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ARAF
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<h2 id="interactions">Interactions</h2> <p>ARAF has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/EFEMP1/I5xUa5K3">EFEMP1</a>,<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li> <li><a href="/facts/MAP2K2/JREAUUts">MAP2K2</a>,<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a></li> <li><a href="/facts/PRPF6/QGq8wq78">PRPF6</a>,<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a><a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a></li> <li><a href="/facts/RRAS/shlwMJ8h">RRAS</a>,<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a><a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a></li> <li><a href="/facts/TIMM44/GNY34KuN">TIMM44</a>,<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> and</li> <li><a href="/facts/TH1L/RY2oIrej">TH1L</a>.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a><a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Belanger BF, Williams WJ, Yin TC (1976). "A flexible renewal process simulator for neural spike trains". <i>IEEE Trans Biomed Eng</i>. 23 (3): 262–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1109%2FTBME.1976.324641">10.1109/TBME.1976.324641</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1262038">1262038</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:2411492">2411492</a>.</li> <li>Popescu NC, Mark GE (1989). "Localization of the pKs gene, a raf related sequence on human chromosomes X and 7". <i>Oncogene</i>. 4 (4): 517–9. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2717185">2717185</a>.</li> <li>Beck TW, Huleihel M, Gunnell M, Bonner TI, Rapp UR (1987). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340454">"The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus"</a>. <i>Nucleic Acids Res</i>. 15 (2): 595–609. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F15.2.595">10.1093/nar/15.2.595</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC340454">340454</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/3029685">3029685</a>.</li> <li>Papin C, Eychène A, Brunet A, Pagès G, Pouysségur J, Calothy G, Barnier JV (1995). "B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222". <i>Oncogene</i>. 10 (8): 1647–51. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7731720">7731720</a>.</li> <li>Lee JE, Beck TW, Brennscheidt U, DeGennaro LJ, Rapp UR (1994). <a href="https://zenodo.org/record/1229628">"The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1)"</a>. <i>Genomics</i>. 20 (1): 43–55. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1994.1125">10.1006/geno.1994.1125</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8020955">8020955</a>.</li> <li>Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S (1994). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394991">"Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1"</a>. <i>EMBO J</i>. 13 (7): 1610–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1994.tb06424.x">10.1002/j.1460-2075.1994.tb06424.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394991">394991</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8157000">8157000</a>.</li> <li>Gardner AM, Vaillancourt RR, Johnson GL (1993). <a href="https://doi.org/10.1016%2FS0021-9258%2817%2946789-5">"Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins"</a>. <i>J. Biol. Chem</i>. 268 (24): 17896–901. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2817%2946789-5">10.1016/S0021-9258(17)46789-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8394352">8394352</a>.</li> <li>Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". <i>Anal. Biochem</i>. 236 (1): 107–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fabio.1996.0138">10.1006/abio.1996.0138</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8619474">8619474</a>.</li> <li>Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL (1996). <a href="https://doi.org/10.1074%2Fjbc.271.6.3265">"Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells"</a>. <i>J. Biol. Chem</i>. 271 (6): 3265–71. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.6.3265">10.1074/jbc.271.6.3265</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8621729">8621729</a>.</li> <li>Boldyreff B, Issinger OG (1997). <a href="https://doi.org/10.1016%2FS0014-5793%2897%2900010-0">"A-Raf kinase is a new interacting partner of protein kinase CK2 beta subunit"</a>. <i>FEBS Lett</i>. 403 (2): 197–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2897%2900010-0">10.1016/S0014-5793(97)00010-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9042965">9042965</a>.</li> <li>Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146">"Large-scale concatenation cDNA sequencing"</a>. <i>Genome Res</i>. 7 (4): 353–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.7.4.353">10.1101/gr.7.4.353</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139146">139146</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9110174">9110174</a>.</li> <li>Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938">"Isoform-specific localization of A-RAF in mitochondria"</a>. <i>Mol. Cell. Biol</i>. 20 (13): 4870–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.20.13.4870-4878.2000">10.1128/MCB.20.13.4870-4878.2000</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938">85938</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10848612">10848612</a>.</li> <li>King TR, Fang Y, Mahon ES, Anderson DH (2000). <a href="https://doi.org/10.1074%2Fjbc.M004720200">"Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3'-kinase"</a>. <i>J. Biol. Chem</i>. 275 (46): 36450–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M004720200">10.1074/jbc.M004720200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10967104">10967104</a>.</li> <li>Fang Y, Johnson LM, Mahon ES, Anderson DH (2002). "Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase". <i>Biochem. Biophys. Res. Commun</i>. 290 (4): 1267–74. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.2002.6347">10.1006/bbrc.2002.6347</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11812000">11812000</a>.</li> <li>Yin XL, Chen S, Yan J, Hu Y, Gu JX (2002). <a href="https://doi.org/10.1016%2FS0167-4889%2801%2900188-4">"Identification of interaction between MEK2 and A-Raf-1"</a>. <i>Biochim. Biophys. Acta</i>. 