Menu
Home
People
Places
Arts
History
Plants & Animals
Science
Life & Culture
Technology
Reference.org
Celltrion
open-in-new
<h2 id="history">History</h2> <p>In 1999, Nexol, Inc. (now Celltrion Healthcare Co., Ltd.) was founded as a global business management consulting firm. In 2002, Celltrion, Inc. was founded as a biopharmaceutical company.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> </p><p>In 2008, Nexol and Celltrion established a global distribution agreement.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> </p><p>In 2009, distribution channels were established in America, Oceania, Europe (<a href="/facts/Hospira/GWLrQzDx">Hospira</a>) and Nexol, Inc. renamed as Celltrion Healthcare Co., Ltd. </p><p>In 2010, distribution channels were established in Japan (<a href="/facts/Nippon_Kayaku/W9mECPMI">Nippon Kayaku</a>), Commonwealth of Independent States (CIS), Eastern Europe, and the <a href="/facts/Middle_East/8CD6pLWv">Middle East</a> (Egis). </p><p>In 2013, distribution channels were added in Europe (Mundipharma, Biogaran, and Kern).<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p><p>In September 30, 2024, Celltrion completed the establishment of its oversees corporation in Vietnam.<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> 22 Oct. 2024. Celltrion secured a 100.4 billion won ($72.8 million) deal for contract development and manufacturing (CDMO) with TEVA Pharmaceuticals International for the migraine treatment Ajovy.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> </p><p>In November 2024, Celltrion acquired iQone Healthcare Switzerland, a pharmaceutical company for around 30 billion won ($21 million). This move will help its expansion in Europe.<a class="footnote-ref" id="fnref:10" href="#fn:10"><sup>10</sup></a> </p> <h2 id="products">Products</h2> <p>The company's products are manufactured at mammalian cell culture facilities designed and built to comply with the United States <a href="/facts/Food_and_Drug_Administration/rCEnh9WB">FDA</a>’s cGMP,<a class="footnote-ref" id="fnref:11" href="#fn:11"><sup>11</sup></a> and the <a href="/facts/European_Medicines_Agency/h9FTtCYc">European Medicines Agency</a>’s GMP standards.<a class="footnote-ref" id="fnref:12" href="#fn:12"><sup>12</sup></a> </p> <h3>Inline product</h3> <p><a href="/facts/Remsima/pk8CdtFV">Remsima</a> (<a href="/facts/Infliximab/pk8CdtFV">infliximab</a>) is a <a href="/facts/Biosimilar/QmgnUAzK">biosimilar</a> <a href="/facts/Monoclonal_antibody/4rUBWB87">monoclonal antibody</a> against <a href="/facts/Tumor_necrosis_factor_alpha/7NWNIaCb">tumor necrosis factor alpha</a> (TNF-α), approved by the <a href="/facts/European_Medicines_Agency/h9FTtCYc">European Medicines Agency</a> (EMA) for treatment of: </p> <ol><li><a href="/facts/Rheumatoid_arthritis/qFK4Xwv7">rheumatoid arthritis</a>,</li> <li>adult <a href="/facts/Crohn%27s_disease/zm55cBtd">Crohn's disease</a>,</li> <li>pediatric Crohn's disease,</li> <li><a href="/facts/Ulcerative_colitis/BIkyFzRj">ulcerative colitis</a>,</li> <li>pediatric ulcerative colitis,</li> <li><a href="/facts/Ankylosing_spondylitis/tHgAlJNd">ankylosing spondylitis</a>,</li> <li><a href="/facts/Psoriatic_arthritis/X3onPL9T">psoriatic arthritis</a>, and</li> <li><a href="/facts/Psoriasis/WW1k1LsH">psoriasis</a>.<a class="footnote-ref" id="fnref:13" href="#fn:13"><sup>13</sup></a></li></ol> <p>In 2012 Remsima was approved by the Republic of Korea's Ministry of Food and Drug Safety (MFDS), previously known as Korea Food and Drug Administration and in 2013 it became the world's first<a class="footnote-ref" id="fnref:14" href="#fn:14"><sup>14</sup></a> <a href="/facts/Biosimilar/QmgnUAzK">biosimilar</a> <a href="/facts/Monoclonal_antibody/4rUBWB87">monoclonal antibody</a> (mAb) approved by the EMA.