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NAPSA
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<h2 id="utility">Utility</h2> <p>Detection of NAPSA gene expression can be used to distinguish <a href="/facts/Adenocarcinoma/TU7W6WbJ">adenocarcinomas</a> from other forms of <a href="/facts/Lung_cancer/LHLdR454">lung cancer</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Koelsch G, Mares M, Metcalf P, Fusek M (1994). <a href="https://doi.org/10.1016%2F0014-5793%2894%2980596-2">"Multiple functions of pro-parts of aspartic proteinase zymogens"</a>. <i>FEBS Lett</i>. 343 (1): 6–10. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1994FEBSL.343....6K">1994FEBSL.343....6K</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2894%2980596-2">10.1016/0014-5793(94)80596-2</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8163018">8163018</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:32345795">32345795</a>.</li> <li>Blundell TL, Guruprasad K, Albert A, et al. (1998). <i>Aspartic Proteinases</i>. Adv. Exp. Med. Biol. Vol. 436. pp. 1–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2F978-1-4615-5373-1_1">10.1007/978-1-4615-5373-1_1</a>. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-1-4613-7452-7. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9561193">9561193</a>.</li> <li>Chuman Y, Bergman A, Ueno T, et al. (2000). <a href="https://doi.org/10.1016%2FS0014-5793%2899%2901493-3">"Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas"</a>. <i>FEBS Lett</i>. 462 (1–2): 129–34. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2899%2901493-3">10.1016/S0014-5793(99)01493-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10580105">10580105</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23355055">23355055</a>.</li> <li>Schauer-Vukasinovic V, Bur D, Kling D, et al. (2000). <a href="https://doi.org/10.1016%2FS0014-5793%2899%2901458-1">"Human napsin A: expression, immunochemical detection, and tissue localization"</a>. <i>FEBS Lett</i>. 462 (1–2): 135–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2899%2901458-1">10.1016/S0014-5793(99)01458-1</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10580106">10580106</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:32798620">32798620</a>.</li> <li>Yan R, Bienkowski MJ, Shuck ME, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity". <i>Nature</i>. 402 (6761): 533–7. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1999Natur.402..533Y">1999Natur.402..533Y</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2F990107">10.1038/990107</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10591213">10591213</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4320087">4320087</a>.</li> <li>Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells". <i>Biochim. Biophys. Acta</i>. 1577 (1): 10–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fs0167-4781%2802%2900400-1">10.1016/s0167-4781(02)00400-1</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12151090">12151090</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li> <li>Brasch F, Ochs M, Kahne T, et al. (2004). <a href="https://doi.org/10.1074%2Fjbc.M306844200">"Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung"</a>. <i>J. Biol. Chem</i>. 278 (49): 49006–14. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M306844200">10.1074/jbc.M306844200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/13129928">13129928</a>.</li> <li>Ota T, Suzuki Y, Nishikawa T, et al. (2004). <a href="https://doi.org/10.1038%2Fng1285">"Complete sequencing and characterization of 21,243 full-length human cDNAs"</a>. <i>Nat. Genet</i>. 36 (1): 40–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng1285">10.1038/ng1285</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14702039">14702039</a>.</li> <li>Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". <i>Nat. Cell Biol</i>. 6 (4): 319–27. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fncb1105">10.1038/ncb1105</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15048123">15048123</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:22767022">22767022</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: NAPSA napsin A aspartic peptidase". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Tatnell PJ, Powell DJ, Hill J, Smith TS, Tew DG, Kay J (11 December 1998). "Napsins: new human aspartic proteinases". FEBS Letters. 441 (1): 43–48. doi:10.1016/s0014-5793(98)01522-1. PMID 9877162. S2CID 27656626. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: NAPSA napsin A aspartic peptidase". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma". Br. J. Cancer. 88 (8): 1229–33. doi:10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747556" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747556</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>