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PPP5C
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><h2 id="interactions">Interactions</h2> <p>PPP5C has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/ASK1/fAPmL4xH">ASK1</a>,<a class="footnote-ref" id="fnref:3" href="#fn:3"><sup>3</sup></a> <a href="/facts/CRY2/YS0gfB1X">CRY2</a><a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a> <a href="/facts/GNA12/Wep4bDGb">GNA12</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a> and <a href="/facts/Rac1/4tNQpMVA">Rac1</a>,<a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Chen MX, McPartlin AE, Brown L, Chen YH, Barker HM, Cohen PT (Sep 1994). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395355">"A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus"</a>. <i>The EMBO Journal</i>. 13 (18): 4278–90. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1002%2Fj.1460-2075.1994.tb06748.x">10.1002/j.1460-2075.1994.tb06748.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395355">395355</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7925273">7925273</a>.</li> <li>Skinner J, Sinclair C, Romeo C, Armstrong D, Charbonneau H, Rossie S (Sep 1997). <a href="https://doi.org/10.1074%2Fjbc.272.36.22464">"Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5"</a>. <i>The Journal of Biological Chemistry</i>. 272 (36): 22464–71. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.36.22464">10.1074/jbc.272.36.22464</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9278397">9278397</a>.</li> <li>Shah BH, Catt KJ (Dec 2006). "Protein phosphatase 5 as a negative key regulator of Raf-1 activation". <i>Trends in Endocrinology and Metabolism</i>. 17 (10): 382–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2Fj.tem.2006.10.013">10.1016/j.tem.2006.10.013</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17084641">17084641</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:45060016">45060016</a>.</li> <li>Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). <a href="https://doi.org/10.1016%2F0014-5793%2892%2981418-L">"p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]"</a>. <i>FEBS Letters</i>. 312 (1): 95–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0014-5793%2892%2981418-L">10.1016/0014-5793(92)81418-L</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/1330687">1330687</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:34940651">34940651</a>.</li> <li>Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". <i>Gene</i>. 138 (1–2): 171–4. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2894%2990802-8">10.1016/0378-1119(94)90802-8</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8125298">8125298</a>.</li> <li>Xu X, Lagercrantz J, Zickert P, Bajalica-Lagercrantz S, Zetterberg A (Jan 1996). "Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene". <i>Biochemical and Biophysical Research Communications</i>. 218 (2): 514–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.1996.0092">10.1006/bbrc.1996.0092</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8561788">8561788</a>.</li> <li>Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (Jun 1997). <a href="https://doi.org/10.1074%2Fjbc.272.26.16224">"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin"</a>. <i>The Journal of Biological Chemistry</i>. 272 (26): 16224–30. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.26.16224">10.1074/jbc.272.26.16224</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9195923">9195923</a>.</li> <li>Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". <i>Gene</i>. 200 (1–2): 149–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0378-1119%2897%2900411-3">10.1016/S0378-1119(97)00411-3</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9373149">9373149</a>.</li> <li>Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". <i>Photochemistry and Photobiology</i>. 66 (5): 727–31. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1751-1097.1997.tb03214.x">10.1111/j.1751-1097.1997.tb03214.x</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9383998">9383998</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:32804361">32804361</a>.</li> <li>Ollendorff V, Donoghue DJ (Dec 1997). <a href="https://doi.org/10.1074%2Fjbc.272.51.32011">"The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex"</a>. <i>The Journal of Biological Chemistry</i>. 272 (51): 32011–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.272.51.32011">10.1074/jbc.272.51.32011</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9405394">9405394</a>.</li> <li>Das AK, Cohen PW, Barford D (Mar 1998). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170467">"The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions"</a>. <i>The EMBO Journal</i>. 17 (5): 1192–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2F17.5.1192">10.1093/emboj/17.5.1192</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170467">1170467</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9482716">9482716</a>.</li> <li>Russell LC, Whitt SR, Chen MS, Chinkers M (Jul 1999). <a href="https://doi.org/10.1074%2Fjbc.274.29.20060">"Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90"</a>. <i>The Journal of Biological Chemistry</i>. 274 (29): 20060–3. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.274.29.20060">10.1074/jbc.274.29.20060</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10400612">10400612</a>.</li> <li>Lubert EJ, Hong Y, Sarge KD (Oct 2001). <a href="https://doi.org/10.1074%2Fjbc.M106906200">"Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5"</a>. <i>The Journal of Biological Chemistry</i>. 276 (42): 38582–7. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M106906200">10.1074/jbc.M106906200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11504734">11504734</a>.</li> <li>Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125685">"Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress"</a>. <i>The EMBO Journal</i>. 20 (21): 6028–36. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Femboj%2F20.21.6028">10.1093/emboj/20.21.6028</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125685">125685</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11689443">11689443</a>.</li> <li>Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S (Oct 2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044491">"Protein phosphatase 5 protects neurons against amyloid-beta toxicity"</a>. <i>Journal of Neurochemistry</i>. 111 (2): 391–402. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fj.1471-4159.2009.06337.x">10.1111/j.1471-4159.2009.06337.x</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044491">3044491</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19686245">19686245</a>.</li> <li>Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). <a href="https://doi.org/10.1016%2FS0960-9822%2802%2901034-5">"Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity"</a>. <i>Current Biology</i>. 12 (15): 1353–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0960-9822%2802%2901034-5">10.1016/S0960-9822(02)01034-5</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12176367">12176367</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:11485795">11485795</a>.</li> <li>Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL (Mar 2006). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458818">"Rac GTPase signaling through the PP5 protein phosphatase"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 103 (13): 5202–6. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2006PNAS..103.5202G">2006PNAS..103.5202G</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.0600080103">10.1073/pnas.0600080103</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458818">1458818</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/16549782">16549782</a>.</li> <li>Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX (2003). "Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5". <i>Neuroscience</i>. 115 (3): 829–37. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0306-4522%2802%2900510-9">10.1016/S0306-4522(02)00510-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12435421">12435421</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:26118803">26118803</a>.</li> <li>Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE (Mar 2003). <a href="https://doi.org/10.1074%2Fjbc.M210993200">"Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression"</a>. <i>The Journal of Biological Chemistry</i>. 278 (11): 9747–53. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M210993200">10.1074/jbc.M210993200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12519780">12519780</a>.</li> <li>Tomsig JL, Snyder SL, Creutz CE (Mar 2003). <a href="https://doi.org/10.1074%2Fjbc.M212632200">"Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif"</a>. <i>The Journal of Biological Chemistry</i>. 278 (12): 10048–54. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M212632200">10.1074/jbc.M212632200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12522145">12522145</a>.</li> <li>Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". <i>Oncogene</i>. 22 (21): 3307–18. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1206406">10.1038/sj.onc.1206406</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12761501">12761501</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:38880905">38880905</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Sep 1995). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics. 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>"Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5536" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5536</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125685" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125685</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795. <a href="https://doi.org/10.1016%2FS0960-9822%2802%2901034-5" target="_blank">https://doi.org/10.1016%2FS0960-9822%2802%2901034-5</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Chatterjee A, Wang L, Armstrong DL, Rossie S (Feb 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". The Journal of Biological Chemistry. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC 2823530. PMID 19948726. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823530" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823530</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>