Orthogenesis

<h2 id="definition">Definition</h2>

Further information: <a href="/facts/Teleology_in_biology/V2yXRhNX">Teleology in biology</a>
The term orthogenesis (from Ancient <a href="/facts/Greek_language/pzDd6eIz">Greek</a>: ὀρθός orthós, "straight", and Ancient <a href="/facts/Greek_language/pzDd6eIz">Greek</a>: γένεσις génesis, "origin") was first used by the biologist <a href="/facts/Wilhelm_Haacke/NnWFUmR8">Wilhelm Haacke</a> in 1893.<a class="footnote-ref" id="fnref:8" href="#fn:8">8</a><a class="footnote-ref" id="fnref:9" href="#fn:9">9</a> <a href="/facts/Theodor_Eimer/u09Gqp8Y">Theodor Eimer</a> was the first to give the word a definition; he defined orthogenesis as "the general law according to which evolutionary development takes place in a noticeable direction, above all in specialized groups".<a class="footnote-ref" id="fnref:10" href="#fn:10">10</a>
In 1922, the zoologist <a href="/facts/Michael_F._Guyer/QYrl740H">Michael F. Guyer</a> wrote:

[Orthogenesis] has meant many different things to many different people, ranging from a mystical <a href="/facts/Inner_perfecting_principle/LcepxU1c">inner perfecting principle</a>, to merely a general trend in development due to the natural constitutional restrictions of the germinal materials, or to the physical limitations imposed by a narrow environment. In most modern statements of the theory, the idea of continuous and progressive change in one or more characters, due according to some to internal factors, according to others to external causes-evolution in a "straight line" seems to be the central idea.<a class="footnote-ref" id="fnref:11" href="#fn:11">11</a>
According to <a href="/facts/Susan_R._Schrepfer/IBW4zFE9">Susan R. Schrepfer</a> in 1983:

Orthogenesis meant literally "straight origins", or "straight line evolution". The term varied in meaning from the overtly vitalistic and theological to the mechanical. It ranged from theories of mystical forces to mere descriptions of a general trend in development due to natural limitations of either the germinal material or the environment ... By 1910, however most who subscribed to orthogenesis hypothesized some physical rather than metaphysical determinant of orderly change.<a class="footnote-ref" id="fnref:12" href="#fn:12">12</a>
In 1988, <a href="/facts/Francisco_J._Ayala/J1YpW9yy">Francisco J. Ayala</a> defined progress as "systematic change in a feature belonging to all the members of a sequence in such a way that posterior members of the sequence exhibit an improvement of that feature". He argued that there are two elements in this definition, directional change and improvement according to some standard. Whether a directional change constitutes an improvement is not a scientific question; therefore Ayala suggested that science should focus on the question of whether there is directional change, without regard to whether the change is "improvement".<a class="footnote-ref" id="fnref:13" href="#fn:13">13</a> This may be compared to <a href="/facts/Stephen_Jay_Gould/FtAcabjg">Stephen Jay Gould</a>'s suggestion of "replacing the idea of progress with an operational notion of directionality".<a class="footnote-ref" id="fnref:14" href="#fn:14">14</a>
In 1989, <a href="/facts/Peter_J._Bowler/d9fHfnoo">Peter J. Bowler</a> defined orthogenesis as:

Literally, the term means evolution in a straight line, generally assumed to be evolution that is held to a regular course by forces internal to the organism. Orthogenesis assumes that variation is not random but is directed <a href="/facts/Teleology_in_biology/V2yXRhNX">towards fixed goals</a>. Selection is thus powerless, and the species is carried automatically in the direction marked out by internal factors controlling variation.<a class="footnote-ref" id="fnref:15" href="#fn:15">15</a>
In 1996, <a href="/facts/Michael_Ruse/mcxEuTom">Michael Ruse</a> defined orthogenesis as "the view that evolution has a kind of momentum of its own that carries organisms along certain tracks".<a class="footnote-ref" id="fnref:16" href="#fn:16">16</a>

<h2 id="history">History</h2>

<h3>Medieval</h3>
The possibility of progress is embedded in the mediaeval <a href="/facts/Great_chain_of_being/rMzBFDtc">great chain of being</a>, with a linear sequence of forms from lowest to highest. The concept, indeed, had its roots in <a href="/facts/Aristotle%27s_biology/jc8E4MBx">Aristotle's biology</a>, from insects that produced only a grub, to fish that laid eggs, and on up to animals with blood and live birth. The medieval chain, as in <a href="/facts/Ramon_Lull/MnK265Y1">Ramon Lull</a>'s Ladder of Ascent and Descent of the Mind, 1305, added steps or levels above humans, with orders of angels reaching up to God at the top.<a class="footnote-ref" id="fnref:17" href="#fn:17">17</a>

<h3>Pre-Darwinian</h3>
The orthogenesis hypothesis had a significant following in the 19th century when evolutionary mechanisms such as <a href="/facts/Lamarckism/5bwVUmP8">Lamarckism</a> were being proposed. The French zoologist <a href="/facts/Jean-Baptiste_Lamarck/3lxaPmqM">Jean-Baptiste Lamarck</a> (1744–1829) himself accepted the idea, and it had a central role in his theory of inheritance of acquired characteristics, the hypothesized mechanism of which resembled the "mysterious inner force" of orthogenesis.<a class="footnote-ref" id="fnref:18" href="#fn:18">18</a> Orthogenesis was particularly accepted by paleontologists who saw in their fossils a directional change, and in <a href="/facts/Invertebrate_paleontology/dRlljgn4">invertebrate paleontology</a> thought there was a gradual and constant directional change. Those who accepted orthogenesis in this way, however, did not necessarily accept that the mechanism that drove orthogenesis was <a href="/facts/Teleology/8YR2sPUf">teleological</a> (had a definite goal). <a href="/facts/Charles_Darwin/uwDLGItY">Charles Darwin</a> himself rarely used the term "evolution" now so commonly used to describe his theory, because the term was strongly associated with orthogenesis, as had been common usage since at least 1647.<a class="footnote-ref" id="fnref:19" href="#fn:19">19</a> His grandfather, the physician and polymath <a href="/facts/Erasmus_Darwin/yyYdTLl5">Erasmus Darwin</a>, was both progressionist and <a href="/facts/Vitalism/wYrVvfUf">vitalist</a>, seeing "the whole cosmos [as] a living thing propelled by an internal vital force" towards "greater perfection".<a class="footnote-ref" id="fnref:20" href="#fn:20">20</a> <a href="/facts/Robert_Chambers_(publisher,_born_1802)/sH8cYgCb">Robert Chambers</a>, in his popular anonymously published 1844 book <a href="/facts/Vestiges_of_the_Natural_History_of_Creation/BYGEzwBw">Vestiges of the Natural History of Creation</a> presented a sweeping narrative account of cosmic transmutation, culminating in the evolution of humanity. Chambers included detailed analysis of the fossil record.<a class="footnote-ref" id="fnref:21" href="#fn:21">21</a>

<h3>With Darwin</h3>

Ruse observed that "Progress (sic, his capitalisation) became essentially a nineteenth-century belief. It gave meaning to life—it offered inspiration—after the collapse [with <a href="/facts/Malthus/fNoDNncG">Malthus</a>'s pessimism and the shock of the <a href="/facts/French_Revolution/PIkDlrC0">French Revolution</a>] of the foundations of the past."<a class="footnote-ref" id="fnref:22" href="#fn:22">22</a>
The Baltic German biologist <a href="/facts/Karl_Ernst_von_Baer/bBBNwlkd">Karl Ernst von Baer</a> (1792–1876) argued for an orthogenetic force in nature, reasoning in a review of Darwin's 1859 <a href="/facts/On_the_Origin_of_Species/zTMxkKVY">On the Origin of Species</a> that "Forces which are not directed—so-called blind forces—can never produce order."<a class="footnote-ref" id="fnref:23" href="#fn:23">23</a><a class="footnote-ref" id="fnref:24" href="#fn:24">24</a><a class="footnote-ref" id="fnref:25" href="#fn:25">25</a> 
In 1864, the Swiss anatomist <a href="/facts/Albert_von_K%C3%B6lliker/eYudoEHx">Albert von Kölliker</a> (1817–1905) presented his orthogenetic theory, <a href="/facts/Heterogenesis/eYudoEHx">heterogenesis</a>, arguing for wholly separate lines of descent with no common ancestor.<a class="footnote-ref" id="fnref:26" href="#fn:26">26</a>
In 1884, the Swiss botanist <a href="/facts/Carl_N%C3%A4geli/LcepxU1c">Carl Nägeli</a> (1817–1891) proposed a version of orthogenesis involving an "inner perfecting principle". <a href="/facts/Gregor_Mendel/4UpILWAz">Gregor Mendel</a> died that same year; Nägeli, who proposed that an "<a href="/facts/Idioplasm/LcepxU1c">idioplasm</a>" transmitted inherited characteristics, dissuaded Mendel from continuing to work on plant genetics.<a class="footnote-ref" id="fnref:27" href="#fn:27">27</a> According to Nägeli many evolutionary developments were nonadaptive and variation was internally programmed.<a class="footnote-ref" id="fnref:28" href="#fn:28">28</a> <a href="/facts/Charles_Darwin/uwDLGItY">Charles Darwin</a> saw this as a serious challenge, replying that "There must be some efficient cause for each slight individual difference", but was unable to provide a specific answer without knowledge of genetics. Further, Darwin was himself somewhat progressionist, believing for example that "Man" was "higher" than the <a href="/facts/Barnacle/cF33rlfE">barnacles</a> he studied.<a class="footnote-ref" id="fnref:29" href="#fn:29">29</a><a class="footnote-ref" id="fnref:30" href="#fn:30">30</a>
Darwin indeed wrote in his 1859 <a href="/facts/Origin_of_Species/zTMxkKVY">Origin of Species</a>:<a class="footnote-ref" id="fnref:31" href="#fn:31">31</a>

