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BCCIP
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<h2 id="interactions">Interactions</h2> <p>BCCIP has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/BRCA2/eDUI83G1">BRCA2</a>,<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> <a href="/facts/P21/gb0VLtY8">P21</a>,<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> and PTPmu (<a href="/facts/PTPRM/laX6IJdP">PTPRM</a>)<a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=BCCIP"><i>BCCIP</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=BCCIP"><i>BCCIP</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes". <i>Biochim. Biophys. Acta</i>. 1125 (2): 203–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0005-2760%2892%2990046-X">10.1016/0005-2760(92)90046-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1571364">1571364</a>.</li> <li>Machackova E, Damborsky J, Valik D, Foretova L (2002). <a href="https://doi.org/10.1002%2Fhumu.1232">"Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic"</a>. <i>Hum. Mutat</i>. 18 (6): 545. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fhumu.1232">10.1002/humu.1232</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11748848">11748848</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:8549550">8549550</a>.</li> <li>Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002). <a href="https://doi.org/10.1002%2Fhumu.9003">"BRCA2 gene mutations in Greek patients with familial breast cancer"</a>. <i>Hum. Mutat</i>. 19 (1): 81–2. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fhumu.9003">10.1002/humu.9003</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11754111">11754111</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25598124">25598124</a>.</li> <li>Robson M, Scheuer L, Nafa K, et al. (2002). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735025">"Unique de novo mutation of BRCA2 in a woman with early onset breast cancer"</a>. <i>J. Med. Genet</i>. 39 (2): 126–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1136%2Fjmg.39.2.126">10.1136/jmg.39.2.126</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1735025">1735025</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11836363">11836363</a>.</li> <li>Strausberg RL, Feingold EA, Grouse LH, et al. (2003). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 99 (26): 16899–903. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2002PNAS...9916899M">2002PNAS...9916899M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.242603899">10.1073/pnas.242603899</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241">139241</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12477932">12477932</a>.</li> <li>Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". <i>Gene</i>. 302 (1–2): 139–46. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0378-1119%2802%2901098-3">10.1016/S0378-1119(02)01098-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12527204">12527204</a>.</li> <li>Ota T, Suzuki Y, Nishikawa T, et al. (2004). <a href="https://doi.org/10.1038%2Fng1285">"Complete sequencing and characterization of 21,243 full-length human cDNAs"</a>. <i>Nat. Genet</i>. 36 (1): 40–5. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng1285">10.1038/ng1285</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14702039">14702039</a>.</li> <li>Meng X, Liu J, Shen Z (2004). <a href="https://doi.org/10.4161%2Fcc.3.3.672">"Inhibition of G1 to S cell cycle progression by BCCIP beta"</a>. <i>Cell Cycle</i>. 3 (3): 343–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4161%2Fcc.3.3.672">10.4161/cc.3.3.672</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14726710">14726710</a>.</li> <li>Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). <a href="https://doi.org/10.1038%2Fnature02462">"The DNA sequence and comparative analysis of human chromosome 10"</a>. <i>Nature</i>. 429 (6990): 375–81. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2004Natur.429..375D">2004Natur.429..375D</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature02462">10.1038/nature02462</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15164054">15164054</a>.</li> <li>Colland F, Jacq X, Trouplin V, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442148">"Functional proteomics mapping of a human signaling pathway"</a>. <i>Genome Res</i>. 14 (7): 1324–32. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2334104">10.1101/gr.2334104</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442148">442148</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15231748">15231748</a>.</li> <li>Gerhard DS, Wagner L, Feingold EA, et al. (2004). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"</a>. <i>Genome Res</i>. 14 (10B): 2121–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgr.2596504">10.1101/gr.2596504</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928">528928</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15489334">15489334</a>.</li> <li>Meng X, Lu H, Shen Z (2007). <a href="https://doi.org/10.4161%2Fcc.3.11.1213">"BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1"</a>. <i>Cell Cycle</i>. 3 (11): 1457–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.4161%2Fcc.3.11.1213">10.4161/cc.3.11.1213</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15539944">15539944</a>.</li> <li>Lu H, Guo X, Meng X, et al. (2005). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549367">"The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair"</a>. <i>Mol. Cell. Biol</i>. 25 (5): 1949–57. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.25.5.1949-1957.2005">10.1128/MCB.25.5.1949-1957.2005</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549367">549367</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15713648">15713648</a>.</li> <li>Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". <i>Cell</i>. 122 (6): 957–68. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cell.2005.08.029">10.1016/j.cell.2005.08.029</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/11858%2F00-001M-0000-0010-8592-0">11858/00-001M-0000-0010-8592-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16169070">16169070</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:8235923">8235923</a>.</li> <li>Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". <i>Nature</i>. 437 (7062): 1173–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2005Natur.437.1173R">2005Natur.437.1173R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fnature04209">10.1038/nature04209</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16189514">16189514</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4427026">4427026</a>.</li> <li>Olsen JV, Blagoev B, Gnad F, et al. (2006). <a href="https://doi.org/10.1016%2Fj.cell.2006.09.026">"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"</a>. <i>Cell</i>. 127 (3): 635–48. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.cell.2006.09.026">10.1016/j.cell.2006.09.026</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17081983">17081983</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:7827573">7827573</a>.</li> <li>Meng X, Yue J, Liu Z, Shen Z (2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679999">"Abrogation of the transactivation activity of p53 by BCCIP down-regulation"</a>. <i>J. Biol. Chem</i>. 282 (3): 1570–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M607520200">10.1074/jbc.M607520200</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679999">2679999</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17135243">17135243</a>.</li> <li>Ewing RM, Chu P, Elisma F, et al. (2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948">"Large-scale mapping of human protein-protein interactions by mass spectrometry"</a>. <i>Mol. Syst. Biol</i>. 3 (1): 89. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fmsb4100134">10.1038/msb4100134</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847948">1847948</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17353931">17353931</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi:10.1038/sj.onc.1204098. PMID 11313963. <a href="https://doi.org/10.1038%2Fsj.onc.1204098" target="_blank">https://doi.org/10.1038%2Fsj.onc.1204098</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase". J Biol Chem. 275 (40): 31145–54. doi:10.1074/jbc.M003031200. PMID 10878006. <a href="https://doi.org/10.1074%2Fjbc.M003031200" target="_blank">https://doi.org/10.1074%2Fjbc.M003031200</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56647</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi:10.1038/sj.onc.1204098. PMID 11313963. <a href="https://doi.org/10.1038%2Fsj.onc.1204098" target="_blank">https://doi.org/10.1038%2Fsj.onc.1204098</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase". J Biol Chem. 275 (40): 31145–54. doi:10.1074/jbc.M003031200. PMID 10878006. <a href="https://doi.org/10.1074%2Fjbc.M003031200" target="_blank">https://doi.org/10.1074%2Fjbc.M003031200</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008). "BCCIP associates with the receptor protein tyrosine phosphatase PTPmu". J Cell Biochem. 105 (4): 1059–72. doi:10.1002/jcb.21907. PMC 2758318. PMID 18773424. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758318" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758318</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> </ol>