<a class="footnote-ref" id="fnref:15" href="#fn:15"><sup>15</sup></a> </p><p>Herzuma is a <a href="/facts/Biosimilar/QmgnUAzK">biosimilar</a> <a href="/facts/Trastuzumab/2jBAnKHl">trastuzumab</a> approved by the MFDS for treatment of early and advanced (metastatic) <a href="/facts/HER2/neu/xue3SgcA">HER2+</a> <a href="/facts/Breast_cancer/6hME580v">breast cancer</a> as well as advanced (metastatic) <a href="/facts/Stomach_cancer/HJjYtkqS">stomach cancer</a>. Herzuma is a HER2+ breast cancer therapy designed to treat aggressive HER positive <a href="/facts/Metastasis/4dadbm6z">metastatic</a> and <a href="/facts/Adjuvant/jnRqeBnG">adjuvant</a> breast cancer, as well as HER2 positive <a href="/facts/Adenocarcinoma/TU7W6WbJ">adenocarcinoma</a> of the stomach that has spread (metastatic or advanced <a href="/facts/Gastric_cancer/HJjYtkqS">gastric cancer</a>).<a class="footnote-ref" id="fnref:16" href="#fn:16"><sup>16</sup></a><a class="footnote-ref" id="fnref:17" href="#fn:17"><sup>17</sup></a><a class="footnote-ref" id="fnref:18" href="#fn:18"><sup>18</sup></a> </p><p>Truxima (previously known as CT-P10) is the first biosimilar of the reference <a href="/facts/Monoclonal_antibody/4rUBWB87">monoclonal antibody</a> <a href="/facts/Rituximab/q6BLRsS6">rituximab</a> that targets CD20 molecule primarily found on the surface of <a href="/facts/B_cell/6Y1tgwwp">B-cells</a>. Its target indications are rheumatoid arthritis, <a href="/facts/Non-Hodgkin_lymphoma/KIFxt74F">non-Hodgkin lymphoma</a> and <a href="/facts/Chronic_Lymphocytic_Leukemia/jbaDruD9">chronic lymphocytic leukemia</a>.<a class="footnote-ref" id="fnref:19" href="#fn:19"><sup>19</sup></a><a class="footnote-ref" id="fnref:20" href="#fn:20"><sup>20</sup></a> It was approved by the EMA in February 2017.<a class="footnote-ref" id="fnref:21" href="#fn:21"><sup>21</sup></a> </p> <h2 id="corporate-governance">Corporate Governance</h2> <table><tbody><tr><th>Company name</th><th>Shareholding ratio</th></tr><tr><td>Celltrion Holdings</td><td>20.05%</td></tr><tr><td>Korea National Pension Service</td><td>7.26%</td></tr><tr><td>Celltrion Skincure</td><td>2.11%</td></tr><tr><td colspan="2"><a href="https://dart.fss.or.kr/dsaf001/main.do?rcpNo=20231114001566">As of Sep 2023.</a></td></tr></tbody></table> <h2 id="see-also">See also</h2> <ul> <li>Companies portal</li><li>South Korea portal</li></ul> <ul><li><a href="/facts/List_of_pharmaceutical_companies/6Do5vAp2">List of pharmaceutical companies</a></li></ul> <h2 id="external-links">External links</h2> <ul><li><a href="https://www.celltrion.com/en-us/home/index">Official website</a></li> <li>Business data for Celltrion: <ul><li><a href="https://www.google.com/finance/quote/068270:KRX">Google</a></li><li><a href="https://www.reuters.com/markets/companies/068270.KS">Reuters</a></li><li><a href="https://finance.yahoo.com/quote/068270.KS">Yahoo!</a></li></ul></li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Company Overview of Celltrion Healthcare Co., Ltd". Bloomberg. <a href="https://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapId=79743107" target="_blank">https://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapId=79743107</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Kang, John. "Korea's New No. 1: Celltrion Cofounder Becomes First Self-Made Billionaire To Claim Top Spot". Forbes. Retrieved 2021-08-06. <a href="https://www.forbes.com/sites/johnkang/2021/06/01/koreas-new-no-1-celltrion-cofounder-becomes-first-self-made-billionaire-to-claim-top-spot/" target="_blank">https://www.forbes.com/sites/johnkang/2021/06/01/koreas-new-no-1-celltrion-cofounder-becomes-first-self-made-billionaire-to-claim-top-spot/</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Jung