1589 (1): 71–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0167-4889%2801%2900188-4">10.1016/S0167-4889(01)00188-4</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11909642">11909642</a>.</li> <li>Yin XL, Chen S, Gu JX (2002). "Identification of TH1 as an interaction partner of A-Raf kinase". <i>Mol. Cell. Biochem</i>. 231 (1–2): 69–74. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1023%2FA%3A1014437024129">10.1023/A:1014437024129</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11952167">11952167</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:19362635">19362635</a>.</li> <li>Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". <i>Genomics</i>. 81 (2): 112–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0888-7543%2802%2900008-3">10.1016/S0888-7543(02)00008-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12620389">12620389</a>.</li> <li>Liu W, Shen X, Yang Y, Yin X, Xie J, Yan J, Jiang J, Liu W, Wang H, Sun M, Zheng Y, Gu J (2004). <a href="https://doi.org/10.1074%2Fjbc.M307994200">"Trihydrophobin 1 is a new negative regulator of A-Raf kinase"</a>. <i>J. Biol. Chem</i>. 279 (11): 10167–75. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M307994200">10.1074/jbc.M307994200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14684750">14684750</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ARAF"><i>ARAF</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ARAF"><i>ARAF</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li><a href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P10398">PDBe-KB</a> provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein kinase A-Raf</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: ARAF V-raf murine sarcoma 3611 viral oncogene homolog". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=369" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=369</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Mark GE, Seeley TW, Shows TB, Mountz JD (September 1986). "Pks, a raf-related sequence in humans". Proc. Natl. Acad. Sci. U.S.A. 83 (17): 6312–6. doi:10.1073/pnas.83.17.6312. PMC 386493. PMID 3529082. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC386493" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC386493</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Lee, J. E.; Beck, T. W.; Wojnowski, L.; Rapp, U. R. (1996-04-18). "Regulation of A-raf expression". Oncogene. 12 (8): 1669–1677. ISSN 0950-9232. PMID 8622887. <a href="/wiki/ISSN_(identifier)" target="_blank">/wiki/ISSN_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Baljuls, Angela; Mueller, Thomas; Drexler, Hannes C. A.; Hekman, Mirko; Rapp, Ulf R. (2007-09-07). "Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates". The Journal of Biological Chemistry. 282 (36): 26575–26590. doi:10.1074/jbc.M702429200. ISSN 0021-9258. PMID 17613527. <a href="https://doi.org/10.1074%2Fjbc.M702429200" target="_blank">https://doi.org/10.1074%2Fjbc.M702429200</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Mercer, Kathryn; Giblett, Susan; Oakden, Anthony; Brown, Jane; Marais, Richard; Pritchard, Catrin (2005-04-25). "A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression". Oncogene. 24 (33): 5207–5217. doi:10.1038/sj.onc.1208707. ISSN 0950-9232. PMID 15856007. <a href="https://doi.org/10.1038%2Fsj.onc.1208707" target="_blank">https://doi.org/10.1038%2Fsj.onc.1208707</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Matallanas, David; Birtwistle, Marc; Romano, David; Zebisch, Armin; Rauch, Jens; Kriegsheim, Alexander von; Kolch, Walter (2011-03-01). "Raf Family Kinases Old Dogs Have Learned New Tricks". Genes & Cancer. 2 (3): 232–260. doi:10.1177/1947601911407323. ISSN 1947-6019. PMC 3128629. PMID 21779496. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128629" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128629</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Rauch, Jens; O'Neill, Eric; Mack, Brigitte; Matthias, Christoph; Munz, Markus; Kolch, Walter; Gires, Olivier (2010-02-15). "Heterogeneous Nuclear Ribonucleoprotein H Blocks MST2-Mediated Apoptosis in Cancer Cells by Regulating a-raf Transcription". Cancer Research. 70 (4): 1679–1688. doi:10.1158/0008-5472.CAN-09-2740. ISSN 0008-5472. PMC 2880479. PMID 20145135. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880479" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880479</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Christofk, Heather R.; Vander Heiden, Matthew G.; Harris, Marian H.; Ramanathan, Arvind; Gerszten, Robert E.; Wei, Ru; Fleming, Mark D.; Schreiber, Stuart L.; Cantley, Lewis C. (2008-03-13). "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth". Nature. 452 (7184): 230–233. doi:10.1038/nature06734. ISSN 0028-0836. PMID 18337823. S2CID 16111842. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Mazurek, Sybille; Drexler, Hannes C. A.; Troppmair, Jakob; Eigenbrodt, Erich; Rapp, Ulf R. (2007-11-01). "Regulation of Pyruvate Kinase Type M2 by A-Raf: A Possible Glycolytic Stop or Go Mechanism". Anticancer Research. 27 (6B): 3963–3971. ISSN 0250-7005. PMID 18225557. <a href="http://ar.iiarjournals.org/content/27/6B/3963" target="_blank">http://ar.iiarjournals.org/content/27/6B/3963</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Nekhoroshkova, Elena; Albert, Stefan; Becker, Matthias; Rapp, Ulf R. (2009-02-27). "A-RAF Kinase Functions in ARF6 Regulated Endocytic Membrane Traffic". PLOS ONE. 4 (2): e4647. doi:10.1371/journal.pone.0004647. ISSN 1932-6203. PMC 2645234. PMID 19247477. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645234" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645234</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Yin XL, Chen S, Yan J, Hu Y, Gu JX (February 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta. 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. PMID 11909642. <a href="https://doi.org/10.1016%2FS0167-4889%2801%2900188-4" target="_blank">https://doi.org/10.1016%2FS0167-4889%2801%2900188-4</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85938</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>Yin XL, Chen S, Gu JX (February 2002). "Identification of TH1 as an interaction partner of A-Raf kinase". Mol. Cell. Biochem. 231 (1–2): 69–74. doi:10.1023/A:1014437024129. PMID 11952167. S2CID 19362635. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> </ol>