The inhabitants of each successive period in the world's history have beaten their predecessors in the race for life, and are, insofar, higher in the scale of nature; and this may account for that vague yet ill-defined sentiment, felt by many palaeontologists, that organisation on the whole has progressed. [Chapter 10]<a class="footnote-ref" id="fnref:32" href="#fn:32">32</a>
As all the living forms of life are the lineal descendants of those which lived long before the Silurian epoch, we may feel certain that the ordinary succession by generation has never once been broken, and that no cataclysm has desolated the whole world. Hence we may look with some confidence to a secure future of equally inappreciable length. And as natural selection works solely by and for the good of each being, all corporeal and mental endowments will tend to progress towards perfection. [Chapter 14]<a class="footnote-ref" id="fnref:33" href="#fn:33">33</a>

In 1898, after studying <a href="/facts/Butterfly/qlSgwlRx">butterfly</a> coloration, <a href="/facts/Theodor_Eimer/u09Gqp8Y">Theodor Eimer</a> (1843–1898) introduced the term orthogenesis with a widely read book, On Orthogenesis: And the Impotence of Natural Selection in Species Formation. Eimer claimed there were trends in <a href="/facts/Evolution/Hj0qAaBk">evolution</a> with no <a href="/facts/Adaptation/5K2gNpDB">adaptive</a> significance that would be difficult to explain by natural selection.<a class="footnote-ref" id="fnref:34" href="#fn:34">34</a> To supporters of orthogenesis, in some cases <a href="/facts/Species/oDg6b96r">species</a> could be led by such trends to <a href="/facts/Extinction/24p5NP2q">extinction</a>.<a class="footnote-ref" id="fnref:35" href="#fn:35">35</a> Eimer linked orthogenesis to <a href="/facts/Lamarckism/5bwVUmP8">neo-Lamarckism</a> in his 1890 book Organic Evolution as the Result of the Inheritance of Acquired Characteristics According to the Laws of Organic Growth. He used examples such as the <a href="/facts/Evolution/Hj0qAaBk">evolution</a> of the <a href="/facts/Horse/uQ3FA0Ak">horse</a> to argue that evolution had proceeded in a regular single direction that was difficult to explain by random variation. Gould described Eimer as a <a href="/facts/Materialist/VKAovnPt">materialist</a> who rejected any <a href="/facts/Vitalist/wYrVvfUf">vitalist</a> or <a href="/facts/Teleological/8YR2sPUf">teleological</a> approach to orthogenesis, arguing that Eimer's criticism of natural selection was common amongst many evolutionists of his generation; they were searching for alternative mechanisms, as they had come to believe that natural selection could not create new <a href="/facts/Species/oDg6b96r">species</a>.<a class="footnote-ref" id="fnref:36" href="#fn:36">36</a>

<h3>Nineteenth and twentieth centuries</h3>
Further information: <a href="/facts/Eclipse_of_Darwinism/UII27Q2m">Eclipse of Darwinism</a>
Numerous versions of orthogenesis (see table) have been proposed. Debate centred on whether such theories were scientific, or whether orthogenesis was inherently vitalistic or essentially theological.<a class="footnote-ref" id="fnref:37" href="#fn:37">37</a> For example, biologists such as <a href="/facts/Maynard_M._Metcalf/f1TBXJqf">Maynard M. Metcalf</a> (1914), <a href="/facts/John_Merle_Coulter/Q3CKQhAV">John Merle Coulter</a> (1915), <a href="/facts/David_Starr_Jordan/qLNo5UIR">David Starr Jordan</a> (1920) and <a href="/facts/Charles_B._Lipman/Rmm5qYC8">Charles B. Lipman</a> (1922) claimed evidence for orthogenesis in <a href="/facts/Bacteria/wC8xSCsU">bacteria</a>, <a href="/facts/Fish/fln4gH9V">fish</a> populations and <a href="/facts/Plant/X5BMDMvS">plants</a>.<a class="footnote-ref" id="fnref:38" href="#fn:38">38</a><a class="footnote-ref" id="fnref:39" href="#fn:39">39</a><a class="footnote-ref" id="fnref:40" href="#fn:40">40</a><a class="footnote-ref" id="fnref:41" href="#fn:41">41</a> In 1950, the German paleontologist <a href="/facts/Otto_Schindewolf/7GqnFfgj">Otto Schindewolf</a> argued that variation tends to move in a predetermined direction. He believed this was purely mechanistic, denying any kind of <a href="/facts/Vitalism/wYrVvfUf">vitalism</a>, but that evolution occurs due to a periodic cycle of evolutionary processes dictated by factors internal to the organism.<a class="footnote-ref" id="fnref:42" href="#fn:42">42</a><a class="footnote-ref" id="fnref:43" href="#fn:43">43</a> In 1964 <a href="/facts/George_Gaylord_Simpson/T159FrGC">George Gaylord Simpson</a> argued that orthogenetic theories such as those promulgated by Du Noüy and Sinnott were essentially theology rather than biology.<a class="footnote-ref" id="fnref:44" href="#fn:44">44</a>
Though evolution is not progressive, it does sometimes proceed in a linear way, reinforcing characteristics in certain lineages, but such examples are entirely consistent with the modern neo-Darwinian theory of evolution.<a class="footnote-ref" id="fnref:45" href="#fn:45">45</a> These examples have sometimes been referred to as orthoselection but are not strictly orthogenetic, and simply appear as linear and constant changes because of environmental and molecular constraints on the direction of change.<a class="footnote-ref" id="fnref:46" href="#fn:46">46</a><a class="footnote-ref" id="fnref:47" href="#fn:47">47</a> The term orthoselection was first used by <a href="/facts/Ludwig_Hermann_Plate/Vwhdmzcy">Ludwig Hermann Plate</a>, and was incorporated into the <a href="/facts/Modern_synthesis_(20th_century)/anJdPq34">modern synthesis</a> by <a href="/facts/Julian_Huxley/pIST2QoX">Julian Huxley</a> and <a href="/facts/Bernard_Rensch/bS7kBRGD">Bernard Rensch</a>.<a class="footnote-ref" id="fnref:48" href="#fn:48">48</a>
Recent work has supported the mechanism and existence of <a href="/facts/Mutation_bias/IBNtNmUa">mutation biased</a> adaptation, meaning that limited local orthogenesis is now seen as possible.<a class="footnote-ref" id="fnref:49" href="#fn:49">49</a><a class="footnote-ref" id="fnref:50" href="#fn:50">50</a><a class="footnote-ref" id="fnref:51" href="#fn:51">51</a>

<h2 id="theories">Theories</h2>
Further information: <a href="/facts/Alternatives_to_evolution_by_natural_selection/dVrGkzvu">Alternatives to evolution by natural selection</a>
For the columns for other philosophies of evolution (i.e., combined theories including any of Lamarckism, Mutationism, Natural selection, and Vitalism), "yes" means that person definitely supports the theory; "no" means explicit opposition to the theory; a blank means the matter is apparently not discussed, not part of the theory.

