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Intracellular parasite
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<h2 id="types">Types</h2> <p>There are two main types of intracellular parasites: Facultative and Obligate.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p><p>Facultative intracellular parasites are capable of living and reproducing in or outside of host cells. Obligate intracellular parasites, on the other hand, need a host cell to live and reproduce. Many of these types of cells require specialized host types, and invasion of host cells occurs in different ways.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p> <h3>Facultative</h3> <p>Facultative intracellular parasites are capable of living and reproducing either inside or outside cells. </p><p>Bacterial examples include: </p> <ul><li><i><a href="/facts/Bartonella_henselae/HSKMLu9j">Bartonella henselae</a></i><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a></li> <li><i><a href="/facts/Francisella_tularensis/JcmsRq6m">Francisella tularensis</a></i></li> <li><i><a href="/facts/Listeria_monocytogenes/Cq1a7zqe">Listeria monocytogenes</a></i><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a></li> <li><a href="/facts/Salmonella_typhi/aj5Ax3uG"><i>Salmonella</i> Typhi</a><a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a></li> <li><i><a href="/facts/Brucella/erCr0WsS">Brucella</a></i></li> <li><i><a href="/facts/Escherichia_coli/nR4Gvl56">Escherichia coli</a></i>, specifically uropathogenic ones<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a></li> <li><i><a href="/facts/Legionella/98PA98kj">Legionella</a></i></li> <li><i><a href="/facts/Mycobacterium/mLn82Axu">Mycobacterium</a></i></li> <li><i><a href="/facts/Nocardia/DChBVQYq">Nocardia</a></i></li> <li><i><a href="/facts/Neisseria/cpbpHsNx">Neisseria</a></i></li> <li><i><a href="/facts/Rhodococcus_equi/9gDLGrPJ">Rhodococcus equi</a></i><a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a></li> <li><i><a href="/facts/Yersinia/R8QWAIcR">Yersinia</a></i></li> <li><i><a href="/facts/Staphylococcus_aureus/9yDVBMsc">Staphylococcus aureus</a></i><a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a></li> <li><i><a href="/facts/Mycobacterium_tuberculosis/cbRjnhIQ">Mycobacterium tuberculosis</a></i> (within the macrophages)<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a></li></ul> <p>Fungal examples include: </p> <ul><li><i><a href="/facts/Histoplasma_capsulatum/lVjdYpM7">Histoplasma capsulatum</a></i>.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a></li> <li><i><a href="/facts/Cryptococcus_neoformans/QdwgHGn1">Cryptococcus neoformans</a></i><a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a></li> <li><i><a href="/facts/Blastomyces_dermatitidis/h2eud0E7">Blastomyces dermatitidis</a></i><a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a></li></ul> <h3>Obligate</h3> <p>Obligate intracellular parasites cannot reproduce outside their host cell, meaning that the parasite's <a href="/facts/Reproduction/nNu0F5Dy">reproduction</a> is entirely reliant on <a href="/facts/Intracellular/UEPUhSN8">intracellular</a> resources. </p><p>All <a href="/facts/Virus/mf88Bcbl">viruses</a> are obligate intracellular parasites. </p><p>Bacterial examples (that affect humans) include: </p> <ul><li><a href="/facts/Chlamydia_(bacterium)/zbm60vHX"><i>Chlamydia</i></a>, and closely related species.<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a></li> <li><i><a href="/facts/Rickettsia/87baaTxT">Rickettsia</a></i></li> <li><i><a href="/facts/Coxiella_(bacterium)/hgKoBUJ5">Coxiella</a></i></li> <li>Certain species of <i><a href="/facts/Mycobacterium/mLn82Axu">Mycobacterium</a></i> such as <i><a href="/facts/Mycobacterium_leprae/UlcawhX9">Mycobacterium leprae</a></i>, that survive in <a href="/facts/Phagocyte/1vbsR9er">phagocytes</a></li> <li><i><a href="/facts/Anaplasma_phagocytophilum/MvlcurRC">Anaplasma phagocytophilum</a></i><a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a></li></ul> <p><a href="/facts/Protozoa/JczTf25H">Protozoan</a> examples (that affect humans) include: </p> <ul><li><a href="/facts/Apicomplexan/UNLTEA18">Apicomplexans</a> (<i><a href="/facts/Plasmodium/Je91qK4F">Plasmodium</a></i> spp., <i><a href="/facts/Toxoplasma_gondii/LzFxHk0j">Toxoplasma gondii</a></i> and <i><a href="/facts/Cryptosporidium_parvum/8YSMIJYp">Cryptosporidium parvum</a></i><a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a>)</li> <li><a href="/facts/Trypanosomatid/grHCxswB">Trypanosomatids</a> (<i><a