Following his parents' divorce, Djerassi and his mother moved to Vienna. Until the age of 14, he attended the same realgymnasium that Sigmund Freud had attended many years earlier; spending summers in Bulgaria with his father.
In December 1939, Djerassi arrived with his mother in the United States, nearly penniless. Djerassi's mother worked in a group practice in upstate New York. In 1949, his father emigrated to the United States, practiced in Pennsylvania and West Virginia, and eventually retired near his son in San Francisco, California.
Djerassi started his college career at Newark Junior College after moving to the United States with his mother when he was 16. He previously had attended the American College of Sofia, a high school in Sofia, Bulgaria, where he became fluent in English. Because of the name of his high school, he was misunderstood and enrolled into Newark Junior College before graduating high school. After a year at Newark Junior College, Djerassi wrote a letter to First Lady Eleanor Roosevelt asking for help with a room and board and tuition scholarship to a four-year college. He received a response from the Institute of International Education with a full scholarship to Tarkio College where he briefly attended, and then studied chemistry at Kenyon College, where he graduated summa cum laude. After one year at CIBA, he moved to the University of Wisconsin–Madison where he earned his PhD in organic chemistry in 1945. His thesis work examined the transformation of the male sex hormone testosterone into the female sex hormone estradiol, through a sequence of chemical reactions.
In 1957, he became vice president of research at Syntex in Mexico City while on leave of absence from Wayne State. In 1960 Djerassi became a professor of chemistry at Stanford University, a position he held until 2002 but only part-time as he never left industry. From 1968 until 1972 he also served as president of Syntex Research at Palo Alto.
The Syntex connection brought wealth to Djerassi. He bought a large tract of land in San Mateo County, California, and started a cattle ranch called SMIP. (Initially an acronym for "Syntex Made It Possible", other variants have been suggested since.) He also assembled a large art collection. His collection of works by Paul Klee was considered to be one of the most significant to be privately held. He arranged for his Klee collections to be donated to the Albertina in Vienna and the San Francisco Museum of Modern Art, effective on his death.
Throughout the 1960s and 1970s, Djerassi continued to do significant scientific work, as a professor in the department of chemistry at Stanford University, and as an entrepreneur. He pioneered novel physical research techniques for mass spectrometry and optical rotatory dispersion and applied them to the areas of organic chemistry and the life sciences. Focusing on the steroid hormones and alkaloids, he elucidated the structure of steroids, an area in which he published over 1,200 papers. His scientific interests were wide-ranging, and his technological achievements include work in instrumentation, pharmaceuticals, insect control, the application of artificial intelligence in biomedical research, and the biology and chemistry of marine organisms.
In 1968, he started a new company, Zoecon, which focused on environmentally soft methods of pest control, using modified insect growth hormones to stop insects from metamorphosing from the larval stage to the pupal and adult stages. Zoecon was eventually acquired by Occidental Petroleum, which later sold it to Sandoz, now Novartis. Part of Zoecon survives in Dallas, Texas, making products to control fleas and other pests.
Djerassi published widely as a novelist, playwright and scientist. In 1985, Djerassi said "I feel like I'd like to lead one more life. I'd like to leave a cultural imprint on society rather than just a technological benefit."
He went on to write several novels in the "science-in-fiction" genre, including Cantor's Dilemma, in which he explored the ethics of modern scientific research through his protagonist, Dr. Cantor. He also wrote four autobiographies, the most recent of which, In Retrospect appeared in 2014. He wrote a number of plays which have been performed and extensively translated. His book Chemistry in Theatre: Insufficiency, Phallacy or Both discusses the potential pedagogic value of using dialogic style and the plot structure of plays with special focus on chemistry.
Djerassi wrote five novels, four of which he described as "science-in-fiction", fiction that portrays the lives of real scientists, with all their accomplishments, conflicts, and aspirations. The genre is also referred to as Lab lit.
