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Dermatitis
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<h2 id="terminology">Terminology</h2> <p>The terms <i>dermatitis</i> and <i>eczema</i> are sometimes used synonymously.<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a><a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a> However the term eczema is often used to specifically mean <a href="/facts/Atopic_dermatitis/DvmdVwWu">atopic dermatitis</a> (also known as atopic eczema).<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a><a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a> Terminology might also differ according to countries. In some languages, dermatitis and eczema mean the same thing, while in other languages dermatitis implies an acute condition and eczema a chronic one.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> </p> <h2 id="signs-and-symptoms">Signs and symptoms</h2> <p>There are several types of dermatitis including <a href="/facts/Atopic_dermatitis/DvmdVwWu">atopic dermatitis</a>, <a href="/facts/Contact_dermatitis/Xm6PEgcw">contact dermatitis</a>, <a href="/facts/Stasis_dermatitis/eChEYExC">stasis dermatitis</a> and <a href="/facts/Seborrhoeic_dermatitis/d1CfhTDG">seborrhoeic dermatitis</a>.<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a> Dermatitis symptoms vary with all different forms of the condition. Although every type of dermatitis has different symptoms, there are certain signs that are common for all of them, including redness of the skin, <a href="/facts/Edema/Q6MI3KdH">swelling</a>, <a href="/facts/Itch/MBWq6SPc">itching</a> and skin lesions with sometimes oozing and scarring. Also, the area of the skin on which the symptoms appear tends to be different with every type of dermatitis, whether on the <a href="/facts/Neck/v69tnMYk">neck</a>, <a href="/facts/Wrist/scSMl0zG">wrist</a>, <a href="/facts/Forearm/Wpe7F8vf">forearm</a>, <a href="/facts/Thigh/HAGbp2M9">thigh</a> or <a href="/facts/Ankle/jk7FpfJs">ankle</a>. </p><p>Although the location may vary, the primary symptom of this condition is itchy skin. More rarely, it may appear on the <a href="/facts/Genital_area/c2ypY14E">genital area</a>, such as the <a href="/facts/Vulva/ECayW89s">vulva</a> or <a href="/facts/Scrotum/w0CeIV5k">scrotum</a>.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a><a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a> Symptoms of this type of dermatitis may be very intense and may come and go. Irritant contact dermatitis is usually more <a href="/facts/Pain/70E79oUn">painful</a> than itchy. </p><p>Although the symptoms of atopic dermatitis vary from person to person, the most common symptoms are dry, itchy, red skin, on light skin. However, this redness does not appear on darker skin and dermatitis can appear darker brown or purple in color.<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a> Typical affected skin areas include the folds of the arms, the back of the <a href="/facts/Knee/gJJScKdB">knees</a>, wrists, <a href="/facts/Face/I1PQ5YLY">face</a> and <a href="/facts/Hand/0yhW6deV">hands</a>. <a href="/facts/Perioral_dermatitis/EFCH6CFJ">Perioral dermatitis</a> refers to a red bumpy rash around the mouth.<a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a> </p><p><a href="/facts/Dermatitis_herpetiformis/Y5VXVe24">Dermatitis herpetiformis</a> symptoms include itching, stinging and a burning sensation. <a href="/facts/Papule/2J7QwJdE">Papules</a> and <a href="/facts/Vesicle_(dermatology)/Vkr5XpeG">vesicles</a> are commonly present.<a class="footnote-ref" id="fnref:35" href="#fn:35"><sup>35</sup></a> The small red bumps experienced in this type of dermatitis are usually about 1 cm in size, red in color and may be found symmetrically grouped or distributed on the upper or lower back, <a href="/facts/Buttocks/dtybFpGI">buttocks</a>, <a href="/facts/Elbow/2bH9FY0F">elbows</a>, knees, neck, <a href="/facts/Shoulder/Hsn5SWq2">shoulders</a> and <a href="/facts/Scalp/yfnQt0n5">scalp</a>. </p><p>The symptoms of <a href="/facts/Seborrhoeic_dermatitis/d1CfhTDG">seborrhoeic dermatitis</a>, on the other hand, tend to appear gradually, from dry or greasy scaling of the scalp (<a href="/facts/Dandruff/JnKQHFzM">dandruff</a>) to scaling of facial areas, sometimes with itching, but without <a href="/facts/Hair_loss/uEPKUafl">hair loss</a>.<a class="footnote-ref" id="fnref:36" href="#fn:36"><sup>36</sup></a> In <a href="/facts/Newborns/gaEL1QL4">newborns</a>, the condition causes a thick and yellowish scalp rash, often accompanied by a <a href="/facts/Irritant_diaper_dermatitis/pWCmNox0">diaper rash</a>. In severe cases, symptoms may appear along the hairline, behind the ears, on the <a href="/facts/Eyebrow/nNLuVRU7">eyebrows</a>, on the bridge of the <a href="/facts/Human_nose/fmhw8BmP">nose</a>, around the nose, on the <a href="/facts/Chest/lwtzfc8K">chest</a>, and on the upper back.<a class="footnote-ref" id="fnref:37" href="#fn:37"><sup>37</sup></a> </p> <h3>Complications</h3> <p>People with eczema should not receive the <a href="/facts/Smallpox_vaccine/r0k5af8p">smallpox vaccination</a> due to risk of developing <a href="/facts/Eczema_vaccinatum/sDzbzpKp">eczema vaccinatum</a>, a potentially severe and sometimes fatal complication.<a class="footnote-ref" id="fnref:38" href="#fn:38"><sup>38</sup></a> Other major health risks for people with dermatitis are viral and bacterial infections because atopic dermatitis patients have deficiencies in their proteins and <a href="/facts/Lipid/TdQR87HX">lipids</a> that have barrier functions along with defects in <a href="/facts/Dendritic_cell/19KBuKFK">dendritic cells</a> and as a result are unable to keep foreign invaders out, leading to recurring infections.<a class="footnote-ref" id="fnref:39" href="#fn:39"><sup>39</sup></a> If left untreated, these infections may be life-threatening, so skin barrier improvement (such as daily moisturizing to minimize <a href="/facts/Transepidermal_water_loss/QaqAk6l9">transepidermal water loss</a>) and anti-inflammatory therapy are recommended as preventative measures.<a class="footnote-ref" id="fnref:40" href="#fn:40"><sup>40</sup></a> </p> <h2 id="cause">Cause</h2> <p>The cause of dermatitis is unknown but is presumed to be a combination of genetic and environmental factors.<a class="footnote-ref" id="fnref:41" href="#fn:41"><sup>41</sup></a> Eczema is not contagious. </p> <h3>Environmental</h3> <p>The <a href="/facts/Hygiene_hypothesis/3pmIpBDc">hygiene hypothesis</a> postulates that the cause of <a href="/facts/Asthma/7GkJvxn3">asthma</a>, eczema, and other allergic diseases is an unusually clean environment in childhood which leads to an insufficient <a href="/facts/Human_microbiota/KerK9YGP">human microbiota</a>. It is supported by epidemiologic studies for asthma.<a class="footnote-ref" id="fnref:42" href="#fn:42"><sup>42</sup></a> The hypothesis states that exposure to bacteria and other immune system modulators is important during development, and missing out on this exposure increases the risk for asthma and allergy.<a class="footnote-ref" id="fnref:43" href="#fn:43"><sup>43</sup></a> One systematic review of literature on eczema found that <a href="/facts/Urban_area/fu9v8h5P">urban</a> areas have an increased prevalence of eczema compared to rural areas.<a class="footnote-ref" id="fnref:44" href="#fn:44"><sup>44</sup></a> While it has been suggested that eczema may sometimes be an allergic reaction to the <a href="/facts/Excrement/r9HDKB8G">excrement</a> from <a href="/facts/House_dust_mite/CwyrgWSA">house dust mites</a>,<a class="footnote-ref" id="fnref:45" href="#fn:45"><sup>45</sup></a> with up to 5% of people showing antibodies to the mites,<a class="footnote-ref" id="fnref:46" href="#fn:46"><sup>46</sup></a> the overall role this plays awaits further corroboration.<a class="footnote-ref" id="fnref:47" href="#fn:47"><sup>47</sup></a> </p> <h4>Malnutrition</h4> <p><a href="/facts/Essential_fatty_acid_deficiency/0WQfcE9D">Essential fatty acid deficiency</a> results in a dermatitis similar to that seen in <a href="/facts/Zinc_deficiency/bfrcrw24">zinc</a> or <a href="/facts/Biotin_deficiency/49X3nRB8">biotin deficiency</a>.<a class="footnote-ref" id="fnref:48" href="#fn:48"><sup>48</sup></a> </p> <h3>Genetic</h3> <p>A number of genes have been associated with eczema, one of which affects production of <a href="/facts/Filaggrin/J0B6WpBc">filaggrin</a>.<a class="footnote-ref" id="fnref:49" href="#fn:49"><sup>49</sup></a> Genome-wide studies found three new <a href="/facts/Copy-number_variation/g7GPKrsx">genetic variants</a> associated with eczema: OVOL1, ACTL9 and IL4-KIF3A.<a class="footnote-ref" id="fnref:50" href="#fn:50"><sup>50</sup></a> </p><p>Eczema occurs about three times more frequently in individuals with <a href="/facts/Celiac_disease/AKd5PkTc">celiac disease</a> and about two times more frequently in relatives of those with celiac disease, potentially indicating a <a href="/facts/Heredity/t0aMmRWx">genetic</a> link between the conditions.<a class="footnote-ref" id="fnref:51" href="#fn:51"><sup>51</sup></a><a class="footnote-ref" id="fnref:52" href="#fn:52"><sup>52</sup></a> </p> <h2 id="diagnosis">Diagnosis</h2> <p>Diagnosis of eczema is based mostly on the <a href="/facts/Medical_history/P2xSfuYF">history</a> and <a href="/facts/Physical_examination/qzI0BK5P">physical examination</a>.<a class="footnote-ref" id="fnref:53" href="#fn:53"><sup>53</sup></a> In uncertain cases, <a href="/facts/Skin_biopsy/PKGyjlnI">skin biopsy</a> may be taken for a <a href="/facts/Histopathologic_diagnosis_of_dermatitis/LGVFh3K5">histopathologic diagnosis of dermatitis</a>.<a class="footnote-ref" id="fnref:54" href="#fn:54"><sup>54</sup></a> Those with eczema may be especially prone to <a href="/facts/Misdiagnosis/1RyM0bdK">misdiagnosis</a> of <a href="/facts/Food_allergies/Nkf1e70o">food allergies</a>.<a class="footnote-ref" id="fnref:55" href="#fn:55"><sup>55</sup></a> </p><p><a href="/facts/Patch_test/TJaD3ERo">Patch tests</a> are used in the diagnosis of allergic contact dermatitis.<a class="footnote-ref" id="fnref:56" href="#fn:56"><sup>56</sup></a><a class="footnote-ref" id="fnref:57" href="#fn:57"><sup>57</sup></a> </p> <h3>Classification</h3> <p>The term <i>eczema</i> refers to a set of clinical characteristics. Classification of the underlying diseases has been haphazard with numerous different classification systems, and many <a href="/facts/Synonym/a3BgMcdu">synonyms</a> being used to describe the same condition.<a class="footnote-ref" id="fnref:58" href="#fn:58"><sup>58</sup></a> </p><p>A type of dermatitis may be described by location (e.g., <a href="/facts/Hand_eczema/zPcTHNuo">hand eczema</a>), by specific appearance (eczema craquele or discoid) or by possible cause (<a href="/facts/Varicose_eczema/eChEYExC">varicose eczema</a>). Further adding to the confusion, many sources use the term <i>eczema</i> interchangeably for the most common type: <a href="/facts/Atopic_dermatitis/DvmdVwWu">atopic dermatitis</a>.