Following the move to Grand Rapids, Anderson went through a rebellious stage; taking drugs, dating a much older boyfriend, and cultivating a punk appearance (dyeing her hair various colors, shaving the sides of her head, sporting a nose piercing and an all-black wardrobe). She was put in therapy at the age of 14. Anderson listened to bands such as Dead Kennedys and Skinny Puppy. She was voted by her classmates as "class clown", "most bizarre girl" and "most likely to be arrested". She was arrested on graduation night for breaking and entering into her high school in an attempt to glue the locks of the doors. She later managed to reduce the charges to trespassing.
Anderson is the eldest of three siblings. Her brother Aaron – who was diagnosed with neurofibromatosis – died in 2011 of a brain tumor, at the age of 30. Aaron was a DJ, a mentor, and a practicing Buddhist. He was in his second year of a PhD program in developmental psychology at Stanford University when he was diagnosed with glioblastoma in 2008. Her sister Zoe is a ceramicist, whom Anderson called "an exceptional artist".
Anderson is bidialectal. With her English accent and background, she was mocked and felt out of place in the American Midwest and soon adopted a Midwestern accent. To this day, she easily shifts between her American and English accents. In May 2013, during an interview with BlogTalkRadio, Anderson addressed the matter of her national identity: "I've been asked whether I feel more like a Brit than an American and I don't know what the answer to that question is. I know that I feel that London is home and I'm very happy with that as my home. I love London as a city and I feel very comfortable there. In terms of identity, I'm still a bit baffled."
Anderson moved to Los Angeles in 1992 and spent a year auditioning. The same year, she appeared in her first feature-length film, The Turning, starring Karen Allen and Tess Harper. The film drama is an adaptation of the play Home Fires Burning.
Although she had once vowed she would never do television work, being out of work for a year changed her mind. Anderson recalled: "First of all, I swore I'd never move to Los Angeles, and once I did, I swore I'd never do television. It was only after being out of work for almost a year that I began going in [to auditions] on some stuff that I would pray that I wouldn't get because I didn't want to be involved in it." She broke into mainstream television in 1993 with a guest appearance on the collegiate drama, Class of '96, on the fledgling Fox Network.
From April 23, 2016, through June 4, 2016, Anderson reprised her role of Blanche DuBois in A Streetcar Named Desire on stage at the new St. Ann's Warehouse in Brooklyn, New York City. On September 13, 2016, Anderson and Rovin published The Sound of Seas; their third and final novel of The EarthEnd Saga trilogy. The same month, she returned to portraying DSU Stella Gibson in the third series of The Fall. Anderson is the narrator of the English dub of Ronja, the Robber's Daughter – Studio Ghibli's anime, which began streaming on Amazon Prime in January 2017. In February 2017, Anderson portrayed Edwina Mountbatten in Gurinder Chadha's Partition drama film Viceroy's House (2017).
From February 2, 2019, through May 11, 2019, Anderson portrayed Margo Channing in a stage production of All About Eve at the Noël Coward Theatre for which she received her third Laurence Olivier Award nomination. On September 7, 2019, it was announced that she will portray former British Prime Minister Margaret Thatcher in the fourth season of the Netflix historical drama series The Crown. Anderson is the second American actress (after Meryl Streep in The Iron Lady) to portray Thatcher in a major production. In a statement Anderson said: "I am so excited to be joining the cast and crew of The Crown and to have the opportunity to portray such a complicated and controversial woman, Thatcher was undoubtedly formidable but I am relishing exploring beneath the surface and, dare I say, falling in love with the icon who, whether loved or despised, defined an era."
Anderson resides with her three children in London, where she has lived since 2002. She has been in a relationship with British screenwriter Peter Morgan since 2016 apart from a short break in 2020.
Anderson has been active in supporting numerous charity organizations, global and social causes, as well as running her own humanitarian ventures. She supports The Trevor Project organization, focused on suicide prevention efforts among LGBTQ youth and attended three of the Trevor Project's "Cracked X-Mas" events to benefit the organization. In 2013, Anderson was made a patron of the Charles Dickens Statue Fund, and was instrumental in securing the funding for UK's first Dickens statue, located in Portsmouth, Hampshire. In June 2016 she became a patron of the Temple Legal Centre, a London-based organization that assists people through the legal process by providing them free family law advice and support. In June 2016, Anderson expressed her support for the United Kingdom to remain a member of the European Union in the run-up to June's referendum on that issue. In January 2018, Anderson was given a City Lit Lifetime Fellowship Award by the adult education college City Literary Institute.
