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Lead-DBS
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<h2 id="notability-and-impact">Notability and impact</h2> <p>According to Husch and colleagues, Lead-DBS is 'arguably the most established toolbox providing a semi-automatic framework for electrode localization'<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> and Milchenko and colleagues described the tool as 'widely used'.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> Regarding the open-source nature of the software, Latorre and colleagues reported that 'A commitment of the community to open science will also democratize and increase the speed of advances with high uptake of currently available initiatives such as Lead-DBS'.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a> The software has been used in a prospective clinical trial<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> which showed that <a href="/facts/Subthalamic_nucleus/2YJLz5rN">subthalamic</a> stimulation settings in patients with <a href="/facts/Parkinson%2527s_disease/xpekKj6x">Parkinson's disease</a> which were generated with Lead-DBS were non-inferior to standard of care treatment.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> In 2022, the software was used to define optimal stimulation networks for <a href="/facts/Deep_brain_stimulation/STmkEI2M">DBS</a> in <a href="/facts/Alzheimer%2527s_disease/w7Ad6tdg">Alzheimer's disease</a>.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a> In 2024, a new algorithm implemented with Lead-DBS was used to personalize DBS treatment in Parkinson's disease.<a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a> Research carried out with Lead-DBS was featured at major news outlets, such as <a href="/facts/CNN/kEYsUQqr">CNN</a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> and <a href="/facts/Fox_News/jyP1hm2q">Fox News</a>.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a> </p> <h2 id="see-also">See also</h2> <ul> <li>Free and open-source software portal</li></ul> <ul><li><a href="/facts/National_Institute_of_Mental_Health/EqxY3XXy">National Institute of Mental Health</a></li> <li><a href="/facts/Neuroimaging/dA5Cteaf">Neuroimaging</a></li> <li><a href="/facts/Statistical_parametric_mapping/NDJ7qx6M">Statistical parametric mapping</a></li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="http://www.lead-dbs.org">Official website</a></li> <li><a href="https://github.com/netstim/leaddbs">Github repository</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Horn, Andreas; Kühn, Andrea A. (February 2015). "Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations". NeuroImage. 107: 127–135. doi:10.1016/j.neuroimage.2014.12.002. PMID 25498389. <a href="https://linkinghub.elsevier.com/retrieve/pii/S1053811914009938" target="_blank">https://linkinghub.elsevier.com/retrieve/pii/S1053811914009938</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Publications – Lead-DBS". www.lead-dbs.org. Retrieved 2024-08-11. <a href="https://www.lead-dbs.org/about/publications/" target="_blank">https://www.lead-dbs.org/about/publications/</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"DFG - GEPRIS - In Richtung netzwerkbasierter Hirnstimulation". gepris.dfg.de. Retrieved 2024-08-11. <a href="https://gepris.dfg.de/gepris/projekt/410169619?context=projekt&task=showDetail&id=410169619&" target="_blank">https://gepris.dfg.de/gepris/projekt/410169619?context=projekt&task=showDetail&id=410169619&</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2024-08-11. <a href="https://reporter.nih.gov/search/PnhyWHKHIUOe8lNufh5yTA/project-details/10503354" target="_blank">https://reporter.nih.gov/search/PnhyWHKHIUOe8lNufh5yTA/project-details/10503354</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Treu, Svenja; Strange, Bryan; Oxenford, Simon; Neumann, Wolf-Julian; Kühn, Andrea; Li, Ningfei; Horn, Andreas (October 2020). "Deep brain stimulation: Imaging on a group level". NeuroImage. 219: 117018. doi:10.1016/j.neuroimage.2020.117018. PMID 32505698. <a href="https://linkinghub.elsevier.com/retrieve/pii/S1053811920305048" target="_blank">https://linkinghub.elsevier.com/retrieve/pii/S1053811920305048</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Treu, Svenja; Strange, Bryan; Oxenford, Simon; Neumann, Wolf-Julian; Kühn, Andrea; Li, Ningfei; Horn, Andreas (October 2020). "Deep brain stimulation: Imaging on a group level". NeuroImage. 219: 117018. doi:10.1016/j.neuroimage.2020.117018. PMID 32505698. <a href="https://linkinghub.elsevier.com/retrieve/pii/S1053811920305048" target="_blank">https://linkinghub.elsevier.com/retrieve/pii/S1053811920305048</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Oxenford, Simón; Roediger, Jan; Neudorfer, Clemens; Milosevic, Luka; Güttler, Christopher; Spindler, Philipp; Vajkoczy, Peter; Neumann, Wolf-Julian; Kühn, Andrea; Horn, Andreas (2022-05-20). "Lead-OR: A multimodal platform for deep brain stimulation surgery". eLife. 11. doi:10.7554/eLife.72929. ISSN 2050-084X. PMC 9177150. PMID 35594135. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177150" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177150</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Butenko, Konstantin; Bahls, Christian; Schröder, Max; Köhling, Rüdiger; van Rienen, Ursula (2020-07-06). Marinazzo, Daniele (ed.). "OSS-DBS: Open-source simulation platform for deep brain stimulation with a comprehensive automated modeling". PLOS Computational Biology. 