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Myogenin
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<h2 id="interactions">Interactions</h2> <p>Myogenin has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with: </p> <ul><li><a href="/facts/MDFI/fPjXVQTu">MDFI</a>,<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a></li> <li><a href="/facts/POLR2C/aqyp7hYC">POLR2C</a>,<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a></li> <li><a href="/facts/Serum_response_factor/QNy7fuaE">Serum response factor</a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li> <li><a href="/facts/Sp1_transcription_factor/Tz4tCgbE">Sp1 transcription factor</a>,<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> and</li> <li><a href="/facts/TCF3/bVTketek">TCF3</a>.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a><a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell TK, Turner D, Rupp R, Hollenberg S (February 1991). "The myoD gene family: nodal point during specification of the muscle cell lineage". <i>Science</i>. 251 (4995): 761–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1991Sci...251..761W">1991Sci...251..761W</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1846704">10.1126/science.1846704</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1846704">1846704</a>.</li> <li>Chakraborty T, Martin JF, Olson EN (September 1992). <a href="https://doi.org/10.1016%2FS0021-9258%2819%2937069-3">"Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system"</a>. <i>The Journal of Biological Chemistry</i>. 267 (25): 17498–501. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0021-9258%2819%2937069-3">10.1016/S0021-9258(19)37069-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1325437">1325437</a>.</li> <li>Funk WD, Wright WE (October 1992). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50156">"Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 89 (20): 9484–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1992PNAS...89.9484F">1992PNAS...89.9484F</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.89.20.9484">10.1073/pnas.89.20.9484</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC50156">50156</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1329097">1329097</a>.</li> <li>Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A, Baltimore D, Weintraub H (July 1991). "Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo". <i>Cell</i>. 66 (2): 305–15. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0092-8674%2891%2990620-E">10.1016/0092-8674(91)90620-E</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1649701">1649701</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:25957022">25957022</a>.</li> <li>Salminen A, Braun T, Buchberger A, Jürs S, Winter B, Arnold HH (November 1991). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289955">"Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins"</a>. <i>The Journal of Cell Biology</i>. 115 (4): 905–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1083%2Fjcb.115.4.905">10.1083/jcb.115.4.905</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289955">2289955</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1659574">1659574</a>.</li> <li>Pearson-White SH (March 1991). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC333794">"Human MyoD: cDNA and deduced amino acid sequence"</a>. <i>Nucleic Acids Research</i>. 19 (5): 1148. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F19.5.1148">10.1093/nar/19.5.1148</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC333794">333794</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1850513">1850513</a>.</li> <li>Olson E, Edmondson D, Wright WE, Lin VK, Guenet JL, Simon-Chazottes D, Thompson LH, Stallings RL, Schroeder WT, Duvic M (November 1990). "Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes". <i>Genomics</i>. 8 (3): 427–34. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0888-7543%2890%2990028-S">10.1016/0888-7543(90)90028-S</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1962752">1962752</a>.</li> <li>Brennan TJ, Olson EN (April 1990). <a href="https://doi.org/10.1101%2Fgad.4.4.582">"Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization"</a>. <i>Genes & Development</i>. 4 (4): 582–95. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1101%2Fgad.4.4.582">10.1101/gad.4.4.582</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2163343">2163343</a>.</li> <li>Braun T, Bober E, Buschhausen-Denker G, Kohtz S, Grzeschik KH, Arnold HH, Kotz S (December 1989). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC402043">"Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products"</a>. <i>The EMBO Journal</i>. 8 (12): 3617–25. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1989.tb08535.x">10.1002/j.1460-2075.1989.tb08535.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC402043">402043</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/2583111">2583111</a>.</li> <li>Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A (March 1996). <a href="https://doi.org/10.1074%2Fjbc.271.9.5258">"Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins"</a>. <i>The Journal of Biological Chemistry</i>. 271 (9): 5258–64. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.271.9.5258">10.1074/jbc.271.9.5258</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8617811">8617811</a>.</li> <li>Chen CM, Kraut N, Groudine M, Weintraub H (September 1996). <a href="https://doi.org/10.1016%2FS0092-8674%2800%2980148-8">"I-mf, a novel myogenic repressor, interacts with members of the MyoD family"</a>. <i>Cell</i>. 86 (5): 731–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0092-8674%2800%2980148-8">10.1016/S0092-8674(00)80148-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8797820">8797820</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:16252710">16252710</a>.</li> <li>Kong Y, Flick MJ, Kudla AJ, Konieczny SF (August 1997). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232327">"Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD"</a>. <i>Molecular and Cellular Biology</i>. 