<a class="footnote-ref" id="fnref:59" href="#fn:59"><sup>59</sup></a> </p><p>The <a href="/facts/European_Academy_of_Allergology_and_Clinical_Immunology/E8MMr2eJ">European Academy of Allergology and Clinical Immunology</a> (EAACI) published a position paper in 2001, which simplifies the nomenclature of allergy-related diseases, including atopic and allergic contact eczemas.<a class="footnote-ref" id="fnref:60" href="#fn:60"><sup>60</sup></a> Non-allergic eczemas are not affected by this proposal. </p> <h4>Histopathologic classification</h4> <p class="note">Main article: <a href="/facts/Histopathologic_diagnosis_of_dermatitis/LGVFh3K5">Histopathologic diagnosis of dermatitis</a></p> <p>By <a href="/facts/Histopathology/9Eggjrg4">histopathology</a>, superficial dermatitis (in the epidermis, papillary dermis, and superficial vascular plexus) can basically be classified into either of the following groups:<a class="footnote-ref" id="fnref:61" href="#fn:61"><sup>61</sup></a> </p> <ul><li>Vesiculobullous lesions</li> <li>Pustular dermatosis</li> <li>Non vesiculobullous, non-pustular</li></ul> <ul><li>With epidermal changes</li> <li>Without epidermal changes. These characteristically have a superficial perivascular inflammatory infiltrate and can be classified by type of cell infiltrate:<a class="footnote-ref" id="fnref:62" href="#fn:62"><sup>62</sup></a></li></ul> <ul><li>Lymphocytic (most common)</li> <li>Lymphoeosinophilic</li> <li>Lymphoplasmacytic</li> <li>Mast cell</li> <li>Lymphohistiocytic</li> <li>Neutrophilic</li></ul> <h3>Common types</h3> <h4>Atopic</h4> <p><a href="/facts/Atopic_dermatitis/DvmdVwWu">Atopic dermatitis</a> is an allergic disease believed to have a hereditary component and often runs in families whose members have <a href="/facts/Asthma/7GkJvxn3">asthma</a>. Itchy <a href="/facts/Rash/W97qGpq6">rash</a> is particularly noticeable on the head and scalp, neck, inside of elbows, behind knees, and buttocks. It is very common in developed countries and rising. Irritant <a href="/facts/Contact_dermatitis/Xm6PEgcw">contact dermatitis</a> is sometimes misdiagnosed as atopic dermatitis. <a href="/facts/Stress_(biology)/H29jPp2B">Stress</a> can cause atopic dermatitis to worsen.<a class="footnote-ref" id="fnref:63" href="#fn:63"><sup>63</sup></a> </p> <h4>Contact</h4> <p><a href="/facts/Contact_dermatitis/Xm6PEgcw">Contact dermatitis</a> is of two types: allergic (resulting from a delayed reaction to an <a href="/facts/Allergen/bnM4cttq">allergen</a>, such as <a href="/facts/Poison_ivy/GnLEC4Ur">poison ivy</a>, <a href="/facts/Nickel/KwMCHYRP">nickel</a>, or <a href="/facts/Balsam_of_Peru/pW5UgJjG">Balsam of Peru</a>),<a class="footnote-ref" id="fnref:64" href="#fn:64"><sup>64</sup></a> and irritant (resulting from direct reaction to a detergent, such as <a href="/facts/Sodium_lauryl_sulfate/H0Q2z7W3">sodium lauryl sulfate</a>, for example). </p><p>Some substances act both as allergen and irritants (wet cement, for example). Other substances cause a problem after sunlight exposure, bringing on <a href="/facts/Phototoxic_dermatitis/xa2TCgo8">phototoxic dermatitis</a>. About three-quarters of cases of contact eczema are of the irritant type, which is the most common occupational skin disease. Contact eczema is curable, provided the offending substance can be avoided and its traces removed from one's environment. (ICD-10 L23; L24; L56.1; L56.0) </p> <h4>Seborrhoeic</h4> <p><a href="/facts/Seborrhoeic_dermatitis/d1CfhTDG">Seborrhoeic dermatitis</a> or seborrheic dermatitis is a condition sometimes classified as a form of eczema that is closely related to <a href="/facts/Dandruff/JnKQHFzM">dandruff</a>. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk. In newborns, it causes a thick, yellow, crusty scalp rash called <a href="/facts/Cradle_cap/AzVMmS3f">cradle cap</a>, which seems related to lack of <a href="/facts/Biotin/WAaVxyB7">biotin</a> and is often curable. (ICD-10 L21; L21.0) </p><p>There is a connection between seborrheic dermatitis and <i><a href="/facts/Malassezia/3uoNQqbL">Malassezia</a></i> fungus, and <a href="/facts/Antifungal/WEk5nS2B">antifungals</a> such as anti-dandruff shampoo can be helpful in treating it.<a class="footnote-ref" id="fnref:65" href="#fn:65"><sup>65</sup></a> </p> <h3>Less common types</h3> <h4>Dyshidrosis</h4> <p><a href="/facts/Dyshidrosis/tNbmxtzX">Dyshidrosis</a> (dyshidrotic eczema, pompholyx, vesicular palmoplantar dermatitis) only occurs on palms, soles, and sides of fingers and toes. Tiny opaque bumps called <a href="/facts/Cutaneous_conditions/Vkr5XpeG">vesicles</a>, thickening, and cracks are accompanied by itching, which gets worse at night. A common type of hand eczema, it worsens in warm weather. (ICD-10 L30.1) </p> <h4>Discoid</h4> <p><a href="/facts/Nummular_dermatitis/DhkFs4It">Discoid eczema</a> (nummular eczema, exudative eczema, microbial eczema) is characterized by round spots of oozing or dry rash, with clear boundaries, often on lower legs. It is usually worse in winter. The cause is unknown, and the condition tends to come and go. (ICD-10 L30.0) </p> <h4>Venous</h4> <p><a href="/facts/Stasis_dermatitis/eChEYExC">Venous eczema</a> (gravitational eczema, stasis dermatitis, varicose eczema) occurs in people with impaired circulation, <a href="/facts/Varicose_veins/esCpdGWs">varicose veins</a>, and <a href="/facts/Edema/Q6MI3KdH">edema</a>, and is particularly common in the ankle area of people over 50. There is redness, scaling, darkening of the skin, and itching. The disorder predisposes to <a href="/facts/Venous_ulcer/4MInAc2e">leg ulcers</a>. (ICD-10 I83.1) </p> <h4>Herpetiformis</h4> <p><a href="/facts/Dermatitis_herpetiformis/Y5VXVe24">Dermatitis herpetiformis</a> (Duhring's disease) causes an intensely itchy and typically symmetrical rash on arms, thighs, knees, and back. It is directly related to <a href="/facts/Celiac_disease/AKd5PkTc">celiac disease</a>, can often be put into remission with an appropriate diet, and tends to get worse at night. (ICD-10 L13.0) </p> <h4>Hyperkeratotic</h4> <p>Hyperkeratotic hand dermatitis presents with hyperkeratotic, fissure-prone, erythematous areas of the middle or proximal palm, and the volar surfaces of the fingers may also be involved.<a class="footnote-ref" id="fnref:66" href="#fn:66"><sup>66</sup></a>: 79 </p> <h4>Neurodermatitis</h4> <p><a href="/facts/Neurodermatitis/jLltAbsN">Neurodermatitis</a> (<a href="/facts/Lichen_simplex_chronicus/jLltAbsN">lichen simplex chronicus</a>, localized scratch dermatitis) is an itchy area of thickened, pigmented eczema patch that results from <a href="/facts/Habit_(psychology)/qISaGCqe">habitual</a> rubbing and scratching. Usually, there is only one spot. Often curable through behaviour modification and anti-inflammatory medication. <a href="/facts/Prurigo_nodularis/yKAHpsgf">Prurigo nodularis</a> is a related disorder showing multiple lumps. (ICD-10 L28.0; L28.1) </p> <h4>Autoeczematization</h4> <p><a href="/facts/Autoeczematization/PcLhyjm3">Autoeczematization</a> (id reaction, auto sensitization) is an eczematous reaction to an infection with <a href="/facts/Parasite/HWPcgky7">parasites</a>, <a href="/facts/Fungi/BHo5DP59">fungi</a>, <a href="/facts/Bacteria/wC8xSCsU">bacteria</a>, or <a href="/facts/Virus/mf88Bcbl">viruses</a>. It is completely curable with the clearance of the original infection that caused it. The appearance varies depending on the cause. It always occurs some distance away from the original infection. (ICD-10 L30.2) </p> <h4>Viral</h4> <p>There are eczemas overlaid by viral infections (<a href="/facts/Eczema_herpeticum/hA33LebS">eczema herpeticum</a> or <a href="/facts/Eczema_vaccinatum/sDzbzpKp">vaccinatum</a>), and eczemas resulting from underlying disease (e.g., <a href="/facts/Lymphoma/418wcMEl">lymphoma</a>). </p><p>Eczemas originating from ingestion of medications, foods, and chemicals, have not yet been clearly systematized. Other rare eczematous disorders exist in addition to those listed here. </p> <h2 id="prevention">Prevention</h2> <p>There have been various studies on the prevention of dermatitis through diet, none of which have proven any positive effect. </p><p>Exclusive <a href="/facts/Breastfeeding/cdWXyYDX">breastfeeding</a> of infants during at least the first few months may decrease the risk.<a class="footnote-ref" id="fnref:67" href="#fn:67"><sup>67</sup></a> There is no good evidence that a mother's diet during <a href="/facts/Pregnancy/vEKYGpep">pregnancy</a> or breastfeeding affects the risk,<a class="footnote-ref" id="fnref:68" href="#fn:68"><sup>68</sup></a> nor is there evidence that delayed introduction of certain foods is useful.<a class="footnote-ref" id="fnref:69" href="#fn:69"><sup>69</sup></a> There is tentative evidence that probiotics in infancy may reduce rates but it is insufficient to recommend its use.<a class="footnote-ref" id="fnref:70" href="#fn:70"><sup>70</sup></a> There is moderate certainty evidence that the use of skin care interventions such as emollients within the first year of life of an infant's life is not effective in preventing eczema.<a class="footnote-ref" id="fnref:71" href="#fn:71"><sup>71</sup></a> In fact, it may increase the risk of skin infection and of unwanted effects such as allergic reaction to certain moisturizers and a stinging sensation.<a class="footnote-ref" id="fnref:72" href="#fn:72"><sup>72</sup></a> </p> <h3>Healthy diet</h3> <p class="note">See also: <a href="/facts/Healthy_diet/sjJBXc4l">Healthy diet</a></p> <p>There has not been adequate evaluation of changing the diet to reduce eczema.<a class="footnote-ref" id="fnref:73" href="#fn:73"><sup>73</sup></a><a class="footnote-ref" id="fnref:74" href="#fn:74"><sup>74</sup></a> There is some evidence that infants with an established <a href="/facts/Egg_allergy/gwlDjA8A">egg allergy</a> may have a reduction in symptoms if eggs are eliminated from their diets.<a class="footnote-ref" id="fnref:75" href="#fn:75"><sup>75</sup></a> Benefits have not been shown for other elimination diets, though the studies are small and poorly executed.<a class="footnote-ref" id="fnref:76" href="#fn:76"><sup>76</sup></a><a class="footnote-ref" id="fnref:77" href="#fn:77"><sup>77</sup></a> Establishing that there is a <a href="/facts/Food_allergy/Nkf1e70o">food allergy</a> before dietary change could avoid unnecessary lifestyle changes.<a class="footnote-ref" id="fnref:78" href="#fn:78"><sup>78</sup></a> </p> <h4>Fatty acids</h4> <p>Oils with fatty acids that have been studied to prevent dermatitis include:<a class="footnote-ref" id="fnref:79" href="#fn:79"><sup>79</sup></a><a class="footnote-ref" id="fnref:80" href="#fn:80"><sup>80</sup></a> </p> <ul><li><a href="/facts/Corn_oil/eebVEq2J">Corn oil</a>: <a href="/facts/Linoleic_acid/E3zEMyb6">Linoleic acid</a> (LA)</li> <li><a href="/facts/Fish_oil/01zGCKh3">Fish oil</a>: <a href="/facts/Eicosapentaenoic_acid/KR6qsu44">Eicosapentaenoic acid</a> (EPA) and <a href="/facts/Docosahexaenoic_acid/kwkBIrSd">docosahexaenoic acid</a> (DHA)</li> <li><a href="/facts/Hemp_seed_oil/uY3rmcW7">Hemp seed oil</a>: <a href="/facts/Linoleic_acid/E3zEMyb6">Linoleic acid</a> (LA), and <a href="/facts/Alpha-Linolenic_acid/8q795eSN">alpha-Linolenic acid</a> (ALA)</li></ul> <p>In the 1950s Arild Hansen showed that infants fed <a href="/facts/Skimmed_milk/MFspysez">skimmed milk</a> developed essential fatty acid deficiency which was characterized by an increased food intake, poor growth, and a scaly dermatitis, and was cured by the administration of <a href="/facts/Corn_oil/eebVEq2J">corn oil</a>. </p> <h2 id="management">Management</h2> <p>There is no known cure for some types of dermatitis, with treatment aiming to control symptoms by reducing inflammation and relieving itching. Contact dermatitis is treated by avoiding what is causing it. </p><p><a href="/facts/Seborrheic_dermatitis/d1CfhTDG">Seborrheic dermatitis</a> is treated with <a href="/facts/Antifungal/WEk5nS2B">antifungals</a> such as anti-dandruff <a href="/facts/Shampoo/ww9bFmT2">shampoo</a>.