href="/facts/Antwerp/v3Rwa1Mu">Antwerp</a>, Amsterdam: Houtekiet. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-90-5240-827-9.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="http://www.janssenpharmaceutica.be/">Janssen Pharmaceutica</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Crissa Shoemaker DeBree (22 June 2011). "Centocor is now Janssen Biotech". The Intelligencer. Gannett Co. <a href="https://www.theintell.com/article/20110622/business/306229510" target="_blank">https://www.theintell.com/article/20110622/business/306229510</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Janssen Vaccines AG". Bloomberg L.P. 2020. <a href="https://www.bloomberg.com/profile/company/0836856D:SW" target="_blank">https://www.bloomberg.com/profile/company/0836856D:SW</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Lopez-Munoz F, Alamo C (2009). "The Consolidation of Neuroleptic Therapy: Janssen, the Discovery of Haloperidol and Its Introduction into Clinical Practice". Brain Research Bulletin. 79 (2): 130–141. doi:10.1016/j.brainresbull.2009.01.005. PMID 19186209. S2CID 7720401. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Crissa Shoemaker DeBree (22 June 2011). "Centocor is now Janssen Biotech". The Intelligencer. Gannett Co. <a href="https://www.theintell.com/article/20110622/business/306229510" target="_blank">https://www.theintell.com/article/20110622/business/306229510</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"Janssen (formerly Crucell)". PATH Malaria Vaccine Initiative. 2020. Archived from the original on 4 April 2023. Retrieved 14 March 2021. <a href="https://web.archive.org/web/20230404050554/https://www.malariavaccine.org/about-us/our-partners/janssen-formerly-crucell" target="_blank">https://web.archive.org/web/20230404050554/https://www.malariavaccine.org/about-us/our-partners/janssen-formerly-crucell</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"Janssen Vaccines AG". Bloomberg L.P. 2020. <a href="https://www.bloomberg.com/profile/company/0836856D:SW" target="_blank">https://www.bloomberg.com/profile/company/0836856D:SW</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>"GEN – News Highlights:Kura Oncology Licenses Janssen's Tipofarnib in Cancer". GEN. <a href="http://www.genengnews.com/gen-news-highlights/kura-oncology-licenses-janssen-s-tipofarnib-in-cancer/81251026/" target="_blank">http://www.genengnews.com/gen-news-highlights/kura-oncology-licenses-janssen-s-tipofarnib-in-cancer/81251026/</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>"GEN – News Highlights:Galapagos Regains Rights to GLPG1690 from Janssen". GEN. 17 March 2015. <a href="http://www.genengnews.com/gen-news-highlights/galapagos-regains-rights-to-glpg1690-from-janssen/81251040/" target="_blank">http://www.genengnews.com/gen-news-highlights/galapagos-regains-rights-to-glpg1690-from-janssen/81251040/</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>"Janssen, MacroGenics Launch Up-to-$740M+ Second Collaboration". GEN. 18 May 2016. <a href="http://www.genengnews.com/gen-news-highlights/janssen-macrogenics-launch-up-to-740m-second-collaboration/81252739/" target="_blank">http://www.genengnews.com/gen-news-highlights/janssen-macrogenics-launch-up-to-740m-second-collaboration/81252739/</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>"Johnson & Johnson, BARDA join forces to prep for pandemic flu, inking deal for vaccine and drug R&D – FiercePharma". fiercepharma.com. Retrieved 12 April 2018. <a href="http://www.fiercepharma.com/vaccines/j-j-barda-partner-up-to-advance-pandemic-flu-preparedness" target="_blank">http://www.fiercepharma.com/vaccines/j-j-barda-partner-up-to-advance-pandemic-flu-preparedness</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>"Janssen Announces U.S. FDA Approval of SPRAVATO™ (esketamine) CIII Nasal Spray for Adults with Treatment-Resistant Depression (TRD) Who Have Cycled Through Multiple Treatments Without Relief". Janssen. Archived from the original on 25 November 2020. Retrieved 7 March 2019. <a href="https://web.archive.org/web/20201125115156/https://www.janssen.com/janssen-announces-us-fda-approval-spravato-esketamine-ciii-nasal-spray-adults-treatment-resistant" target="_blank">https://web.archive.org/web/20201125115156/https://www.janssen.com/janssen-announces-us-fda-approval-spravato-esketamine-ciii-nasal-spray-adults-treatment-resistant</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Nir SM (29 June 2021). "Major Trial Against Opioid Suppliers Begins in New York". The New York Times. ISSN 0362-4331. Retrieved 1 July 2021. <a href="https://www.nytimes.com/2021/06/29/nyregion/opioids-in-new-york.html" target="_blank">https://www.nytimes.com/2021/06/29/nyregion/opioids-in-new-york.html</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Nir SM (26 June 2021). "Johnson & Johnson to Pay New York $230 Million to Settle Opioid Case". The New York Times. ISSN 0362-4331. Retrieved 1 July 2021. <a href="https://www.nytimes.com/2021/06/26/nyregion/johnson-johnson-opioid-lawsuit-new-york.html" target="_blank">https://www.nytimes.com/2021/06/26/nyregion/johnson-johnson-opioid-lawsuit-new-york.html</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>George