href="/facts/Leishmania/HRBfbTYR">Leishmania</a></i> spp. and <i><a href="/facts/Trypanosoma_cruzi/T9N2Bojt">Trypanosoma cruzi</a></i>)</li></ul> <p><a href="/facts/Fungal/BHo5DP59">Fungal</a> examples (that affect humans) include: </p> <ul><li><i><a href="/facts/Pneumocystis_jirovecii/lzPGB7an">Pneumocystis jirovecii</a></i><a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a></li></ul> <p>The <a href="/facts/Mitochondria/ErHqrdJ1">mitochondria</a> in eukaryotic cells may also have originally been such parasites, but ended up forming a <a href="/facts/Mutualism_(biology)/29hCDDS2">mutualistic</a> relationship (<a href="/facts/Endosymbiotic_theory/2gHlgj4j">endosymbiotic theory</a>).<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> </p><p>Study of obligate pathogens is difficult because they cannot usually be reproduced outside the host. However, in 2009 scientists reported a technique allowing the <a href="/facts/Q-fever/bfmvfjU4">Q-fever</a> pathogen <i><a href="/facts/Coxiella_burnetii/XvNfSTkg">Coxiella burnetii</a></i> to grow in an <a href="/facts/Axenic/Yb0GdPrB">axenic</a> culture and suggested the technique may be useful for study of other pathogens.<a class="footnote-ref" id="fnref:22" href="#fn:22"><sup>22</sup></a> </p> <h3>Unusual examples</h3> <p><a href="/facts/Polypodium_(animal)/xLW2bS4y"><i>Polypodium</i></a> is a rare metazoan (animal) intracellular parasite, distinct from most if not all other intracellular parasites for this reason. It lives inside the unfertilized egg cells (oocytes) of fish.<a class="footnote-ref" id="fnref:23" href="#fn:23"><sup>23</sup></a> </p> <h2 id="invasion">Invasion</h2> <p>When an intracellular parasite goes to enter a host cell, it is particular about the type of host cell. This is because most intracellular parasites are able to infect only a few different cell types.<a class="footnote-ref" id="fnref:24" href="#fn:24"><sup>24</sup></a> </p> <ul><li>Viruses use a number of host receptors to gain entry to the cell, usually by causing <a href="/facts/Endocytosis/NJjChLNj">endocytosis</a>.<a class="footnote-ref" id="fnref:25" href="#fn:25"><sup>25</sup></a> See <a href="/facts/Viral_entry/1EFshHzW">viral entry</a> for more on this well-studied topic.</li> <li>Bacteria are also generally small enough to be engulfed by endocytosis, which they trigger with adhesins. Unlike viruses, they can and often do manipulate the cell's behavior beforehand, by injecting effector proteins into the cytosol.<a class="footnote-ref" id="fnref:26" href="#fn:26"><sup>26</sup></a></li> <li>Protists are generally too big to enter through endocytosis; they use alternate ways.<a class="footnote-ref" id="fnref:27" href="#fn:27"><sup>27</sup></a> <ul><li><i>Plasmodium</i> and <i>Toxoplasma gondii</i> are <a href="/facts/Apicomplexans/UNLTEA18">apicomplexans</a>, named for the fact they have a "apical complex", used for gaining entry into the cell. The apicomplexan first moves on the cell looking for an ideal receptor. When the receptor is found, it re-orients itself so the apical complex points at the cell. It then secretes a number of proteins to form a <i>moving junction</i>, through which it gains entry.<a class="footnote-ref" id="fnref:28" href="#fn:28"><sup>28</sup></a></li> <li><i><a href="/facts/Trypanosoma_cruzi/T9N2Bojt">Trypanosoma cruzi</a></i> and <i><a href="/facts/Leishmania/HRBfbTYR">Leishmania</a></i> enter by subverting the pathways for <a href="/facts/Plasma_membrane/vAXSD0DT">plasma membrane</a> repair. All nucleated cells use calcium concentration as a signal for membrane damage. <i>T. cruzi</i> attaches to the target cell then increases the calcium concentration inside, disrupting the actin network and triggering the repair mechanism. Lysosomes are recruited to this disruption and release their contents to the extracellular side, as a way to replenish the plasma membrane. <i>T. cruzi</i> take advantage of the excess membrane to form a vacuole in the host cell, gaining entry.<a class="footnote-ref" id="fnref:29" href="#fn:29"><sup>29</sup></a> Because this repair mechanism is universal to all cells with a nucleus, <i>T. cruzi</i> is not picky about the target cell type. <i>Leishmania</i> also uses this mechanism.<a class="footnote-ref" id="fnref:30" href="#fn:30"><sup>30</sup></a></li> <li><i>Leishmania</i> can also trigger <a href="/facts/Phagocytosis/eBrv2XKV">phagocytosis</a>. It is able to withstand the degradation process the cell carries out following phagocytosis.