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CDKN2BAS
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<h2 id="see-also">See also</h2> <ul><li><a href="/facts/Long_noncoding_RNA/FHyAb6hP">Long noncoding RNA</a></li></ul> <h2 id="further-reading">Further reading</h2> <ul><li>Mußotter T, Kluwe L, Högel J, Nguyen R, Cooper DN, Mautner VF, Kehrer-Sawatzki H (October 2012). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500256">"Non-coding RNA ANRIL and the number of plexiform neurofibromas in patients with NF1 microdeletions"</a>. <i>BMC Medical Genetics</i>. 13: 98. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1186%2F1471-2350-13-98">10.1186/1471-2350-13-98</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500256">3500256</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/23101500">23101500</a>.</li> <li>McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. (June 2007). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711874">"A common allele on chromosome 9 associated with coronary heart disease"</a>. <i>Science</i>. 316 (5830): 1488–1491. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2007Sci...316.1488M">2007Sci...316.1488M</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1142447">10.1126/science.1142447</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711874">2711874</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17478681">17478681</a>.</li> <li>Folkersen L, Kyriakou T, Goel A, Peden J, Mälarstig A, Paulsson-Berne G, et al. (November 2009). Reitsma PH (ed.). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765615">"Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants"</a>. <i>PLOS ONE</i>. 4 (11): e7677. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2009PLoSO...4.7677F">2009PLoSO...4.7677F</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pone.0007677">10.1371/journal.pone.0007677</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765615">2765615</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19888323">19888323</a>.</li> <li>Uno S, Zembutsu H, Hirasawa A, Takahashi A, Kubo M, Akahane T, et al. (August 2010). "A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese". <i>Nature Genetics</i>. 42 (8): 707–710. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.612">10.1038/ng.612</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20601957">20601957</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:205356736">205356736</a>.</li> <li>Wrensch M, Jenkins RB, Chang JS, Yeh RF, Xiao Y, Decker PA, et al. (August 2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923561">"Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility"</a>. <i>Nature Genetics</i>. 41 (8): 905–908. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.408">10.1038/ng.408</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923561">2923561</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19578366">19578366</a>.</li> <li>Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, et al. (December 2008). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682433">"Susceptibility loci for intracranial aneurysm in European and Japanese populations"</a>. <i>Nature Genetics</i>. 40 (12): 1472–1477. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.240">10.1038/ng.240</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682433">2682433</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18997786">18997786</a>.</li> <li>Sato K, Nakagawa H, Tajima A, Yoshida K, Inoue I (September 2010). <a href="https://doi.org/10.3892%2For_00000910">"ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1"</a>. <i>Oncology Reports</i>. 24 (3): 701–707. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.3892%2For_00000910">10.3892/or_00000910</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20664976">20664976</a>.</li> <li>Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, et al. (May 2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861730">"Genome-wide association study of intracranial aneurysm identifies three new risk loci"</a>. <i>Nature Genetics</i>. 42 (5): 420–425. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.563">10.1038/ng.563</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861730">2861730</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20364137">20364137</a>.</li> <li>Broadbent HM, Peden JF, Lorkowski S, Goel A, Ongen H, Green F, et al. (March 2008). <a href="https://doi.org/10.1093%2Fhmg%2Fddm352">"Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p"</a>. <i>Human Molecular Genetics</i>. 17 (6): 806–814. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1093%2Fhmg%2Fddm352">10.1093/hmg/ddm352</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/18048406">18048406</a>.</li> <li>Hashikata H, Liu W, Inoue K, Mineharu Y, Yamada S, Nanayakkara S, et al. (June 2010). <a href="https://doi.org/10.1161%2FSTROKEAHA.109.576694">"Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients"</a>. <i>Stroke</i>. 41 (6): 1138–1144. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1161%2FSTROKEAHA.109.576694">10.1161/STROKEAHA.109.576694</a>. <a href="/facts/Hdl_(identifier)/rdebSxmC">hdl</a>:<a href="https://hdl.handle.net/2433%2F142049">2433/142049</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20395613">20395613</a>.</li> <li>Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, et al. (June 2007). "A common variant on chromosome 9p21 affects the risk of myocardial infarction". <i>Science</i>. 