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MCM4
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<h2 id="function">Function</h2> <p>The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the <a href="/facts/Pre-replication_complex/4jdpMYQa">pre-replication complex</a> (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Mini_Chromosome_Maintenance/MbJFI5Nd">Mini Chromosome Maintenance</a></li></ul> <h2 id="interactions">Interactions</h2> <p>MCM4 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/Cell_division_cycle_7-related_protein_kinase/9VnQG5fk">Cell division cycle 7-related protein kinase</a>,<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a></li> <li><a href="/facts/MCM2/jr3Hyc8T">MCM2</a>,<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li> <li><a href="/facts/MCM6/scCxDYAp">MCM6</a>,<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a><a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a><a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a><a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li> <li><a href="/facts/MCM7/Tw5pQE12">MCM7</a>,<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a><a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a><a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a><a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a></li> <li><a href="/facts/ORC1L/mwvRPSw6">ORC1L</a>,<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a></li> <li><a href="/facts/ORC2L/oa4Mw8yz">ORC2L</a>,<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a></li> <li><a href="/facts/ORC3L/uRmdBIpr">ORC3L</a>,<a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a></li> <li><a href="/facts/ORC4L/fot6cfcj">ORC4L</a>,<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a></li> <li><a href="/facts/ORC5L/59T60ey1">ORC5L</a>,<a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a></li> <li><a href="/facts/ORC6L/qKI3bcfk">ORC6L</a>,<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> and</li> <li><a href="/facts/Replication_protein_A1/oFlz54bY">Replication protein A1</a>.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Hu B, Burkhart R, Schulte D, Musahl C, Knippers R (1994). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310560">"The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins"</a>. <i>Nucleic Acids Res</i>. 21 (23): 5289–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F21.23.5289-a">10.1093/nar/21.23.5289-a</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310560">310560</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8265339">8265339</a>.</li> <li>Schulte D, Richter A, Burkhart R, Musahl C, Knippers R (1996). <a href="https://doi.org/10.1111%2Fj.1432-1033.1996.00144.x">"Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins"</a>. <i>Eur. J. Biochem</i>. 235 (1–2): 144–51. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-1033.1996.00144.x">10.1111/j.1432-1033.1996.00144.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8631321">8631321</a>.</li> <li>Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (1996). <a href="https://doi.org/10.1074%2Fjbc.271.39.24115">"Binding of human minichromosome maintenance proteins with histone H3"</a>. <i>J. Biol. Chem</i>. 271 (39): 24115–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.39.24115">10.1074/jbc.271.39.24115</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8798650">8798650</a>.</li> <li>Ladenburger EM, Fackelmayer FO, Hameister H, Knippers R (1997). "MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12→q13". <i>Cytogenet. Cell Genet</i>. 77 (3–4): 268–70. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1159%2F000134594">10.1159/000134594</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9284934">9284934</a>.</li> <li>Ishimi Y (1997). <a href="https://doi.org/10.1074%2Fjbc.272.39.24508">"A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex"</a>. <i>J. Biol. Chem</i>. 272 (39): 24508–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.39.24508">10.1074/jbc.272.39.24508</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9305914">9305914</a>.</li> <li>Connelly MA, Zhang H, Kieleczawa J, Anderson CW (1998). "The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11". <i>Genomics</i>. 47 (1): 71–83. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1997.5076">10.1006/geno.1997.5076</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9465298">9465298</a>.</li> <li>Fujita M, Yamada C, Tsurumi T, Hanaoka F, Matsuzawa K, Inagaki M (1998). <a href="https://doi.org/10.1074%2Fjbc.273.27.17095">"Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase"</a>. <i>J. Biol. Chem</i>. 273 (27): 17095–101. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.27.17095">10.1074/jbc.273.27.17095</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9642275">9642275</a>.</li> <li>You Z, Komamura Y, Ishimi Y (2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84885">"Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity"</a>. <i>Mol. Cell. Biol</i>. 19 (12): 8003–15. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.19.12.8003">10.1128/MCB.19.12.8003</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84885">84885</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10567526">10567526</a>.</li> <li>Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M (2000). <a href="https://doi.org/10.1074%2Fjbc.M909040199">"Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2"</a>. <i>J. Biol. Chem</i>. 275 (21): 16235–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M909040199">10.1074/jbc.M909040199</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10748114">10748114</a>.