Chitin synthase

<h2 id="production">Production</h2>
<p>Chitin Synthase is manufactured in the <a href="/facts/Rough_endoplasmic_reticulum/DVbLA7GE">rough endoplasmic reticulum</a> of fungi as the inactive form, <a href="/facts/Zymogen/Qa9SGXVS">zymogen</a>. The zymogen is then packaged into chitosomes in the <a href="/facts/Golgi_apparatus/F91pGb3t">golgi apparatus</a>. Chitosomes bring the zymogen to the <a href="/facts/Hyphal/xogd3AHz">hyphal</a> tip of a mold or yeast cell membrane. Chitin synthase is placed into the interior side of the cell membrane and then activated.
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<h2 id="inhibition">Inhibition</h2>
<p><a href="/facts/Benzoylurea_insecticide/wxrUGBM6">Benzoylurea</a> as well as <a href="/facts/Insect_growth_regulator/wdMKz354">other insecticides</a> act as <a href="/facts/Insect_growth_regulator/wdMKz354">insect growth regulators</a> by inhibiting this enzyme and thus preventing the formation of <a href="/facts/Chitin/Fo1f8b86">chitin</a>.<a class="footnote-ref" id="fnref:1" href="#fn:1"><sup>1</sup></a> They are in <a href="/facts/Insecticide_Resistance_Action_Committee/j72wrfn1">IRAC</a> <a href="/facts/Mode_of_action/NT1TCXTS">mode of action</a> groups 10, 15 and 16.<a class="footnote-ref" id="fnref:2" href="#fn:2"><sup>2</sup></a>
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<ul><li>GLASER L, BROWN DH (1957). "The synthesis of chitin in cell-free extracts of Neurospora crassa". <i>J. Biol. Chem</i>. 228 (2): 729–42. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/13475355">13475355</a>.</li>
<li>Sburlati A, Cabib E (1986). "Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae". <i>J. Biol. Chem</i>. 261 (32): 15147–52. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2945823">2945823</a>.</li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1"><p>Douris, Vassilis; Steinbach, Denise; Panteleri, Rafaela; Livadaras, Ioannis; Pickett, John Anthony; Van Leeuwen, Thomas; Nauen, Ralf; Vontas, John (2016). "2016". Proceedings of the National Academy of Sciences. 113 (51): 14692–14697. doi:10.1073/pnas.1618258113. PMC 5187681. PMID 27930336. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187681" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187681</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li>
<li id="fn:2"><p>"The IRAC Mode of Action Classification Online". Insecticide Resistance Action Committee (IRAC). Retrieved 7 December 2024. <a href="https://irac-online.org/mode-of-action/classification-online/" target="_blank">https://irac-online.org/mode-of-action/classification-online/</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li>
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Chitin synthase open-in-new

Chitin synthase