After his success with prose literature in the Science-in-Fiction genre, Djerassi started to write plays. Theatre, even more so than prose, seemed to fulfill his desire to work in a more “dialogical” environment than the monological natural sciences had allowed him to do. According to British director Andy Jordan, who has produced all of his plays in England, Djerassi's dramatic works are "not wholly or straightforwardly naturalistic or realistic […but] avowedly text-driven, where ideas, themes, words and language were majorly important, a fact I had always to be conscious of as the director.2
As in his novels, Djerassi's plays incorporate the life and achievements of (sometimes famous) scientists as well as new scientific technologies. The science in his plays is always scientifically plausible although the dramatic personae and locations are fictitious. By placing scientists and research into dramatic worlds, he raises critical questions about the sciences as cultural systems and looks into internal conflicts and contradictions in science and between scientists. The constant competition between them, the need for priority in new scientific discoveries even if the required speed necessitates risky and immoral means, as well as the problematic consequences of new discoveries are important topics of the plays.
Connected with many of these questions is the role of women in the sciences (including researchers’ wives and female friends). Djerassi's plays recognize the special contributions women make as scientists and to science, both directly and indirectly. His female characters are usually depicted as strong and independent, proving a strong impact of feminist thinking on his work.
Djerassi's plays have found their way into theaters around the globe and have been translated into many European and Asian languages. Djerassi repeatedly revised his plays and some of them have different versions and multiple endings (especially An Immaculate Misconception: the nationalities of the main characters vary, also the endings). Where possible, Djerassi also cooperated with directors in the production of dramatic performances. All of his plays have been published in book form, many of them in a number of languages. Some of them can be downloaded from his website.
Djerassi wrote numerous poems that were published in journals or anthologies. Some of the poems reflected his life as a chemist (e.g. Why are chemists not poets or The clock runs backwards), others his personal life (e.g. A Diary of Pique).
Djerassi described himself as a "Jewish atheist".
Djerassi was married three times and had two children. He and Virginia Jeremiah were married in 1943 and divorced in 1950. Djerassi married writer Norma Lundholm (1917–2006) later that year. They had two children together, and were divorced in 1976. One year after his second divorce, Djerassi began a relationship with Diane Middlebrook, a Stanford University professor of English and biographer. In 1985, they were married and they lived between San Francisco and London, until her death on December 15, 2007, due to cancer.
On July 5, 1978, Djerassi's artist daughter Pamela (born 1950; from his second marriage, to Norma Lundholm), committed suicide, which is described in his autobiography. With Middlebrook's help, Djerassi then considered how he could help living artists, rather than collecting works of dead ones. He visited existing artist colonies, such as Yaddo and MacDowell, and decided to create his own, the Djerassi Resident Artists Program. He closed his cattle ranch and converted the barn and houses to residential and work space for artists. He and his wife moved to a high rise in San Francisco that they had renovated.
Carl Djerassi died on January 30, 2015, at the age of 91, from complications of liver and bone cancer. Upon his death he was survived by his son and grandson.
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Priest, Susanna Hornig, ed. (2010). "Science Theater". Encyclopedia of science and technology communication. Thousand Oaks, Calif.: SAGE. p. 742. ISBN 978-1-4129-5920-9. Retrieved February 2, 2015. 978-1-4129-5920-9
Walter Grünzweig, ed., The SciArtist: Carl Djerassi's Science-in-Literature in Transatlantic and Interdisciplinary Contexts, Berlin et al.: Lit Verlag, 2012.