Jin SEO - EY World Entrepreneur Of The Year™ 2024 Judges". www.ey.com. Retrieved 2024-11-08. <a href="https://www.ey.com/en_gl/weoy/judges/jung-jin-seo" target="_blank">https://www.ey.com/en_gl/weoy/judges/jung-jin-seo</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"History | ABOUT US". www.celltrionhealthcare.com. Retrieved 2020-01-22. <a href="https://www.celltrionhealthcare.com/en-us/aboutus/history" target="_blank">https://www.celltrionhealthcare.com/en-us/aboutus/history</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>"VaxGen Biopharmaceutical Manufacturing Plant - Pharmaceutical Technology". Retrieved 2020-01-22. <a href="https://www.pharmaceutical-technology.com/projects/vaxgen/" target="_blank">https://www.pharmaceutical-technology.com/projects/vaxgen/</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>MacDonald, Gareth (15 October 2014). "Biosimilars going global but EMA still setting the regulatory pace". BioPharma-reporter.com. <a href="http://www.biopharma-reporter.com/Markets-Regulations/Biosimilars-going-global-but-EMA-still-setting-the-regulatory-pace" target="_blank">http://www.biopharma-reporter.com/Markets-Regulations/Biosimilars-going-global-but-EMA-still-setting-the-regulatory-pace</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Indukern Group Press Release 2015. Indukern Group Press Release <a href="http://www.grupoindukern.com/wp-content/uploads/2015/01/150114_-Indukern-Group-Press-Release1.pdf?lang=en" target="_blank">http://www.grupoindukern.com/wp-content/uploads/2015/01/150114_-Indukern-Group-Press-Release1.pdf?lang=en</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>https://n.news.naver.com/mnews/article/008/0005095329 <a href="https://n.news.naver.com/mnews/article/008/0005095329" target="_blank">https://n.news.naver.com/mnews/article/008/0005095329</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>"Celltrion signs $72.8 million deal for migraine drug Ajovy". Korea JoongAng. 2024. <a href="https://koreajoongangdaily.joins.com/news/2024-10-22/business/industry/Celltrion-signs-728-million-deal-for-migraine-drug-Ajovy/2160919/" target="_blank">https://koreajoongangdaily.joins.com/news/2024-10-22/business/industry/Celltrion-signs-728-million-deal-for-migraine-drug-Ajovy/2160919/</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> <li id="fn:10"><p>"Celltrion acquires Swiss firm iQone Healthcare". The Pharma Letter. Retrieved 15 November 2024. <a href="https://www.thepharmaletter.com/celltrion-acquires-swiss-firm-iqone-healthcare" target="_blank">https://www.thepharmaletter.com/celltrion-acquires-swiss-firm-iqone-healthcare</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></p></li> <li id="fn:11"><p>"S.Korea's Celltrion gets FDA OK to make Bristol-Myers' Orencia". Reuters. 18 December 2007. Archived from the original on 24 September 2015. Retrieved 30 June 2017. <a href="https://www.reuters.com/article/celltrion-fda-idUSWNAS480020071218" target="_blank">https://www.reuters.com/article/celltrion-fda-idUSWNAS480020071218</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></p></li> <li id="fn:12"><p>"Europe approves first biosimilar antibody drug". Reuters. 