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<h2 id="interactions">Interactions</h2> <p>GRAP has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/Linker_of_activated_T_cells/9pTsf4cY">Linker of activated T cells</a>.<a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a> </p> <h2 id="further-reading">Further reading</h2> <ul><li>Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". <i>Oncogene</i>. 16 (7): 891–901. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.onc.1201607">10.1038/sj.onc.1201607</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9484780">9484780</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:28452652">28452652</a>.</li> <li>Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). <a href="https://doi.org/10.1016%2FS0092-8674%2800%2980901-0">"LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation"</a>. <i>Cell</i>. 92 (1): 83–92. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0092-8674%2800%2980901-0">10.1016/S0092-8674(00)80901-0</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9489702">9489702</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:1806525">1806525</a>.</li> <li>Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". <i>FEBS Letters</i>. 509 (2): 255–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0014-5793%2801%2903174-X">10.1016/S0014-5793(01)03174-X</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11741599">11741599</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:33084576">33084576</a>.</li> <li>Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). <a href="https://doi.org/10.1074%2Fjbc.M304594200">"GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2"</a>. <i>The Journal of Biological Chemistry</i>. 278 (36): 34641–53. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M304594200">10.1074/jbc.M304594200</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12819203">12819203</a>.</li> <li>Shiraiwa H, Takei M, Yoshikawa T, Azuma T, Kato M, Mitamura K, Ueki T, Kida A, Horie T, Seki N, Sawada S (2004). <a href="https://doi.org/10.1177%2F147323000403200308">"Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome"</a>. <i>The Journal of International Medical Research</i>. 32 (3): 284–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1177%2F147323000403200308">10.1177/147323000403200308</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/15174222">15174222</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological Chemistry. 271 (21): 12129–32. doi:10.1074/jbc.271.21.12129. PMID 8647802. <a href="https://doi.org/10.1074%2Fjbc.271.21.12129" target="_blank">https://doi.org/10.1074%2Fjbc.271.21.12129</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Jan 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". The Journal of Biological Chemistry. 272 (2): 894–902. doi:10.1074/jbc.272.2.894. PMID 8995379. <a href="https://doi.org/10.1074%2Fjbc.272.2.894" target="_blank">https://doi.org/10.1074%2Fjbc.272.2.894</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>"Entrez Gene: GRAP GRB2-related adaptor protein". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>"Entrez Gene: GRAP GRB2-related adaptor protein". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10750</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. doi:10.1016/S0092-8674(00)80901-0. PMID 9489702. S2CID 1806525. <a href="https://doi.org/10.1016%2FS0092-8674%2800%2980901-0" target="_blank">https://doi.org/10.1016%2FS0092-8674%2800%2980901-0</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. doi:10.1021/bi025554o. PMID 12186560. <a href="/wiki/Doi_(identifier)" target="_blank">/wiki/Doi_(identifier)</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> </ol>