J (26 October 1998). "Centocor making its mark in biotech". Philadelphia Business Journal. Retrieved 4 May 2020. <a href="https://www.bizjournals.com/philadelphia/stories/1998/10/26/focus3.html" target="_blank">https://www.bizjournals.com/philadelphia/stories/1998/10/26/focus3.html</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>George J (26 October 1998). "Centocor making its mark in biotech". Philadelphia Business Journal. Retrieved 4 May 2020. <a href="https://www.bizjournals.com/philadelphia/stories/1998/10/26/focus3.html" target="_blank">https://www.bizjournals.com/philadelphia/stories/1998/10/26/focus3.html</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>George J (26 October 2011). "Johnson & Johnson '05 plant explosion: A lesson learned". Philadelphia Business Journal. <a href="https://www.bizjournals.com/philadelphia/blog/john-george/2011/10/johnson-johnson-05-plant-explosion.html" target="_blank">https://www.bizjournals.com/philadelphia/blog/john-george/2011/10/johnson-johnson-05-plant-explosion.html</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>"Trend For 1997 Strong Sales Continues In USA – Pharmaceutical industry". thepharmaletter.com. Retrieved 4 May 2020. <a href="https://www.thepharmaletter.com/article/trend-for-1997-strong-sales-continues-in-usa" target="_blank">https://www.thepharmaletter.com/article/trend-for-1997-strong-sales-continues-in-usa</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Bishop T (24 May 1999). "Centocor profit growth best among Phila. Inc". Philadelphia Business Journal. <a href="https://www.bizjournals.com/philadelphia/stories/1999/05/24/focus3.html" target="_blank">https://www.bizjournals.com/philadelphia/stories/1999/05/24/focus3.html</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Centocor reaches agreement to sell oncology diagnostics business, 1998 press release <a href="http://www.fdi.com/documents/news/103098.pdf" target="_blank">http://www.fdi.com/documents/news/103098.pdf</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>Langreth R (22 July 1999). "Johnson & Johnson to Purchase Centocor for $4.9 Billion in Stock". The Wall Street Journal. ISSN 0099-9660. Retrieved 4 May 2020. <a href="https://www.wsj.com/articles/SB932559168720832483" target="_blank">https://www.wsj.com/articles/SB932559168720832483</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> <li id="fn:21"><p>Saul S (21 February 2007). "Drug Gets a Cameo in a Film Backed by Its Maker". The New York Times. ISSN 0362-4331. <a href="https://www.nytimes.com/2007/02/21/business/media/21adco.html" target="_blank">https://www.nytimes.com/2007/02/21/business/media/21adco.html</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></p></li> <li id="fn:22"><p>Centocor Ortho Biotech Acquires RespiVert Archived 5 June 2010 at the Wayback Machine News article from InfoGrok. <a href="http://www.infogrok.com/index.php/pharmaceutical/centocor-ortho-biotech-acquires-respivert.html" target="_blank">http://www.infogrok.com/index.php/pharmaceutical/centocor-ortho-biotech-acquires-respivert.html</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></p></li> <li id="fn:23"><p>George J. "Remicade maker Centocor Ortho Biotech changing name". Philadelphia Business Journal. Retrieved 15 January 2019. <a href="https://www.bizjournals.com/philadelphia/blog/john-george/2011/06/remicade-maker-centocor-ortho-biotech.html" target="_blank">https://www.bizjournals.com/philadelphia/blog/john-george/2011/06/remicade-maker-centocor-ortho-biotech.html</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></p></li> <li id="fn:24"><p>"Janssen Joins MacroGenics in Up-to-$700M Cancer Collaboration". GEN – Genetic Engineering and Biotechnology News. 22 December 2014. Retrieved 11 December 2019. <a href="https://www.genengnews.com/topics/translational-medicine/janssen-joins-macrogenics-in-up-to-700m-cancer-collaboration/" target="_blank">https://www.genengnews.com/topics/translational-medicine/janssen-joins-macrogenics-in-up-to-700m-cancer-collaboration/</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></p></li> <li id="fn:25"><p>"Janssen, Isis Pharma Ink Up-to-$835M Antisense Agreement". GEN – Genetic Engineering and Biotechnology News. 5 January 2015. Retrieved 11 December 2019. <a href="https://www.genengnews.com/topics/omics/janssen-isis-pharma-ink-up-to-835m-antisense-agreement/" target="_blank">https://www.genengnews.com/topics/omics/janssen-isis-pharma-ink-up-to-835m-antisense-agreement/</a> <a href="#fnref:25" class="footnote-back-ref">↩</a></p></li> <li id="fn:26"><p>"XBiotech Announces Agreement to Sell True Human Antibody Bermekimab Targeting IL-1a to Janssen". BioSpace. Retrieved 4 May 2020. <a href="https://www.biospace.com/article/xbiotech-announces-agreement-to-sell-true-human-antibody-bermekimab-targeting-il-1a-to-janssen/" target="_blank">https://www.biospace.com/article/xbiotech-announces-agreement-to-sell-true-human-antibody-bermekimab-targeting-il-1a-to-janssen/</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></p></li> <li id="fn:27"><p>"Janssen to Acquire Investigational Bermekimab from XBiotech". BioSpace. 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