In 2008, Anderson co-founded South African Youth Education for Sustainability (SAYes), which helps in empowering marginalised young people in South Africa through youth mentoring. The nonprofit organization provides youth leaving children's homes with guidance that enables them to develop their skills, further their education, and source suitable housing in order to participate in society as independent adults.
Anderson is a supporter of various women's organizations and social movements. She has been a long-time supporter of the Feminist Majority Foundation (FMF). In 1996, Anderson became FMF's spokesperson and participated as a team leader in the FMF's Million4Roe campaign. In March 1999, she attended an FMF event to stop gender apartheid in Afghanistan and in April 2002, she appeared on Hollywood Squares to benefit the FMF's campaign to aid Afghan women and girls. Anderson participated in Eve Ensler's Vagina Monologues, including a stage performance on February 14, 1999. Anderson is a supporter of Ensler's V-Day movement aiming to end violence against women and girls.
In 2009, Anderson was named as one of 20 most powerful women in British theatre and was dubbed "The Honorary Brit" by Harper's Bazaar and Tiffany & Co.'s list. In 2010, Anderson was named Honorary Associate of The London Film School (LFS).
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Gillian Anderson, Jennifer Nadel. "WE: A Manifesto for Women Everywhere". Simon & Schuster. Retrieved September 13, 2016. http://books.simonandschuster.com/WE/Gillian-Anderson/9781501126277
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Evans, Greg (February 23, 2017). "'American Gods': Starz Sets Premiere Date, Gives First Look at New Fantasy Series". Deadline Hollywood. Retrieved April 24, 2017. https://deadline.com/2017/02/american-gods-starz-premiere-date-first-look-art-1201955368/
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Wiseman, Andreas (September 13, 2016). "Agatha Christie thriller 'Crooked House' underway". Screen Daily. Retrieved September 14, 2016. http://m.screendaily.com/5109411.article/
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Tucker, Grant (January 20, 2019). "Gillian Anderson to play Margaret Thatcher in Netflix's The Crown". The Times (subscription required). Retrieved January 21, 2019. https://www.thetimes.co.uk/article/gillian-anderson-to-play-margaret-thatcher-in-the-crown-6kp5cltb2
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Codik, Emily (May 15, 2015). "Gillian Anderson Is in DC, and the Reason for Her Visit Might Surprise You". Washingtonian. Retrieved August 19, 2015. http://www.washingtonian.com/blogs/afterhours/museums/gillian-anderson-darren-waterston-filthy-lucre-sackler.php
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Walden, Celia (August 1, 2014). "I have a healthy appreciation of Ryan Gosling". Glamour. Retrieved September 14, 2015. http://www.gilliananderson.ws/transcripts/10_15/14glamour.shtml
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Minton, Elise (June 24, 2016). "Gillian Anderson's Beauty Secrets Revealed!". New Beauty. Retrieved October 26, 2016. https://www.newbeauty.com/blog/dailybeauty/9552-gillian-andersons-beauty-secrets-revealed
Gillian Anderson is bidialectal – what that means and how she got her accents. Today.com. Retrieved 12 June 2021 https://www.today.com/popculture/why-gillian-anderson-has-both-british-american-accents-t210707
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"Exclusive: Gillian Anderson, Partner Mark Griffiths Split". Us Weekly. Retrieved August 8, 2012. http://www.usmagazine.com/celebrity-news/news/gillian-anderson-partner-mark-griffiths-split--201278
Hicklin, Aaron (March 13, 2012). "The Double Life of Gillian Anderson". Out. Retrieved September 21, 2015. http://www.out.com/entertainment/television/2012/03/13/gillian-anderson-lesbian-love-xfiles-Miss-Havisham