<a class="footnote-ref" id="fnref:81" href="#fn:81"><sup>81</sup></a> </p> <h3>Lifestyle</h3> <p>Bathing once or more a day is recommended, usually for five to ten minutes in warm water.<a class="footnote-ref" id="fnref:82" href="#fn:82"><sup>82</sup></a><a class="footnote-ref" id="fnref:83" href="#fn:83"><sup>83</sup></a> <a href="/facts/Soap/S3nJa1oY">Soaps</a> should be avoided, as they tend to strip the skin of natural oils and lead to excessive dryness.<a class="footnote-ref" id="fnref:84" href="#fn:84"><sup>84</sup></a> The <a href="/facts/American_Academy_of_Dermatology/SIgvayfV">American Academy of Dermatology</a> suggests using a controlled amount of bleach diluted in a bath to help with atopic dermatitis.<a class="footnote-ref" id="fnref:85" href="#fn:85"><sup>85</sup></a> </p><p>People can wear clothing designed to manage the itching, scratching and peeling.<a class="footnote-ref" id="fnref:86" href="#fn:86"><sup>86</sup></a> </p><p><a href="/facts/House_dust_mite/CwyrgWSA">House dust mite</a> reduction and avoidance measures have been studied in low quality trials and have not shown evidence of improving eczema.<a class="footnote-ref" id="fnref:87" href="#fn:87"><sup>87</sup></a> </p> <h3>Moisturizers</h3> <p>Low-quality evidence indicates that moisturizing agents (<a href="/facts/Emollients/wKvt6bT2">emollients</a>) may reduce eczema severity and lead to fewer flares.<a class="footnote-ref" id="fnref:88" href="#fn:88"><sup>88</sup></a> In children, oil–based formulations appear to be better, and water–based formulations are not recommended.<a class="footnote-ref" id="fnref:89" href="#fn:89"><sup>89</sup></a> It is unclear if moisturizers that contain <a href="/facts/Ceramide/nLdl2GCr">ceramides</a> are more or less effective than others.<a class="footnote-ref" id="fnref:90" href="#fn:90"><sup>90</sup></a> Products that contain dyes, perfumes, or peanuts should not be used.<a class="footnote-ref" id="fnref:91" href="#fn:91"><sup>91</sup></a> <a href="/facts/Occlusive_dressing/Ib4nBe5l">Occlusive dressings</a> at night may be useful.<a class="footnote-ref" id="fnref:92" href="#fn:92"><sup>92</sup></a> </p><p>Some <a href="/facts/Moisturizer/wKvt6bT2">moisturizers</a> or <a href="/facts/Barrier_cream/QTShDpot">barrier creams</a> may reduce irritation in occupational irritant hand dermatitis,<a class="footnote-ref" id="fnref:93" href="#fn:93"><sup>93</sup></a> a skin disease that can affect people in jobs that regularly come into contact with water, <a href="/facts/Detergent/4FLKXR6p">detergents</a>, <a href="/facts/Chemical_substance/EWcXU41d">chemicals</a> or other irritants.<a class="footnote-ref" id="fnref:94" href="#fn:94"><sup>94</sup></a> Some emollients may reduce the number of flares in people with dermatitis.<a class="footnote-ref" id="fnref:95" href="#fn:95"><sup>95</sup></a> </p> <h3>Medications</h3> <h4>Corticosteroids</h4> <p>If symptoms are well controlled with moisturizers, steroids may only be required when flares occur.<a class="footnote-ref" id="fnref:96" href="#fn:96"><sup>96</sup></a> <a href="/facts/Corticosteroids/jeL2QeIL">Corticosteroids</a> are effective in controlling and suppressing symptoms in most cases.<a class="footnote-ref" id="fnref:97" href="#fn:97"><sup>97</sup></a> Once daily use is generally enough.<a class="footnote-ref" id="fnref:98" href="#fn:98"><sup>98</sup></a> For mild-moderate eczema a weak steroid may be used (e.g., <a href="/facts/Hydrocortisone/zvRCrYXG">hydrocortisone</a>), while in more severe cases a higher-potency steroid (e.g., <a href="/facts/Clobetasol_propionate/NQnltdL3">clobetasol propionate</a>) may be used. In severe cases, oral or injectable corticosteroids may be used. While these usually bring about rapid improvements, they have greater side effects. </p><p>Long term use of topical steroids may result in <a href="/facts/Skin_atrophy/NgXwLHL2">skin atrophy</a>, <a href="/facts/Stria/sbAURYBF">stria</a>, and <a href="/facts/Telangiectasia/72MBl6oP">telangiectasia</a>.<a class="footnote-ref" id="fnref:99" href="#fn:99"><sup>99</sup></a> Their use on delicate skin (face or groin) is therefore typically with caution.<a class="footnote-ref" id="fnref:100" href="#fn:100"><sup>100</sup></a> They are, however, generally well tolerated.<a class="footnote-ref" id="fnref:101" href="#fn:101"><sup>101</sup></a> <a href="/facts/Red_burning_skin/WxWQ6j9g">Red burning skin</a>, where the skin turns red upon stopping steroid use, has been reported among adults who use topical steroids at least daily for more than a year.<a class="footnote-ref" id="fnref:102" href="#fn:102"><sup>102</sup></a> </p> <h4>Antihistamines</h4> <p>There is little evidence supporting the use of <a href="/facts/Antihistamine/HuMC25lt">antihistamine</a> medications for the relief of dermatitis.<a class="footnote-ref" id="fnref:103" href="#fn:103"><sup>103</sup></a><a class="footnote-ref" id="fnref:104" href="#fn:104"><sup>104</sup></a> Sedative antihistamines, such as <a href="/facts/Diphenhydramine/XbbIg1Nv">diphenhydramine</a>, may be useful in those who are unable to sleep due to eczema.<a class="footnote-ref" id="fnref:105" href="#fn:105"><sup>105</sup></a> Second generation antihistamines have minimal evidence of benefit.<a class="footnote-ref" id="fnref:106" href="#fn:106"><sup>106</sup></a> Of the second generation antihistamines studied, <a href="/facts/Fexofenadine/sLWI9VBq">fexofenadine</a> is the only one to show evidence of improvement in itching with minimal side effects.<a class="footnote-ref" id="fnref:107" href="#fn:107"><sup>107</sup></a> </p> <h4>Immunosuppressants</h4> <p>Topical <a href="/facts/Immunosuppressant/ctlB3Hda">immunosuppressants</a> like <a href="/facts/Pimecrolimus/RVtEK3Dk">pimecrolimus</a> and <a href="/facts/Tacrolimus/Apj3X5S6">tacrolimus</a> may be better in the short term and appear equal to steroids after a year of use.<a class="footnote-ref" id="fnref:108" href="#fn:108"><sup>108</sup></a> Their use is reasonable in those who do not respond to or are not tolerant of steroids.<a class="footnote-ref" id="fnref:109" href="#fn:109"><sup>109</sup></a><a class="footnote-ref" id="fnref:110" href="#fn:110"><sup>110</sup></a> Treatments are typically recommended for short or fixed periods of time rather than indefinitely.<a class="footnote-ref" id="fnref:111" href="#fn:111"><sup>111</sup></a><a class="footnote-ref" id="fnref:112" href="#fn:112"><sup>112</sup></a> Tacrolimus 0.1% has generally proved more effective than pimecrolimus, and equal in effect to mid-potency topical steroids.<a class="footnote-ref" id="fnref:113" href="#fn:113"><sup>113</sup></a> There is no association to increased risk of cancer from topical use of pimecrolimus nor tacrolimus.<a class="footnote-ref" id="fnref:114" href="#fn:114"><sup>114</sup></a><a class="footnote-ref" id="fnref:115" href="#fn:115"><sup>115</sup></a> </p><p>When eczema is severe and does not respond to other forms of treatment, systemic <a href="/facts/Immunosuppressant/ctlB3Hda">immunosuppressants</a> are sometimes used. Immunosuppressants can cause significant side effects and some require regular blood tests. The most commonly used are <a href="/facts/Cyclosporin/tcIToHvK">cyclosporin</a>, <a href="/facts/Azathioprine/CmeIK3ca">azathioprine</a>, and <a href="/facts/Methotrexate/LoDvhRKX">methotrexate</a>. </p><p><a href="/facts/Dupilumab/EYSHml2o">Dupilumab</a> is a new<a class="footnote-ref" id="fnref:116" href="#fn:116"><sup>116</sup></a> medication that improves eczema lesions, especially moderate to severe eczema.<a class="footnote-ref" id="fnref:117" href="#fn:117"><sup>117</sup></a> Dupilumab, a monoclonal antibody, suppresses inflammation by targeting the <a href="/facts/Interleukin-4_receptor/1Xh5aYyA">interleukin-4 receptor</a>. </p> <h4>Antifungals</h4> <p><a href="/facts/Antifungal/WEk5nS2B">Antifungals</a> are used in the treatment of <a href="/facts/Seborrheic_dermatitis/d1CfhTDG">seborrheic dermatitis</a>.<a class="footnote-ref" id="fnref:118" href="#fn:118"><sup>118</sup></a> </p> <h4>Others</h4> <p>In September 2021, <a href="/facts/Ruxolitinib/WUkFQnnW">ruxolitinib cream</a> (Opzelura) was approved by the U.S. <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a> (FDA) for the topical treatment of mild to moderate atopic dermatitis.<a class="footnote-ref" id="fnref:119" href="#fn:119"><sup>119</sup></a> It is a topical <a href="/facts/Janus_kinase_inhibitor/xweMafbr">Janus kinase inhibitor</a>.<a class="footnote-ref" id="fnref:120" href="#fn:120"><sup>120</sup></a> </p> <h3>Light therapy</h3> <h4>Narrowband UVB</h4> <p><a href="/facts/Atopic_dermatitis/DvmdVwWu">Atopic dermatitis</a> (AD) may be treated with <a href="/facts/Narrowband/76nBsRml">narrowband</a> <a href="/facts/UVB/kncBUqn5">UVB</a>,<a class="footnote-ref" id="fnref:121" href="#fn:121"><sup>121</sup></a> which increases <a href="/facts/Calcifediol/H8jsbUpR">25-hydroxyvitamin D3</a> in persons in individuals with AD.<a class="footnote-ref" id="fnref:122" href="#fn:122"><sup>122</sup></a> </p><p><a href="/facts/Phototherapy/yHtqwaRm">Light therapy</a> using <a href="/facts/Heliotherapy/yHtqwaRm">heliotherapy</a>, balneophototherapy, <a href="/facts/Psoralen/8HjlV1z7">psoralen</a> plus UVA (<a href="/facts/PUVA_therapy/bsn8AlNL">PUVA therapy</a>), light has tentative support but the quality of the evidence is not very good compared with narrowband UVB and UVA1.<a class="footnote-ref" id="fnref:123" href="#fn:123"><sup>123</sup></a> <a href="/facts/UVB/kncBUqn5">UVB</a> is more effective than UVA1 for treatment of atopical dermatitis.<a class="footnote-ref" id="fnref:124" href="#fn:124"><sup>124</sup></a> </p><p>Overexposure to ultraviolet light carries its own risks, particularly that of <a href="/facts/Skin_cancer/r9BWEX7W">skin cancer</a>.<a class="footnote-ref" id="fnref:125" href="#fn:125"><sup>125</sup></a> </p> <h3>Alternative medicine</h3> <h4>Topical</h4> <p><a href="/facts/Chiropractic/GzfjsnFv">Chiropractic</a> spinal manipulation lacks evidence to support its use for dermatitis.<a class="footnote-ref" id="fnref:126" href="#fn:126"><sup>126</sup></a> There is little evidence supporting the use of psychological treatments.<a class="footnote-ref" id="fnref:127" href="#fn:127"><sup>127</sup></a> While dilute bleach baths have been used for infected dermatitis there is little evidence for this practice.<a class="footnote-ref" id="fnref:128" href="#fn:128"><sup>128</sup></a> </p> <h4>Supplements</h4> <ul><li><a href="/facts/Sulfur/IK0amTfM">Sulfur</a>: There is currently no scientific evidence for the claim that sulfur treatment relieves eczema.