316 (5830): 1491–1493. <a href="/facts/Bibcode_(identifier)/9HtdQSGB">Bibcode</a>:<a href="https://ui.adsabs.harvard.edu/abs/2007Sci...316.1491H">2007Sci...316.1491H</a>. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1126%2Fscience.1142842">10.1126/science.1142842</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/17478679">17478679</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:71851374">71851374</a>.</li> <li>Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, et al. (December 2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233727">"Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations"</a>. <i>Familial Cancer</i>. 9 (4): 625–633. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1007%2Fs10689-010-9356-3">10.1007/s10689-010-9356-3</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233727">3233727</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20574843">20574843</a>.</li> <li>Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, et al. (August 2009). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501476">"Genome-wide association study identifies five susceptibility loci for glioma"</a>. <i>Nature Genetics</i>. 41 (8): 899–904. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.407">10.1038/ng.407</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501476">4501476</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19578367">19578367</a>.</li> <li>Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, Chen LZ, et al. (July 2010). "A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci". <i>Nature Genetics</i>. 42 (7): 599–603. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.601">10.1038/ng.601</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20512145">20512145</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:205356689">205356689</a>.</li> <li>Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, Maranian M, et al. (June 2010). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632836">"Genome-wide association study identifies five new breast cancer susceptibility loci"</a>. <i>Nature Genetics</i>. 42 (6): 504–507. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1038%2Fng.586">10.1038/ng.586</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632836">3632836</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/20453838">20453838</a>.</li> <li>Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, Nothnagel M, El Mokhtari NE, et al. (February 2009). Marchini J (ed.). <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632758">"Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis"</a>. <i>PLOS Genetics</i>. 5 (2): e1000378. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1371%2Fjournal.pgen.1000378">10.1371/journal.pgen.1000378</a>. <a href="/facts/PMC_(identifier)/dX1zMt71">PMC</a> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632758">2632758</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/19214202">19214202</a>.</li> <li>Chen L, Qu H, Guo M, Zhang Y, Cui Y, Yang Q, et al. (April 2020). <a href="https://doi.org/10.1111%2Fjcpt.13060">"ANRIL and atherosclerosis"</a>. <i>Journal of Clinical Pharmacy and Therapeutics</i>. 45 (2): 240–248. <a href="/facts/Doi_(identifier)/muM9Etpq">doi</a>:<a href="https://doi.org/10.1111%2Fjcpt.13060">10.1111/jcpt.13060</a>. <a href="/facts/PMID_(identifier)/JlHAvMHt">PMID</a> <a href="https://pubmed.ncbi.nlm.nih.gov/31703157">31703157</a>. <a href="/facts/S2CID_(identifier)/ldJsHa2Y">S2CID</a> <a href="https://api.semanticscholar.org/CorpusID:207956113">207956113</a>.</li></ul> <h2 id="external-links">External links</h2> <ul><li></li> <li><a href="http://rfam.xfam.org/family?entry=RF01909">Page for CDKN2B antisense RNA 1 intronic conserved region</a> at <a href="/facts/Rfam/pl9awpRM">Rfam</a></li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CDKN2B-AS"><i>CDKN2B-AS</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CDKN2B-AS"><i>CDKN2B-AS</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li> <li>Human <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=CDKN2B-AS1"><i>CDKN2B-AS1</i></a> genome location and <a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=CDKN2B-AS1"><i>CDKN2B-AS1</i></a> gene details page in the <a href="/facts/UCSC_Genome_Browser/kwumPyLb">UCSC Genome Browser</a>.</li></ul> <h2 id="references">References</h2> <ol> <li id="fn:1"><p>Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B (April 2010). Gibson G (ed.). "Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression". PLOS Genetics. 6 (4): e1000899. doi:10.1371/journal.pgen.1000899. PMC 2851566. PMID 20386740. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851566" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851566</a> <a href="#fnref:1" class="footnote-back-ref">↩</a></p></li> <li id="fn:2"><p>Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Molecular Cell. 38 (5): 662–674. doi:10.1016/j.molcel.2010.03.021. PMC 2886305. PMID 20541999. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886305" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886305</a> <a href="#fnref:2" class="footnote-back-ref">↩</a></p></li> <li id="fn:3"><p>Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M, Xiong Y (April 2011). "Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene". Oncogene. 30 (16): 1956–1962. doi:10.1038/onc.2010.568. PMC 3230933. PMID 21151178. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230933" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230933</a> <a href="#fnref:3" class="footnote-back-ref">↩</a></p></li> </ol>