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Curtis, Nick (December 3, 2014). "Gillian Anderson: Self destruction is my default mode". London Evening Standard. Retrieved August 26, 2015. https://www.standard.co.uk/showbiz/celebrity-news/gillian-anderson-self-destruction-is-my-default-mode-9897489.html
Turchiano, Danielle (January 16, 2015). "'The Fall's' Gillian Anderson on Season 2 "Surprises", 'Hannibal's' Darkness". The Hollywood Reporter. Retrieved September 18, 2015. https://www.hollywoodreporter.com/live-feed/falls-gillian-anderson-season-2-762644
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Woods, Judith (March 24, 2015). "Gillian Anderson: It's time somebody was brave enough to ask me out". The Daily Telegraph. Retrieved September 15, 2015. https://www.telegraph.co.uk/news/celebritynews/11489711/Gillian-Anderson-Its-time-somebody-was-brave-enough-to-ask-me-out.html
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"Gillian Anderson Headlines Trevor Project Fundraiser to Help Gay Teens". December 12, 1999. Retrieved April 3, 2016. http://www.gilliananderson.ws/transcripts/99_00/99cxmas.shtml
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"Patrons and Trustees". templelegalcentre.org. Retrieved August 2, 2016. http://www.templelegalcentre.org/trustees
Gillian Anderson [@GillianA] (June 21, 2016). "Watch #Voting Live! @ 7.45 pm TONIGHT w/ @bastilledan @rioferdy5 @MaverickSabre @sulibreaks https://www.facebook.com/sofarsounds" (Tweet). Retrieved August 24, 2016 – via Twitter. https://x.com/GillianA/status/745279425395167232
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Larry Kaplan (March 9, 1998). "Gillian's Plea: "Save my sick brother"". New Weekly. Retrieved November 9, 2015. http://www.gilliananderson.ws/transcripts/98/98newweekly.shtml
"Neurofibromatosis Inc., the NF support group of West Michigan and Rosemary and Gillian Anderson". Library of Congress. May 20, 1996. Retrieved October 5, 2015. http://thomas.loc.gov/cgi-bin/query/z?r104:S20MY6-667:
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"SAYes Transition Mentoring". Retrieved May 8, 2017. http://sayesmentoring.org
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"Buskaid – Helping Young Black Musicians in South Africa Townships". buskaid.org. Retrieved September 13, 2015. https://www.buskaid.org.za/photos.htm
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Kellaway, Kate (April 22, 2001). "Talking 'bout our genitalia". The Guardian. Retrieved October 7, 2015. https://www.theguardian.com/theobserver/2001/apr/22/features.review27
"Power To Do Good – Benefit V-Day: A Global Movement to End Violence Against Women and Girls Worldwide". Archived from the original on July 21, 2015. Retrieved July 28, 2015. https://web.archive.org/web/20150721043542/http://www.powertodogood.com/TheOfficialGillianAndersonWebsite_BedeliaDuMaurierStore_s/1873.htm
"Sold Out Rock for Choice Concert Sends a Powerful Message: We Won't Go Back!". feminist.org. April 9, 2001. Retrieved September 9, 2015. https://feminist.org/news/newsbyte/uswirestory.asp?id=5426
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"Stand with the women of Burma to end rape and sexual violence". Burma Campaign UK. October 9, 2015. Retrieved March 12, 2016. http://burmacampaign.org.uk/take-action/stand-with-the-women-of-burma-to-end-rape-and-sexual-violence
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"International Literacy Centre – Champions". UCL Institute of Education. Retrieved August 8, 2016. http://www.ucl.ac.uk/international-literacy/reading-recovery/champions
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"XF Auction Week 6 Has Started". The Official Gillian Anderson Website. February 28, 2016. Retrieved April 3, 2015. http://www.gilliananderson.ws/cgi-bin/news/viewnews.cgi?id=EuVyyAupEymdPiQsnH
