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HOXB2
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<h2 id="function">Function</h2> <p>This gene is a member of the <a href="/facts/Antp/LC8ANlxq">Antp</a> homeobox family and encodes a <a href="/facts/Nuclear_protein/S03lX9Ye">nuclear protein</a> with a <a href="/facts/Homeobox/bpvuuw3v">homeobox</a> <a href="/facts/DNA-binding_domain/x2vlHUKl">DNA-binding domain</a>. It is included in a <a href="/facts/Gene_cluster/0Goyb8eB">cluster</a> of homeobox B genes located on <a href="/facts/Chromosome_17/SzAlnKTV">chromosome 17</a>. The encoded protein functions as a <a href="/facts/DNA_sequence/hsPsNCQW">sequence</a>-specific <a href="/facts/Transcription_factor/wro0DPHe">transcription factor</a> that is involved in development. Increased <a href="/facts/Gene_expression/alCPohLR">expression of this gene</a> is associated with <a href="/facts/Pancreatic_cancer/6h9GIInW">pancreatic cancer</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Homeobox/bpvuuw3v">Homeobox</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52286">"A homeodomain protein binds to gamma-globin gene regulatory sequences"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 88 (16): 7318–22. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1991PNAS...88.7318L">1991PNAS...88.7318L</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.88.16.7318">10.1073/pnas.88.16.7318</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52286">52286</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1871139">1871139</a>.</li> <li>Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". <i>Differentiation; Research in Biological Diversity</i>. 40 (3): 191–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1432-0436.1989.tb00598.x">10.1111/j.1432-0436.1989.tb00598.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2570724">2570724</a>.</li> <li>Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335308">"The human HOX gene family"</a>. <i>Nucleic Acids Research</i>. 17 (24): 10385–402. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F17.24.10385">10.1093/nar/17.24.10385</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC335308">335308</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2574852">2574852</a>.</li> <li>Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". <i>Genome</i>. 31 (2): 745–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1139%2Fg89-133">10.1139/g89-133</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2576652">2576652</a>.</li> <li>Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC454515">"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages"</a>. <i>The EMBO Journal</i>. 7 (7): 2131–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1988.tb03052.x">10.1002/j.1460-2075.1988.tb03052.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC454515">454515</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2901346">2901346</a>.</li> <li>Vieille-Grosjean I, Huber P (Mar 1995). <a href="https://doi.org/10.1074%2Fjbc.270.9.4544">"Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells"</a>. <i>The Journal of Biological Chemistry</i>. 270 (9): 4544–50. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.9.4544">10.1074/jbc.270.9.4544</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7876223">7876223</a>.</li> <li>Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395231">"The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins"</a>. <i>The EMBO Journal</i>. 13 (14): 3339–47. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1994.tb06636.x">10.1002/j.1460-2075.1994.tb06636.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395231">395231</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7913891">7913891</a>.</li> <li>Guazzi S, Pintonello ML, Viganò A, Boncinelli E (May 1998). <a href="https://doi.org/10.1074%2Fjbc.273.18.11092">"Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells"</a>. <i>The Journal of Biological Chemistry</i>. 273 (18): 11092–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.18.11092">10.1074/jbc.273.18.11092</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9556594">9556594</a>.</li> <li>Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). <a href="https://doi.org/10.1016%2FS0896-6273%2800%2980728-X">"Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain"</a>. <i>Neuron</i>. 22 (4): 677–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0896-6273%2800%2980728-X">10.1016/S0896-6273(00)80728-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10230789">10230789</a>.</li> <li>Case SS, Huber P, Lloyd JA (Nov 1999). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". <i>DNA and Cell Biology</i>. 18 (11): 805–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1089%2F104454999314809">10.1089/104454999314809</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10595394">10595394</a>.</li> <li>Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850338">"HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema"</a>. <i>The American Journal of Pathology</i>. 158 (3): 955–66. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0002-9440%2810%2964042-4">10.1016/S0002-9440(10)64042-4</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850338">1850338</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11238043">11238043</a>.</li> <li>Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99922">"The HOX homeodomain proteins block CBP histone acetyltransferase activity"</a>. <i>Molecular and Cellular Biology</i>. 21 (21): 7509–22. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.21.21.7509-7522.2001">10.1128/MCB.21.21.7509-7522.2001</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99922">99922</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11585930">11585930</a>.</li> <li>Liu X, Zhang X (Feb 2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". <i>Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi</i>. 5 (1): 12–5. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11835749">11835749</a>.</li> <li>Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". <i>Teratology</i>. 65 (2): 50–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Ftera.10009">10.1002/tera.10009</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11857506">11857506</a>.</li> <li>Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). <a href="https://doi.org/10.1038%2Fsj.onc.1206328">"Regulation of Hoxb2 by APL-associated PLZF protein"</a>. <i>Oncogene</i>. 22 (24): 3685–97. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1206328">10.1038/sj.onc.1206328</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12802276">12802276</a>.</li> <li>Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". <i>Clinical Cancer Research</i>. 11 (9): 3587–96. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1158%2F1078-0432.CCR-04-1813">10.1158/1078-0432.CCR-04-1813</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15867264">15867264</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:15485235">15485235</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=HOXB2+protein%2C+human">HOXB2+protein,+human</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: HOXB2 homeobox B2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: HOXB2 homeobox B2". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> </ol>