Guthrie, Julian (October 15, 2014). "Act 2 for pill's inventor: Carl Djerassi writing plays at 91". SFGate. Retrieved February 2, 2015. http://www.sfgate.com/science/article/Act-2-for-pill-s-inventor-Carl-Djerassi-5824940.php
"Good Chemistry Yields 'Oxygen'". Science & Technology. April 30, 2001. Retrieved February 2, 2015. http://www.djerassi.com/oxygen3/
Calamia, Donald V. (September 1, 2005). "Curtain Calls". Between the Lines News. Archived from the original on February 2, 2015. Retrieved February 2, 2015. https://web.archive.org/web/20150202185433/http://www.pridesource.com/article.html?article=15585
McNamee, Dardis (June 19, 2012). "Carl Djerassi: The Poet of Progressive Science". The Vienna Review. Archived from the original on February 2, 2015. Retrieved February 2, 2015. https://web.archive.org/web/20150202184608/http://www.viennareview.net/commentary/kaffeehaus/carl-djerassi-the-poet-of-progressive-science
The Clock Runs Backwards, Brownsville, OR: Story Line Press, 1991. ISBN 0-934257-75-2 /wiki/ISBN_(identifier)
A Diary of Pique/ Tagebuch des Grolls, Haymon Verlag, Innsbruck, 2012. ISBN 978-3-85218-719-8 /wiki/ISBN_(identifier)
The Politics of Contraception, New York & London: W. W. Norton, 1979. ISBN 0-393-01264-6 /wiki/ISBN_(identifier)
Steroids Made it Possible, Washington, DC: American Chemical Society, 1990. ISBN 0-8412-1773-4
/wiki/American_Chemical_Society
The Pill, Pygmy Chimps, and Degas' Horse, Basic Books, 1992. ISBN 0-465-05758-6 (autobiography) /wiki/ISBN_(identifier)
From the Lab into The World: A Pill for People, Pets, and Bugs, American Chemical Society, 1994. ISBN 0-8412-2808-6 /wiki/ISBN_(identifier)
Paul Klee: Masterpieces of the Djerassi Collection, (coeditor), Prestel Publishing, 2002. ISBN 3-7913-2779-8 /wiki/ISBN_(identifier)
Dalla pillola alla penna, Di Renzo Editore, 2004. ISBN 88-8323-086-8 /wiki/ISBN_(identifier)
This Man's Pill: Reflections on the 50th Birthday of the Pill, Oxford University Press, USA, 2004. ISBN 0-19-860695-8 (autobiography) /wiki/ISBN_(identifier)
In Retrospect : From the Pill to the Pen, Imperial College Press, USA, 2014. ISBN 978-1-78326-532-9 (autobiography) /wiki/ISBN_(identifier)
Cantor's Dilemma, Penguin, 1989. ISBN 0-14-014359-9 /wiki/ISBN_(identifier)
"Review of Cantor's Dilemma by Carl Djerassi". Kirkus Reviews. September 1, 1989. https://www.kirkusreviews.com/book-reviews/carl-djerassi-2/cantors-dilemma/
"Review of Cantor's Review by Carl Djerassi". Publishers Weekly. October 1, 1989. https://www.publishersweekly.com/978-0-385-26183-8
The Bourbaki Gambit, Penguin, 1994. ISBN 0-14-025485-4 /wiki/ISBN_(identifier)
"Review of The Bourbaki Gambit by Carl Djerassi". Kirkus Reviews. October 1, 1994. https://www.kirkusreviews.com/book-reviews/carl-djerassi-3/the-bourbaki-gambit-2/
"Review of The Bourbaki Gambit by Carl Djerassi". Publishers Weekly. August 29, 1994. https://www.publishersweekly.com/978-0-8203-1652-9
The Futurist and Other Stories, London & Sydney: Macdonald, 1989. ISBN 0-356-17500-6 /wiki/ISBN_(identifier)
How I Beat Coca-Cola and Other Tales of One-Upmanship, Madison: Terrace Books/U Wisconsin P, 2013. ISBN 978-0-299-29504-2 /wiki/ISBN_(identifier)
Marx, Deceased. A Novel, Athens & London: U of Georgia P, 1996. ISBN 0-8203-1835-3 /wiki/ISBN_(identifier)
Menachem's Seed. A Novel, Athens & London: U Georgia P, 1997. ISBN 0-8203-1925-2 /wiki/ISBN_(identifier)
NO. A Novel, Athens & London: The U of Georgia P, 1998. ISBN 0-8203-2032-3 /wiki/ISBN_(identifier)
Chemistry in Theatre: Insufficiency, Phallacy or Both, Imperial College Press, 2012. ISBN 978-1-84816-937-1 /wiki/ISBN_(identifier)
Foreplay: Hannah Arendt, the Two Adornos, and Walter Benjamin, Madison: U Wisconsin P, 2011. ISBN 978-0-299-28334-6 /wiki/ISBN_(identifier)
An Immaculate Misconception: Sex in an Age of Mechanical Reproduction, London: Imperial College Press, 2000. ISBN 1-86094-248-2 (adapted from the novel Menachem's Seed) /wiki/ISBN_(identifier)
L.A. Theatre Works, Audio Theatre Collection CD, 2004. ISBN 1-58081-286-4 /wiki/ISBN_(identifier)