Ritman, Alex (March 4, 2016). "Benedict Cumberbatch, Jude Law to Sponsor Child Refugees". The Hollywood Reporter. Retrieved January 17, 2018. https://www.hollywoodreporter.com/news/benedict-cumberbatch-jude-law-refugees-872706
UCL Institute of Education [@IOE_London] (July 7, 2017). "Gillian Anderson @GillianA has been awarded a @UCL Honorary Fellowship for her support of the @ILC_IOE's #ReadingRecovery programme. B. ;)" (Tweet). Retrieved July 9, 2017 – via Twitter. /wiki/UCL_Institute_of_Education
"Celebrities boycott Botswana over Bushmen". AFRAN Study and Research Institute. November 8, 2010. Retrieved September 11, 2015. http://www.afran.info/modules/news/article.php?storyid=5656
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"First ever aerial footage of uncontacted Amazon tribe released". uncontactedtribes.org. February 4, 2011. Retrieved June 12, 2016. http://www.uncontactedtribes.org/brazilfootage
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"Celebrities call for a new conservation that respects tribal peoples' rights". Survival International. September 9, 2015. Retrieved September 11, 2015. http://www.survivalinternational.org/news/10900
"Message from Gillian Anderson: Save the Amazon". Greenpeace. March 7, 2014. Retrieved September 14, 2015. https://www.youtube.com/watch?v=7Jyx3GpjhUQ
"Gillian Anderson for Cheetah Conservation Fund". Cheetah Conservation Fund. December 30, 2013. Retrieved September 9, 2015. http://cheetah.org/video/gillian-anderson-for-cheetah-conservation-fund
"Fish love". http://www.fishlove.co.uk/
"Gillian Anderson Shows her Support for Positive Luxury". Positive Luxury. November 13, 2015. Retrieved June 12, 2016. http://blog.positiveluxury.com/2015/11/gillian-anderson-shows-her-support-for-positive-luxury
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"The Artist's Garden: American Impressionism". Exhibition on Screen. Retrieved March 17, 2017. https://exhibitiononscreen.com/films/the-artists-garden
Petski, Denise (May 14, 2021). "Gillian Anderson To Play Elle Fanning's Mother In Season 2 Of Hulu's 'The Great'". Deadline Hollywood. Archived from the original on May 14, 2021. Retrieved May 14, 2021. https://deadline.com/2021/05/gillian-anderson-elle-fannings-mother-season-2-hulu-the-great-elle-fanning-1234756266/
Andreeva, Nellie (February 22, 2021). "Gillian Anderson To Star As Eleanor Roosevelt In 'The First Lady' Showtime Limited Series". Deadline Hollywood. Retrieved February 22, 2021. https://deadline.com/2021/02/gillian-anderson-eleanor-roosevelt-the-first-lady-showtime-1234698357/
"Hal featuring Gillian Anderson – Extremis Original Edit". Retrieved April 3, 2016. http://www.hamariweb.uk/watch?v=gIx7amfJefw
"The G-Files: the search for Gillian Anderson's roots". Retrieved October 4, 2006. http://gfiles.toddverbeek.com
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"Benedict Cumberbatch and Gillian Anderson do it by the book". The Guardian. December 11, 2013. Retrieved February 6, 2016. https://www.theguardian.com/media/2013/dec/11/benedict-cumberbatch-gillian-anderson-letters-live
"Production Page". Young Vic Theatre. Retrieved August 20, 2014. http://www.youngvic.org/whats-on/a-streetcar-named-desire
Sian Cain (February 5, 2016). "Russell Brand, Benedict Cumberbatch and Gillian Anderson return to Letters Live". The Guardian. Retrieved February 6, 2016. https://www.theguardian.com/books/2016/feb/05/russell-brand-benedict-cumberbatch-gillian-anderson-letters-live-2016
"St. Ann's Warehouse – A Young Vic & Joshua Andrews Co-Production". St. Ann's Warehouse. Retrieved July 18, 2015. http://stannswarehouse.org/show/streetcar-named-desire
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"All About Eve". Retrieved February 21, 2020. http://allabouteveplay.com/
