Acyclic spaces occur in topology, where they can be used to construct other, more interesting topological spaces.
For instance, if one removes a single point from a manifold M which is a homology sphere, one gets such a space. The homotopy groups of an acyclic space X do not vanish in general, because the fundamental group π 1 ( X ) {\displaystyle \pi _{1}(X)} need not be trivial. For example, the punctured Poincaré homology sphere is an acyclic, 3-dimensional manifold which is not contractible.
This gives a repertoire of examples, since the first homology group is the abelianization of the fundamental group. With every perfect group G one can associate a (canonical, terminal) acyclic space, whose fundamental group is a central extension of the given group G.
The homotopy groups of these associated acyclic spaces are closely related to Quillen's plus construction on the classifying space BG.
An acyclic group is a group G whose classifying space BG is acyclic; in other words, all its (reduced) homology groups vanish, i.e., H ~ i ( G ; Z ) = 0 {\displaystyle {\tilde {H}}_{i}(G;\mathbf {Z} )=0} , for all i ≥ 0 {\displaystyle i\geq 0} . Every acyclic group is thus a perfect group, meaning its first homology group vanishes: H 1 ( G ; Z ) = 0 {\displaystyle H_{1}(G;\mathbf {Z} )=0} , and in fact, a superperfect group, meaning the first two homology groups vanish: H 1 ( G ; Z ) = H 2 ( G ; Z ) = 0 {\displaystyle H_{1}(G;\mathbf {Z} )=H_{2}(G;\mathbf {Z} )=0} . The converse is not true: the binary icosahedral group is superperfect (hence perfect) but not acyclic.