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Angiopoietin 1
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<h2 id="interactions">Interactions</h2> <p>Angiopoietin 1 has been shown to <a href="/facts/Protein-protein_interaction/etvm9Wmg">interact</a> with <a href="/facts/TEK_tyrosine_kinase/HwJL8pPl">TEK tyrosine kinase</a>.<a class="footnote-ref" id="fnref:4" href="#fn:4"><sup>4</sup></a><a class="footnote-ref" id="fnref:5" href="#fn:5"><sup>5</sup></a><a class="footnote-ref" id="fnref:6" href="#fn:6"><sup>6</sup></a><a class="footnote-ref" id="fnref:7" href="#fn:7"><sup>7</sup></a> </p> <h2 id="placental-malaria">Placental Malaria</h2> <p>Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with <i>Plasmodium</i> (the causative agent of malaria).<a class="footnote-ref" id="fnref:8" href="#fn:8"><sup>8</sup></a> In a mouse model of PM, <i>Plasmodium</i> infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta.<a class="footnote-ref" id="fnref:9" href="#fn:9"><sup>9</sup></a> This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM. </p> <h2 id="see-also">See also</h2> <ul><li><a href="/facts/Angiopoietin/eK3rqdHE">Angiopoietin</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Nakajima D, Okazaki N, Yamakawa H (2003). <a href="https://doi.org/10.1093%2Fdnares%2F9.3.99">"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones"</a>. <i>DNA Res</i>. 9 (3): 99–106. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F9.3.99">10.1093/dnares/9.3.99</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/12168954">12168954</a>.</li> <li>Metheny-Barlow LJ, Li LY (2004). <a href="https://doi.org/10.1038%2Fsj.cr.7290176">"The enigmatic role of angiopoietin-1 in tumor angiogenesis"</a>. <i>Cell Res</i>. 13 (5): 309–17. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fsj.cr.7290176">10.1038/sj.cr.7290176</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/14672554">14672554</a>.</li> <li>Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling". <i>Curr. Mol. Med</i>. 6 (8): 831–41. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.2174%2F156652406779010795">10.2174/156652406779010795</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17168735">17168735</a>.</li> <li>Nomura N, Miyajima N, Sazuka T (1995). <a href="https://doi.org/10.1093%2Fdnares%2F1.1.27">"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1"</a>. <i>DNA Res</i>. 1 (1): 27–35. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F1.1.27">10.1093/dnares/1.1.27</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7584026">7584026</a>.</li> <li>Nomura N, Miyajima N, Sazuka T (1995). <a href="https://doi.org/10.1093%2Fdnares%2F1.1.47">"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)"</a>. <i>DNA Res</i>. 1 (1): 47–56. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fdnares%2F1.1.47">10.1093/dnares/1.1.47</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7584028">7584028</a>.</li> <li>Rüegg C, Pytela R (1995). "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein". <i>Gene</i>. 160 (2): 257–62. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2F0378-1119%2895%2900240-7">10.1016/0378-1119(95)00240-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/7642106">7642106</a>.</li> <li>Davis S, Aldrich TH, Jones PF (1997). <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981812-7">"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning"</a>. <i>Cell</i>. 87 (7): 1161–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0092-8674%2800%2981812-7">10.1016/S0092-8674(00)81812-7</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8980223">8980223</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:17197564">17197564</a>.</li> <li>Suri C, Jones PF, Patan S (1997). <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981813-9">"Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis"</a>. <i>Cell</i>. 87 (7): 1171–80. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0092-8674%2800%2981813-9">10.1016/S0092-8674(00)81813-9</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/8980224">8980224</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:15926708">15926708</a>.</li> <li>Maisonpierre PC, Suri C, Jones PF (1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". <i>Science</i>. 277 (5322): 55–60. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.277.5322.55">10.1126/science.277.5322.55</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9204896">9204896</a>.