Plunkett, John (November 29, 2007). "X Files star Gillian Anderson to appear in Radio 4 play". The Independent. Retrieved October 30, 2015. https://www.theguardian.com/media/2007/nov/29/bbc.radio?gusrc=rss&feed=media
"Exit to Eden by Anne Rice, Gillian Anderson, Anne Rampling". Better World Books. Retrieved October 14, 2015. http://www.betterworldbooks.com/exit-to-eden-id-0679421718.aspx
"X-Files Collection: "Antibodies", "Ground Zero", "Ruins"". Goodreads. Retrieved October 14, 2015. http://www.goodreads.com/book/show/5989718-x-files-collection
"The Guardian of the Pool". Hachette Book Group. July 1, 2009. Retrieved December 24, 2015. http://www.hachettebookgroup.com/titles/none/the-guardian-of-the-pool/9781600248351/
"David Eagleman's Sum". The Literary Platform. June 4, 2010. Retrieved December 24, 2015. http://theliteraryplatform.com/2010/06/david-eaglemans-sum/
"Charlotte Brontë – L'Ingratitude". London Review of Books. March 8, 2012. Retrieved May 8, 2016. http://www.lrb.co.uk/v34/n05/charlotte-bronte/lingratitude
"Switch Bitch". Goodreads. September 13, 2012. Retrieved December 24, 2015. https://www.goodreads.com/book/show/21041105-switch-bitch/
Gillian Anderson. "A Vision of Fire (The EarthEnd Saga #1)". Simon & Schuster. Retrieved October 14, 2015. http://books.simonandschuster.com/A-Vision-of-Fire/Gillian-Anderson/9781442372948
Gillian Anderson. "A Dream of Ice (The EarthEnd Saga #2)". Simon & Schuster. Retrieved October 14, 2015. http://books.simonandschuster.com/A-Dream-of-Ice/Gillian-Anderson/9781442395633
Gillian Anderson. "The Sound of Seas (The EarthEnd Saga #3)". Simon & Schuster. Retrieved August 2, 2016. http://books.simonandschuster.com/The-Sound-of-Seas/Gillian-Anderson/9781508229933
"BBC Radio 4 – A History of Ideas". BBC. Retrieved February 26, 2016. https://www.bbc.co.uk/programmes/articles/3vVjcY47k2p5Wsnj3ZFHV5W/a-history-of-ideas
"Review: Royal Ballet – Woolf Works – Royal Opera House". londondance.com. May 12, 2015. Retrieved October 14, 2015. http://londondance.com/articles/reviews/royal-ballet-woolf-works-royal-opera-house
"Let's Chris Rea and Get us Home". The London Economic. December 21, 2015. Retrieved December 23, 2015. http://thelondoneconomic.com/travel/lets-chris-rea-and-get-us-home/21/12
Gillian Anderson, Jennifer Nadel. "WE A Manifesto for Women Everywhere". Simon & Schuster. Retrieved September 13, 2016. http://books.simonandschuster.com/WE/Gillian-Anderson/9781508214373
"The X-Files: Cold Cases". Audible. Retrieved April 13, 2017. http://www.audible.co.uk/pd/Sci-Fi-Fantasy/The-X-Files-Cold-Cases-Audiobook/B06Y4C6FGV
"The X-Files: Stolen Lives". Audible. Retrieved October 18, 2017. https://www.audible.co.uk/pd/Sci-Fi-Fantasy/The-X-Files-Stolen-Lives-Audiobook/B07454S3PK
"Extremis – Hal". AllMusic. Retrieved October 31, 2017. https://www.allmusic.com/album/extremis-1-mw0001016356
"Judi Dench and Helen Mirren ranked among powers of theatre". The Daily Telegraph. March 6, 2009. Retrieved February 27, 2016. https://www.telegraph.co.uk/culture/theatre/4942642/Judi-Dench-and-Helen-Mirren-ranked-among-powers-of-theatre.html
"Gillian Anderson, Jack Gold and Chrissy Bright become Honorary Associates at LFS Annual Show". lfs.org.uk. December 14, 2010. Retrieved October 12, 2015. http://news.lfs.org.uk/2010/12/gillian-anderson-jack-gold-and-chrissy.html
"Honorary British awards to foreign nationals – 2016 – Publications – Government of the United Kingdom". Government of the United Kingdom. August 11, 2016. Retrieved January 16, 2017. https://www.gov.uk/government/publications/honorary-british-awards-to-foreign-nationals-2016
Turchiano, Danielle (January 8, 2018). "Gillian Anderson Reflects on How 'The X-Files' Launched a Career of Acting, Writing, Directing". Variety. Retrieved January 9, 2018. https://variety.com/2018/tv/features/gillian-anderson-the-x-files-bleak-house-the-fall-interview-1202648042/