It is sometimes claimed that surgeons used to refuse to operate during the full Moon because of the increased risk of death of the patient through blood loss. One team, in Barcelona, Spain, reported a weak correlation between lunar phase and hospital admissions due to gastrointestinal bleeding, but only when comparing full Moon days to all non-full Moon days lumped together. This methodology has been criticized, and the statistical significance of the results disappears if one compares day 29 of the lunar cycle (full Moon) to days 9, 12, 13, or 27 of the lunar cycle, which all have an almost equal number of hospital admissions. The Spanish team acknowledged that the wide variation in the number of admissions throughout the lunar cycle limited the interpretation of the results.
A study into epilepsy found a significant negative correlation between the mean number of epileptic seizures per day and the fraction of the Moon that is illuminated, but the effect resulted from the overall brightness of the night, rather than from the moon phase per se.
A study of 13,029 motorcyclists killed in nighttime crashes found that there were 5.3% more fatalities on nights with a full moon compared to other nights. The authors speculate that the increase might be due to visual distractions created by the moon, especially when it is near the horizon and appears abruptly between trees, around turns, etc.
Several studies have argued that the stock market's average returns are much higher during the half of the month closest to the new moon than the half closest to the full moon. The reasons for this have not been studied, but the authors suggest this may be due to lunar influences on mood. Another study has found contradictory results and questioned these claims.
A meta-analysis of thirty-seven studies that examined relationships between the Moon's four phases and human behavior revealed no significant correlation. The authors found that, of twenty-three studies that had claimed to show correlation, nearly half contained at least one statistical error. Similarly, in a review of twenty studies examining correlations between Moon phase and suicides, most of the twenty studies found no correlation, and the ones that did report positive results were inconsistent with each other. A 1978 review of the literature also found that lunar phases and human behavior are not related.
As for how the belief started in the first place, a 1999 study conjectures that the alleged connection of moon to lunacy might be a ‘cultural fossil’ from a time before the advent of outdoor lighting, when the bright light of the full moon might have induced sleep deprivation in people living outside, thereby triggering erratic behaviour in predisposed people with mental conditions such as bipolar disorder.
Evidence for lunar effect in reptiles, birds and mammals is scant, but among reptiles marine iguanas (which live in the Galápagos Islands) time their trips to the sea in order to arrive at low tide.
A relationship between the Moon and the birth rate of cows was reported in a 2016 study.
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