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TIMP3
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<h2 id="see-also">See also</h2> <ul><li><a href="/facts/TIMP1/doujfV9l">TIMP1</a>, <a href="/facts/TIMP2/rB4AKzUs">TIMP2</a>, <a href="/facts/TIMP4/UEo2NTsy">TIMP4</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Li Z, Clarke MP, Barker MD, McKie N (2007). "TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights". <i>Expert Reviews in Molecular Medicine</i>. 7 (24): 1–15. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1017%2FS1462399405010045">10.1017/S1462399405010045</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16259644">16259644</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:20685857">20685857</a>.</li> <li>Docherty AJ, Lyons A, Smith BJ, et al. (1985). "Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity". <i>Nature</i>. 318 (6041): 66–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1985Natur.318...66D">1985Natur.318...66D</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2F318066a0">10.1038/318066a0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/3903517">3903517</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:4325067">4325067</a>.</li> <li>Forsius HR, Eriksson AW, Suvanto EA, Alanko HI (1983). "Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance". <i>Am. J. Ophthalmol</i>. 94 (5): 634–49. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0002-9394%2882%2990009-5">10.1016/0002-9394(82)90009-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7148944">7148944</a>.</li> <li>Wick M, Härönen R, Mumberg D, et al. (1995). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136034">"Structure of the human TIMP-3 gene and its cell cycle-regulated promoter"</a>. <i>Biochem. J</i>. 311. ( Pt 2) (2): 549–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1042%2Fbj3110549">10.1042/bj3110549</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1136034">1136034</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7487894">7487894</a>.</li> <li>Jacobson SG, Cideciyan AV, Regunath G, et al. (1995). "Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.". <i>Nat. Genet</i>. 11 (1): 27–32. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng0995-27">10.1038/ng0995-27</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7550309">7550309</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:7779127">7779127</a>.</li> <li>Higuchi T, Kanzaki H, Nakayama H, et al. (1995). "Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human endometrial stromal cells". <i>Endocrinology</i>. 136 (11): 4973–81. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1210%2Fendo.136.11.7588231">10.1210/endo.136.11.7588231</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7588231">7588231</a>.</li> <li>Wilde CG, Hawkins PR, Coleman RT, et al. (1995). "Cloning and characterization of human tissue inhibitor of metalloproteinases-3". <i>DNA Cell Biol</i>. 13 (7): 711–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1089%2Fdna.1994.13.711">10.1089/dna.1994.13.711</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7772252">7772252</a>.</li> <li>Apte SS, Olsen BR, Murphy G (1995). <a href="https://doi.org/10.1074%2Fjbc.270.24.14313">"The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family"</a>. <i>J. Biol. Chem</i>. 270 (24): 14313–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.270.24.14313">10.1074/jbc.270.24.14313</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7782289">7782289</a>.</li> <li>Kishnani NS, Staskus PW, Yang TT, et al. (1995). "Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix". <i>Matrix Biol</i>. 14 (6): 479–88. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0945-053X%2895%2990005-5">10.1016/0945-053X(95)90005-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7795886">7795886</a>.</li> <li>Weber BH, Vogt G, Pruett RC, et al. (1995). "Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy". <i>Nat. Genet</i>. 8 (4): 352–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng1294-352">10.1038/ng1294-352</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7894485">7894485</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:19386047">19386047</a>.</li> <li>Weber BH, Vogt G, Wolz W, et al. (1994). "Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter". <i>Nat. Genet</i>. 7 (2): 158–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng0694-158">10.1038/ng0694-158</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7920634">7920634</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:22060034">22060034</a>.</li> <li>Jones SE, Jomary C, Neal MJ (1994). "Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa". <i>FEBS Lett</i>. 352 (2): 171–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2894%2900951-1">10.1016/0014-5793(94)00951-1</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7925969">7925969</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33038960">33038960</a>.</li> <li>Wick M, Bürger C, Brüsselbach S, et al. (1994). <a href="https://doi.org/10.1016%2FS0021-9258%2817%2932259-7">"A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence"</a>. <i>J. Biol. Chem</i>. 269 (29): 18953–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2817%2932259-7">10.1016/S0021-9258(17)32259-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8034652">8034652</a>.</li> <li>Silbiger SM, Jacobsen VL, Cupples RL, Koski RA (1994). "Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family". <i>Gene</i>. 141 (2): 293–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2894%2990588-6">10.1016/0378-1119(94)90588-6</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8163205">8163205</a>.</li> <li>Uría JA, Ferrando AA, Velasco G, et al. (1994). "Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family". <i>Cancer Res</i>. 54 (8): 2091–4. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8174111">8174111</a>.</li> <li>Byrne JA, Tomasetto C, Rouyer N, et al. (1996). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229996">"The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression"</a>. <i>Mol. Med</i>. 1 (4): 418–27. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2FBF03401579">10.1007/BF03401579</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229996">2229996</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8521299">8521299</a>.</li> <li>Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". <i>Anal. Biochem</i>. 236 (1): 107–13. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fabio.1996.0138">10.1006/abio.1996.0138</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8619474">8619474</a>.</li> <li>Felbor U, Stöhr H, Amann T, et al. (1996). "A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features". <i>Hum. Mol. Genet</i>. 4 (12): 2415–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fhmg%2F4.12.2415">10.1093/hmg/4.12.2415</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8634721">8634721</a>.</li> <li>Carrero-Valenzuela RD, Klein ML, Weleber RG, et al. (1996). "Sorsby fundus dystrophy. A family with the Ser181Cys mutation of the tissue inhibitor of metalloproteinases 3". <i>Arch. Ophthalmol</i>. 114 (6): 737–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1001%2Farchopht.1996.01100130729016">10.1001/archopht.1996.01100130729016</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8639088">8639088</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li>The <a href="/facts/MEROPS/kgboIz3H">MEROPS</a> online database for peptidases and their inhibitors: <a href="http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I35.003">I35.003</a></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. 19 (1): 86–90. doi:10.1006/geno.1994.1016. PMID 8188246. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295. S2CID 12563403. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7078" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7078</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>