Tizoc was a son of the princess Atotoztli II and her cousin, prince Tezozomoc. He was a grandson of Emperors Moctezuma I and Itzcoatl. He was a descendant of the King Cuauhtototzin.
He was successor of his brother Axayacatl and was succeeded by his other brother, Ahuitzotl; his sister was the Queen Chalchiuhnenetzin, married to Moquihuix, tlatoani of Tlatelōlco. He was an uncle of Emperors Cuauhtémoc, Moctezuma II and Cuitláhuac and grandfather of Diego de San Francisco Tehuetzquititzin.
Most sources agree that Tizoc took power in 1481 (the Aztec year "2 House"), succeeding his older brother. Although Tizoc's reign was relatively short, he began the rebuilding of the Great Pyramid of Tenochtitlan (a task completed by his younger brother in 1487), and also put down a rebellion of the Matlatzincan peoples of the Toluca Valley.
According to the Codex Mendoza, during Tizoc's reign the āltepēmeh of Tonalimoquetzayan, Toxico, Ecatepec, Cillán, Tecaxic, Tolocan, Yancuitlan, Tlappan, Atezcahuacan, Mazatlán, Xochiyetla, Tamapachco, Ecatliquapechco and Miquetlan were conquered.
Tizoc died in 1486, though it is still somewhat unclear how. Some sources suggest that he was poisoned, others that he fell to illness.
"Tízoc, "El que hace sacrificio" (14811486)" [Tízoc, “He who makes sacrifices” (14811486)]. Archeologia Mexicana (in Spanish). 13 July 2016. Retrieved June 4, 2019. https://arqueologiamexicana.mx/mexico-antiguo/tizoc-el-que-hace-sacrificio-1481-1486 ↩
Tuerenhout, Dirk R. Van (2005). The Aztecs: New Perspectives. ABC-CLIO. p. 43. ISBN 978-1-57607-921-8. 978-1-57607-921-8 ↩
Aguilar-Moreno, Manuel (2007). Handbook to Life in the Aztec World. Oxford University Press. p. 82. ISBN 978-0-19-533083-0. 978-0-19-533083-0 ↩