Musca was one of the 12 constellations established by the astronomer Petrus Plancius from the observations of the southern sky by the Dutch explorers Pieter Dirkszoon Keyser and Frederick de Houtman, who had sailed on the first Dutch trading expedition, known as the Eerste Schipvaart, to the East Indies. De Houtman included it in his southern star catalogue in 1598 under the Dutch name De Vlieghe, "The Fly". They assigned four stars to the constellation, with a star that would be later designated as Beta Muscae marking the head, Gamma the body, and Alpha and Delta the left and right wings, respectively. It first appeared on a 35-cm-diameter (14-in) celestial globe published in 1598 in Amsterdam by Plancius with Jodocus Hondius, though was unnamed. The first depiction of this constellation in a celestial atlas was in the German cartographer Johann Bayer's Uranometria of 1603, though Bayer termed it Apis— "the Bee", a name by which it was known for the next two centuries. A 1603 celestial globe by Willem Blaeu depicts it as providing nourishment for the nearby constellation Chamaeleon—its tongue trying to catch the insect.
Delta and Epsilon mark the fly's left wing and right wing, respectively. With an apparent magnitude of 3.62, Delta is an orange giant of spectral type K2III located around 91 light-years away. Epsilon Muscae is a red giant of spectral type M5III and semiregular variable that ranges between magnitudes 3.99 and 4.31 over approximately 40 days. It has expanded to 130 times the Sun's diameter and 1800 to 2300 its luminosity. It was a star originally 1.5 to 2 times as massive as the Sun. Although of a similar distance—around 302 light-years—to the stars of the Lower Centaurus Crux subgroup, it is moving much faster at around 100 km/s and does not share a common origin. To the northwest lies Mu Muscae, an orange giant of spectral type K4III that varies between apparent magnitude 4.71 and 4.76, and has been classified as a slow, irregular variable. Near Mu is Lambda Muscae, the third-brightest star in the constellation and a white main-sequence star of spectral type A7V around 128 light-years distant from Earth.
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