Theories of orthogenesis in <a href="/facts/Evolutionary_biology/8tBoG55U">evolutionary biology</a><a class="footnote-ref" id="fnref:52" href="#fn:52">52</a><table><tbody><tr><th>Author</th><th>Title</th><th>Field</th><th>Date</th><th><a href="/facts/Lamarckism/5bwVUmP8">Lamarck.</a></th><th><a href="/facts/Mutationism/9mDsWUET">Mutat.</a></th><th><a href="/facts/Natural_selection/JXTte6en">Nat. Sel.</a></th><th><a href="/facts/Vitalism/wYrVvfUf">Vital.</a></th><th>Features</th></tr><tr><td><a href="/facts/Jean-Baptiste_Lamarck/3lxaPmqM">Lamarck</a></td><td><a href="/facts/Inherent_progressive_tendency/3lxaPmqM">Inherent progressive tendency</a></td><td>Zoology</td><td>1809</td><td>yes</td><td></td><td></td><td></td><td>In his <a href="/facts/Philosophie_Zoologique/jh109E3x">Philosophie Zoologique</a>, inherent progressive tendency drives organisms continuously towards greater <a href="/facts/Evolution_of_biological_complexity/aNhaSk5R">complexity</a>, in separate lineages (<a href="/facts/Phylum/ELT3Jyax">phyla</a>), no <a href="/facts/Extinction/24p5NP2q">extinction</a>.<a class="footnote-ref" id="fnref:53" href="#fn:53">53</a> ("<a href="/facts/Lamarckism/5bwVUmP8">Lamarckism</a>", use and disuse, and <a href="/facts/Inheritance_of_acquired_characteristics/5bwVUmP8">inheritance of acquired characteristics</a>, was a secondary aspect of this, an adaptive force creating species within a phylum.<a class="footnote-ref" id="fnref:54" href="#fn:54">54</a>)</td></tr><tr><td><a href="/facts/Karl_Ernst_von_Baer/bBBNwlkd">Baer</a></td><td><a href="/facts/Purposeful_creation/bBBNwlkd">Purposeful creation</a></td><td>Embryology</td><td>1859</td><td></td><td></td><td></td><td></td><td>"Forces which are not directed—so-called blind forces—can never produce order."<a class="footnote-ref" id="fnref:55" href="#fn:55">55</a></td></tr><tr><td><a href="/facts/Albert_von_K%C3%B6lliker/eYudoEHx">Kölliker</a></td><td><a href="/facts/Heterogenesis/eYudoEHx">Heterogenesis</a></td><td>Anatomy</td><td>1864</td><td>yes</td><td></td><td></td><td></td><td>Wholly separate lines of descent with no common ancestor<a class="footnote-ref" id="fnref:56" href="#fn:56">56</a></td></tr><tr><td><a href="/facts/Edward_Drinker_Cope/Wup4Ic7k">Cope</a></td><td><a href="/facts/Law_of_acceleration/Wup4Ic7k">Law of acceleration</a></td><td>Palaeontology</td><td>1868</td><td>yes</td><td></td><td></td><td></td><td>Combined orthogenetic constraints with <a href="/facts/Lamarckian/5bwVUmP8">Lamarckian</a> use and disuse. "On the Origin of Genera";<a class="footnote-ref" id="fnref:57" href="#fn:57">57</a><a class="footnote-ref" id="fnref:58" href="#fn:58">58</a><a class="footnote-ref" id="fnref:59" href="#fn:59">59</a> See also <a href="/facts/Cope%27s_rule/bYRMtxMP">Cope's rule</a> (linear increase in size of species)</td></tr><tr><td><a href="/facts/Carl_N%C3%A4geli/LcepxU1c">Nägeli</a></td><td><a href="/facts/Inner_perfecting_principle/LcepxU1c">Inner perfecting principle</a></td><td>Botany</td><td>1884</td><td>yes</td><td></td><td>no</td><td></td><td>An "<a href="/facts/Idioplasm/LcepxU1c">idioplasm</a>" transmitted inherited characteristics; many evolutionary developments nonadaptive; variation internally programmed.<a class="footnote-ref" id="fnref:60" href="#fn:60">60</a><a class="footnote-ref" id="fnref:61" href="#fn:61">61</a></td></tr><tr><td><a href="/facts/Herbert_Spencer/d1qsSq4r">Spencer</a></td><td>Progressionism'The Development Hypothesis'</td><td>Social theory</td><td>1852</td><td>Yes<a class="footnote-ref" id="fnref:62" href="#fn:62">62</a></td><td></td><td></td><td></td><td>Cultural value of progress; "Spencer has no rivals when it comes to open, flagrant connections of social Progress with evolutionary progress."—<a href="/facts/Michael_Ruse/mcxEuTom">Michael Ruse</a><a class="footnote-ref" id="fnref:63" href="#fn:63">63</a></td></tr><tr><td><a href="/facts/Charles_Darwin/uwDLGItY">Darwin</a></td><td>(concept of higher and lower species), <a href="/facts/Pangenesis/WdI1u2Qr">Pangenesis</a></td><td>Evolution</td><td>1859</td><td>yes</td><td></td><td>yes</td><td></td><td><a href="/facts/Origin_of_Species/zTMxkKVY">Origin of Species</a> is somewhat progressionist, e.g. man higher than animals, alongside <a href="/facts/Natural_selection/JXTte6en">natural selection</a><a class="footnote-ref" id="fnref:64" href="#fn:64">64</a><a class="footnote-ref" id="fnref:65" href="#fn:65">65</a> Pangenesis theory of inheritance by gemmules from all over body was <a href="/facts/Lamarckism/5bwVUmP8">Lamarckian</a>: parents could <a href="/facts/Inheritance_of_acquired_characters/5bwVUmP8">pass on traits acquired</a> in lifetime.<a class="footnote-ref" id="fnref:66" href="#fn:66">66</a><a class="footnote-ref" id="fnref:67" href="#fn:67">67</a></td></tr><tr><td><a href="/facts/Wilhelm_Haacke/NnWFUmR8">Haacke</a></td><td>Orthogenesis</td><td>Zoology</td><td>1893</td><td>yes</td><td></td><td></td><td></td><td>Accompanied by <a href="/facts/Epimorphism_(biology)/NnWFUmR8">epimorphism</a>, a tendency to increasing perfection<a class="footnote-ref" id="fnref:68" href="#fn:68">68</a><a class="footnote-ref" id="fnref:69" href="#fn:69">69</a></td></tr><tr><td><a href="/facts/Theodor_Eimer/u09Gqp8Y">Eimer</a></td><td>Orthogenesis</td><td>Zoology</td><td>1898</td><td></td><td></td><td>no</td><td></td><td>On Orthogenesis: And the Impotence of Natural Selection in Species Formation: trends in <a href="/facts/Evolution/Hj0qAaBk">evolution</a> with no adaptive significance, claimed hard to explain by natural selection.<a class="footnote-ref" id="fnref:70" href="#fn:70">70</a><a class="footnote-ref" id="fnref:71" href="#fn:71">71</a></td></tr><tr><td><a href="/facts/Henri_Bergson/CortzHrD">Bergson</a></td><td><a href="/facts/%C3%89lan_vital/SkpAcVTa">Elan vital</a></td><td>Philosophy</td><td>1907</td><td></td><td></td><td></td><td>yes</td><td><a href="/facts/Creative_Evolution_(book)/Un1b3Wpv">Creative Evolution</a><a class="footnote-ref" id="fnref:72" href="#fn:72">72</a></td></tr><tr><td><a href="/facts/Hans_Przibram/8FxNf9sY">Przibram</a></td><td><a href="/facts/Apogenesis/TKjwUPmA">Apogenesis</a></td><td>Embryology</td><td>1910s</td><td></td><td></td><td></td><td></td><td><a class="footnote-ref" id="fnref:73" href="#fn:73">73</a></td></tr><tr><td><a href="/facts/Ludwig_Hermann_Plate/Vwhdmzcy">Plate</a></td><td><a href="/facts/Orthoselection/Vwhdmzcy">Orthoselection</a> or Old-Darwinism</td><td>Zoology</td><td>1913</td><td>yes</td><td>yes</td><td>yes</td><td></td><td>Combined theory<a class="footnote-ref" id="fnref:74" href="#fn:74">74</a></td></tr><tr><td><a href="/facts/Daniele_Rosa/rrJqUUBE">Rosa</a></td><td><a href="/facts/Hologenesis/rrJqUUBE">Hologenesis</a></td><td>Zoology</td><td>1918</td><td>yes</td><td></td><td></td><td></td><td>Hologenesis: a New Theory of Evolution and the Geographical Distribution of Living Beings<a class="footnote-ref" id="fnref:75" href="#fn:75">75</a><a class="footnote-ref" id="fnref:76" href="#fn:76">76</a></td></tr><tr><td><a href="/facts/Charles_Otis_Whitman/RkvDtPFI">Whitman</a></td><td>Orthogenesis</td><td>Zoology</td><td>1919</td><td>no</td><td>no</td><td>no</td><td></td><td>Orthogenetic Evolution in Pigeons posthumous<a class="footnote-ref" id="fnref:77" href="#fn:77">77</a><a class="footnote-ref" id="fnref:78" href="#fn:78">78</a></td></tr><tr><td><a href="/facts/Lev_Berg/M8JW340r">Berg</a></td><td><a href="/facts/Nomogenesis/M8JW340r">Nomogenesis</a></td><td>Zoology</td><td>1926</td><td>no</td><td>yes</td><td>no</td><td></td><td>Chemical forces direct evolution, leading to humans<a class="footnote-ref" id="fnref:79" href="#fn:79">79</a><a class="footnote-ref" id="fnref:80" href="#fn:80">80</a><a class="footnote-ref" id="fnref:81" href="#fn:81">81</a></td></tr><tr><td><a href="/facts/Othenio_Abel/LY4x0LS9">Abel</a></td><td>Trägheitsgesetz (the law of inertia)</td><td>Palaeontology</td><td>1928</td><td></td><td></td><td></td><td></td><td>based on <a href="/facts/Dollo%27s_law_of_irreversibility/yMQ1smNq">Dollo's law of irreversibility</a> of evolution (which can be explained without orthogenesis as a statistical improbability that a path should be exactly reversed)<a class="footnote-ref" id="fnref:82" href="#fn:82">82</a></td></tr><tr><td><a href="/facts/Andr%C3%A9_Michel_Lwoff/Np6dqyjP">Lwoff</a></td><td><a href="/facts/Physiological_degradation/Np6dqyjP">Physiological degradation</a></td><td>Physiology</td><td>1930s–1940s</td><td>yes</td><td></td><td></td><td></td><td>Directed loss of functions in microorganisms<a class="footnote-ref" id="fnref:83" href="#fn:83">83</a><a class="footnote-ref" id="fnref:84" href="#fn:84">84</a><a class="footnote-ref" id="fnref:85" href="#fn:85">85</a></td></tr><tr><td><a href="/facts/Karl_Beurlen/lB9IgTtm">Beurlen</a></td><td>Orthogenesis</td><td>Palaeontology</td><td>1930</td><td>no</td><td></td><td>no</td><td></td><td>Start is random metakinesis, generating variety; then palingenesis (in Beurlen's sense, repeating developmental pathway of ancestors) as mechanism for orthogenesis<a class="footnote-ref" id="fnref:86" href="#fn:86">86</a></td></tr><tr><td>Victor Jollos [pl]</td><td>Directed mutation</td><td>Protozoology, Zoology</td><td>1931</td><td>yes</td><td></td><td></td><td></td><td>Combined orthogenesis with <a href="/facts/Lamarckism/5bwVUmP8">Lamarckism</a> (inheriting acquired characteristics after heat shock as dauermodifications, passed on by plasmatic inheritance in the <a href="/facts/Cytoplasm/Wa0sE6xf">cytoplasm</a>)<a class="footnote-ref" id="fnref:87" href="#fn:87">87</a></td></tr><tr><td><a href="/facts/Henry_Fairfield_Osborn/jnULPElT">Osborn</a></td><td><a href="/facts/Aristogenesis/jnULPElT">Aristogenesis</a></td><td>Palaeontology</td><td>1934</td><td>yes</td><td>no</td><td>no</td><td></td><td><a class="footnote-ref" id="fnref:88" href="#fn:88">88</a><a class="footnote-ref" id="fnref:89" href="#fn:89">89</a></td></tr><tr><td><a href="/facts/John_Christopher_Willis/KPvrJIHc">Willis</a></td><td><a href="/facts/Differentiation_(orthogenesis)/KPvrJIHc">Differentiation (orthogenesis)</a></td><td>Botany</td><td>1942</td><td></td><td></td><td></td><td>yes</td><td>a force "working upon some definite law that we do not yet comprehend", compromise between special creation and natural selection, driven by large mutations involving chromosome alterations<a class="footnote-ref" id="fnref:90" href="#fn:90">90</a></td></tr><tr><td><a href="/facts/Pierre_Lecomte_du_No%C3%BCy/g0vcDrFq">Noüy</a></td><td><a href="/facts/Telefinalism/g0vcDrFq">Telefinalism</a></td><td>Biophysics</td><td>1947</td><td></td><td></td><td></td><td>yes</td><td>In book Human Destiny,<a class="footnote-ref" id="fnref:91" href="#fn:91">91</a> essentially religious<a class="footnote-ref" id="fnref:92" href="#fn:92">92</a></td></tr><tr><td>Vandel [fr]</td><td><a href="/facts/Organicism/SUXDuB0v">Organicism</a></td><td>Zoology</td><td>1949</td><td></td><td></td><td>No</td><td></td><td>L'Homme et L'Evolution<a class="footnote-ref" id="fnref:93" href="#fn:93">93</a></td></tr><tr><td><a href="/facts/Edmund_Ware_Sinnott/VRxeELhm">Sinnott</a></td><td><a href="/facts/Telism/VRxeELhm">Telism</a></td><td>Botany</td><td>1950</td><td></td><td></td><td></td><td>yes</td><td>In book Cell and Psyche,<a class="footnote-ref" id="fnref:94" href="#fn:94">94</a> essentially religious<a class="footnote-ref" id="fnref:95" href="#fn:95">95</a></td></tr><tr><td><a href="/facts/Otto_Schindewolf/7GqnFfgj">Schindewolf</a></td><td><a href="/facts/Typostrophism/7GqnFfgj">Typostrophism</a></td><td>Palaeontology</td><td>1950</td><td></td><td>yes</td><td></td><td></td><td>Basic Questions in Paleontology: Geologic Time, Organic Evolution and Biological Systematics; evolution due to periodic cycle of processes dictated by factors internal to organism.<a class="footnote-ref" id="fnref:96" href="#fn:96">96</a><a class="footnote-ref" id="fnref:97" href="#fn:97">97</a></td></tr><tr><td><a href="/facts/Pierre_Teilhard_de_Chardin/lxJNfoam">Teilhard de Chardin</a></td><td><a href="/facts/Directed_additivity/lxJNfoam">Directed additivity</a><a href="/facts/Omega_Point/f7LJbxDC">Omega Point</a></td><td>Palaeontology<a href="/facts/Mysticism/3Rfb7zEd">Mysticism</a></td><td>1959</td><td></td><td></td><td></td><td>yes</td><td><a href="/facts/The_Phenomenon_of_Man/U46Rowhj">The Phenomenon of Man</a> posthumous; combined orthogenesis with non-material vitalist directive force aiming for a supposed "<a href="/facts/Omega_Point/f7LJbxDC">Omega Point</a>" with creation of consciousness. <a href="/facts/Noosphere/zCetV7d7">Noosphere</a> concept from <a href="/facts/Vladimir_Vernadsky/uu84bBgI">Vladimir Vernadsky</a>.<a class="footnote-ref" id="fnref:98" href="#fn:98">98</a> Censured by Gaylord Simpson for nonscientific spiritualistic "doubletalk".<a class="footnote-ref" id="fnref:99" href="#fn:99">99</a><a class="footnote-ref" id="fnref:100" href="#fn:100">100</a><a class="footnote-ref" id="fnref:101" href="#fn:101">101</a></td></tr><tr><td><a href="/facts/L%C3%A9on_Croizat/F453KEVK">Croizat</a></td><td><a href="/facts/Biological_synthesis_(philosophy)/F453KEVK">Biological synthesis</a><a href="/facts/Panbiogeography/HsHCQ3xV">Panbiogeography</a></td><td>Botany</td><td>1964</td><td></td><td></td><td></td><td></td><td>mechanistic, caused by <a href="/facts/Developmental_constraint/F453KEVK">developmental constraints</a> or <a href="/facts/Phylogenetic_constraint/F453KEVK">phylogenetic constraints</a><a class="footnote-ref" id="fnref:102" href="#fn:102">102</a><a class="footnote-ref" id="fnref:103" href="#fn:103">103</a></td></tr><tr><td>Lima-de-Faria</td><td><a href="/facts/Autoevolutionism/REr0K8ob">Autoevolutionism</a></td><td>Physics, Chemistry</td><td>1988</td><td>No</td><td>No</td><td>No</td><td>No</td><td>Natural selection is immaterial so cannot work.<a class="footnote-ref" id="fnref:104" href="#fn:104">104</a></td></tr></tbody></table>