Oxygen (with Roald Hoffmann, coauthor), Weinheim et al.: WILEY-VCH, 2001. ISBN 3-527-30413-4 /wiki/Roald_Hoffmann
Newton's Darkness: Two Dramatic Views, (with David Pinner, coauthor), London: Imperial College Press, 2004. ISBN 1-86094-390-X /wiki/ISBN_(identifier)
Sex in an Age of Technological Reproduction: ICSI and TABOOS, Madison: U Wisconsin P, 2008. ISBN 978-0-299-22790-6 /wiki/ISBN_(identifier)
Djerassi, Carl (2014). Ciencia en Teatro – Cuatro Obras. Translated by Baizán, Àgata; Hernández, Jorge F. Mexico: Fondo de Cultura Económico. pp. 191–355. ISBN 978-607-16-1969-3. 978-607-16-1969-3
"Ernest Guenther Award in the Chemistry of Natural Products". American Chemical Society. Retrieved April 3, 2020. https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/ernest-guenther-award-in-the-chemistry-of-natural-products.html
National Science Foundation – The President's National Medal of Science https://www.nsf.gov/od/nms/recip_details.cfm?recip_id=106
"SCI Perkin Medal". Science History Institute. May 31, 2016. Retrieved March 24, 2018. https://www.sciencehistory.org/sci-perkin-medal
National Inventors Hall of Fame Archived July 9, 2010, at the Wayback Machine http://www.invent.org/hall_of_fame/44.html
"American Institute of Chemists Gold Medal". Science History Institute. May 31, 2016. Retrieved February 21, 2018. https://www.sciencehistory.org/american-institute-of-chemists-gold-medal
"Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement. https://achievement.org/our-history/golden-plate-awards/#science-exploration
Sturchio, Jeffrey L.; Thackray, Arnold (July 31, 1985). Carl Djerassi, Transcript of an Interview Conducted by Jeffrey L. Sturchio and Arnold Thackray at Stanford University on July 31, 1985 (PDF). Philadelphia, PA: Center for History of Chemistry. https://oh.sciencehistory.org/sites/default/files/djerassi_c_0017_suppl.pdf
"Reply to a parliamentary question" (PDF) (in German). p. 1219. Retrieved November 28, 2012. http://www.parlament.gv.at/PAKT/VHG/XXIV/AB/AB_10542/imfname_251156.pdf
Reisch, Marc (June 5, 2000). "Carl Djerassi Receives Othmer Gold Medal". Chemical & Engineering News. 78 (23): 79. doi:10.1021/cen-v078n023.p079. https://doi.org/10.1021%2Fcen-v078n023.p079
"Othmer Gold Medal". Science History Institute. Retrieved June 12, 2014. https://www.sciencehistory.org/othmer-gold-medal
"American Institute of Chemists Gold Medal". Science History Institute. May 31, 2016. Retrieved February 21, 2018. https://www.sciencehistory.org/american-institute-of-chemists-gold-medal
Weintraub, Bob. "Pincus, Djerassi and Oral Contraceptives", Chemistry in Israel, Bulletin of the Israel Chemical Society. August 2005, pp. 47–50. https://drive.google.com/file/d/1y_30HHlitenXG4rNMEtViLW1YbOOXy6a_OND_nD_5z-0tAjAjB-EyGT9PS-m/edit
"Reply to a parliamentary question" (PDF) (in German). p. 1833. Retrieved November 28, 2012. http://www.parlament.gv.at/PAKT/VHG/XXIV/AB/AB_10542/imfname_251156.pdf
Composite Gazetteer of Antarctica: Djerassi Glacier. http://data.aad.gov.au/aadc/gaz/scar/display_name.cfm?gaz_id=136910
"Foreign Members". Royal Society. Retrieved March 20, 2012. http://royalsociety.org/about-us/fellowship/foreign-members/
"Pill inventor Carl Djerassi to receive Edinburgh Medal", BBC News, April 8, 2011. https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-13013712
"Honorary Degree Recipients". American University in Bulgaria. Retrieved November 2, 2024. https://www.aubg.edu/about-us/honorary-degree-recipients/
"Carl Djerassi erhielt Ehrendoktorat", University of Innsbruck, June 6, 2014. http://www.uibk.ac.at/ipoint/news/2014/carl-djerassi-erhielt-ehrendoktorat-der-uni-innsbruck.html.de
Inglis-Arkell, Esther, "What Are the Unwritten Rules of Winning a Nobel Prize?", Gizmodo, October 9, 2015 (published & accessed). https://gizmodo.com/what-are-the-unwritten-rules-of-winning-a-nobel-prize-1735682317
"Carl Djerassi: The Steroid King". Carl Djerassi: The Steroid King. N.p., n.d. Web. October 1, 2016. His parents were both Jewish, but although young Carl was bar mitzvahed, the family was not religiously observant. He characterizes himself as a "Jewish atheist".