<a class="footnote-ref" id="fnref:129" href="#fn:129"><sup>129</sup></a></li> <li><a href="/facts/Chinese_herbology/JF2XKnhH">Chinese herbology</a>: it is unclear whether Chinese herbs help or harm.<a class="footnote-ref" id="fnref:130" href="#fn:130"><sup>130</sup></a> Dietary supplements are commonly used by people with eczema.<a class="footnote-ref" id="fnref:131" href="#fn:131"><sup>131</sup></a></li> <li>Neither <a href="/facts/Evening_primrose_oil/PPKjTxue">evening primrose oil</a> nor <a href="/facts/Borage_seed_oil/RBHCHAcd">borage seed oil</a> taken orally have been shown to be effective.<a class="footnote-ref" id="fnref:132" href="#fn:132"><sup>132</sup></a> Both are associated with <a href="/facts/Gastrointestinal_disease/S4UzQRFA">gastrointestinal upset</a>.<a class="footnote-ref" id="fnref:133" href="#fn:133"><sup>133</sup></a></li> <li><a href="/facts/Probiotics/gQNAN6ly">Probiotics</a> are likely to make little to no difference in symptoms.<a class="footnote-ref" id="fnref:134" href="#fn:134"><sup>134</sup></a></li></ul> <h2 id="prognosis">Prognosis</h2> <p>Most cases are well managed with topical treatments and ultraviolet light.<a class="footnote-ref" id="fnref:135" href="#fn:135"><sup>135</sup></a> About 2% of cases are not.<a class="footnote-ref" id="fnref:136" href="#fn:136"><sup>136</sup></a> In more than 60% of young children, the condition subsides by <a href="/facts/Adolescence/XUkTHFyd">adolescence</a>.<a class="footnote-ref" id="fnref:137" href="#fn:137"><sup>137</sup></a> </p> <h2 id="epidemiology">Epidemiology</h2> <p>Globally dermatitis affected approximately 230 million people as of 2010 (3.5% of the population).<a class="footnote-ref" id="fnref:138" href="#fn:138"><sup>138</sup></a> Dermatitis is most commonly seen in <a href="/facts/Infancy/gaEL1QL4">infancy</a>, with female predominance of eczema presentations occurring during the reproductive period of 15–49 years.<a class="footnote-ref" id="fnref:139" href="#fn:139"><sup>139</sup></a> In the UK about 20% of children have the condition, while in the United States about 10% are affected.<a class="footnote-ref" id="fnref:140" href="#fn:140"><sup>140</sup></a> </p><p>Although little data on the rates of eczema over time exists prior to the 1940s, the rate of eczema has been found to have increased substantially in the latter half of the 20th century, with eczema in school-aged children being found to increase between the late 1940s and 2000.<a class="footnote-ref" id="fnref:141" href="#fn:141"><sup>141</sup></a> In the <a href="/facts/Developed_world/sqwTSDHm">developed world</a> there has been rise in the rate of eczema over time. The incidence and lifetime prevalence of eczema in England has been seen to increase in recent times.<a class="footnote-ref" id="fnref:142" href="#fn:142"><sup>142</sup></a><a class="footnote-ref" id="fnref:143" href="#fn:143"><sup>143</sup></a> </p><p>Dermatitis affected about 10% of U.S. workers in 2010, representing over 15 million workers with dermatitis. Prevalence rates were higher among females than among males and among those with some college education or a college degree compared to those with a high school diploma or less. Workers employed in healthcare and social assistance industries and life, physical, and social science occupations had the highest rates of reported dermatitis. About 6% of dermatitis cases among U.S. workers were attributed to work by a healthcare professional, indicating that the prevalence rate of work-related dermatitis among workers was at least 0.6%.<a class="footnote-ref" id="fnref:144" href="#fn:144"><sup>144</sup></a> </p> <h2 id="etymology-and-history">Etymology and history</h2> <p>The term <i>atopic dermatitis</i> was coined in 1933 by Wise and Sulzberger.<a class="footnote-ref" id="fnref:145" href="#fn:145"><sup>145</sup></a> <a href="/facts/Sulfur/IK0amTfM">Sulfur</a> as a topical treatment for eczema was fashionable in the Victorian and Edwardian eras.<a class="footnote-ref" id="fnref:146" href="#fn:146"><sup>146</sup></a> </p><p>The word <i>dermatitis</i> is from the Greek δέρμα <i>derma</i> 'skin' and -ῖτις <i>-itis</i> 'inflammation' and <i>eczema</i> is from <a href="/facts/Greek_language/pzDd6eIz">Greek</a>: ἔκζεμα <i>ekzema</i> 'eruption'.<a class="footnote-ref" id="fnref:147" href="#fn:147"><sup>147</sup></a> </p> <h2 id="society-and-culture">Society and culture</h2> <p>Some cosmetics are marketed as hypoallergenic to imply that their use is less likely to lead to an allergic reaction than other products.<a class="footnote-ref" id="fnref:148" href="#fn:148"><sup>148</sup></a> However, the term <i>hypoallergenic</i> is not regulated,<a class="footnote-ref" id="fnref:149" href="#fn:149"><sup>149</sup></a> and no research has been done showing that products labeled <i>hypoallergenic</i> are less problematic than any others. In 1977, courts overruled the U.S. <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">Food and Drug Administration</a>'s regulation of the use of the term hypoallergenic.<a class="footnote-ref" id="fnref:150" href="#fn:150"><sup>150</sup></a> In 2019, the <a href="/facts/European_Union/6GYcR8qM">European Union</a> released a document about claims made concerning cosmetics,<a class="footnote-ref" id="fnref:151" href="#fn:151"><sup>151</sup></a> but this was issued as guidance, not a regulation.<a class="footnote-ref" id="fnref:152" href="#fn:152"><sup>152</sup></a> </p> <h2 id="research">Research</h2> <p><a href="/facts/Monoclonal_antibody/4rUBWB87">Monoclonal antibodies</a> are under preliminary research to determine their potential as treatments for atopic dermatitis, with only <a href="/facts/Dupilumab/EYSHml2o">dupilumab</a> showing evidence of efficacy, as of 2018.<a class="footnote-ref" id="fnref:153" href="#fn:153"><sup>153</sup></a><a class="footnote-ref" id="fnref:154" href="#fn:154"><sup>154</sup></a> </p> <h2 id="notes">Notes</h2> <h2 id="external-links">External links</h2> Look up <i>dermatitis</i> in Wiktionary, the free dictionary. Wikimedia Commons has media related to Dermatitis. <ul><li><a href="https://www.aad.org/public/diseases/eczema">Eczema Resource Center</a>. American Academy of Dermatology.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. (May 2004). "Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003". The Journal of Allergy and Clinical Immunology. 113 (5): 832–836. doi:10.1016/j.jaci.2003.12.591. PMID 15131563. <a href="https://doi.org/10.1016%2Fj.jaci.2003.12.591" target="_blank">https://doi.org/10.1016%2Fj.jaci.2003.12.591</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>James WD, Elston D, Treat JR, Rosenbach MA, Neuhaus I (2019). Andrews' Diseases of the Skin: Clinical Dermatology. Elsevier Health Sciences. p. 482. ISBN 978-0-323-55188-5. <a href="978-0-323-55188-5" target="_blank">978-0-323-55188-5</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>Habif TP (2015). Clinical Dermatology (6 ed.). Elsevier Health Sciences. p. 171. ISBN 978-0-323-26607-9. Archived from the original on 17 August 2016. Retrieved 5 July 2016. <a href="978-0-323-26607-9" target="_blank">978-0-323-26607-9</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B (June 2016). "Allergic contact dermatitis: Patient management and education". Journal of the American Academy of Dermatology. 74 (6): 1043–1054. doi:10.1016/j.jaad.2015.02.1144. PMID 27185422. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>Lurati AR (February 2015). "Occupational risk assessment and irritant contact dermatitis". Workplace Health & Safety. 63 (2): 81–87, quiz 88. doi:10.1177/2165079914565351. PMID 25881659. S2CID 40077567. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055577" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055577</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> <li id="fn:21"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></p></li> <li id="fn:22"><p>Adkinson NF (2014). Middleton's Allergy: Principles and Practice (8 ed.). Philadelphia: Elsevier Saunders. p. 566. ISBN 978-0-323-08593-9. Archived from the original on 15 August 2016. <a href="978-0-323-08593-9" target="_blank">978-0-323-08593-9</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></p></li> <li id="fn:23"><p>Wilkinson M, Orton D (2016). "Allergic Contact Dermatitis". In Barker J, Bleiker TO, Chalmers R, Creamer D (eds.). Rook's Textbook of Dermatology (9 ed.). John Wiley & Sons. p. 128.4. ISBN 978-1-118-44117-6. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-118-44117-6" target="_blank">978-1-118-44117-6</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></p></li> <li id="fn:24"><p>Frosch PJ (2013). Textbook of Contact Dermatitis (2nd ed.). Berlin, Heidelberg: Springer Berlin Heidelberg. p. 42. ISBN 978-3-662-03104-9. Archived from the original on 16 August 2016. <a href="978-3-662-03104-9" target="_blank">978-3-662-03104-9</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></p></li> <li id="fn:25"><p>Nedorost ST (2012). Generalized Dermatitis in Clinical Practice. Springer Science & Business Media. pp. 1–3, 9, 13–14. ISBN 978-1-4471-2897-7. Archived from the original on 15 August 2016. Retrieved 29 July 2016. <a href="978-1-4471-2897-7" target="_blank">978-1-4471-2897-7</a> <a href="#fnref:25" class="footnote-back-ref">↩</a></p></li> <li id="fn:26"><p>"Dermatitis and eczema". ICD-11 for Mortality and Morbidity Statistics. 2024. Retrieved 12 August 2024. <a href="https://icd.who.int/browse/2024-01/mms/en#1887882424" target="_blank">https://icd.who.int/browse/2024-01/mms/en#1887882424</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></p></li> <li id="fn:27"><p>Bershad SV (November 2011). "In the clinic. Atopic dermatitis (eczema)". Annals of Internal Medicine. 155 (9): ITC51–15, quiz ITC516. doi:10.7326/0003-4819-155-9-201111010-01005. PMID 22041966. S2CID 207536375. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:27" class="footnote-back-ref">↩</a></p></li> <li id="fn:28"><p>Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. (May 2004). "Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003". The Journal of Allergy and Clinical Immunology. 113 (5): 832–836. doi:10.1016/j.jaci.2003.12.591. PMID 15131563. <a href="https://doi.org/10.1016%2Fj.jaci.2003.12.591" target="_blank">https://doi.org/10.1016%2Fj.jaci.2003.12.591</a> <a href="#fnref:28" class="footnote-back-ref">↩</a></p></li> <li id="fn:29"><p>Ring J, Przybilla B, Ruzicka T (2006). Handbook of atopic eczema. Birkhäuser. p. 4. ISBN 978-3-540-23133-2. Retrieved 4 May 2010. <a href="978-3-540-23133-2" target="_blank">978-3-540-23133-2</a> <a href="#fnref:29" class="footnote-back-ref">↩</a></p></li> <li id="fn:30"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:30" class="footnote-back-ref">↩</a></p></li> <li id="fn:31"><p>"Neurodermatitis (lichen simplex)". DermNet New Zealand Trust. 2017. Archived from the original on 2 February 2017. Retrieved 29 January 2017. <a href="http://www.dermnetnz.org/topics/lichen-simplex" target="_blank">http://www.dermnetnz.org/topics/lichen-simplex</a> <a href="#fnref:31" class="footnote-back-ref">↩</a></p></li> <li id="fn:32"><p>"Neurodermatitis". Mayo Clinic. 