In the early tubular heart, the bulbus cordis is the major outflow pathway.2 It receives blood from the primitive ventricle, and passes it to the truncus arteriosus.34 After heart looping, it is located slightly to the left of the ventricle.5
Further information: Heart development
The early bulbus cordis is formed by the fifth week of development.6 The truncus arteriosus is derived from it later.7
The adjacent walls of the bulbus cordis and ventricle approximate, fuse, and finally disappear, and the bulbus cordis now communicates freely with the right ventricle, while the junction of the bulbus with the truncus arteriosus is brought directly ventral to and applied to the atrial canal.
By the upgrowth of the ventricular septum the bulbus cordis is separated from the left ventricle, but remains an integral part of the right ventricle, of which it forms the infundibulum.
Together, the bulbus cordis and the primitive ventricle give rise to the ventricles of the formed heart.
The bulbus cordis is shared in the development of many animals, including frogs8 and fish.9
This article incorporates text in the public domain from page 513 of the 20th edition of Gray's Anatomy (1918)
Larsen, William J (2001). Human Embryology (3rd ed.). Elsevier. p. 160. ISBN 0-443-06583-7. 0-443-06583-7 ↩
Carlson, Bruce M. (2014), "Development of the Heart", Reference Module in Biomedical Sciences, Elsevier, ISBN 978-0-12-801238-3, retrieved 2021-01-05 978-0-12-801238-3 ↩
De Iuliis, Gerardo; Pulerà, Dino (2011-01-01), De Iuliis, Gerardo; Pulerà, Dino (eds.), "Chapter 6 – The Frog", The Dissection of Vertebrates (2nd ed.), Boston: Academic Press, pp. 127–145, ISBN 978-0-12-375060-0, retrieved 2021-01-05 978-0-12-375060-0 ↩
Belmont, John W. (2015), Moody, Sally A. (ed.), "Chapter 33 – Genetic and Developmental Basis of Congenital Cardiovascular Malformations", Principles of Developmental Genetics (2nd ed.), Oxford: Academic Press, pp. 607–633, ISBN 978-0-12-405945-0, retrieved 2021-01-05 978-0-12-405945-0 ↩
Zaccone, G.; Marino, F.; Zaccone, D. (2011), "Design and Physiology of the Heart | Intracardiac Neurons and Neurotransmitters in Fish", in Farrell, Anthony P. (ed.), Encyclopedia of Fish Physiology, San Diego: Academic Press, pp. 1067–1072, ISBN 978-0-08-092323-9, retrieved 2021-01-05 978-0-08-092323-9 ↩