The various <a href="/facts/Alternatives_to_evolution_by_natural_selection/dVrGkzvu">alternatives to Darwinian evolution</a> by natural selection were not necessarily mutually exclusive. The evolutionary philosophy of the American palaeontologist <a href="/facts/Edward_Drinker_Cope/Wup4Ic7k">Edward Drinker Cope</a> is a case in point. Cope, a religious man, began his career denying the possibility of evolution. In the 1860s, he accepted that evolution could occur, but, influenced by Agassiz, rejected natural selection. Cope accepted instead the theory of recapitulation of evolutionary history during the growth of the embryo - that <a href="/facts/Ontogeny_recapitulates_phylogeny/Fc8dFDpy">ontogeny recapitulates phylogeny</a>, which Agassiz believed showed a divine plan leading straight up to man, in a pattern revealed both in <a href="/facts/Embryology/4mvpSkhC">embryology</a> and <a href="/facts/Palaeontology/60n5yldd">palaeontology</a>. Cope did not go so far, seeing that evolution created a branching tree of forms, as Darwin had suggested. Each evolutionary step was however non-random: the direction was determined in advance and had a regular pattern (orthogenesis), and steps were not adaptive but part of a divine plan (theistic evolution). This left unanswered the question of why each step should occur, and Cope switched his theory to accommodate functional adaptation for each change. Still rejecting natural selection as the cause of adaptation, Cope turned to Lamarckism to provide the force guiding evolution. Finally, Cope supposed that Lamarckian use and disuse operated by causing a vitalist growth-force substance, "bathmism", to be concentrated in the areas of the body being most intensively used; in turn, it made these areas develop at the expense of the rest. Cope's complex set of beliefs thus assembled five evolutionary philosophies: recapitulationism, orthogenesis, theistic evolution, Lamarckism, and vitalism.<a class="footnote-ref" id="fnref:105" href="#fn:105">105</a> Other palaeontologists and field naturalists continued to hold beliefs combining orthogenesis and Lamarckism until the modern synthesis in the 1930s.<a class="footnote-ref" id="fnref:106" href="#fn:106">106</a>

<h2 id="status">Status</h2>
<h3>In science</h3>

The stronger versions of the orthogenetic hypothesis began to lose popularity when it became clear that they were inconsistent with the patterns found by <a href="/facts/Paleontology/60n5yldd">paleontologists</a> in the <a href="/facts/Fossil_record/by7NzIA1">fossil record</a>, which were non-rectilinear (richly branching) with many complications. The hypothesis was abandoned by mainstream biologists when no mechanism could be found that would account for the process, and the theory of evolution by natural selection came to prevail.<a class="footnote-ref" id="fnref:107" href="#fn:107">107</a> The historian of biology Edward J. Larson commented that

At theoretical and philosophical levels, Lamarckism and orthogenesis seemed to solve too many problems to be dismissed out of hand—yet biologists could never reliably document them happening in nature or in the laboratory. Support for both concepts evaporated rapidly once a plausible alternative appeared on the scene.<a class="footnote-ref" id="fnref:108" href="#fn:108">108</a>
The <a href="/facts/Modern_synthesis_(20th_century)/anJdPq34">modern synthesis</a> of the 1930s and 1940s, in which the <a href="/facts/Genetics/bu8wne0A">genetic</a> mechanisms of evolution were incorporated, appeared to refute the hypothesis for good. As more was understood about these mechanisms it came to be held that there was no naturalistic way in which the newly discovered mechanism of <a href="/facts/Heredity/t0aMmRWx">heredity</a> could be far-sighted or have a memory of past trends. Orthogenesis was seen to lie outside the <a href="/facts/Methodological_naturalism/Glvu6ASA">methodological naturalism</a> of the sciences.<a class="footnote-ref" id="fnref:109" href="#fn:109">109</a><a class="footnote-ref" id="fnref:110" href="#fn:110">110</a><a class="footnote-ref" id="fnref:111" href="#fn:111">111</a>

By 1948, the evolutionary biologist <a href="/facts/Ernst_Mayr/GFajn2Tp">Ernst Mayr</a>, as editor of the journal Evolution, made the use of the term orthogenesis taboo: "It might be well to abstain from use of the word 'orthogenesis' .. since so many of the geneticists seem to be of the opinion that the use of the term implies some supernatural force."<a class="footnote-ref" id="fnref:112" href="#fn:112">112</a><a class="footnote-ref" id="fnref:113" href="#fn:113">113</a> For these and other reasons, belief in evolutionary progress has remained "a persistent <a href="/facts/Heresy/1eHqC2km">heresy</a>",<a class="footnote-ref" id="fnref:114" href="#fn:114">114</a> among evolutionary biologists including <a href="/facts/E._O._Wilson/YuXAKxp7">E. O. Wilson</a><a class="footnote-ref" id="fnref:115" href="#fn:115">115</a> and <a href="/facts/Simon_Conway_Morris/c4kHVblJ">Simon Conway Morris</a>, although often denied or veiled. The philosopher of biology <a href="/facts/Michael_Ruse/mcxEuTom">Michael Ruse</a> wrote that "some of the most significant of today's evolutionists are progressionists, and that because of this we find (absolute) progressionism alive and well in their work."<a class="footnote-ref" id="fnref:116" href="#fn:116">116</a> He argued that progressionism has harmed the status of <a href="/facts/Evolutionary_biology/8tBoG55U">evolutionary biology</a> as a mature, professional science.<a class="footnote-ref" id="fnref:117" href="#fn:117">117</a> Presentations of evolution remain characteristically progressionist, with humans at the top of the "Tower of Time" in the <a href="/facts/Smithsonian_Institution/pqC74ta9">Smithsonian Institution</a> in <a href="/facts/Washington_D.C./enXPK156">Washington D.C.</a>, while <a href="/facts/Scientific_American/jkl8bhUN">Scientific American</a> magazine could illustrate the history of life leading progressively from mammals to dinosaurs to primates and finally man. Ruse noted that at the popular level, progress and evolution are simply synonyms, as they were in the nineteenth century, though confidence in the value of cultural and technological progress has declined.<a class="footnote-ref" id="fnref:118" href="#fn:118">118</a>
The discipline of <a href="/facts/Evolutionary_developmental_biology/gl4ysPCa">evolutionary developmental biology</a>, however, is open to an expanded concept of heredity that incorporates the physics of <a href="/facts/Self-organization/NSGBKxUa">self-organization</a>. With its rise in the late 20th-early 21st centuries, ideas of constraint and preferred directions of morphological change have made a reappearance in evolutionary theory.<a class="footnote-ref" id="fnref:119" href="#fn:119">119</a>