2015. Archived from the original on 16 June 2010. Retrieved 6 November 2010. <a href="http://www.mayoclinic.com/health/neurodermatitis/ds00712/dsection=symptoms" target="_blank">http://www.mayoclinic.com/health/neurodermatitis/ds00712/dsection=symptoms</a> <a href="#fnref:32" class="footnote-back-ref">↩</a></p></li> <li id="fn:33"><p>Hewett L (2 September 2022). "Eczema in skin of color: What you need to know". National Eczema Association. Retrieved 16 November 2023. <a href="https://nationaleczema.org/blog/eczema-in-skin-of-color/" target="_blank">https://nationaleczema.org/blog/eczema-in-skin-of-color/</a> <a href="#fnref:33" class="footnote-back-ref">↩</a></p></li> <li id="fn:34"><p>"Periorificial dermatitis". DermNet New Zealand Trust. 2017. Archived from the original on 2 February 2017. Retrieved 29 January 2017. <a href="http://www.dermnetnz.org/topics/periorificial-dermatitis/" target="_blank">http://www.dermnetnz.org/topics/periorificial-dermatitis/</a> <a href="#fnref:34" class="footnote-back-ref">↩</a></p></li> <li id="fn:35"><p>"Dermatitis herpetiformis". DermNet New Zealand Trust. 2017. Archived from the original on 2 February 2017. Retrieved 29 January 2017. <a href="http://www.dermnetnz.org/topics/dermatitis-herpetiformis" target="_blank">http://www.dermnetnz.org/topics/dermatitis-herpetiformis</a> <a href="#fnref:35" class="footnote-back-ref">↩</a></p></li> <li id="fn:36"><p>"Seborrheic dermatitis". DermNet New Zealand Trust. 2017. Archived from the original on 2 February 2017. Retrieved 29 January 2017. <a href="http://www.dermnetnz.org/topics/seborrhoeic-dermatitis" target="_blank">http://www.dermnetnz.org/topics/seborrhoeic-dermatitis</a> <a href="#fnref:36" class="footnote-back-ref">↩</a></p></li> <li id="fn:37"><p>"Seborrheic Dermatitis". Merck Manual, Consumer Version. <a href="https://www.merckmanuals.com/home/skin-disorders/itching-and-dermatitis/seborrheic-dermatitis" target="_blank">https://www.merckmanuals.com/home/skin-disorders/itching-and-dermatitis/seborrheic-dermatitis</a> <a href="#fnref:37" class="footnote-back-ref">↩</a></p></li> <li id="fn:38"><p>"CDC Smallpox | Smallpox (Vaccinia) Vaccine Contraindications (Info for Clinicians)". Emergency.cdc.gov. 7 February 2007. Archived from the original on 25 January 2010. Retrieved 7 February 2010. <a href="https://web.archive.org/web/20100125041841/http://emergency.cdc.gov/agent/smallpox/vaccination/contraindications-clinic.asp" target="_blank">https://web.archive.org/web/20100125041841/http://emergency.cdc.gov/agent/smallpox/vaccination/contraindications-clinic.asp</a> <a href="#fnref:38" class="footnote-back-ref">↩</a></p></li> <li id="fn:39"><p>Wang V, Boguniewicz J, Boguniewicz M, Ong PY (January 2021). "The infectious complications of atopic dermatitis". Annals of Allergy, Asthma & Immunology. 126 (1): 3–12. doi:10.1016/j.anai.2020.08.002. PMC 7411503. PMID 32771354. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411503" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411503</a> <a href="#fnref:39" class="footnote-back-ref">↩</a></p></li> <li id="fn:40"><p>Wang V, Boguniewicz J, Boguniewicz M, Ong PY (January 2021). "The infectious complications of atopic dermatitis". Annals of Allergy, Asthma & Immunology. 126 (1): 3–12. doi:10.1016/j.anai.2020.08.002. PMC 7411503. PMID 32771354. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411503" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411503</a> <a href="#fnref:40" class="footnote-back-ref">↩</a></p></li> <li id="fn:41"><p>"Handout on Health: Atopic Dermatitis (A type of eczema)". NIAMS. May 2013. Archived from the original on 30 May 2015. Retrieved 29 July 2016. <a href="http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp" target="_blank">http://www.niams.nih.gov/health_info/Atopic_Dermatitis/default.asp</a> <a href="#fnref:41" class="footnote-back-ref">↩</a></p></li> <li id="fn:42"><p>Bufford JD, Gern JE (May 2005). "The hygiene hypothesis revisited". Immunology and Allergy Clinics of North America. 25 (2): 247–262, v–vi. doi:10.1016/j.iac.2005.03.005. PMID 15878454. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:42" class="footnote-back-ref">↩</a></p></li> <li id="fn:43"><p>"Atopic Dermatitis (Eczema)". The Lecturio Medical Concept Library. Retrieved 2 July 2021. <a href="https://www.lecturio.com/concepts/atopic-dermatitis-eczema/" target="_blank">https://www.lecturio.com/concepts/atopic-dermatitis-eczema/</a> <a href="#fnref:43" class="footnote-back-ref">↩</a></p></li> <li id="fn:44"><p>Schram M, Tedja A, Spijker R, Bos J, Williams H, Spuls P (16 March 2010). "Is there a rural/urban gradient in the prevalence of eczema? A systematic review". British Journal of Dermatology. 162 (5): 964–973. doi:10.1111/j.1365-2133.2010.09689.x. ISSN 0007-0963. PMID 20331459. S2CID 205259960. Retrieved 8 March 2022. <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2010.09689.x" target="_blank">https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2010.09689.x</a> <a href="#fnref:44" class="footnote-back-ref">↩</a></p></li> <li id="fn:45"><p>Carswell F, Thompson S (July 1986). "Does natural sensitisation in eczema occur through the skin?". Lancet. 2 (8497): 13–15. doi:10.1016/S0140-6736(86)92560-2. PMID 2873316. S2CID 23111491. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:45" class="footnote-back-ref">↩</a></p></li> <li id="fn:46"><p>Henszel Ł, Kuźna-Grygiel W (2006). "[House dust mites in the etiology of allergic diseases]". Annales Academiae Medicae Stetinensis (in Polish). 52 (2): 123–127. PMID 17633128. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:46" class="footnote-back-ref">↩</a></p></li> <li id="fn:47"><p>Atopic Dermatitis at eMedicine <a href="http://www.emedicine.com/Derm/topic38.htm#" target="_blank">http://www.emedicine.com/Derm/topic38.htm#</a> <a href="#fnref:47" class="footnote-back-ref">↩</a></p></li> <li id="fn:48"><p>James WD, Elston D, Treat JR, Rosenbach MA, Neuhaus I (2019). Andrews' Diseases of the Skin: Clinical Dermatology. Elsevier Health Sciences. p. 482. ISBN 978-0-323-55188-5. <a href="978-0-323-55188-5" target="_blank">978-0-323-55188-5</a> <a href="#fnref:48" class="footnote-back-ref">↩</a></p></li> <li id="fn:49"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:49" class="footnote-back-ref">↩</a></p></li> <li id="fn:50"><p>Paternoster L, Standl M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, et al. (December 2011). "Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis". Nature Genetics. 44 (2): 187–192. doi:10.1038/ng.1017. PMC 3272375. PMID 22197932. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272375" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272375</a> <a href="#fnref:50" class="footnote-back-ref">↩</a></p></li> <li id="fn:51"><p>Caproni M, Bonciolini V, D'Errico A, Antiga E, Fabbri P (2012). "Celiac disease and dermatologic manifestations: many skin clue to unfold gluten-sensitive enteropathy". Gastroenterology Research and Practice. 2012. Hindawi Publishing Corporation: 952753. doi:10.1155/2012/952753. PMC 3369470. PMID 22693492. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369470" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369470</a> <a href="#fnref:51" class="footnote-back-ref">↩</a></p></li> <li id="fn:52"><p>Ciacci C, Cavallaro R, Iovino P, Sabbatini F, Palumbo A, Amoruso D, et al. (June 2004). "Allergy prevalence in adult celiac disease". The Journal of Allergy and Clinical Immunology. 113 (6): 1199–1203. doi:10.1016/j.jaci.2004.03.012. PMID 15208605. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:52" class="footnote-back-ref">↩</a></p></li> <li id="fn:53"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:53" class="footnote-back-ref">↩</a></p></li> <li id="fn:54"><p>"Eczema". University of Maryland Medical Center. Archived from the original on 27 July 2016. <a href="http://umm.edu/health/medical/altmed/condition/eczema" target="_blank">http://umm.edu/health/medical/altmed/condition/eczema</a> <a href="#fnref:54" class="footnote-back-ref">↩</a></p></li> <li id="fn:55"><p>Atkins D (March 2008). "Food allergy: diagnosis and management". Primary Care. 35 (1): 119–140, vii. doi:10.1016/j.pop.2007.09.003. PMID 18206721. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:55" class="footnote-back-ref">↩</a></p></li> <li id="fn:56"><p>Johansen JD, Frosch PJ, Lepoittevin JP (2010). Contact Dermatitis. Springer. ISBN 978-3-642-03827-3. Archived from the original on 5 July 2014. Retrieved 21 April 2014. <a href="978-3-642-03827-3" target="_blank">978-3-642-03827-3</a> <a href="#fnref:56" class="footnote-back-ref">↩</a></p></li> <li id="fn:57"><p>Rietschel RL, Fowler JF (2008). Fisher's Contact Dermatitis (6th ed.). Hamilton, Ontario: BC Decker Inc. ISBN 978-1-55009-378-0. Retrieved 21 April 2014. <a href="978-1-55009-378-0" target="_blank">978-1-55009-378-0</a> <a href="#fnref:57" class="footnote-back-ref">↩</a></p></li> <li id="fn:58"><p>Johansen JD, Hald M, Andersen BL, Laurberg G, Danielsen A, Avnstorp C, et al. (Danish Contact Dermatitis Group) (2011). "Classification of hand eczema: clinical and aetiological types. Based on the guideline of the Danish Contact Dermatitis Group". Contact Dermatitis. 65 (1): 13–21. doi:10.1111/j.1600-0536.2011.01911.x. PMID 21658054. S2CID 30780460. Retrieved 2 July 2021. <a href="https://pubmed.ncbi.nlm.nih.gov/21658054/" target="_blank">https://pubmed.ncbi.nlm.nih.gov/21658054/</a> <a href="#fnref:58" class="footnote-back-ref">↩</a></p></li> <li id="fn:59"><p>"Atopic Dermatitis (Eczema)". The Lecturio Medical Concept Library. Retrieved 2 July 2021. <a href="https://www.lecturio.com/concepts/atopic-dermatitis-eczema/" target="_blank">https://www.lecturio.com/concepts/atopic-dermatitis-eczema/</a> <a href="#fnref:59" class="footnote-back-ref">↩</a></p></li> <li id="fn:60"><p>Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. (September 2001). "A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force". Allergy. 56 (9): 813–824. doi:10.1034/j.1398-9995.2001.t01-1-00001.x (inactive 6 February 2025). PMID 11551246.{{cite journal}}: CS1 maint: DOI inactive as of February 2025 (link) <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:60" class="footnote-back-ref">↩</a></p></li> <li id="fn:61"><p>Alsaad KO, Ghazarian D (December 2005). "My approach to superficial inflammatory dermatoses". Journal of Clinical Pathology. 58 (12): 1233–1241. doi:10.1136/jcp.2005.027151. PMC 1770784. PMID 16311340. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770784" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770784</a> <a href="#fnref:61" class="footnote-back-ref">↩</a></p></li> <li id="fn:62"><p>Alsaad KO, Ghazarian D (December 2005). "My approach to superficial inflammatory dermatoses". Journal of Clinical Pathology. 58 (12): 1233–1241. doi:10.1136/jcp.2005.027151. PMC 1770784. PMID 16311340. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770784" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770784</a> <a href="#fnref:62" class="footnote-back-ref">↩</a></p></li> <li id="fn:63"><p>Atopic Dermatitis National Eczema Association. <a href="https://nationaleczema.org/eczema/types-of-eczema/atopic-dermatitis/" target="_blank">https://nationaleczema.org/eczema/types-of-eczema/atopic-dermatitis/</a> <a href="#fnref:63" class="footnote-back-ref">↩</a></p></li> <li id="fn:64"><p>"Balsam of Peru contact allergy". Dermnetnz.org. 28 December 2013. Archived from the original on 5 March 2014. Retrieved 5 March 2014. <a href="http://dermnetnz.org/dermatitis/balsam-of-peru-allergy.html" target="_blank">http://dermnetnz.org/dermatitis/balsam-of-peru-allergy.html</a> <a href="#fnref:64" class="footnote-back-ref">↩</a></p></li> <li id="fn:65"><p>Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:65" class="footnote-back-ref">↩</a></p></li> <li id="fn:66"><p>James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0. <a href="/wiki/ISBN_(identifier)" target="_blank">/wiki/ISBN_(identifier)</a> <a href="#fnref:66" class="footnote-back-ref">↩</a></p></li> <li id="fn:67"><p>Greer FR, Sicherer SH, Burks AW (April 2019). "The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods". Pediatrics. 143 (4): e20190281. doi:10.1542/peds.2019-0281. PMID 30886111. <a href="https://doi.org/10.1542%2Fpeds.2019-0281" target="_blank">https://doi.org/10.1542%2Fpeds.2019-0281</a> <a href="#fnref:67" class="footnote-back-ref">↩</a></p></li> <li id="fn:68"><p>Greer FR, Sicherer SH, Burks AW (April 2019). "The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods". Pediatrics. 143 (4): e20190281. doi:10.1542/peds.2019-0281. PMID 30886111. <a href="https://doi.org/10.1542%2Fpeds.2019-0281" target="_blank">https://doi.org/10.1542%2Fpeds.2019-0281</a> <a href="#fnref:68" class="footnote-back-ref">↩</a></p></li> <li id="fn:69"><p>Greer FR, Sicherer SH, Burks AW (April 2019). "The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods". Pediatrics. 143 (4): e20190281. doi:10.1542/peds.2019-0281. PMID 30886111. <a href="https://doi.org/10.1542%2Fpeds.2019-0281" target="_blank">https://doi.org/10.1542%2Fpeds.2019-0281</a> <a href="#fnref:69" class="footnote-back-ref">↩</a></p></li> <li id="fn:70"><p>Kalliomäki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mercenier A (March 2010). "Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of allergic diseases by probiotics". The Journal of Nutrition. 140 (3): 713S – 721S. doi:10.3945/jn.109.113761. PMID 20130079. <a href="https://doi.org/10.3945%2Fjn.109.113761" target="_blank">https://doi.org/10.3945%2Fjn.109.113761</a> <a href="#fnref:70" class="footnote-back-ref">↩</a></p></li> <li id="fn:71"><p>Kelleher MM, Phillips R, Brown SJ, Cro S, Cornelius V, Carlsen KC, et al. (14 November 2022). "Skin care interventions in infants for preventing eczema and food allergy". The Cochrane Database of Systematic Reviews. 2022 (11): CD013534. doi:10.1002/14651858.CD013534.pub3. ISSN 1469-493X. PMC 9661877. PMID 36373988. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661877" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661877</a> <a href="#fnref:71" class="footnote-back-ref">↩</a></p></li> <li id="fn:72"><p>Kelleher MM, Phillips R, Brown SJ, Cro S, Cornelius V, Carlsen KC, et al. (14 November 2022). "Skin care interventions in infants for preventing eczema and food allergy". The Cochrane Database of Systematic Reviews. 2022 (11): CD013534. doi:10.1002/14651858.CD013534.pub3. ISSN 1469-493X. PMC 9661877. PMID 36373988. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661877" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661877</a> <a href="#fnref:72" class="footnote-back-ref">↩</a></p></li> <li id="fn:73"><p>Bath-Hextall F, Delamere FM, Williams HC (January 2008). Bath-Hextall FJ (ed.). "Dietary exclusions for established atopic eczema". The Cochrane Database of Systematic Reviews. 2008 (1): CD005203. doi:10.1002/14651858.CD005203.pub2. PMC 6885041. PMID 18254073. Archived from the original on 21 October 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/</a> <a href="#fnref:73" class="footnote-back-ref">↩</a></p></li> <li id="fn:74"><p>Institute for Quality and Efficiency in Health Care. "Eczema: Can eliminating particular foods help?". Informed Health Online. Institute for Quality and Efficiency in Health Care. Archived from the original on 21 October 2013. Retrieved 24 June 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0005096/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0005096/</a> <a href="#fnref:74" class="footnote-back-ref">↩</a></p></li> <li id="fn:75"><p>Bath-Hextall F, Delamere FM, Williams HC (January 2008). Bath-Hextall FJ (ed.). "Dietary exclusions for established atopic eczema". The Cochrane Database of Systematic Reviews. 2008 (1): CD005203. doi:10.1002/14651858.CD005203.pub2. PMC 6885041. PMID 18254073. Archived from the original on 21 October 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/</a> <a href="#fnref:75" class="footnote-back-ref">↩</a></p></li> <li id="fn:76"><p>Bath-Hextall F, Delamere FM, Williams HC (January 2008). Bath-Hextall FJ (ed.). "Dietary exclusions for established atopic eczema". The Cochrane Database of Systematic Reviews. 2008 (1): CD005203. doi:10.1002/14651858.CD005203.pub2. PMC 6885041. PMID 18254073. Archived from the original on 21 October 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/</a> <a href="#fnref:76" class="footnote-back-ref">↩</a></p></li> <li id="fn:77"><p>Institute for Quality and Efficiency in Health Care. "Eczema: Can eliminating particular foods help?". Informed Health Online. Institute for Quality and Efficiency in Health Care. Archived from the original on 21 October 2013. Retrieved 24 June 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0005096/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0005096/</a> <a href="#fnref:77" class="footnote-back-ref">↩</a></p></li> <li id="fn:78"><p>Bath-Hextall F, Delamere FM, Williams HC (January 2008). Bath-Hextall FJ (ed.). "Dietary exclusions for established atopic eczema". The Cochrane Database of Systematic Reviews. 2008 (1): CD005203. doi:10.1002/14651858.CD005203.pub2. PMC 6885041. PMID 18254073. Archived from the original on 21 October 2013. <a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013319/</a> <a href="#fnref:78" class="footnote-back-ref">↩</a></p></li> <li id="fn:79"><p>Søyland E, Funk J, Rajka G, Sandberg M, Thune P, Rustad L, et al. (June 1994). "Dietary supplementation with very long-chain n-3 fatty acids in patients with atopic dermatitis. A double-blind, multicentre study". The British Journal of Dermatology. 130 (6): 757–764. doi:10.1111/j.1365-2133.1994.tb03414.x. PMID 8011502. S2CID 25066444. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:79" class="footnote-back-ref">↩</a></p></li> <li id="fn:80"><p>Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, et al. (April 2005). "Efficacy of dietary hempseed oil in patients with atopic dermatitis". The Journal of Dermatological Treatment. 16 (2): 87–94. doi:10.1080/09546630510035832. PMID 16019622. S2CID 18445488. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:80" class="footnote-back-ref">↩</a></p></li> <li id="fn:81"><p>Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:81" class="footnote-back-ref">↩</a></p></li> <li id="fn:82"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:82" class="footnote-back-ref">↩</a></p></li> <li id="fn:83"><p>"Coping with atopic dermatitis". 2017. Retrieved 11 September 2017. <a href="https://www.aad.org/public/diseases/eczema/atopic-dermatitis#tips" target="_blank">https://www.aad.org/public/diseases/eczema/atopic-dermatitis#tips</a> <a href="#fnref:83" class="footnote-back-ref">↩</a></p></li> <li id="fn:84"><p>Gutman AB, Kligman AM, Sciacca J, James WD (December 2005). "Soak and smear: a standard technique revisited". Archives of Dermatology. 141 (12): 1556–1559. doi:10.1001/archderm.141.12.1556. PMID 16365257. <a href="https://doi.org/10.1001%2Farchderm.141.12.1556" target="_blank">https://doi.org/10.1001%2Farchderm.141.12.1556</a> <a href="#fnref:84" class="footnote-back-ref">↩</a></p></li> <li id="fn:85"><p>"Atopic dermatitis: Bleach bath therapy". www.aad.org. Archived from the original on 29 July 2020. Retrieved 4 May 2020. <a href="https://web.archive.org/web/20200729202648/https://www.aad.org/public/diseases/eczema/childhood/treating/bleach-bath" target="_blank">https://web.archive.org/web/20200729202648/https://www.aad.org/public/diseases/eczema/childhood/treating/bleach-bath</a> <a href="#fnref:85" class="footnote-back-ref">↩</a></p></li> <li id="fn:86"><p>Ricci G, Patrizi A, Bellini F, Medri M (2006). "Use of textiles in atopic dermatitis: care of atopic dermatitis". Respiration. Current Problems in Dermatology. 33 (3): 127–143. doi:10.1159/000093940. hdl:11585/110806. ISBN 978-3-8055-8121-9. PMID 16766885. <a href="978-3-8055-8121-9" target="_blank">978-3-8055-8121-9</a> <a href="#fnref:86" class="footnote-back-ref">↩</a></p></li> <li id="fn:87"><p>Nankervis H, Pynn EV, Boyle RJ, Rushton L, Williams HC, Hewson DM, et al. (January 2015). "House dust mite reduction and avoidance measures for treating eczema". The Cochrane Database of Systematic Reviews. 1 (5): CD008426. doi:10.1002/14651858.CD008426.pub2. hdl:10044/1/21547. PMC 8407038. PMID 25598014. <a href="http://www.cochrane.org/CD008426/SKIN_house-dust-mite-reduction-and-avoidance-measures-treating-eczema" target="_blank">http://www.cochrane.org/CD008426/SKIN_house-dust-mite-reduction-and-avoidance-measures-treating-eczema</a> <a href="#fnref:87" class="footnote-back-ref">↩</a></p></li> <li id="fn:88"><p>van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BW (February 2017). "Emollients and moisturisers for eczema". The Cochrane Database of Systematic Reviews. 2 (8): CD012119. doi:10.1002/14651858.CD012119.pub2. PMC 6464068. PMID 28166390. <a href="http://www.cochrane.org/CD012119/SKIN_emollients-and-moisturisers-eczema" target="_blank">http://www.cochrane.org/CD012119/SKIN_emollients-and-moisturisers-eczema</a> <a href="#fnref:88" class="footnote-back-ref">↩</a></p></li> <li id="fn:89"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:89" class="footnote-back-ref">↩</a></p></li> <li id="fn:90"><p>Jungersted JM, Agner T (August 2013). "Eczema and ceramides: an update". Contact Dermatitis. 69 (2): 65–71. doi:10.1111/cod.12073. PMID 23869725. S2CID 9471706. <a href="https://doi.org/10.1111%2Fcod.12073" target="_blank">https://doi.org/10.1111%2Fcod.12073</a> <a href="#fnref:90" class="footnote-back-ref">↩</a></p></li> <li id="fn:91"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:91" class="footnote-back-ref">↩</a></p></li> <li id="fn:92"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:92" class="footnote-back-ref">↩</a></p></li> <li id="fn:93"><p>Bauer A, Rönsch H, Elsner P, Dittmar D, Bennett C, Schuttelaar ML, et al. (April 2018). "Interventions for preventing occupational irritant hand dermatitis" (PDF). The Cochrane Database of Systematic Reviews. 2018 (4): CD004414. doi:10.1002/14651858.CD004414.pub3. PMC 6494486. PMID 29708265. Archived from the original (PDF) on 6 March 2020. Retrieved 26 June 2019. <a href="https://web.archive.org/web/20200306150356/http://eprints.nottingham.ac.uk/51952/1/CD004414.pdf" target="_blank">https://web.archive.org/web/20200306150356/http://eprints.nottingham.ac.uk/51952/1/CD004414.pdf</a> <a href="#fnref:93" class="footnote-back-ref">↩</a></p></li> <li id="fn:94"><p>Bauer A, Rönsch H, Elsner P, Dittmar D, Bennett C, Schuttelaar ML, et al. (April 2018). "Interventions for preventing occupational irritant hand dermatitis" (PDF). The Cochrane Database of Systematic Reviews. 