17 (8): 4750–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2Fmcb.17.8.4750">10.1128/mcb.17.8.4750</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232327">232327</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9234731">9234731</a>.</li> <li>Langlands K, Yin X, Anand G, Prochownik EV (August 1997). <a href="https://doi.org/10.1074%2Fjbc.272.32.19785">"Differential interactions of Id proteins with basic-helix-loop-helix transcription factors"</a>. <i>The Journal of Biological Chemistry</i>. 272 (32): 19785–93. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.32.19785">10.1074/jbc.272.32.19785</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9242638">9242638</a>.</li> <li>Biesiada E, Hamamori Y, Kedes L, Sartorelli V (April 1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050">"Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter"</a>. <i>Molecular and Cellular Biology</i>. 19 (4): 2577–84. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1128%2FMCB.19.4.2577">10.1128/MCB.19.4.2577</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050">84050</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10082523">10082523</a>.</li> <li>Tseng BS, Cavin ST, Hoffman EP, Iannaccone ST, Mancias P, Booth FW, Butler IJ (May 1999). "Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies". <i>Genomics</i>. 57 (3): 419–23. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1998.5719">10.1006/geno.1998.5719</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10329008">10329008</a>.</li> <li>Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP (September 1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148632">"A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1"</a>. <i>Nucleic Acids Research</i>. 27 (18): 3752–61. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fnar%2F27.18.3752">10.1093/nar/27.18.3752</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148632">148632</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10471746">10471746</a>.</li> <li>Onions J, Hermann S, Grundström T (April 2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". <i>Biochemistry</i>. 39 (15): 4366–74. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fbi992533u">10.1021/bi992533u</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10757985">10757985</a>.</li> <li>Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (October 2002). <a href="https://doi.org/10.1096%2Ffj.02-0123fje">"The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin"</a>. <i>FASEB Journal</i>. 16 (12): 1639–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1096%2Ffj.02-0123fje">10.1096/fj.02-0123fje</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12207009">12207009</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:30243193">30243193</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://meshb.nlm.nih.gov/record/ui?name=Myogenin">Myogenin</a> at the U.S. National Library of Medicine <a href="/facts/Medical_Subject_Headings/C57g2JuF">Medical Subject Headings</a> (MeSH)</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"MYOG - Myogenin - Homo sapiens (Human) - MYOG gene & protein". www.uniprot.org. <a href="https://www.uniprot.org/uniprot/P15173" target="_blank">https://www.uniprot.org/uniprot/P15173</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH (August 1993). "Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene". Nature. 364 (6437): 501–6. Bibcode:1993Natur.364..501H. doi:10.1038/364501a0. PMID 8393145. S2CID 4372223. <a href="/wiki/Bibcode_(identifier)" target="_blank">/wiki/Bibcode_(identifier)</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nonaka I, Nabeshima Y (August 1993). "Myogenin gene disruption results in perinatal lethality because of severe muscle defect". Nature. 364 (6437): 532–5. Bibcode:1993Natur.364..532N. doi:10.1038/364532a0. PMID 8393146. S2CID 4055548. <a href="/wiki/Bibcode_(identifier)" target="_blank">/wiki/Bibcode_(identifier)</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Chen CM, Kraut N, Groudine M, Weintraub H (September 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/s0092-8674(00)80148-8. PMID 8797820. S2CID 16252710. <a href="https://doi.org/10.1016%2Fs0092-8674%2800%2980148-8" target="_blank">https://doi.org/10.1016%2Fs0092-8674%2800%2980148-8</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB Journal. 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009. S2CID 30243193. <a href="https://doi.org/10.1096%2Ffj.02-0123fje" target="_blank">https://doi.org/10.1096%2Ffj.02-0123fje</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Biesiada E, Hamamori Y, Kedes L, Sartorelli V (April 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Molecular and Cellular Biology. 19 (4): 2577–84. doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A (March 1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". The Journal of Biological Chemistry. 271 (9): 5258–64. doi:10.1074/jbc.271.9.5258. PMID 8617811. <a href="https://doi.org/10.1074%2Fjbc.271.9.5258" target="_blank">https://doi.org/10.1074%2Fjbc.271.9.5258</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Biesiada E, Hamamori Y, Kedes L, Sartorelli V (April 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Molecular and Cellular Biology. 19 (4): 2577–84. doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84050</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Langlands K, Yin X, Anand G, Prochownik EV (August 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry. 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. PMID 9242638. <a href="https://doi.org/10.1074%2Fjbc.272.32.19785" target="_blank">https://doi.org/10.1074%2Fjbc.272.32.19785</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>Chakraborty T, Martin JF, Olson EN (September 1992). "Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system". The Journal of Biological Chemistry. 267 (25): 17498–501. doi:10.1016/S0021-9258(19)37069-3. PMID 1325437. <a href="https://doi.org/10.1016%2FS0021-9258%2819%2937069-3" target="_blank">https://doi.org/10.1016%2FS0021-9258%2819%2937069-3</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> </ol>