<h3>In popular culture</h3>

Further information: <a href="/facts/March_of_Progress/hkRW50Tc">March of Progress</a>
In popular culture, progressionist images of evolution are widespread. The historian Jennifer Tucker, writing in <a href="/facts/The_Boston_Globe/6avrtpCk">The Boston Globe</a>, notes that <a href="/facts/Thomas_Henry_Huxley/NUNXtNdr">Thomas Henry Huxley</a>'s 1863 illustration comparing the skeletons of apes and humans "has become an iconic and instantly recognizable visual shorthand for evolution."<a class="footnote-ref" id="fnref:120" href="#fn:120">120</a> She calls its history extraordinary, saying that it is "one of the most intriguing, and most misleading, drawings in the modern history of science." Nobody, Tucker observes, supposes that the "monkey-to-man" sequence accurately depicts Darwinian evolution. The Origin of Species had only one illustration, a diagram showing that random events create a process of branching evolution, a view that Tucker notes is broadly acceptable to modern biologists. But Huxley's image recalled the great chain of being, implying with the force of a visual image a "logical, evenly paced progression" leading up to Homo sapiens, a view denounced by <a href="/facts/Stephen_Jay_Gould/FtAcabjg">Stephen Jay Gould</a> in <a href="/facts/Wonderful_Life_(book)/d975HBhr">Wonderful Life</a>.<a class="footnote-ref" id="fnref:121" href="#fn:121">121</a>

Popular perception, however, had seized upon the idea of linear progress. <a href="/facts/Edward_Linley_Sambourne/3bCYa848">Edward Linley Sambourne</a>'s Man is But a Worm, drawn for Punch's Almanack, mocked the idea of any evolutionary link between humans and animals, with a sequence from chaos to earthworm to apes, primitive men, a Victorian beau, and Darwin in a pose that according to Tucker recalls <a href="/facts/Michelangelo/uKw8rLk4">Michelangelo</a>'s figure of <a href="/facts/Adam/nM1GQfk8">Adam</a> in his fresco adorning the ceiling of the <a href="/facts/Sistine_Chapel/Wo0TlkST">Sistine Chapel</a>. This was followed by a flood of variations on the evolution-as-progress theme, including The New Yorker's 1925 "The Rise and Fall of Man", the sequence running from a chimpanzee to <a href="/facts/Neanderthal_man/19rBo6ze">Neanderthal man</a>, <a href="/facts/Socrates/djIKjImv">Socrates</a>, and finally the lawyer <a href="/facts/William_Jennings_Bryan/8hxxy4Wu">William Jennings Bryan</a> who argued for the anti-evolutionist prosecution in the <a href="/facts/Scopes_Trial/RM50y3Ck">Scopes Trial</a> on the State of Tennessee law limiting the teaching of evolution. Tucker noted that <a href="/facts/Rudolph_Franz_Zallinger/t0JKIIIu">Rudolph Franz Zallinger</a>'s 1965 "<a href="/facts/March_of_Progress/hkRW50Tc">The Road to Homo Sapiens</a>" fold-out illustration in <a href="/facts/F._Clark_Howell/5FbtJlCD">F. Clark Howell</a>'s Early Man, showing a sequence of 14 walking figures ending with modern man, fitted the palaeoanthropological discoveries "not into a branching Darwinian scheme, but into the framework of the original Huxley diagram." Howell ruefully commented that the "powerful and emotional" graphic had overwhelmed his Darwinian text.<a class="footnote-ref" id="fnref:122" href="#fn:122">122</a>

<h3>Sliding between meanings</h3>
Scientists, Ruse argues, continue to slide easily from one notion of progress to another: even committed Darwinians like <a href="/facts/Richard_Dawkins/x8Q24PJG">Richard Dawkins</a> embed the idea of cultural progress in a theory of cultural units, <a href="/facts/Meme/65Qsyhak">memes</a>, that act much like genes.<a class="footnote-ref" id="fnref:123" href="#fn:123">123</a> Dawkins can speak of "progressive rather than random ... trends in evolution".<a class="footnote-ref" id="fnref:124" href="#fn:124">124</a><a class="footnote-ref" id="fnref:125" href="#fn:125">125</a> Dawkins and <a href="/facts/John_Krebs,_Baron_Krebs/4ShgbvHX">John Krebs</a> deny the "earlier [Darwinian] prejudice"<a class="footnote-ref" id="fnref:126" href="#fn:126">126</a> that there is anything "inherently progressive about evolution",<a class="footnote-ref" id="fnref:127" href="#fn:127">127</a><a class="footnote-ref" id="fnref:128" href="#fn:128">128</a> but, Ruse argues, the feeling of progress comes from evolutionary <a href="/facts/Arms_race/o8nvYPVu">arms races</a> which remain in Dawkins's words "by far the most satisfactory explanation for the existence of the advanced and complex machinery that animals and plants possess".<a class="footnote-ref" id="fnref:129" href="#fn:129">129</a><a class="footnote-ref" id="fnref:130" href="#fn:130">130</a>
Ruse concludes his detailed analysis of the idea of Progress, meaning a progressionist philosophy, in evolutionary biology by stating that evolutionary thought came out of that philosophy. Before Darwin, Ruse argues, evolution was just a <a href="/facts/Pseudoscience/kdNzoLeS">pseudoscience</a>; Darwin made it respectable, but "only as popular science". "There it remained frozen, for nearly another hundred years",<a class="footnote-ref" id="fnref:131" href="#fn:131">131</a> until mathematicians such as Fisher<a class="footnote-ref" id="fnref:132" href="#fn:132">132</a> provided "both <a href="/facts/Population_genetics/v55qAnKu">models</a> and status", enabling evolutionary biologists to construct the <a href="/facts/Modern_synthesis_(20th_century)/anJdPq34">modern synthesis</a> of the 1930s and 1940s. That made biology a professional science, at the price of ejecting the notion of progress. That, Ruse argues, was a significant cost to "people [biologists] still firmly committed to Progress" as a philosophy.<a class="footnote-ref" id="fnref:133" href="#fn:133">133</a>

<h2 id="facilitated-variation">Facilitated variation</h2>

Main article: <a href="/facts/Facilitated_variation/v9BxGVfg">Facilitated variation</a>
Biology has largely rejected the idea that evolution is guided in any way,<a class="footnote-ref" id="fnref:134" href="#fn:134">134</a><a class="footnote-ref" id="fnref:135" href="#fn:135">135</a> but the evolution of some features is indeed <a href="/facts/Facilitated_variation/v9BxGVfg">facilitated</a> by the genes of the <a href="/facts/Developmental-genetic_toolkit/wRe0E6BN">developmental-genetic toolkit</a> studied in <a href="/facts/Evolutionary_developmental_biology/gl4ysPCa">evolutionary developmental biology</a>. An example is the development of wing pattern in some species of <a href="/facts/Heliconius/ktDMEUNl">Heliconius</a> butterfly, which have <a href="/facts/Parallel_evolution/WNYPe6td">independently evolved</a> similar patterns. These butterflies are <a href="/facts/M%C3%BCllerian_mimicry/eKf9Q4s5">Müllerian mimics</a> of each other, so natural selection is the driving force, but their wing patterns, which arose in separate evolutionary events, are controlled by the same genes.<a class="footnote-ref" id="fnref:136" href="#fn:136">136</a>

<h2 id="see-also">See also</h2>
<ul><li><a href="/facts/Adaptive_mutation/jfgAqkIJ">Adaptive mutation</a></li>
<li><a href="/facts/Convergent_evolution/dd0L8z4R">Convergent evolution</a> (contrastable with orthogenesis, not involving teleology)</li>
<li><a href="/facts/Devolution_(biology)/aSu2BzXU">Devolution</a></li>
<li><a href="/facts/Directed_evolution/DYJs0Hm2">Directed evolution</a> (in protein engineering)</li>
<li><a href="/facts/Directed_evolution_(transhumanism)/axJhTbtQ">Directed evolution (transhumanism)</a></li>
<li><a href="/facts/Evolutionism/Mrl8xAkT">Evolutionism</a></li>
<li><a href="/facts/Evolution_of_biological_complexity/aNhaSk5R">Evolution of biological complexity</a></li>
<li><a href="/facts/History_of_evolutionary_thought/Ah1RKqf0">History of evolutionary thought</a></li>
<li><a href="/facts/Structuralism_(biology)/bYod1m4P">Structuralism</a></li>
<li><a href="/facts/Teleonomy/5287sFD9">Teleonomy</a></li>
<li><a href="/facts/Teleological_argument/moED4Cjz">Teleological argument</a></li></ul>

