The development of ASTOS (formerly named ALTOS) started in 1989 at the DLR in Oberpfaffenhofen and MBB (now Astrium). In 1991 the Institute of Flight Mechanics and Control (IFR) at the University of Stuttgart under the head of Prof. Klaus Well took the responsibility for the development of ASTOS. In 1999 the commercialization of ASTOS began. In the period 2001-2006 ASTOS was sold by Technology Transfer Initiative of the University of Stuttgart (TTI). Since September 2006, the newly founded company Astos Solutions GmbH is responsible for development and sales of ASTOS.
ASTOS is being extensively used in aerospace agencies and industry since 1998, hereafter a not complete list of project is presented where the software was involved during the design or accomplishment of the space mission.