10 September 2013. Archived from the original on 24 September 2015. Retrieved 30 June 2017. <a href="https://www.reuters.com/article/us-celltrion-hospira-europe-idUSBRE9890IX20130910" target="_blank">https://www.reuters.com/article/us-celltrion-hospira-europe-idUSBRE9890IX20130910</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></p></li> <li id="fn:13"><p>"Remsima Assessment report" (PDF). Committee for Medicinal Products for Human Use (CHMP). June 27, 2013. <a href="http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002576/WC500151486.pdf" target="_blank">http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002576/WC500151486.pdf</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></p></li> <li id="fn:14"><p>Stanton, Dan (17 July 2013). "EMA Approves First MAb Biosimilars". BioPharma-reporter.com. <a href="http://www.biopharma-reporter.com/Markets-Regulations/EMA-Approves-First-MAb-Biosimilars" target="_blank">http://www.biopharma-reporter.com/Markets-Regulations/EMA-Approves-First-MAb-Biosimilars</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></p></li> <li id="fn:15"><p>"Remsima Assessment report" (PDF). Committee for Medicinal Products for Human Use (CHMP). June 27, 2013. <a href="http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002576/WC500151486.pdf" target="_blank">http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002576/WC500151486.pdf</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></p></li> <li id="fn:16"><p>"Biosimilar trastuzumab approved in Korea". Generics and Biosimilars Initiative. 17 January 2014. <a href="http://gabionline.net/Biosimilars/News/Biosimilar-trastuzumab-approved-in-Korea" target="_blank">http://gabionline.net/Biosimilars/News/Biosimilar-trastuzumab-approved-in-Korea</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></p></li> <li id="fn:17"><p>"Herzuma approved by the Ministry of Food and Drug Safety of the Republic of Korea". Ministry of Food and Drug Safety of the Republic of Korea. 15 January 2014. <a href="http://www.mfds.go.kr/index.do?mid=675&seq=22584&cmd=v" target="_blank">http://www.mfds.go.kr/index.do?mid=675&seq=22584&cmd=v</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></p></li> <li id="fn:18"><p>"Celltrion gets nod for 2nd biosimilar in local market". JoongAng Ilbo. 16 January 2014. <a href="http://koreajoongangdaily.joins.com/news/article/Article.aspx?aid=2983589" target="_blank">http://koreajoongangdaily.joins.com/news/article/Article.aspx?aid=2983589</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></p></li> <li id="fn:19"><p>"A Randomized, Controlled, Multicenter, 2‑Arm, Parallel‑Group, Double-Blind Study To Demonstrate The Equivalence Of CT-P10 To Innovator Rituximab With Respect To Pharmacokinetic Profile In Patients With Rheumatoid Arthritis", ACR/ARHP Annual Meeting 2013, ACR/ARHP Annual Meeting, 2013, archived from the original on 2015-04-15, retrieved 2013-10-28 <a href="https://archive.today/20150415080010/https://ww2.rheumatology.org/apps/MyAnnualMeeting/Abstract/36875" target="_blank">https://archive.today/20150415080010/https://ww2.rheumatology.org/apps/MyAnnualMeeting/Abstract/36875</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></p></li> <li id="fn:20"><p>Brinks, Vera (December 15, 2005), Immunogenicity of biosimilar monoclonal antibodies, Generics and Biosimilars Initiative, retrieved September 20, 2013 <a href="http://gabi-journal.net/immunogenicity-of-biosimilar-monoclonal-antibodies.html" target="_blank">http://gabi-journal.net/immunogenicity-of-biosimilar-monoclonal-antibodies.html</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></p></li> <li id="fn:21"><p>"Celltrion's Rituximab Biosimilar Truxima Approved in Europe - GEN". GEN. 22 February 2017. <a href="http://www.genengnews.com/gen-news-highlights/celltrions-rituximab-biosimilar-truxima-approved-in-europe/81253914?q=truxima" target="_blank">http://www.genengnews.com/gen-news-highlights/celltrions-rituximab-biosimilar-truxima-approved-in-europe/81253914?q=truxima</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></p></li> </ol>