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HIP2
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<h2 id="interactions">Interactions</h2> <p>HIP2 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/Huntingtin/fYK4y480">Huntingtin</a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> and <a href="/facts/RNF2/dbsLmjbF">RNF2</a>.<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Petersén A, Mani K, Brundin P (1999). "Recent advances on the pathogenesis of Huntington's disease". <i>Exp. Neurol</i>. 157 (1): 1–18. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fexnr.1998.7006">10.1006/exnr.1998.7006</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10222105">10222105</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:12974652">12974652</a>.</li> <li>Coux O, Goldberg AL (1998). <a href="https://doi.org/10.1074%2Fjbc.273.15.8820">"Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1"</a>. <i>J. Biol. Chem</i>. 273 (15): 8820–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.15.8820">10.1074/jbc.273.15.8820</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9535861">9535861</a>.</li> <li>Whitby FG, Xia G, Pickart CM, Hill CP (1999). <a href="https://doi.org/10.1074%2Fjbc.273.52.34983">"Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes"</a>. <i>J. Biol. Chem</i>. 273 (52): 34983–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.52.34983">10.1074/jbc.273.52.34983</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9857030">9857030</a>.</li> <li>Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I (2000). <a href="https://doi.org/10.1161%2F01.ATV.20.1.128">"Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis"</a>. <i>Arterioscler. Thromb. Vasc. Biol</i>. 20 (1): 128–34. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1161%2F01.ATV.20.1.128">10.1161/01.ATV.20.1.128</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10634809">10634809</a>.</li> <li>Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I (2000). "Regulation of macrophage-specific gene expression by degenerated lipoproteins". <i>Electrophoresis</i>. 21 (2): 338–46. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2F%28SICI%291522-2683%2820000101%2921%3A2%3C338%3A%3AAID-ELPS338%3E3.0.CO%3B2-9">10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10675012">10675012</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:22857626">22857626</a>.</li> <li>Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". <i>FEBS Lett</i>. 503 (1): 61–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2801%2902689-8">10.1016/S0014-5793(01)02689-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11513855">11513855</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:42977319">42977319</a>.</li> <li>Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". <i>Nat. Biotechnol</i>. 21 (5): 566–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnbt810">10.1038/nbt810</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12665801">12665801</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:23783563">23783563</a>.</li> <li>Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, <a href="/facts/Bernhard_Landwehrmeyer/J1s2MYJ9">Landwehrmeyer BG</a>, Lehrach H, Wanker EE (2004). <a href="https://doi.org/10.1016%2Fj.molcel.2004.09.016">"A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease"</a>. <i>Mol. Cell</i>. 15 (6): 853–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.molcel.2004.09.016">10.1016/j.molcel.2004.09.016</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15383276">15383276</a>.</li> <li>Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"</a>. <i>Genome Res</i>. 16 (1): 55–65. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.4039406">10.1101/gr.4039406</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129">1356129</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16344560">16344560</a>.</li> <li>Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V (2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1520313">"E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 103 (31): 11589–94. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2006PNAS..10311589F">2006PNAS..10311589F</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.0605215103">10.1073/pnas.0605215103</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1520313">1520313</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16868077">16868077</a>.</li> <li>de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". <i>Mol. Cell. Neurosci</i>. 34 (1): 10–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.mcn.2006.09.006">10.1016/j.mcn.2006.09.006</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17092742">17092742</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:9704303">9704303</a>.</li> <li>Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948">"Large-scale mapping of human protein-protein interactions by mass spectrometry"</a>. <i>Mol. Syst. Biol</i>. 3 (1): 89. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fmsb4100134">10.1038/msb4100134</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948">1847948</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17353931">17353931</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625. <a href="https://doi.org/10.1074%2Fjbc.271.32.19385" target="_blank">https://doi.org/10.1074%2Fjbc.271.32.19385</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885. S2CID 32160828. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: HIP2 huntingtin interacting protein 2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: HIP2 huntingtin interacting protein 2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625. <a href="https://doi.org/10.1074%2Fjbc.271.32.19385" target="_blank">https://doi.org/10.1074%2Fjbc.271.32.19385</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202. <a href="https://doi.org/10.1093%2Fhmg%2F7.9.1463" target="_blank">https://doi.org/10.1093%2Fhmg%2F7.9.1463</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. S2CID 42977319. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> </ol>