Early wins for Kasowitz included obtaining a $300 million settlement on behalf of 3,500 Alabama residents who were allegedly poisoned by seepage from a Monsanto Company plant manufacturing PCBs. On the defense side, Kasowitz has represented cigarette manufacturer Liggett Group for over 20 years, and in the late 1990s broke ranks with Big Tobacco in negotiated historic settlements of smoking and health litigation, which led to industry-wide settlements.
In Spring 2017, Kasowitz told associates that he had been personally responsible for the abrupt dismissal of U.S. Attorney Preet Bharara on March 11, 2017, having previously warned Trump, "This guy is going to get you".
Kasowitz departed Trump's White House legal team on July 20, 2017 (see below).
Kasowitz is married to Lori Kasowitz, whom he met while she was working as a manager at Mayer Brown. In 2001, they created the Marc E. and Lori A. Kasowitz Scholarship at Cornell Law School. In 2007, they pledged an additional $250,000 to the law school's endowment. He and his twin brother, Stephen established a scholarship at Hopkins School, which they attended growing up.
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