</li> <li>Ristimäki A, Narko K, Enholm B (1998). <a href="https://doi.org/10.1074%2Fjbc.273.14.8413">"Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C"</a>. <i>J. Biol. Chem</i>. 273 (14): 8413–8. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.14.8413">10.1074/jbc.273.14.8413</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9525952">9525952</a>.</li> <li>Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". <i>Genomics</i>. 48 (3): 389–91. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fgeno.1997.5207">10.1006/geno.1997.5207</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9545648">9545648</a>.</li> <li>Witzenbichler B, Maisonpierre PC, Jones P (1998). <a href="https://doi.org/10.1074%2Fjbc.273.29.18514">"Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2"</a>. <i>J. Biol. Chem</i>. 273 (29): 18514–21. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.273.29.18514">10.1074/jbc.273.29.18514</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9660821">9660821</a>.</li> <li>Sato A, Iwama A, Takakura N (1998). <a href="https://doi.org/10.1093%2Fintimm%2F10.8.1217">"Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells"</a>. <i>Int. Immunol</i>. 10 (8): 1217–27. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fintimm%2F10.8.1217">10.1093/intimm/10.8.1217</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/9723709">9723709</a>.</li> <li>Valenzuela DM, Griffiths JA, Rojas J (1999). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26709">"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans"</a>. <i>Proc. Natl. Acad. Sci. U.S.A</i>. 96 (5): 1904–9. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/1999PNAS...96.1904V">1999PNAS...96.1904V</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1073%2Fpnas.96.5.1904">10.1073/pnas.96.5.1904</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26709">26709</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10051567">10051567</a>.</li> <li>Grosios K, Leek JP, Markham AF (1999). "Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping". <i>Cytogenet. Cell Genet</i>. 84 (1–2): 118–20. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1159%2F000015235">10.1159/000015235</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10343124">10343124</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:40232421">40232421</a>.</li> <li>Procopio WN, Pelavin PI, Lee WM, Yielding NM (1999). <a href="https://doi.org/10.1074%2Fjbc.274.42.30196">"Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity"</a>. <i>J. Biol. Chem</i>. 274 (42): 30196–201. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.274.42.30196">10.1074/jbc.274.42.30196</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10514510">10514510</a>.</li> <li>Huang YQ, Li JJ, Karpatkin S (2000). "Identification of a family of alternatively spliced mRNA species of angiopoietin-1". <i>Blood</i>. 95 (6): 1993–9. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1182%2Fblood.V95.6.1993">10.1182/blood.V95.6.1993</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10706866">10706866</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:34946654">34946654</a>.</li> <li>Kim I, Kim JH, Ryu YS (2000). <a href="https://doi.org/10.1074%2Fjbc.M910084199">"Characterization and expression of a novel alternatively spliced human angiopoietin-2"</a>. <i>J. Biol. Chem</i>. 275 (24): 18550–6. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1074%2Fjbc.M910084199">10.1074/jbc.M910084199</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10766762">10766762</a>.</li> <li>Dunk C, Shams M, Nijjar S (2000). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850068">"Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development"</a>. <i>Am. J. Pathol</i>. 156 (6): 2185–99. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1016%2FS0002-9440%2810%2965089-4">10.1016/S0002-9440(10)65089-4</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850068">1850068</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10854239">10854239</a>.</li> <li>Krikun G, Schatz F, Finlay T (2000). <a href="https://doi.org/10.1006%2Fbbrc.2000.3277">"Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation"</a>. <i>Biochem. Biophys. Res. Commun</i>. 275 (1): 159–63. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1006%2Fbbrc.2000.3277">10.1006/bbrc.2000.3277</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/10944458">10944458</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ANGPT1"><i>ANGPT1</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ANGPT1"><i>ANGPT1</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <p><i>This article incorporates text from the <a href="/facts/United_States_National_Library_of_Medicine/Hzty0MCX">United States National Library of Medicine</a>, which is in the <a href="/facts/Public_domain/YWKMDKw4">public domain</a>.</i> </p> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>"Entrez Gene: ANGPT1 angiopoietin 1". <a href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284" target="_blank">https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Suri, Chitra; Jones, Pamela F; Patan, Sybill; Bartunkova, Sona; Maisonpierre, Peter C; Davis, Samuel; Sato, Thomas N; Yancopoulos, George D (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171–80. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224. S2CID 15926708. <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981813-9" target="_blank">https://doi.org/10.1016%2FS0092-8674%2800%2981813-9</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Kappou D, Sifakis S, Konstantinidou A, et al. Role of angiopoietin/Tie system in pregnancy.Experimental and Therapeutic Medicine. 2015; 9(4): 1091-1096. <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> <li id="fn:4"><p>Fiedler, Ulrike; Krissl, Tanja; Koidl, Stefanie; Weiss, Cornelia; Koblizek, Thomas; Deutsch, Urban; Martiny-Baron, Georg; Marmé, Dieter; Augustin, Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. 278 (3). United States: 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764. <a href="https://doi.org/10.1074%2Fjbc.M208550200" target="_blank">https://doi.org/10.1074%2Fjbc.M208550200</a> <a href="#fnref:4" class="footnote-back-ref">↩</a></p></li> <li id="fn:5"><p>Davis, S; Aldrich, T H; Jones, P F; Acheson, A; Compton, D L; Jain, V; Ryan, T E; Bruno, J; Radziejewski, C; Maisonpierre, P C; Yancopoulos, G D (Dec 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7). United States: 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223. S2CID 17197564. <a href="https://doi.org/10.1016%2FS0092-8674%2800%2981812-7" target="_blank">https://doi.org/10.1016%2FS0092-8674%2800%2981812-7</a> <a href="#fnref:5" class="footnote-back-ref">↩</a></p></li> <li id="fn:6"><p>Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (Aug 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. 10 (8). ENGLAND: 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709. <a href="https://doi.org/10.1093%2Fintimm%2F10.8.1217" target="_blank">https://doi.org/10.1093%2Fintimm%2F10.8.1217</a> <a href="#fnref:6" class="footnote-back-ref">↩</a></p></li> <li id="fn:7"><p>Maisonpierre, P C; Suri, C; Jones, P F; Bartunkova, S; Wiegand, S J; Radziejewski, C; Compton, D; McClain, J; Aldrich, T H; Papadopoulos, N; Daly, T J; Davis, S; Sato, T N; Yancopoulos, G D (Jul 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322). UNITED STATES: 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896. <a href="/wiki/Science_(journal)" target="_blank">/wiki/Science_(journal)</a> <a href="#fnref:7" class="footnote-back-ref">↩</a></p></li> <li id="fn:8"><p>Ataíde, Ricardo; Murillo, Oscar; Dombrowski, Jamille G.; Souza, Rodrigo M.; Lima, Flávia A.; Lima, Giselle F. M. C.; Hristov, Angélica D.; Valle, Suiane C. N.; Santi, Silvia M. Di (2015-06-19). "Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta". PLOS Neglected Tropical Diseases. 9 (6): e0003824. doi:10.1371/journal.pntd.0003824. ISSN 1935-2735. PMC 4475015. PMID 26090803. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475015" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475015</a> <a href="#fnref:8" class="footnote-back-ref">↩</a></p></li> <li id="fn:9"><p>Silver, Karlee L.; Zhong, Kathleen; Leke, Rose G. F.; Taylor, Diane Wallace; Kain, Kevin C. (2010-03-01). "Dysregulation of angiopoietins is associated with placental malaria and low birth weight". PLOS ONE. 5 (3): e9481. Bibcode:2010PLoSO...5.9481S. doi:10.1371/journal.pone.0009481. ISSN 1932-6203. PMC 2830425. PMID 20208992. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830425" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830425</a> <a href="#fnref:9" class="footnote-back-ref">↩</a></p></li> </ol>