<h2 id="sources">Sources</h2>
<ul><li><a href="/facts/Peter_J._Bowler/d9fHfnoo">Bowler, Peter J.</a> (1983). The Eclipse of Darwinism: anti-Darwinian evolutionary theories in the decades around 1900. Johns Hopkins University Press. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-8018-4391-4.</li>
<li><a href="/facts/Peter_J._Bowler/d9fHfnoo">Bowler, Peter J.</a> (1989). <a href="https://archive.org/details/evolutionhistory0000bowl">Evolution: The History of an Idea</a>. University of California Press. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-520-06385-3.</li>
<li><a href="/facts/Richard_Dawkins/x8Q24PJG">Dawkins, Richard</a> (1986). <a href="https://archive.org/details/blindwatchmaker0000dawk">The Blind Watchmaker</a>. Longman. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-393-31570-7.</li>
<li>Larson, Edward J. (2004). <a href="https://archive.org/details/evolutionremarka00lars">Evolution</a>. Modern Library. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-679-64288-6.</li>
<li><a href="/facts/Michael_Ruse/mcxEuTom">Ruse, Michael</a> (1996). <a href="https://archive.org/details/monadtomanconcep0000ruse">Monad to man: the Concept of Progress in Evolutionary Biology</a>. Harvard University Press. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0-674-03248-4.</li></ul>
<h2 id="further-reading">Further reading</h2>
<ul><li><a href="/facts/William_Bateson/vx1g3kgg">Bateson, William</a> (1909). "<a href="https://gutenberg.org/etext/1909">Heredity and variation in modern lights</a>", in Darwin and Modern Science (A.C. Seward ed.) Cambridge University Press. Chapter V.</li>
<li><a href="/facts/Daniel_Dennett/I5bzs3V6">Dennett, Daniel</a> (1995). <a href="/facts/Darwin%27s_Dangerous_Idea/xbrRemxk">Darwin's Dangerous Idea</a>. Simon & Schuster. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 978-0140167344.</li>
<li><a href="/facts/Julian_Huxley/pIST2QoX">Huxley, Julian</a> (1942). <a href="/facts/Evolution:_The_Modern_Synthesis/VhorpVWH">Evolution: The Modern Synthesis</a>, London: George Allen and Unwin.</li>
<li><a href="/facts/Ernst_Mayr/GFajn2Tp">Mayr, Ernst</a> (2002). What Evolution Is. Weidenfeld and Nicolson. <a href="/facts/ISBN_(identifier)/15AdSPa9">ISBN</a> 9780297607410.</li>
<li><a href="/facts/George_Gaylord_Simpson/T159FrGC">Simpson, George G.</a> (1957). Life Of The Past: Introduction to Paleontology. Yale University Press, p. 119.</li>
<li>Wilkins, John (1997). <a href="http://www.talkorigins.org/faqs/macroevolution.html">"What is macroevolution?"</a> 13 October 2004.</li></ul>
<h2 id="external-links">External links</h2>
<ul><li><a href="https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html">What our most famous evolutionary cartoon gets wrong</a></li></ul>