2018 (4): CD004414. doi:10.1002/14651858.CD004414.pub3. PMC 6494486. PMID 29708265. Archived from the original (PDF) on 6 March 2020. Retrieved 26 June 2019. <a href="https://web.archive.org/web/20200306150356/http://eprints.nottingham.ac.uk/51952/1/CD004414.pdf" target="_blank">https://web.archive.org/web/20200306150356/http://eprints.nottingham.ac.uk/51952/1/CD004414.pdf</a> <a href="#fnref:94" class="footnote-back-ref">↩</a></p></li> <li id="fn:95"><p>van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BW (February 2017). "Emollients and moisturisers for eczema". The Cochrane Database of Systematic Reviews. 2 (8): CD012119. doi:10.1002/14651858.CD012119.pub2. PMC 6464068. PMID 28166390. <a href="http://www.cochrane.org/CD012119/SKIN_emollients-and-moisturisers-eczema" target="_blank">http://www.cochrane.org/CD012119/SKIN_emollients-and-moisturisers-eczema</a> <a href="#fnref:95" class="footnote-back-ref">↩</a></p></li> <li id="fn:96"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:96" class="footnote-back-ref">↩</a></p></li> <li id="fn:97"><p>Hoare C, Li Wan Po A, Williams H (2000). "Systematic review of treatments for atopic eczema". Health Technology Assessment. 4 (37): 1–191. doi:10.3310/hta4370. PMC 4782813. PMID 11134919. Retrieved 18 November 2009.[dead link] <a href="https://doi.org/10.3310%2Fhta4370" target="_blank">https://doi.org/10.3310%2Fhta4370</a> <a href="#fnref:97" class="footnote-back-ref">↩</a></p></li> <li id="fn:98"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:98" class="footnote-back-ref">↩</a></p></li> <li id="fn:99"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:99" class="footnote-back-ref">↩</a></p></li> <li id="fn:100"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:100" class="footnote-back-ref">↩</a></p></li> <li id="fn:101"><p>Bewley A (May 2008). "Expert consensus: time for a change in the way we advise our patients to use topical corticosteroids". The British Journal of Dermatology. 158 (5): 917–920. doi:10.1111/j.1365-2133.2008.08479.x. PMID 18294314. S2CID 46445371. <a href="https://doi.org/10.1111%2Fj.1365-2133.2008.08479.x" target="_blank">https://doi.org/10.1111%2Fj.1365-2133.2008.08479.x</a> <a href="#fnref:101" class="footnote-back-ref">↩</a></p></li> <li id="fn:102"><p>Oakley A. "Topical corticosteroid withdrawal". DermNet NZ. DermNet New Zealand Trust. Archived from the original on 16 March 2016. <a href="http://www.dermnetnz.org/reactions/topical-steroid-withdrawal.html" target="_blank">http://www.dermnetnz.org/reactions/topical-steroid-withdrawal.html</a> <a href="#fnref:102" class="footnote-back-ref">↩</a></p></li> <li id="fn:103"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:103" class="footnote-back-ref">↩</a></p></li> <li id="fn:104"><p>Apfelbacher CJ, van Zuuren EJ, Fedorowicz Z, Jupiter A, Matterne U, Weisshaar E (February 2013). "Oral H1 antihistamines as monotherapy for eczema". The Cochrane Database of Systematic Reviews. 2013 (2): CD007770. doi:10.1002/14651858.CD007770.pub2. PMC 6823266. PMID 23450580. <a href="http://www.cochrane.org/CD007770/SKIN_effects-antihistamines-eczema" target="_blank">http://www.cochrane.org/CD007770/SKIN_effects-antihistamines-eczema</a> <a href="#fnref:104" class="footnote-back-ref">↩</a></p></li> <li id="fn:105"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:105" class="footnote-back-ref">↩</a></p></li> <li id="fn:106"><p>Matterne U, Böhmer MM, Weisshaar E, Jupiter A, Carter B, Apfelbacher CJ (January 2019). "Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema". The Cochrane Database of Systematic Reviews. 1 (1): CD012167. doi:10.1002/14651858.CD012167.pub2. PMC 6360926. PMID 30666626. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360926" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360926</a> <a href="#fnref:106" class="footnote-back-ref">↩</a></p></li> <li id="fn:107"><p>Matterne U, Böhmer MM, Weisshaar E, Jupiter A, Carter B, Apfelbacher CJ (January 2019). "Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema". The Cochrane Database of Systematic Reviews. 1 (1): CD012167. doi:10.1002/14651858.CD012167.pub2. PMC 6360926. PMID 30666626. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360926" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360926</a> <a href="#fnref:107" class="footnote-back-ref">↩</a></p></li> <li id="fn:108"><p>Shams K, Grindlay DJ, Williams HC (August 2011). "What's new in atopic eczema? An analysis of systematic reviews published in 2009-2010". Clinical and Experimental Dermatology. 36 (6): 573–577, quiz 577–578. doi:10.1111/j.1365-2230.2011.04078.x. PMID 21718344. S2CID 42321918. <a href="https://doi.org/10.1111%2Fj.1365-2230.2011.04078.x" target="_blank">https://doi.org/10.1111%2Fj.1365-2230.2011.04078.x</a> <a href="#fnref:108" class="footnote-back-ref">↩</a></p></li> <li id="fn:109"><p>Carr WW (August 2013). "Topical calcineurin inhibitors for atopic dermatitis: review and treatment recommendations". Paediatric Drugs. 15 (4): 303–310. doi:10.1007/s40272-013-0013-9. PMC 3715696. PMID 23549982. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715696" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715696</a> <a href="#fnref:109" class="footnote-back-ref">↩</a></p></li> <li id="fn:110"><p>"Atopic eczema - Treatment". NHS Choices, London, UK. 12 February 2016. Archived from the original on 16 January 2017. Retrieved 27 January 2017. <a href="http://www.nhs.uk/Conditions/Eczema-(atopic)/Pages/Treatment.aspx" target="_blank">http://www.nhs.uk/Conditions/Eczema-(atopic)/Pages/Treatment.aspx</a> <a href="#fnref:110" class="footnote-back-ref">↩</a></p></li> <li id="fn:111"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:111" class="footnote-back-ref">↩</a></p></li> <li id="fn:112"><p>"Medication Guide. Elidel® (pimecrolimus) Cream, 1%" (PDF). US Food and Drug Administration. March 2014. Archived (PDF) from the original on 11 February 2017. Retrieved 27 January 2017. <a href="https://www.fda.gov/downloads/drugs/drugsafety/ucm088587.pdf" target="_blank">https://www.fda.gov/downloads/drugs/drugsafety/ucm088587.pdf</a> <a href="#fnref:112" class="footnote-back-ref">↩</a></p></li> <li id="fn:113"><p>Torley D, Futamura M, Williams HC, Thomas KS (July 2013). "What's new in atopic eczema? An analysis of systematic reviews published in 2010–11". Clinical and Experimental Dermatology. 38 (5): 449–456. doi:10.1111/ced.12143. PMID 23750610. S2CID 24638685. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:113" class="footnote-back-ref">↩</a></p></li> <li id="fn:114"><p>"Medication Guide. Elidel® (pimecrolimus) Cream, 1%" (PDF). US Food and Drug Administration. March 2014. Archived (PDF) from the original on 11 February 2017. Retrieved 27 January 2017. <a href="https://www.fda.gov/downloads/drugs/drugsafety/ucm088587.pdf" target="_blank">https://www.fda.gov/downloads/drugs/drugsafety/ucm088587.pdf</a> <a href="#fnref:114" class="footnote-back-ref">↩</a></p></li> <li id="fn:115"><p>Devasenapathy N, Chu A, Wong M, Srivastava A, Ceccacci R, Lin C, et al. (1 January 2023). "Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis". The Lancet Child & Adolescent Health. 7 (1): 13–25. doi:10.1016/S2352-4642(22)00283-8. ISSN 2352-4642. PMID 36370744. S2CID 253470127. <a href="https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00283-8/abstract" target="_blank">https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00283-8/abstract</a> <a href="#fnref:115" class="footnote-back-ref">↩</a></p></li> <li id="fn:116"><p>Dupilumab received approval from the US Food and Drug Administration for moderate-to-severe atopic dermatitis in 2017[72] and for asthma in 2018.[73] <a href="/wiki/Dupilumab" target="_blank">/wiki/Dupilumab</a> <a href="#fnref:116" class="footnote-back-ref">↩</a></p></li> <li id="fn:117"><p>Sawangjit R, Dilokthornsakul P, Lloyd-Lavery A, Lai NM, Dellavalle R, Chaiyakunapruk N (September 2020). "Systemic treatments for eczema: a network meta-analysis". The Cochrane Database of Systematic Reviews. 2020 (9): CD013206. doi:10.1002/14651858.cd013206.pub2. PMC 8128359. PMID 32927498. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128359" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128359</a> <a href="#fnref:117" class="footnote-back-ref">↩</a></p></li> <li id="fn:118"><p>Borda LJ, Perper M, Keri JE (March 2019). "Treatment of seborrheic dermatitis: a comprehensive review". The Journal of Dermatological Treatment. 30 (2): 158–169. doi:10.1080/09546634.2018.1473554. PMID 29737895. S2CID 13686180. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:118" class="footnote-back-ref">↩</a></p></li> <li id="fn:119"><p>"Incyte Announces U.S. FDA Approval of Opzelura (ruxolitinib) Cream, a Topical JAK Inhibitor, for the Treatment of Atopic Dermatitis (AD)". Incyte. 21 September 2021. Retrieved 21 September 2021 – via Business Wire. <a href="https://www.businesswire.com/news/home/20210921006072/en/" target="_blank">https://www.businesswire.com/news/home/20210921006072/en/</a> <a href="#fnref:119" class="footnote-back-ref">↩</a></p></li> <li id="fn:120"><p>"Incyte Announces U.S. FDA Approval of Opzelura (ruxolitinib) Cream, a Topical JAK Inhibitor, for the Treatment of Atopic Dermatitis (AD)". Incyte. 21 September 2021. Retrieved 21 September 2021 – via Business Wire. <a href="https://www.businesswire.com/news/home/20210921006072/en/" target="_blank">https://www.businesswire.com/news/home/20210921006072/en/</a> <a href="#fnref:120" class="footnote-back-ref">↩</a></p></li> <li id="fn:121"><p>Gambichler T, Breuckmann F, Boms S, Altmeyer P, Kreuter A (April 2005). "Narrowband UVB phototherapy in skin conditions beyond psoriasis". Journal of the American Academy of Dermatology. 52 (4): 660–670. doi:10.1016/j.jaad.2004.08.047. PMID 15793518. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:121" class="footnote-back-ref">↩</a></p></li> <li id="fn:122"><p>Le P, Tu J, Gebauer K, Brown S (May 2016). "Serum 25-hydroxyvitamin D increases with NB-UVB and UVA/UVB phototherapy in patients with psoriasis and atopic dermatitis in Western Australia". The Australasian Journal of Dermatology. 57 (2): 115–121. doi:10.1111/ajd.12315. PMID 25916422. S2CID 41245703. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:122" class="footnote-back-ref">↩</a></p></li> <li id="fn:123"><p>Gambichler T (March 2009). "Management of atopic dermatitis using photo(chemo)therapy". Archives of Dermatological Research. 301 (3): 197–203. doi:10.1007/s00403-008-0923-5. PMID 19142651. S2CID 29045951. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:123" class="footnote-back-ref">↩</a></p></li> <li id="fn:124"><p>Meduri NB, Vandergriff T, Rasmussen H, Jacobe H (August 2007). "Phototherapy in the management of atopic dermatitis: a systematic review". Photodermatology, Photoimmunology & Photomedicine. 