</li> <li>Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115166">"The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G2 phase"</a>. <i>Nucleic Acids Res</i>. 28 (23): 4769–77. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F28.23.4769">10.1093/nar/28.23.4769</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC115166">115166</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11095689">11095689</a>.</li> <li>Lee JK, Hurwitz J (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14543">"Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 98 (1): 54–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2001PNAS...98...54L">2001PNAS...98...54L</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.98.1.54">10.1073/pnas.98.1.54</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC14543">14543</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11136247">11136247</a>.</li> <li>Ishimi Y, Komamura-Kohno Y (2001). <a href="https://doi.org/10.1074%2Fjbc.M104480200">"Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity"</a>. <i>J. Biol. Chem</i>. 276 (37): 34428–33. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M104480200">10.1074/jbc.M104480200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11454864">11454864</a>.</li> <li>You Z, Ishimi Y, Masai H, Hanaoka F (2003). <a href="https://doi.org/10.1074%2Fjbc.M205769200">"Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex"</a>. <i>J. Biol. Chem</i>. 277 (45): 42471–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M205769200">10.1074/jbc.M205769200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12207017">12207017</a>.</li> <li>Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". <i>J. Mol. Biol</i>. 327 (1): 111–28. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0022-2836%2803%2900079-2">10.1016/S0022-2836(03)00079-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12614612">12614612</a>.</li> <li>Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (2004). <a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x">"Mammalian Mcm2/4/6/7 complex forms a toroidal structure"</a>. <i>Genes Cells</i>. 8 (5): 413–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x">10.1046/j.1365-2443.2003.00645.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12694531">12694531</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:27707848">27707848</a>.</li> <li>Ishimi Y, Komamura-Kohno Y, Kwon HJ, Yamada K, Nakanishi M (2003). <a href="https://doi.org/10.1074%2Fjbc.M213252200">"Identification of MCM4 as a target of the DNA replication block checkpoint system"</a>. <i>J. Biol. Chem</i>. 278 (27): 24644–50. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M213252200">10.1074/jbc.M213252200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12714602">12714602</a>.</li> <li>Johnson EM, Kinoshita Y, Daniel DC (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156728">"A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3–13"</a>. <i>Nucleic Acids Res</i>. 31 (11): 2915–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2Fgkg395">10.1093/nar/gkg395</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156728">156728</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12771218">12771218</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Musahl C, Schulte D, Burkhart R, Knippers R (August 1995). "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins". Eur J Biochem. 230 (3): 1096–101. doi:10.1111/j.1432-1033.1995.tb20660.x (inactive 25 December 2024). PMID 7601140.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link) <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: MCM4 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4173" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4173</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. S2CID 27707848. <a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x" target="_blank">https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650. <a href="https://doi.org/10.1074%2Fjbc.271.39.24115" target="_blank">https://doi.org/10.1074%2Fjbc.271.39.24115</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>You Z, Komamura Y, Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. doi:10.1128/MCB.19.12.8003. PMC 84885. PMID 10567526. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84885" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84885</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. S2CID 27707848. <a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x" target="_blank">https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650. <a href="https://doi.org/10.1074%2Fjbc.271.39.24115" target="_blank">https://doi.org/10.1074%2Fjbc.271.39.24115</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>You Z, Ishimi Y, Masai H, Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017. <a href="https://doi.org/10.1074%2Fjbc.M205769200" target="_blank">https://doi.org/10.1074%2Fjbc.M205769200</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531. S2CID 27707848. <a href="https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x" target="_blank">https://doi.org/10.1046%2Fj.1365-2443.2003.00645.x</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650. <a href="https://doi.org/10.1074%2Fjbc.271.39.24115" target="_blank">https://doi.org/10.1074%2Fjbc.271.39.24115</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>You Z, Ishimi Y, Masai H, Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017. <a href="https://doi.org/10.1074%2Fjbc.M205769200" target="_blank">https://doi.org/10.1074%2Fjbc.M205769200</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. 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