<h2 id="references">References</h2>

<ol>
<li id="fn:1">Bowler 1989, pp. 268–270. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></li>
<li id="fn:2">Mayr, Ernst (1988). Toward a New Philosophy of Biology: Observations of an Evolutionist. Harvard University Press. p. 499. ISBN 978-0-674-89666-6. <a href="978-0-674-89666-6" target="_blank">978-0-674-89666-6</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></li>
<li id="fn:3">Ruse 1996, pp. 526–539. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></li>
<li id="fn:4">Ulett, Mark A. (2014). "Making the case for orthogenesis: The popularization of definitely directed evolution (1890–1926)". Studies in History and Philosophy of Biological and Biomedical Sciences. 45: 124–132. doi:10.1016/j.shpsc.2013.11.009. PMID 24368232. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></li>
<li id="fn:5">Ruse 1996, p. 447. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></li>
<li id="fn:6">Letter from Ernst Mayr to R. H. Flower, Evolution papers, 23 January 1948 <a href="/wiki/Ernst_Mayr" target="_blank">/wiki/Ernst_Mayr</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></li>
<li id="fn:7">Simpson, George Gaylord (1953). Life of the Past: An Introduction to Paleontology. Yale University Press. p. 125. <a href="/wiki/George_Gaylord_Simpson" target="_blank">/wiki/George_Gaylord_Simpson</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></li>
<li id="fn:8">Levit, Georgy S.; Olsson, Lennart (2006). "'Evolution on Rails': Mechanisms and Levels of Orthogenesis" (PDF). Annals of the History and Philosophy of Biology (11): 99–138. <a href="https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y" target="_blank">https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></li>
<li id="fn:9">Gould, Stephen Jay (2002). The Structure of Evolutionary Theory. Harvard University Press. pp. 351–352. ISBN 978-0-674-00613-3. <a href="978-0-674-00613-3" target="_blank">978-0-674-00613-3</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></li>
<li id="fn:10">Lane, David H. (1996). The Phenomenon of Teilhard: Prophet for a New Age. Mercer University Press. pp. 60–64. ISBN 978-0-86554-498-7. <a href="978-0-86554-498-7" target="_blank">978-0-86554-498-7</a> <a href="#fnref:10" class="footnote-back-ref">↩</a></li>
<li id="fn:11">Guyer, Michael F. (1922). "Orthogenesis and Serological Phenomena". The American Naturalist. 56 (643): 116–133. doi:10.1086/279852. JSTOR 2456504. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:11" class="footnote-back-ref">↩</a></li>
<li id="fn:12">Schrepfer, Susan R. (1983). Fight to Save the Redwoods: A History of the Environmental Reform, 1917–1978. University of Wisconsin Press. pp. 81–82. ISBN 978-0-299-08854-5. <a href="978-0-299-08854-5" target="_blank">978-0-299-08854-5</a> <a href="#fnref:12" class="footnote-back-ref">↩</a></li>
<li id="fn:13">Ayala, Francisco J. (1988). "Can progress be defined as a biological concept?". In Nitecki, M. (ed.). Evolutionary Progress. University of Chicago Press. pp. 75–96. ISBN 978-0-226-58693-9. <a href="978-0-226-58693-9" target="_blank">978-0-226-58693-9</a> <a href="#fnref:13" class="footnote-back-ref">↩</a></li>
<li id="fn:14">Gould, Stephen Jay (1997). Full House: The Spread of Excellence from Plato to Darwin. Harmony. ISBN 978-0-609-80140-6. <a href="978-0-609-80140-6" target="_blank">978-0-609-80140-6</a> <a href="#fnref:14" class="footnote-back-ref">↩</a></li>
<li id="fn:15">Bowler 1989, pp. 268–270. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:15" class="footnote-back-ref">↩</a></li>
<li id="fn:16">Ruse 1996, p. 261. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:16" class="footnote-back-ref">↩</a></li>
<li id="fn:17">Ruse 1996, pp. 21–23. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:17" class="footnote-back-ref">↩</a></li>
<li id="fn:18">Gould, Stephen J. (2001). The lying stones of Marrakech : penultimate reflections in natural history. Vintage. pp. 119–121. ISBN 978-0-09-928583-0. <a href="978-0-09-928583-0" target="_blank">978-0-09-928583-0</a> <a href="#fnref:18" class="footnote-back-ref">↩</a></li>
<li id="fn:19">Gould, Stephen Jay (1977). Darwin's Dilemma: The Odyssey of Evolution. W. W. Norton. ISBN 978-0-393-06425-4. Archived from the original on 2019-12-16. Retrieved 2019-08-01. {{cite book}}: |work= ignored (help) <a href="978-0-393-06425-4" target="_blank">978-0-393-06425-4</a> <a href="#fnref:19" class="footnote-back-ref">↩</a></li>
<li id="fn:20">Daly, J. P. (4 March 2018). "The Botanic Universe: Generative Nature and Erasmus Darwin's Cosmic Transformism". Republics of Letters. 6: 1–57. Archived from the original on 1 July 2022. Retrieved 7 December 2021. <a href="https://web.archive.org/web/20220701140038/https://arcade.stanford.edu/rofl/botanic-universe-generative-nature-and-erasmus-darwins-cosmic-transformism" target="_blank">https://web.archive.org/web/20220701140038/https://arcade.stanford.edu/rofl/botanic-universe-generative-nature-and-erasmus-darwins-cosmic-transformism</a> <a href="#fnref:20" class="footnote-back-ref">↩</a></li>
<li id="fn:21">Bowler 1989, p. 134. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:21" class="footnote-back-ref">↩</a></li>
<li id="fn:22">Ruse 1996, p. 29. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:22" class="footnote-back-ref">↩</a></li>
<li id="fn:23">Brown, Keven; Von Kitzing, Eberhard (2001). Evolution and Bahá'í Belief: ʻAbduʼl-Bahá's Response to Nineteenth-century Darwinism. Kalimat Press. p. 159. ISBN 978-1-890688-08-0. <a href="978-1-890688-08-0" target="_blank">978-1-890688-08-0</a> <a href="#fnref:23" class="footnote-back-ref">↩</a></li>
<li id="fn:24">Barbieri, Marcello (2013). Biosemiotics: Information, Codes and Signs in Living Systems. Nova Science Publishers. p. 7. ISBN 978-1-60021-612-1. <a href="978-1-60021-612-1" target="_blank">978-1-60021-612-1</a> <a href="#fnref:24" class="footnote-back-ref">↩</a></li>
<li id="fn:25">Jacobsen, Eric Paul (2005). From Cosmology to Ecology: The Monist World-view in Germany from 1770 to 1930. Peter Lang. p. 100. ISBN 978-0-8204-7231-7. <a href="978-0-8204-7231-7" target="_blank">978-0-8204-7231-7</a> <a href="#fnref:25" class="footnote-back-ref">↩</a></li>
<li id="fn:26">Vucinich, Alexander (1988). Darwin in Russian Thought. University of California Press. p. 137. ISBN 978-0-520-06283-2. <a href="978-0-520-06283-2" target="_blank">978-0-520-06283-2</a> <a href="#fnref:26" class="footnote-back-ref">↩</a></li>
<li id="fn:27">Mawer, Simon (2006). Gregor Mendel: planting the seeds of genetics. Harry N. Abrams. ISBN 978-0-8109-5748-0. <a href="978-0-8109-5748-0" target="_blank">978-0-8109-5748-0</a> <a href="#fnref:27" class="footnote-back-ref">↩</a></li>
<li id="fn:28">Bowler 1989, pp. 268–270. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:28" class="footnote-back-ref">↩</a></li>
<li id="fn:29">Watson, Marc; Angle, Barbara (2017). Man's Selection: Charles Darwin's Theory of Creation, Evolution, And Intelligent Design. BookBaby. pp. 146–150. ISBN 978-1-936883-14-1. <a href="978-1-936883-14-1" target="_blank">978-1-936883-14-1</a> <a href="#fnref:29" class="footnote-back-ref">↩</a></li>
<li id="fn:30">Ruse 1996, pp. 154–155, 162. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:30" class="footnote-back-ref">↩</a></li>
<li id="fn:31">Darwin, Charles (1859). On the Origin of Species By Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life. Chapters 10, 14. <a href="/wiki/Charles_Darwin" target="_blank">/wiki/Charles_Darwin</a> <a href="#fnref:31" class="footnote-back-ref">↩</a></li>
<li id="fn:32">Darwin, Charles (1859). On the Origin of Species By Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life. Chapters 10, 14. <a href="/wiki/Charles_Darwin" target="_blank">/wiki/Charles_Darwin</a> <a href="#fnref:32" class="footnote-back-ref">↩</a></li>
<li id="fn:33">Darwin, Charles (1859). On the Origin of Species By Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life. Chapters 10, 14. <a href="/wiki/Charles_Darwin" target="_blank">/wiki/Charles_Darwin</a> <a href="#fnref:33" class="footnote-back-ref">↩</a></li>
<li id="fn:34">Shanahan, Timothy (2004). The Evolution of Darwinism: Selection, Adaptation, and Progress in Evolutionary Biology. Cambridge University Press. p. 121. ISBN 978-0-521-54198-5. <a href="978-0-521-54198-5" target="_blank">978-0-521-54198-5</a> <a href="#fnref:34" class="footnote-back-ref">↩</a></li>
<li id="fn:35">Sapp, Jan (2003). Genesis: The Evolution of Biology. Oxford University Press. pp. 69–70. ISBN 978-0-19-515619-5. <a href="978-0-19-515619-5" target="_blank">978-0-19-515619-5</a> <a href="#fnref:35" class="footnote-back-ref">↩</a></li>
<li id="fn:36">Gould, Stephen Jay (2002). The Structure of Evolutionary Theory. Harvard University Press. pp. 355–364. ISBN 978-0-674-00613-3. <a href="978-0-674-00613-3" target="_blank">978-0-674-00613-3</a> <a href="#fnref:36" class="footnote-back-ref">↩</a></li>
<li id="fn:37">Simpson, George Gaylord (1964). Evolutionary Theology: The New Mysticism. Harcourt, Brace & World. pp. 213–233. {{cite book}}: |work= ignored (help) <a href="/wiki/George_Gaylord_Simpson" target="_blank">/wiki/George_Gaylord_Simpson</a> <a href="#fnref:37" class="footnote-back-ref">↩</a></li>
<li id="fn:38">Metcalf, Maynard M. (1913). "Adaptation Through Natural Selection and Orthogenesis". The American Naturalist. 47 (554): 65–71. doi:10.1086/279329. JSTOR 2455865. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:38" class="footnote-back-ref">↩</a></li>
<li id="fn:39">John Merle Coulter. (1915). A Suggested Explanation of 'Orthogenesis' in Plants Science, Vol. 42, No. 1094. pp. 859–863. <a href="/wiki/John_Merle_Coulter" target="_blank">/wiki/John_Merle_Coulter</a> <a href="#fnref:39" class="footnote-back-ref">↩</a></li>
<li id="fn:40">Starr, Jordan David (1920). "Orthogenesis among Fishes". Science. 52 (1331): 13–14. Bibcode:1920Sci....52...13S. doi:10.1126/science.52.1331.13-a. JSTOR 1646251. PMID 17793787. <a href="/wiki/David_Starr_Jordan" target="_blank">/wiki/David_Starr_Jordan</a> <a href="#fnref:40" class="footnote-back-ref">↩</a></li>
<li id="fn:41">Lipman, Charles B. (1922). "Orthogenesis in Bacteria". The American Naturalist. 56 (643): 105–115. doi:10.1086/279851. JSTOR 2456503. S2CID 85365933. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:41" class="footnote-back-ref">↩</a></li>
<li id="fn:42">Kwa, Chunglin (2011). Styles of Knowing: A New History of Science from Ancient Times to the Present. University of Pittsburgh Press. p. 237. ISBN 978-0-8229-6151-2. <a href="978-0-8229-6151-2" target="_blank">978-0-8229-6151-2</a> <a href="#fnref:42" class="footnote-back-ref">↩</a></li>
<li id="fn:43">Dimichele, William A. (1995). "Basic Questions in Paleontology: Geologic Time, Organic Evolution, and Biological Systematics, by Otto H. Schindewolf" (PDF). Review of Palaeobotany and Palynology. 84 (3–4): 481–483. doi:10.1016/0034-6667(95)90007-1.[permanent dead link‍] <a href="http://si-pddr.si.edu/jspui/bitstream/10088/7124/1/paleo_1995_DiMichele_Schindewolf_book_review_RPP.pdf" target="_blank">http://si-pddr.si.edu/jspui/bitstream/10088/7124/1/paleo_1995_DiMichele_Schindewolf_book_review_RPP.pdf</a> <a href="#fnref:43" class="footnote-back-ref">↩</a></li>
<li id="fn:44">Simpson, George Gaylord (1964). Evolutionary Theology: The New Mysticism. Harcourt, Brace & World. pp. 213–233. {{cite book}}: |work= ignored (help) <a href="/wiki/George_Gaylord_Simpson" target="_blank">/wiki/George_Gaylord_Simpson</a> <a href="#fnref:44" class="footnote-back-ref">↩</a></li>
<li id="fn:45">Jepsen, Glenn L. (1949). "Selection. Orthogenesis, and the Fossil Record". Proceedings of the American Philosophical Society. 93 (6): 479–500. PMID 15408469. <a href="/wiki/PMID_(identifier)" target="_blank">/wiki/PMID_(identifier)</a> <a href="#fnref:45" class="footnote-back-ref">↩</a></li>
<li id="fn:46">Jacobs, Susan C.; Larson, Allan; Cheverud, James M. (1995). "Phylogenetic Relationships and Orthogenetic Evolution of Coat Color Among Tamarins (Genus Saguinus)". Systematic Biology. 44 (4): 515–532. doi:10.1093/sysbio/44.4.515. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:46" class="footnote-back-ref">↩</a></li>
<li id="fn:47">Ranganath, H. A.; Hägel, K. (1981). "Karyotypic orthoselection in Drosophila" (PDF). Naturwissenschaften. 68 (10): 527–528. Bibcode:1981NW.....68..527R. doi:10.1007/bf00365385. S2CID 29736048. <a href="https://zenodo.org/records/10764278/files/Ranganath%20%26%20Haegele,%201981.pdf" target="_blank">https://zenodo.org/records/10764278/files/Ranganath%20%26%20Haegele,%201981.pdf</a> <a href="#fnref:47" class="footnote-back-ref">↩</a></li>
<li id="fn:48">Levit, Georgy S.; Olsson, Lennart (2006). "'Evolution on Rails': Mechanisms and Levels of Orthogenesis" (PDF). Annals of the History and Philosophy of Biology (11): 99–138. <a href="https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y" target="_blank">https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y</a> <a href="#fnref:48" class="footnote-back-ref">↩</a></li>