16 (7): e1008023. Bibcode:2020PLSCB..16E8023B. doi:10.1371/journal.pcbi.1008023. ISSN 1553-7358. PMC 7384674. PMID 32628719. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384674" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384674</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Horn, Andreas; Li, Ningfei; Dembek, Till A.; Kappel, Ari; Boulay, Chadwick; Ewert, Siobhan; Tietze, Anna; Husch, Andreas; Perera, Thushara; Neumann, Wolf-Julian; Reisert, Marco; Si, Hang; Oostenveld, Robert; Rorden, Christopher; Yeh, Fang-Cheng (January 2019). "Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging". NeuroImage. 184: 293–316. doi:10.1016/j.neuroimage.2018.08.068. PMC 6286150. PMID 30179717. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286150" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286150</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Neudorfer, Clemens; Butenko, Konstantin; Oxenford, Simon; Rajamani, Nanditha; Achtzehn, Johannes; Goede, Lukas; Hollunder, Barbara; Ríos, Ana Sofía; Hart, Lauren; Tasserie, Jordy; Fernando, Kavisha B.; Nguyen, T. A. Khoa; Al-Fatly, Bassam; Vissani, Matteo; Fox, Michael (March 2023). "Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks". NeuroImage. 268: 119862. doi:10.1016/j.neuroimage.2023.119862. PMC 10144063. PMID 36610682. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144063" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144063</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>Husch, Andreas; V. Petersen, Mikkel; Gemmar, Peter; Goncalves, Jorge; Hertel, Frank (2018). "PaCER - A fully automated method for electrode trajectory and contact reconstruction in deep brain stimulation". NeuroImage: Clinical. 17: 80–89. doi:10.1016/j.nicl.2017.10.004. PMC 5645007. PMID 29062684. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645007" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645007</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>Milchenko, Mikhail; Snyder, Abraham Z.; Campbell, Meghan C.; Dowling, Joshua L.; Rich, Keith M.; Brier, Lindsey M.; Perlmutter, Joel S.; Norris, Scott A. (October 2018). "ESM-CT: a precise method for localization of DBS electrodes in CT images". Journal of Neuroscience Methods. 308: 366–376. doi:10.1016/j.jneumeth.2018.09.009. PMC 6205293. PMID 30201271. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205293" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205293</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Latorre, Anna; Rocchi, Lorenzo; Sadnicka, Anna (2021-05-14). "The Expanding Horizon of Neural Stimulation for Hyperkinetic Movement Disorders". Frontiers in Neurology. 12. doi:10.3389/fneur.2021.669690. ISSN 1664-2295. PMC 8160223. PMID 34054710. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160223" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8160223</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Roediger, Jan; Dembek, Till A; Achtzehn, Johannes; Busch, Johannes L; Krämer, Anna-Pauline; Faust, Katharina; Schneider, Gerd-Helge; Krause, Patricia; Horn, Andreas; Kühn, Andrea A (February 2023). "Automated deep brain stimulation programming based on electrode location: a randomised, crossover trial using a data-driven algorithm". The Lancet Digital Health. 5 (2): e59 – e70. doi:10.1016/S2589-7500(22)00214-X. PMID 36528541. <a href="https://linkinghub.elsevier.com/retrieve/pii/S258975002200214X" target="_blank">https://linkinghub.elsevier.com/retrieve/pii/S258975002200214X</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Berlin, Charité-Universitätsmedizin. "Press reports". www.charite.de. Retrieved 2024-08-11. <a href="https://www.charite.de/en/service/press_reports/artikel/detail/deep_brain_stimulation_for_parkinsons_disease_new_algorithm_for_the_adjustment_of_stimulation_sett/" target="_blank">https://www.charite.de/en/service/press_reports/artikel/detail/deep_brain_stimulation_for_parkinsons_disease_new_algorithm_for_the_adjustment_of_stimulation_sett/</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>"Researchers map deep brain stimulation target for Alzheimer's disease". EurekAlert!. Retrieved 2024-08-11. <a href="https://www.eurekalert.org/news-releases/974384" target="_blank">https://www.eurekalert.org/news-releases/974384</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>"New Deep Brain Stimulation Algorithm May Help Personalize Parkinson's Disease Treatment | Mass General Brigham". www.massgeneralbrigham.org. Retrieved 2024-08-11. <a href="https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/new-deep-brain-stimulation-algorithm-for-parkinsons" target="_blank">https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/new-deep-brain-stimulation-algorithm-for-parkinsons</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Goodman, Brenda (2024-03-15). "Deep brain stimulation didn't work for a young OCD patient until new brain maps changed everything". CNN. Retrieved 2024-08-11. <a href="https://www.cnn.com/2024/03/15/health/deep-brain-stimulation-ocd-study-wellness/index.html" target="_blank">https://www.cnn.com/2024/03/15/health/deep-brain-stimulation-ocd-study-wellness/index.html</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Rudy, Melissa (2024-03-04). "Researchers find sources of four brain disorders, which could lead to new treatments". Fox News. Retrieved 2024-08-11. <a href="https://www.foxnews.com/health/researchers-sources-four-brain-disorders-new-treatments" target="_blank">https://www.foxnews.com/health/researchers-sources-four-brain-disorders-new-treatments</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> </ol>