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Chrysanthemyl diphosphate synthase
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<p>In <a href="/facts/Enzymology/DSI1Fh7y">enzymology</a>, a chrysanthemyl diphosphate synthase (<a href="/facts/Enzyme_Commission_number/Y5GNLRKX">EC</a> <a href="https://enzyme.expasy.org/EC/2.5.1.67">2.5.1.67</a>) is an <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> involved in the <a href="/facts/Biosynthesis/aFk7Tk7f">biosynthesis</a> of <a href="/facts/Terpenoid/1GvG7W7v">terpenoids</a>. This <a href="/facts/Enzyme/DSI1Fh7y">enzyme</a> is also known as CPPase. It <a href="/facts/Catalysis/LPBS7TQC">catalyzes</a> the <a href="/facts/Chemical_reaction/GpqWlKrz">chemical reaction</a> shown below (color-coded to show how precursors link): </p> <p>The <a href="/facts/Substrate_(biochemistry)/6MnaV19h">substrate</a> of CPPase is <a href="/facts/Dimethylallyl_diphosphate/F5WVQmBj">dimethylallyl diphosphate</a>. The two <a href="/facts/Product_(chemistry)/8uCoDUdv">products</a> are <a href="/facts/Diphosphate/L9FPEkhF">diphosphate</a> and chrysanthemyl diphosphate. </p><p>This enzyme is involved in the biosynthesis of <a href="/facts/Pyrethrin/7p2KNrlc">pyrethrins</a>, highly potent <a href="/facts/Insecticide/1xYL3MSD">insecticides</a> found in some flowers. The <a href="/facts/List_of_enzymes/w2RP6EwU">systematic name</a> of this enzyme class is dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming). </p> <ul><li>Shattuck-Eidens DM, Wrobel WM, Peiser GD, Poulter CD (2001). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31842">"Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 98 (8): 4373–8. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2001PNAS...98.4373R">2001PNAS...98.4373R</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.071543598">10.1073/pnas.071543598</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC31842">31842</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/11287653">11287653</a>.</li> <li>Erickson HK, Poulter CD (2003). "Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway". <i>J. Am. Chem. Soc</i>. 125 (23): 6886–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1021%2Fja034520g">10.1021/ja034520g</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12783539">12783539</a>.</li></ul>