23 (4): 106–112. doi:10.1111/j.1600-0781.2007.00291.x. PMID 17598862. S2CID 25684608. <a href="https://doi.org/10.1111%2Fj.1600-0781.2007.00291.x" target="_blank">https://doi.org/10.1111%2Fj.1600-0781.2007.00291.x</a> <a href="#fnref:124" class="footnote-back-ref">↩</a></p></li> <li id="fn:125"><p>Stöppler MC (31 May 2007). "Psoriasis PUVA Treatment Can Increase Melanoma Risk". MedicineNet. Archived from the original on 29 September 2007. Retrieved 17 October 2007. <a href="http://www.medicinenet.com/script/main/art.asp?articlekey=548" target="_blank">http://www.medicinenet.com/script/main/art.asp?articlekey=548</a> <a href="#fnref:125" class="footnote-back-ref">↩</a></p></li> <li id="fn:126"><p>Eldred DC, Tuchin PJ (November 1999). "Treatment of acute atopic eczema by chiropractic care. A case study". Australasian Chiropractic & Osteopathy. 8 (3): 96–101. PMC 2051093. PMID 17987197. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2051093" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2051093</a> <a href="#fnref:126" class="footnote-back-ref">↩</a></p></li> <li id="fn:127"><p>Ersser SJ, Cowdell F, Latter S, Gardiner E, Flohr C, Thompson AR, et al. (January 2014). "Psychological and educational interventions for atopic eczema in children". The Cochrane Database of Systematic Reviews. 2014 (1): CD004054. doi:10.1002/14651858.CD004054.pub3. PMC 6457897. PMID 24399641. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457897" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457897</a> <a href="#fnref:127" class="footnote-back-ref">↩</a></p></li> <li id="fn:128"><p>Barnes TM, Greive KA (November 2013). "Use of bleach baths for the treatment of infected atopic eczema". The Australasian Journal of Dermatology. 54 (4): 251–258. doi:10.1111/ajd.12015. PMID 23330843. S2CID 19644659. <a href="https://doi.org/10.1111%2Fajd.12015" target="_blank">https://doi.org/10.1111%2Fajd.12015</a> <a href="#fnref:128" class="footnote-back-ref">↩</a></p></li> <li id="fn:129"><p>"Sulfur". University of Maryland Medical Center. 1 April 2002. Archived from the original on 5 August 2012. Retrieved 15 October 2007. <a href="http://www.umm.edu/altmed/articles/000328.htm" target="_blank">http://www.umm.edu/altmed/articles/000328.htm</a> <a href="#fnref:129" class="footnote-back-ref">↩</a></p></li> <li id="fn:130"><p>Armstrong NC, Ernst E (August 1999). "The treatment of eczema with Chinese herbs: a systematic review of randomized clinical trials". British Journal of Clinical Pharmacology. 48 (2): 262–264. doi:10.1046/j.1365-2125.1999.00004.x. PMC 2014284. PMID 10417508. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014284" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014284</a> <a href="#fnref:130" class="footnote-back-ref">↩</a></p></li> <li id="fn:131"><p>Bath-Hextall FJ, Jenkinson C, Humphreys R, Williams HC (February 2012). Bath-Hextall FJ (ed.). "Dietary supplements for established atopic eczema". The Cochrane Database of Systematic Reviews. 2 (2): CD005205. doi:10.1002/14651858.CD005205.pub3. PMC 6517242. PMID 22336810. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517242" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517242</a> <a href="#fnref:131" class="footnote-back-ref">↩</a></p></li> <li id="fn:132"><p>Bamford JT, Ray S, Musekiwa A, van Gool C, Humphreys R, Ernst E (April 2013). Bamford JT (ed.). "Oral evening primrose oil and borage oil for eczema". The Cochrane Database of Systematic Reviews. 4 (4): CD004416. doi:10.1002/14651858.CD004416.pub2. PMC 8105655. PMID 23633319. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105655" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105655</a> <a href="#fnref:132" class="footnote-back-ref">↩</a></p></li> <li id="fn:133"><p>Bamford JT, Ray S, Musekiwa A, van Gool C, Humphreys R, Ernst E (April 2013). Bamford JT (ed.). "Oral evening primrose oil and borage oil for eczema". The Cochrane Database of Systematic Reviews. 4 (4): CD004416. doi:10.1002/14651858.CD004416.pub2. PMC 8105655. PMID 23633319. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105655" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105655</a> <a href="#fnref:133" class="footnote-back-ref">↩</a></p></li> <li id="fn:134"><p>Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang ML, Roberts A, et al. (November 2018). "Probiotics for treating eczema". The Cochrane Database of Systematic Reviews. 2018 (11): CD006135. doi:10.1002/14651858.CD006135.pub3. PMC 6517242. PMID 30480774. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517242" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517242</a> <a href="#fnref:134" class="footnote-back-ref">↩</a></p></li> <li id="fn:135"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:135" class="footnote-back-ref">↩</a></p></li> <li id="fn:136"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:136" class="footnote-back-ref">↩</a></p></li> <li id="fn:137"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:137" class="footnote-back-ref">↩</a></p></li> <li id="fn:138"><p>Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. (December 2012). "Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2163–2196. doi:10.1016/S0140-6736(12)61729-2. PMC 6350784. PMID 23245607. <a href="http://www.documentation.ird.fr/hor/fdi:010059240" target="_blank">http://www.documentation.ird.fr/hor/fdi:010059240</a> <a href="#fnref:138" class="footnote-back-ref">↩</a></p></li> <li id="fn:139"><p>Osman M, Hansell AL, Simpson CR, Hollowell J, Helms PJ (February 2007). "Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care". Primary Care Respiratory Journal. 16 (1): 28–35. doi:10.3132/pcrj.2007.00006. PMC 6634172. PMID 17297524. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634172" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634172</a> <a href="#fnref:139" class="footnote-back-ref">↩</a></p></li> <li id="fn:140"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:140" class="footnote-back-ref">↩</a></p></li> <li id="fn:141"><p>Taylor B, Wadsworth J, Wadsworth M, Peckham C (December 1984). "Changes in the reported prevalence of childhood eczema since the 1939–45 war". Lancet. 2 (8414): 1255–1257. doi:10.1016/S0140-6736(84)92805-8. PMID 6150286. S2CID 2842761. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:141" class="footnote-back-ref">↩</a></p></li> <li id="fn:142"><p>McAleer MA, Flohr C, Irvine AD (July 2012). "Management of difficult and severe eczema in childhood" (PDF). BMJ. 345: e4770. doi:10.1136/bmj.e4770. hdl:2262/75991. PMID 22826585. S2CID 36038433. <a href="http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf" target="_blank">http://www.tara.tcd.ie/bitstream/2262/75991/1/PMID%2022826585%20Difficult%20and%20severe%20AD%20in%20childhood.pdf</a> <a href="#fnref:142" class="footnote-back-ref">↩</a></p></li> <li id="fn:143"><p>Simpson CR, Newton J, Hippisley-Cox J, Sheikh A (March 2009). "Trends in the epidemiology and prescribing of medication for eczema in England". Journal of the Royal Society of Medicine. 102 (3): 108–117. doi:10.1258/jrsm.2009.080211. PMC 2746851. PMID 19297652. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746851" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746851</a> <a href="#fnref:143" class="footnote-back-ref">↩</a></p></li> <li id="fn:144"><p>Luckhaupt SE, Dahlhamer JM, Ward BW, Sussell AL, Sweeney MH, Sestito JP, et al. (June 2013). "Prevalence of dermatitis in the working population, United States, 2010 National Health Interview Survey". American Journal of Industrial Medicine. 56 (6): 625–634. doi:10.1002/ajim.22080. PMID 22674651. <a href="https://zenodo.org/record/1229093" target="_blank">https://zenodo.org/record/1229093</a> <a href="#fnref:144" class="footnote-back-ref">↩</a></p></li> <li id="fn:145"><p>Textbook of Atopic Dermatitis. Taylor & Francis. 1 May 2008. p. 1. ISBN 978-0-203-09144-9. Archived from the original on 28 May 2016. <a href="978-0-203-09144-9" target="_blank">978-0-203-09144-9</a> <a href="#fnref:145" class="footnote-back-ref">↩</a></p></li> <li id="fn:146"><p>"Sulfur". University of Maryland Medical Center. 1 April 2002. Archived from the original on 5 August 2012. Retrieved 15 October 2007. <a href="http://www.umm.edu/altmed/articles/000328.htm" target="_blank">http://www.umm.edu/altmed/articles/000328.htm</a> <a href="#fnref:146" class="footnote-back-ref">↩</a></p></li> <li id="fn:147"><p>"Definition of ECZEMA". www.merriam-webster.com. Archived from the original on 22 February 2016. Retrieved 15 February 2016. <a href="http://www.merriam-webster.com/dictionary/eczema" target="_blank">http://www.merriam-webster.com/dictionary/eczema</a> <a href="#fnref:147" class="footnote-back-ref">↩</a></p></li> <li id="fn:148"><p>Center for Food Safety and Applied Nutrition (1 September 2020). ""Hypoallergenic" Cosmetics". FDA. <a href="https://www.fda.gov/cosmetics/cosmetics-labeling-claims/hypoallergenic-cosmetics" target="_blank">https://www.fda.gov/cosmetics/cosmetics-labeling-claims/hypoallergenic-cosmetics</a> <a href="#fnref:148" class="footnote-back-ref">↩</a></p></li> <li id="fn:149"><p>Murphy LA, White IR, Rastogi SC (May 2004). "Is hypoallergenic a credible term?". Clinical and Experimental Dermatology. 29 (3): 325–7. doi:10.1111/j.1365-2230.2004.01521.x. PMID 15115531. S2CID 41482522. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:149" class="footnote-back-ref">↩</a></p></li> <li id="fn:150"><p>Center for Food Safety and Applied Nutrition (1 September 2020). ""Hypoallergenic" Cosmetics". FDA. <a href="https://www.fda.gov/cosmetics/cosmetics-labeling-claims/hypoallergenic-cosmetics" target="_blank">https://www.fda.gov/cosmetics/cosmetics-labeling-claims/hypoallergenic-cosmetics</a> <a href="#fnref:150" class="footnote-back-ref">↩</a></p></li> <li id="fn:151"><p>"Technical document on cosmetic claims". ec.europa.eu. European Commission. Retrieved 7 December 2020. <a href="https://ec.europa.eu/docsroom/documents/24847/" target="_blank">https://ec.europa.eu/docsroom/documents/24847/</a> <a href="#fnref:151" class="footnote-back-ref">↩</a></p></li> <li id="fn:152"><p>Kulliney K (6 September 2019). "EU 'free from' cosmetics claims technical document is guidance, not regulation: Expert". cosmeticsdesign-europe.com. Retrieved 7 December 2020. <a href="https://www.cosmeticsdesign-europe.com/Article/2019/09/06/Cosmetics-free-from-claims-guidance-EU-explained" target="_blank">https://www.cosmeticsdesign-europe.com/Article/2019/09/06/Cosmetics-free-from-claims-guidance-EU-explained</a> <a href="#fnref:152" class="footnote-back-ref">↩</a></p></li> <li id="fn:153"><p>Snast I, Reiter O, Hodak E, Friedland R, Mimouni D, Leshem YA (April 2018). "Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis". American Journal of Clinical Dermatology. 19 (2): 145–165. doi:10.1007/s40257-017-0324-7. PMID 29098604. S2CID 4220890. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:153" class="footnote-back-ref">↩</a></p></li> <li id="fn:154"><p>Lauffer F, Ring J (2016). "Target-oriented therapy: Emerging drugs for atopic dermatitis". Expert Opinion on Emerging Drugs. 21 (1): 81–89. doi:10.1517/14728214.2016.1146681. PMID 26808004. S2CID 207484890. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:154" class="footnote-back-ref">↩</a></p></li> </ol>