Specific types of neurotransmitter transporters include the following:
Note that there is no plasmalemmal acetylcholine transporter, as acetylcholine is terminated via rapid metabolism into choline by cholinesterase enzymes, and choline is subsequently transported back into the cell and reconverted into acetylcholine.
Transporters associated with histamine and the endocannabinoids have not yet been identified.
A variety of neurotransmitter reuptake transporters are pharmacotherapeutic targets for modulating the synaptic neurotransmitter concentration, and therefore neurotransmission.
Vesicular transporters could provide an alternative therapeutic target for the modulation of chemical neurotransmission, as the activity of these transporters could affect the quantity of neurotransmitter released.7
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Varoqui H, Erickson JD (October 1997). "Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function". Molecular Neurobiology. 15 (2): 165–91. doi:10.1007/BF02740633. PMID 9396009. S2CID 26111849. /wiki/Doi_(identifier) ↩
Prior C, Marshall IG, Parsons SM (November 1992). "The pharmacology of vesamicol: an inhibitor of the vesicular acetylcholine transporter". General Pharmacology. 23 (6): 1017–22. doi:10.1016/0306-3623(92)90280-w. PMID 1487110. /wiki/Doi_(identifier) ↩