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Sodium salicylate
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<h2 id="properties">Properties</h2> <p>Sodium salicylate is of the <a href="/facts/Salicylate/qz7RRQCR">salicylate</a> family. It is a shiny white powder with an aromatic taste.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a> </p> <h2 id="uses">Uses</h2> <p>It is used in medicine as an <a href="/facts/Analgesic/xLj4XBcq">analgesic</a> and <a href="/facts/Antipyretic/lBVzyUFN">antipyretic</a>.<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> Sodium salicylate also acts as <a href="/facts/Non-steroidal_anti-inflammatory_drug/coIkzl4s">non-steroidal anti-inflammatory drug</a> (NSAID), and induces <a href="/facts/Apoptosis/8dVzSm4y">apoptosis</a> in cancer cells <a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> and also <a href="/facts/Necrosis/zCPsTeWx">necrosis</a>.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> It is also a potential replacement for <a href="/facts/Aspirin/opMK4qLk">aspirin</a> for people sensitive to it. It may also be used as a phosphor for the detection of <a href="/facts/Vacuum_ultraviolet/kncBUqn5">vacuum ultraviolet</a> radiation and <a href="/facts/Beta_particle/x8b3ttLn">beta radiation</a>.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> </p> <h2 id="external-links">External links</h2> Wikimedia Commons has media related to Sodium salicylate. <ul><li><a href="http://www.chemicalland21.com/lifescience/phar/SODIUM%20SALICYLATE.htm">Chemicalland21</a></li> <li><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5900&ncount=51#Synonyms">Some synonyms</a></li> <li><a href="http://physchem.ox.ac.uk/MSDS/SO/sodium_salicylate.html">Safety data for sodium salicylate at Oxford University</a> <a href="https://web.archive.org/web/20060523222443/http://physchem.ox.ac.uk/MSDS/SO/sodium_salicylate.html">Archived</a> 2006-05-23 at the <a href="/facts/Wayback_Machine/nmQ3a6JC">Wayback Machine</a></li> <li><a href="https://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=43094">Sodium salicylate, definitions at National Cancer Institute</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009 <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Sodium salicylate | 54-21-7". ChemicalBook. Archived from the original on 2024-09-02. Retrieved 2024-09-02. <a href="https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm" target="_blank">https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Sodium salicylate | 54-21-7". ChemicalBook. Archived from the original on 2024-09-02. Retrieved 2024-09-02. <a href="https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm" target="_blank">https://m.chemicalbook.com/ChemicalProductProperty_EN_CB1255762.htm</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Klampfer, Lidija; Jörg Cammenga; Hans-Georg Wisniewski; Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood. 93 (7): 2386–94. doi:10.1182/blood.V93.7.2386. PMID 10090950. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Rae, Colin; Susana Langa; Steven J. Tucker; David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA. 104 (31): 12790–5. Bibcode:2007PNAS..10412790R. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937545" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937545</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Stark, Lesley A.; et al. (May 2007). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis. 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819. <a href="https://doi.org/10.1093%2Fcarcin%2Fbgl220" target="_blank">https://doi.org/10.1093%2Fcarcin%2Fbgl220</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Schwenger, Paul; Edward Y. Skolnik; Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry. 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494. <a href="https://doi.org/10.1074%2Fjbc.271.14.8089" target="_blank">https://doi.org/10.1074%2Fjbc.271.14.8089</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Samson, James. "Vacuum Ultraviolet Spectroscopy" (PDF). Pied Publications. Archived from the original (PDF) on October 16, 2006. Retrieved July 26, 2012. <a href="https://web.archive.org/web/20061016104429/http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf" target="_blank">https://web.archive.org/web/20061016104429/http://www.mcphersoninc.com/detectors/Sodium%20Salicylate.pdf</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> </ol>