<a class="footnote-ref" id="fnref:31" href="#fn:31"><sup>31</sup></a></li> <li>Microsporidians, which are tiny protozoans related to fungi, seems to form "polar tubes" that poke into the target cell.<a class="footnote-ref" id="fnref:32" href="#fn:32"><sup>32</sup></a></li></ul></li></ul> <p>Other intracellular parasites have developed different ways to enter a host cell that do not require a specific component or action from within the host cell. An example is intracellular parasites using a method called gliding motility. This is the use of an actin-myosin motor that is connected to the intracellular parasites' cytoskeleton. </p> <h2 id="nutrition">Nutrition</h2> <p>The majority of intracellular parasites must keep host cells alive as long as possible while they are reproducing and growing. In order to grow, they need nutrients that might be scarce in their free form in the cell. To study the mechanism that intracellular parasites use to obtain nutrients, <i><a href="/facts/Legionella_pneumophila/UrQCVYkg">Legionella pneumophila</a></i>, a bacterial facultative intracellular parasite, has been used as a model. It is known that <i>Legionella pneumophila</i> obtains nutrients by promoting host <a href="/facts/Proteasome/8vTtg2MI">proteasomal</a> degradation. Self-degradation of host proteins into <a href="/facts/Amino_acids/WDxYwBny">amino acids</a> provides the parasite with its primary carbon and energy source.<a class="footnote-ref" id="fnref:33" href="#fn:33"><sup>33</sup></a> </p> <h2 id="susceptibility">Susceptibility</h2> <p>People with <a href="/facts/T_cell_deficiencies/WMzYhbec">T cell deficiencies</a> are particularly susceptible to intracellular pathogens.<a class="footnote-ref" id="fnref:34" href="#fn:34"><sup>34</sup></a> </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Myzocytosis/AwsTAmWq">Myzocytosis</a></li> <li><a href="/facts/Phagocyte/1vbsR9er">Pathogen evasion and resistance</a></li></ul> <h2 id="explanatory-notes">Explanatory notes</h2> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Horta, Maria Fátima; Andrade, Luciana Oliveira; Martins-Duarte, Érica Santos; Castro-Gomes, Thiago (15 February 2020). "Cell invasion by intracellular parasites – the many roads to infection". Journal of Cell Science. 133 (4). doi:10.1242/jcs.232488. PMID 32079731. <a href="https://doi.org/10.1242%2Fjcs.232488" target="_blank">https://doi.org/10.1242%2Fjcs.232488</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Leon-Sicairos, Nidia; Reyes-Cortes, Ruth; Guadrón-Llanos, Alma M.; Madueña-Molina, Jesús; Leon-Sicairos, Claudia; Canizalez-Román, Adrian (2015). "Strategies of Intracellular Pathogens for Obtaining Iron from the Environment". BioMed Research International. 2015: 1–17. doi:10.1155/2015/476534. ISSN 2314-6133. PMC 4450229. PMID 26120582. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Thakur, A; Mikkelsen, H; Jungersen, G (2019). "Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies". Journal of Immunology Research. 2019: 1356540. doi:10.1155/2019/1356540. PMID 31111075. <a href="https://doi.org/10.1155%2F2019%2F1356540" target="_blank">https://doi.org/10.1155%2F2019%2F1356540</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Leon-Sicairos, Nidia; Reyes-Cortes, Ruth; Guadrón-Llanos, Alma M.; Madueña-Molina, Jesús; Leon-Sicairos, Claudia; Canizalez-Román, Adrian (2015). "Strategies of Intracellular Pathogens for Obtaining Iron from the Environment". BioMed Research International. 2015: 1–17. doi:10.1155/2015/476534. ISSN 2314-6133. PMC 4450229. PMID 26120582. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Leon-Sicairos, Nidia; Reyes-Cortes, Ruth; Guadrón-Llanos, Alma M.; Madueña-Molina, Jesús; Leon-Sicairos, Claudia; Canizalez-Román, Adrian (2015). "Strategies of Intracellular Pathogens for Obtaining Iron from the Environment". BioMed Research International. 2015: 1–17. doi:10.1155/2015/476534. ISSN 2314-6133. PMC 4450229. PMID 26120582. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450229</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>"Bartonella henselae" (PDF). Archived from the original (PDF) on 2020-11-01. Retrieved 2018-01-20. <a href="https://web.archive.org/web/20201101192301/https://www.vetmed.auburn.edu/wp-content/uploads/2015/03/Bartonella-henselae.pdf" target="_blank">https://web.archive.org/web/20201101192301/https://www.vetmed.auburn.edu/wp-content/uploads/2015/03/Bartonella-henselae.pdf</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Dramsi, Shaynoor; Cossart, Pascale (2002-03-18). "Listeriolysin O". 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