<li id="fn:49">Yampolsky, L. Y.; Stoltzfus, A. (2001). "Bias in the introduction of variation as an orienting factor in evolution". Evolution & Development. 3 (2): 73–83. doi:10.1046/j.1525-142x.2001.003002073.x. PMID 11341676. S2CID 26956345. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:49" class="footnote-back-ref">↩</a></li>
<li id="fn:50">Stoltzfus, A. (2006). "Mutation-Biased Adaptation in a Protein NK Model". Molecular Biology and Evolution. 23 (10): 1852–1862. doi:10.1093/molbev/msl064. PMID 16857856. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:50" class="footnote-back-ref">↩</a></li>
<li id="fn:51">Stoltzfus, A.; Yampolsky, L. Y. (2009). "Climbing Mount Probable: Mutation as a Cause of Nonrandomness in Evolution". Journal of Heredity. 100 (5): 637–647. doi:10.1093/jhered/esp048. PMID 19625453. <a href="https://doi.org/10.1093%2Fjhered%2Fesp048" target="_blank">https://doi.org/10.1093%2Fjhered%2Fesp048</a> <a href="#fnref:51" class="footnote-back-ref">↩</a></li>
<li id="fn:52">Cigna, Arrigo A.; Durante, Marco, eds. (2007). Radiation Risk Estimates in Normal and Emergency Situations. Springer Science & Business Media. p. 213. ISBN 978-1-4020-4956-9. <a href="978-1-4020-4956-9" target="_blank">978-1-4020-4956-9</a> <a href="#fnref:52" class="footnote-back-ref">↩</a></li>
<li id="fn:53">Gould, Stephen Jay (1977). Darwin's Dilemma: The Odyssey of Evolution. W. W. Norton. ISBN 978-0-393-06425-4. Archived from the original on 2019-12-16. Retrieved 2019-08-01. {{cite book}}: |work= ignored (help) <a href="978-0-393-06425-4" target="_blank">978-0-393-06425-4</a> <a href="#fnref:53" class="footnote-back-ref">↩</a></li>
<li id="fn:54">Gould, Stephen J. (2001). The lying stones of Marrakech : penultimate reflections in natural history. Vintage. pp. 119–121. ISBN 978-0-09-928583-0. <a href="978-0-09-928583-0" target="_blank">978-0-09-928583-0</a> <a href="#fnref:54" class="footnote-back-ref">↩</a></li>
<li id="fn:55">Brown, Keven; Von Kitzing, Eberhard (2001). Evolution and Bahá'í Belief: ʻAbduʼl-Bahá's Response to Nineteenth-century Darwinism. Kalimat Press. p. 159. ISBN 978-1-890688-08-0. <a href="978-1-890688-08-0" target="_blank">978-1-890688-08-0</a> <a href="#fnref:55" class="footnote-back-ref">↩</a></li>
<li id="fn:56">Vucinich, Alexander (1988). Darwin in Russian Thought. University of California Press. p. 137. ISBN 978-0-520-06283-2. <a href="978-0-520-06283-2" target="_blank">978-0-520-06283-2</a> <a href="#fnref:56" class="footnote-back-ref">↩</a></li>
<li id="fn:57">Popov, Igor (7 April 2005). "The Persistence of Heresy: The Concepts of Directed Evolution (Orthogenesis)". Archived from the original on 15 April 2017. Retrieved 15 April 2017. <a href="https://web.archive.org/web/20170415202806/http://www.kli.ac.at/events/event-detail/1112872500/the-persistence-of-heresy-the-concepts-of-directed-evolution-orthogenesis" target="_blank">https://web.archive.org/web/20170415202806/http://www.kli.ac.at/events/event-detail/1112872500/the-persistence-of-heresy-the-concepts-of-directed-evolution-orthogenesis</a> <a href="#fnref:57" class="footnote-back-ref">↩</a></li>
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<li id="fn:61">Levit, Georgy S.; Olsson, Lennart (2006). "'Evolution on Rails': Mechanisms and Levels of Orthogenesis" (PDF). Annals of the History and Philosophy of Biology (11): 99–138. <a href="https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y" target="_blank">https://www.univerlag.uni-goettingen.de/bitstream/handle/3/isbn-978-3-938616-85-7/annals%2011_DGGBT.pdf?sequence=1&isAllowed=y</a> <a href="#fnref:61" class="footnote-back-ref">↩</a></li>
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<li id="fn:63">Ruse 1996, pp. 181–191. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:63" class="footnote-back-ref">↩</a></li>
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<li id="fn:72">Bowler 1989, pp. 116–117. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:72" class="footnote-back-ref">↩</a></li>
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<li id="fn:84">Lwoff, A. (1944). L'evolution physiologique. Etude des pertes de fonctions chez les microorganismes. Paris: Hermann. pp. 1–308. L'idée s'imposa que les microorganismes avaient subi des pertes de fonction. Celles-ci apparurent comme la manifestation d'une évolution physiologique, definie comme une degradation, une orthogenese regressive. <a href="/wiki/Andr%C3%A9_Michel_Lwoff" target="_blank">/wiki/Andr%C3%A9_Michel_Lwoff</a> <a href="#fnref:84" class="footnote-back-ref">↩</a></li>
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<li id="fn:108">Larson 2004, p. 127. - Larson, Edward J. (2004). Evolution. Modern Library. ISBN 978-0-679-64288-6. <a href="https://archive.org/details/evolutionremarka00lars" target="_blank">https://archive.org/details/evolutionremarka00lars</a> <a href="#fnref:108" class="footnote-back-ref">↩</a></li>
<li id="fn:109">Gould, Stephen Jay (2002). The Structure of Evolutionary Theory. pp. Chapter 7, section "Synthesis as Restriction". ISBN 978-0-674-00613-3. <a href="978-0-674-00613-3" target="_blank">978-0-674-00613-3</a> <a href="#fnref:109" class="footnote-back-ref">↩</a></li>
<li id="fn:110">Levinton, Jeffrey S. (2001). Genetics, Paleontology, and Macroevolution. Cambridge University Press. pp. 14–16. ISBN 978-0-521-80317-5. <a href="978-0-521-80317-5" target="_blank">978-0-521-80317-5</a> <a href="#fnref:110" class="footnote-back-ref">↩</a></li>
<li id="fn:111">Montgomery, Georgina M.; Largent, Mark A. (2015). A Companion to the History of American Science. Wiley. p. 218. ISBN 978-1-4051-5625-7. With the integration of Mendelian genetics and population genetics into evolutionary theory in the 1930s a new generation of biologists applied mathematical techniques to investigate how changes in the frequency of genes in populations combined with natural selection could produce species change. This demonstrated that Darwinian natural selection was the primary mechanism for evolution and that other models of evolution, such as neo-Lamarckism and orthogenesis, were invalid. <a href="978-1-4051-5625-7" target="_blank">978-1-4051-5625-7</a> <a href="#fnref:111" class="footnote-back-ref">↩</a></li>
<li id="fn:112">Ruse 1996, p. 447. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:112" class="footnote-back-ref">↩</a></li>
<li id="fn:113">Letter from Ernst Mayr to R. H. Flower, Evolution papers, 23 January 1948 <a href="/wiki/Ernst_Mayr" target="_blank">/wiki/Ernst_Mayr</a> <a href="#fnref:113" class="footnote-back-ref">↩</a></li>
<li id="fn:114">Popov, Igor (7 April 2005). "The Persistence of Heresy: The Concepts of Directed Evolution (Orthogenesis)". Archived from the original on 15 April 2017. Retrieved 15 April 2017. <a href="https://web.archive.org/web/20170415202806/http://www.kli.ac.at/events/event-detail/1112872500/the-persistence-of-heresy-the-concepts-of-directed-evolution-orthogenesis" target="_blank">https://web.archive.org/web/20170415202806/http://www.kli.ac.at/events/event-detail/1112872500/the-persistence-of-heresy-the-concepts-of-directed-evolution-orthogenesis</a> <a href="#fnref:114" class="footnote-back-ref">↩</a></li>
<li id="fn:115">Ruse, Michael (31 March 2010). "Edward O. Wilson on Sociobiology". The Chronicle of Higher Education. Retrieved 4 April 2017. <a href="/wiki/Michael_Ruse" target="_blank">/wiki/Michael_Ruse</a> <a href="#fnref:115" class="footnote-back-ref">↩</a></li>
<li id="fn:116">Ruse 1996, p. 536. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:116" class="footnote-back-ref">↩</a></li>
<li id="fn:117">Ruse 1996, p. 530. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:117" class="footnote-back-ref">↩</a></li>
<li id="fn:118">Ruse 1996, pp. 526–539. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:118" class="footnote-back-ref">↩</a></li>
<li id="fn:119">see, for example, Müller, Gerd B.; Newman, Stuart A., eds. (2003). Origination of Organismal Form. Bradford. ISBN 978-0-262-13419-4. <a href="978-0-262-13419-4" target="_blank">978-0-262-13419-4</a> <a href="#fnref:119" class="footnote-back-ref">↩</a></li>
<li id="fn:120">Tucker, Jennifer (28 October 2012). "What our most famous evolutionary cartoon gets wrong". The Boston Globe. Retrieved 29 December 2017. <a href="https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html" target="_blank">https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html</a> <a href="#fnref:120" class="footnote-back-ref">↩</a></li>
<li id="fn:121">Tucker, Jennifer (28 October 2012). "What our most famous evolutionary cartoon gets wrong". The Boston Globe. Retrieved 29 December 2017. <a href="https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html" target="_blank">https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html</a> <a href="#fnref:121" class="footnote-back-ref">↩</a></li>
<li id="fn:122">Tucker, Jennifer (28 October 2012). "What our most famous evolutionary cartoon gets wrong". The Boston Globe. Retrieved 29 December 2017. <a href="https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html" target="_blank">https://www.bostonglobe.com/ideas/2012/10/27/what-our-most-famous-evolutionary-cartoon-gets-wrong/drKMD5121W6EUxXJ4pF0YL/story.html</a> <a href="#fnref:122" class="footnote-back-ref">↩</a></li>
<li id="fn:123">Ruse 1996, pp. 526–539. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:123" class="footnote-back-ref">↩</a></li>
<li id="fn:124">Dawkins, Richard; Krebs, J. R. (1979). "Arms races between and within species". Proceedings of the Royal Society B. 205 (1161): 489–511. Bibcode:1979RSPSB.205..489D. doi:10.1098/rspb.1979.0081. PMID 42057. S2CID 9695900. <a href="/wiki/Richard_Dawkins" target="_blank">/wiki/Richard_Dawkins</a> <a href="#fnref:124" class="footnote-back-ref">↩</a></li>
<li id="fn:125">Ruse 1996, p. 466. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:125" class="footnote-back-ref">↩</a></li>
<li id="fn:126">Ruse 1996, p. 468. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:126" class="footnote-back-ref">↩</a></li>
<li id="fn:127">Dawkins 1986, p. 178. - Dawkins, Richard (1986). The Blind Watchmaker. Longman. ISBN 978-0-393-31570-7. <a href="https://archive.org/details/blindwatchmaker0000dawk" target="_blank">https://archive.org/details/blindwatchmaker0000dawk</a> <a href="#fnref:127" class="footnote-back-ref">↩</a></li>
<li id="fn:128">Ruse 1996, p. 468. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:128" class="footnote-back-ref">↩</a></li>
<li id="fn:129">Dawkins 1986, p. 181. - Dawkins, Richard (1986). The Blind Watchmaker. Longman. ISBN 978-0-393-31570-7. <a href="https://archive.org/details/blindwatchmaker0000dawk" target="_blank">https://archive.org/details/blindwatchmaker0000dawk</a> <a href="#fnref:129" class="footnote-back-ref">↩</a></li>
<li id="fn:130">Ruse 1996, p. 468. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:130" class="footnote-back-ref">↩</a></li>
<li id="fn:131">Ruse 1996, pp. 526–539. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:131" class="footnote-back-ref">↩</a></li>
<li id="fn:132">Ruse 1996, pp. 292–295. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:132" class="footnote-back-ref">↩</a></li>
<li id="fn:133">Ruse 1996, pp. 526–539. - Ruse, Michael (1996). Monad to man: the Concept of Progress in Evolutionary Biology. Harvard University Press. ISBN 978-0-674-03248-4. <a href="https://archive.org/details/monadtomanconcep0000ruse" target="_blank">https://archive.org/details/monadtomanconcep0000ruse</a> <a href="#fnref:133" class="footnote-back-ref">↩</a></li>
<li id="fn:134">Bowler 1989, p. 270. - Bowler, Peter J. (1989). Evolution: The History of an Idea. University of California Press. ISBN 978-0-520-06385-3. <a href="https://archive.org/details/evolutionhistory0000bowl" target="_blank">https://archive.org/details/evolutionhistory0000bowl</a> <a href="#fnref:134" class="footnote-back-ref">↩</a></li>
<li id="fn:135">Larson 2004, p. 127. - Larson, Edward J. (2004). Evolution. Modern Library. ISBN 978-0-679-64288-6. <a href="https://archive.org/details/evolutionremarka00lars" target="_blank">https://archive.org/details/evolutionremarka00lars</a> <a href="#fnref:135" class="footnote-back-ref">↩</a></li>
<li id="fn:136">Baxter, S.W.; Papa, R.; Chamberlain, N.; Humphray, S.J.; Joron, M.; Morrison, C.; ffrench-Constant, R.H.; McMillan, W.O.; Jiggins, C.D. (2008). "Convergent Evolution in the Genetic Basis of Mullerian Mimicry in Heliconius Butterflies". Genetics. 180 (3): 1567–1577. doi:10.1534/genetics.107.082982. PMC 2581958. PMID 18791259. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581958" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581958</a> <a href="#fnref:136" class="footnote-back-ref">↩</a></li>
</ol>

Orthogenesis open-in-new

Orthogenesis