Lennon, Troy (February 3, 2015). "Father of the pill became patron of young artists". The Daily Telegraph (Australia). Retrieved February 2, 2015. http://www.heraldsun.com.au/news/father-of-the-pill-became-patron-of-young-artists/story-fnpoi7d0-1227205391534?nk=92a64cd90b71698c3f631b579aebe0c1
"Obituary: Norma Lundholm Djerassi, writer, poet, world traveler". almanacnews.com. December 13, 2006. Retrieved April 7, 2020. https://almanacnews.com/print/story/2006/12/13/obituary-norma-lundholm-djerassi-writer-poet-world-traveler
Sleeman, Elizabeth, ed. (2003). The International Who's Who 2004 (67th ed.). London: Europa. p. 437. ISBN 978-1-85743-217-6. Retrieved February 2, 2015. 978-1-85743-217-6
Haven, Cynthia, "Diane Middlebrook, professor emeritus and legendary biographer, dies at 68", Stanford University, January 9, 2008. http://news.stanford.edu/news/2008/january9/middlebrook-010908.html
Haven, Cynthia, "Diane Middlebrook, professor emeritus and legendary biographer, dies at 68", Stanford University, January 9, 2008. http://news.stanford.edu/news/2008/january9/middlebrook-010908.html
Mills, John, Which Yet Survive. Impressions of Friends, Family and Encounters, Quartet Books, London, 2017
A Conversation with Carl Djerassi on Vimeo interviewed by Roger Kornberg, Annual Review of Biochemistry https://vimeo.com/59485470
Carl Djerassi, Desert Island Discs, BBC Radio 4, 2002. https://www.bbc.co.uk/programmes/p00947hh
Wood, Gaby (April 14, 2007). "Father of the pill". The Guardian. Retrieved February 4, 2015. https://www.theguardian.com/lifeandstyle/2007/apr/15/healthandwellbeing.features1
"Djerassi Resident Artists Program". Archived from the original on February 14, 2015. Retrieved February 4, 2015. https://web.archive.org/web/20150214174510/http://djerassi.org/programhistory.html
King, John (September 7, 2011). "Diane Middlebrook Memorial Writers' Residences". SFGate. Retrieved February 4, 2015. http://www.sfgate.com/entertainment/article/Diane-Middlebrook-Memorial-Writers-Residences-2311176.php
"Cass Calder Smith's Bold New Cabins at the Djerassi Resident Artists Program". Architectural Digest. June 8, 2012. Retrieved February 4, 2015. http://www.architecturaldigest.com/blogs/daily/2012/06/cass-calder-smith-djerassi-resident-artists-program
Robert D. McFadden (January 31, 2015). "Carl Djerassi, 91, a Creator of the Birth Control Pill, Dies". The New York Times. Retrieved January 31, 2015. Carl Djerassi, an eminent chemist who 63 years ago synthesized a hormone that changed the world by creating the key ingredient for the oral contraceptive known as 'the pill,' died at his home in San Francisco on Friday. He was 91. His son, Dale, said the cause was complications of liver and bone cancer.... https://www.nytimes.com/2015/02/01/us/carl-djerassi-dies-at-91-forever-altered-reproductive-practices-as-a-creator-of-the-pill.html
"Carl Djerassi, Who Helped Discover Birth Control Pill, Dies at 91". forward.com. January 31, 2015. http://forward.com/articles/213863/carl-djerassi-who-helped-discover-birth-control-pi/?